BGC0002203 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002203 (Beauveria bassiana ARSEF 2860)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	33,767	beauverolide Ba/beauverolide Ka/beauverolide Ca	NRPS:Type I+PKS+other:other	100%

BGC0002203 - Region 1 - NRPS,T1PKS

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Location: 1 - 33,767 nt. (total: 33,767 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,768
Label		BGC0002203

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002203	1.57	NRP, Polyketide, Other	beauveriolide B, beauveriolide C, beauveriolide D	Beauveria bassiana ARSEF 2860
BGC0002259	0.90	Polyketide, NRP	beauveriolide I, beauveriolide III	Cordyceps militaris CM01
BGC0002191	0.64	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002515	0.61	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002525	0.61	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0001252	0.60	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002155	0.60	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001899	0.57	Polyketide	abscisic acid	Leptosphaeria maculans JN3
BGC0000146	0.56	Polyketide	solanapyrone D	Alternaria solani
BGC0000343	0.54	NRP	enterobactin	Pseudomonas sp. J465

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002203	1.00	NRP, Polyketide, Other	beauveriolide B, beauveriolide C, beauveriolide D	Beauveria bassiana ARSEF 2860
BGC0002259	0.85	Polyketide, NRP	beauveriolide I, beauveriolide III	Cordyceps militaris CM01
BGC0002191	0.65	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000343	0.65	NRP	enterobactin	Pseudomonas sp. J465
BGC0002515	0.64	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002525	0.64	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0001252	0.64	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002155	0.63	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001261	0.62	NRP	AM-toxin	Alternaria alternata
BGC0001899	0.62	Polyketide	abscisic acid	Leptosphaeria maculans JN3

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33767:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X - Phe - D-Ile)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 32324:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X - Phe - D-Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BBA_08219

PKS_AT (558..878): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 69.7
Methylmalonyl-CoA: 64.8
Malonyl-CoA: 52.0
Ethylmalonyl-CoA: 41.2
2-Methylbutyryl-CoA: 29.4
Isobutyryl-CoA: 29.3
Propionyl-CoA: 24.6
Benzoyl-CoA: 18.3
fatty_acid: 17.5
trans-1,2-CPDA: 16.4
3-Methylbutyryl-CoA: 15.1
inactive: 11.9
CHC-CoA: 10.7
Acetyl-CoA: 0.0

BBA_08221

AMP-binding (33..463): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GIGYVGAIVK
Nearest Stachelhaus code(s):: nohBza GLGLVGAIIK (32% 8Å match)
Stachelhaus code match:: 70% (weak)

BBA_08222

Search NORINE for peptide: strict or relaxed

AMP-binding (686..1080): X

nrpys: Phe, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFCVIGIIK
Nearest Stachelhaus code(s):: Phe or Trp DAFCVIGIIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2251..2643): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DPTIVGAIIK
Nearest Stachelhaus code(s):: Phe DPTIVGAIIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3352..3745): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMHMMGVMIK
Nearest Stachelhaus code(s):: Ile DMHMMGVMIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)