BGC0002211 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002211 (Paraphaeosphaeria sporulosa)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	47,520	High	HEx-pks1 polyketide	PKS

BGC0002211 - Region 1 - T1PKS

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Location: 1 - 47,520 nt. (total: 47,520 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 47,521
Label		BGC0002211

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

CC84DRAFT_1195956: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

CC84DRAFT_1205319: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

CC84DRAFT_1216878: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthase

CC84DRAFT_1091839: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002211.3	1.00	PKS	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0002228.3	0.68	NRPS	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.65	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002211.3	1.00	PKS	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0002228.3	0.68	NRPS	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.65	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 47520:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CC84DRAFT_1091839: pk

PKS_AT (594..908): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; 2-Methylbutyryl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 76.3
Methoxymalonyl-CoA: 65.3
Malonyl-CoA: 55.7
Isobutyryl-CoA: 45.2
Propionyl-CoA: 33.6
fatty_acid: 33.1
Ethylmalonyl-CoA: 31.1
3-Methylbutyryl-CoA: 26.5
2-Methylbutyryl-CoA: 24.2
Benzoyl-CoA: 14.8
inactive: 13.2
Acetyl-CoA: 12.2
trans-1,2-CPDA: 11.0
CHC-CoA: 10.7

Link to PARAS substrate predictor