BGC0002222 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002222 (Diffractella curvata)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	33,018	zopfiellin	PKS	100%

BGC0002222 - Region 1 - T1PKS

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Location: 1 - 33,018 nt. (total: 33,018 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,019
Label		BGC0002222

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002222	1.00	Polyketide	zopfiellin	Diffractella curvata
BGC0002224	0.86	Polyketide	zopfiellin	Diffractella curvata
BGC0001252	0.33	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002191	0.33	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001606	0.32	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002155	0.30	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002194	0.30	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002515	0.27	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002525	0.27	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002223	0.24	Polyketide	scytalidin	Scytalidium album

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002222	1.00	Polyketide	zopfiellin	Diffractella curvata
BGC0002224	0.95	Polyketide	zopfiellin	Diffractella curvata
BGC0001252	0.66	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002191	0.66	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001606	0.66	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002155	0.64	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002194	0.63	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002515	0.60	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002525	0.60	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002223	0.57	Polyketide	scytalidin	Scytalidium album

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33018:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

zopA

PKS_AT (617..933): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 72.6
Methoxymalonyl-CoA: 66.7
Malonyl-CoA: 60.6
Ethylmalonyl-CoA: 48.1
Isobutyryl-CoA: 33.6
2-Methylbutyryl-CoA: 32.2
Propionyl-CoA: 28.3
Benzoyl-CoA: 22.1
trans-1,2-CPDA: 11.6
3-Methylbutyryl-CoA: 9.5
fatty_acid: 6.0
inactive: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0