BGC0002206 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002206 (Trichoderma guizhouense)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	39,474	harziphilone/t22azaphilone/isoharziphilone-1/isoharziphilone-2/compound 4/compound 1	PKS	100%

BGC0002206 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 39,474 nt. (total: 39,474 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 39,475
Label		BGC0002206

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002206	1.00	Polyketide	harziphilone, t22azaphilone, isoharziphilone-1, isoharziphilone-2, compound 4, compound 1	Trichoderma guizhouense
BGC0000099	0.37	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002429	0.32	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0001606	0.32	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002515	0.32	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002191	0.32	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001252	0.32	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002194	0.32	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002224	0.32	Polyketide	zopfiellin	Diffractella curvata
BGC0002222	0.31	Polyketide	zopfiellin	Diffractella curvata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002206	1.00	Polyketide	harziphilone, t22azaphilone, isoharziphilone-1, isoharziphilone-2, compound 4, compound 1	Trichoderma guizhouense
BGC0000099	0.70	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002429	0.66	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0001606	0.66	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002515	0.66	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002191	0.66	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001252	0.65	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002194	0.65	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002224	0.65	Polyketide	zopfiellin	Diffractella curvata
BGC0002222	0.64	Polyketide	zopfiellin	Diffractella curvata

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 39474:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: A0O28_0102280 + A0O28_0102340

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

A0O28_0102280

PKS_AT (611..945): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 60.8
Methylmalonyl-CoA: 57.8
Malonyl-CoA: 40.6
Benzoyl-CoA: 40.2
Isobutyryl-CoA: 38.5
Ethylmalonyl-CoA: 26.2
Propionyl-CoA: 23.1
trans-1,2-CPDA: 19.6
inactive: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

A0O28_0102340

PKS_AT (989..1286): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 86.9
inactive: 56.1
Methoxymalonyl-CoA: 56.0
Methylmalonyl-CoA: 47.1
Ethylmalonyl-CoA: 31.4
Propionyl-CoA: 24.4
Benzoyl-CoA: 23.3
CHC-CoA: 22.8
Isobutyryl-CoA: 18.6
2-Methylbutyryl-CoA: 16.5
Acetyl-CoA: 16.4
fatty_acid: 15.0
trans-1,2-CPDA: 13.7
3-Methylbutyryl-CoA: 0.0