BGC0002214 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002214 (Hydnomerulius pinastri MD-312)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	50,658	High	methyl (2S)-4-methyl-2-(octanoylamino)pentanoate	PKS

BGC0002214 - Region 1 - T1PKS

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Location: 1 - 50,658 nt. (total: 50,658 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 50,659
Label		BGC0002214

Tailoring functions

Oxidoreductases: oxygenase

HYDPIDRAFT_116705: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

HYDPIDRAFT_31894: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

HYDPIDRAFT_97846: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

HYDPIDRAFT_97981: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: synthase

HYDPIDRAFT_189823: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002214.3	1.00	PKS	methyl (2S)-4-methyl-2-(octanoylamino)pentanoate	Hydnomerulius pinastri MD-312
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.65	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002445.3	0.54	terpene	armillyl orsellinate, 8α-hydroxy-6-protoilludene	Armillaria gallica
BGC0002721.2	0.52	saccharide	α-hydroxynitrile glucoside, β-hydroxynitrile glucoside, γ-hydroxynitrile glucoside	Hordeum vulgare subsp. vulgare
BGC0002213.3	0.51	PKS	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002214.3	1.00	PKS	methyl (2S)-4-methyl-2-(octanoylamino)pentanoate	Hydnomerulius pinastri MD-312
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.65	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002445.3	0.54	terpene	armillyl orsellinate, 8α-hydroxy-6-protoilludene	Armillaria gallica
BGC0002721.2	0.52	saccharide	α-hydroxynitrile glucoside, β-hydroxynitrile glucoside, γ-hydroxynitrile glucoside	Hordeum vulgare subsp. vulgare
BGC0002213.3	0.51	PKS	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 50658:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HYDPIDRAFT_189823: pk

PKS_AT (504..817): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 59.6
Methoxymalonyl-CoA: 49.1
Ethylmalonyl-CoA: 35.8
Propionyl-CoA: 33.3
Isobutyryl-CoA: 27.8
Malonyl-CoA: 23.1
fatty_acid: 21.3
2-Methylbutyryl-CoA: 20.3
CHC-CoA: 15.0
inactive: 11.7
trans-1,2-CPDA: 10.7
Benzoyl-CoA: 10.2
3-Methylbutyryl-CoA: 4.7
Acetyl-CoA: 1.9

Link to PARAS substrate predictor