BGC0002204: flavichalasine F biosynthetic gene cluster from Aspergillus flavipes
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Location: 1 - 39,708 nt. (total: 39,708 nt).
This entry is originally from NCBI GenBank MT586757.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002204
Short description flavichalasine F biosynthetic gene cluster from Aspergillus flavipes
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • NRPS (Type I)
Loci
MT586757.1
via Knock-out studies
Compounds
  • flavichalasine F
  • flavichalasine G
  • aspochalasin C
  • aspochalasin E
  • aspochalasin M
  • TMC-169
  • aspergillin PZ
Species Aspergillus flavipes [taxonomy]
References
Chemical products information
flavichalasine F Evidence:
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Chemical database entries
NPAtlas
flavichalasine G Evidence:
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Chemical database entries
NPAtlas
aspochalasin C Evidence:
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Chemical database entries
ChemSpider
PubCHEM
aspochalasin E Evidence:
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Chemical database entries
NPAtlas
PubCHEM
aspochalasin M Evidence:
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Chemical database entries
NPAtlas
TMC-169 Evidence:
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Chemical database entries
NPAtlas
aspergillin PZ Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QOG08941.1
  • ffsC
 1549 - 2759 (+) FfsC
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    • QOG08942.1
    • ffsR
    		 4065 - 6005 (+) FfsR
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      • QOG08943.1
      • ffsD
      		 6612 - 8317 (+) FfsD
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        • QOG08944.1
        • ffsA
        		 9389 - 21912 (+) FfsA
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          • QOG08945.1
          • ffsH
          		 25197 - 26995 (+) FfsH
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            • QOG08946.1
            • ffsI
            		 27323 - 28405 (-) FfsI
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              • QOG08947.1
              		 28617 - 29969 (-) FfsE
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                • QOG08948.1
                • ffsF
                		 30307 - 31542 (+) FfsF
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                  • QOG08949.1
                  • ffsJ
                  		 32006 - 33850 (+) FfsJ
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                    • QOG08950.1
                    • ffs-Orf1
                    		 34064 - 35773 (-) hypothetical protein
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                      • QOG08951.1
                      • ffs-Orf2
                      		 36626 - 38253 (-) hypothetical protein
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                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        Unk01
                        Type
                        nrps-type1
                        Genes
                        ffsA
                        Substrates
                        leucine (evidence: Structure-based inference [1])
                        Integrated Monomers
                        Domains
                        adenylation
                        Annotation changelog

                        Entry version: next

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2024-06-04
                        MIBiG v4 annotathon
                        • (ID: D44UGPXERIZAXNCG2VXZP5I3)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Changed chemical structures for compounds: aspochalasin E.
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-10-07
                        Added chemical structures for compounds: flavichalasine G, flavichalasine F.
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-10-07
                        Added NPAtlas links to compounds: flavichalasine G, aspochalasin E, flavichalasine F.
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Entry added
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Added NRP substrate specificities
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
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