BGC0002215 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002215 (Endocarpon pusillum Z07020)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	46,808	High	HEx-pks23 polyketide	PKS

BGC0002215 - Region 1 - T1PKS

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Location: 1 - 46,808 nt. (total: 46,808 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,809
Label		BGC0002215

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

EPUS_05787: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

EPUS_05789: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

EPUS_05795: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: methyltransferase

EPUS_05794: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

EPUS_05790: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002215.3	1.00	PKS	HEx-pks23 polyketide	Endocarpon pusillum Z07020
BGC0002175.3	0.79	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.79	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.78	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.77	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000037.4	0.62	PKS	cichorine	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002215.3	1.00	PKS	HEx-pks23 polyketide	Endocarpon pusillum Z07020
BGC0002175.3	0.79	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.79	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.78	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.77	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000037.4	0.62	PKS	cichorine	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 46808:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

EPUS_05790: mal

PKS_AT (927..1224): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 80.5
Methoxymalonyl-CoA: 42.5
Methylmalonyl-CoA: 36.8
inactive: 31.4
Propionyl-CoA: 25.2
Benzoyl-CoA: 15.5
Ethylmalonyl-CoA: 14.4
fatty_acid: 10.7
Isobutyryl-CoA: 10.7
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor