BGC0002203: beauverolide Ba biosynthetic gene cluster from Beauveria bassiana ARSEF 2860
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Location: 140,202 - 173,968 nt. (total: 33,767 nt).
This entry is originally from NCBI GenBank JH725181.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002203
Short description beauverolide Ba biosynthetic gene cluster from Beauveria bassiana ARSEF 2860
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
  • other (other)
Loci
JH725181.1
140202 - 173968
via Knock-out studies
Compounds
  • beauverolide Ba
  • beauverolide Ka
  • beauverolide Ca
Species Beauveria bassiana ARSEF 2860 [taxonomy]
References
Chemical products information
beauverolide Ba Evidence: Mass spectrometry [1]
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C31H49N3O5
beauverolide Ka Evidence: Mass spectrometry [1]
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C37H50N4O5
beauverolide Ca Evidence: Mass spectrometry [1]
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C35H49N3O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBA_08217
  • EJP62830.1
 140202 - 141354 (+) 2OG-Fe(II) oxygenase family oxidoreductase
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    • BBA_08218
    • EJP62831.1
    		 141718 - 142455 (-) Acyl-CoA N-acyltransferase
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      • BBA_08219
      • EJP62832.1
      		 144519 - 152525 (-) polyketide synthase, putative
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        • BBA_08220
        • EJP62833.1
        		 154066 - 155550 (+) trichothecene 3-O-acetyltransferase
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          • BBA_08221
          • EJP62834.1
          		 155886 - 158183 (-) 4-coumarate-CoA ligase
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            • BBA_08222
            • EJP62835.1
            		 158763 - 173968 (+) nonribosomal peptide synthase, putative
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              Biosynthesis information

              Biosynthetic modules

              Name
              Unk01
              Type
              nrps-type1
              Genes
              BBA_08222
              Substrates
              valine, phenylalanine, tryptophan (evidence: Structure-based inference, Mass spectrometry)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk02
              Type
              nrps-type1
              Genes
              BBA_08222
              Substrates
              phenylalanine (evidence: Structure-based inference [2])
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk03
              Type
              nrps-type1
              Genes
              BBA_08222
              Substrates
              isoleucine (evidence: Structure-based inference [2])
              Integrated Monomers
              Domains
              adenylation
              Annotation changelog

              Entry version: next

              Date
              Changes
              Submitters
              Reviewers
              2024-05-18
              MIBiG v4 annotathon
              • (ID: JJ7RTSDO447PEX22VJY25UR5)
              • (ID: 4B6CAZ6GBFQV2DK75DYGLHB6)
              • (ID: IGMARHSR3IS5UOGRYN2CEMQD)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Entry added
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Added NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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