BGC0002222 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002222 (Diffractella curvata)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	40,991	High	zopfiellin	PKS

BGC0002222 - Region 1 - T1PKS

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Location: 1 - 40,991 nt. (total: 40,991 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 40,992
Label		BGC0002222

Tailoring functions

Oxidoreductases: synthase

zopA: Hydroxylation, Other

MITE: MITE0000120Hydroxylation, Other (identity: 100.00%)
smcogs: SMCOG1093: Beta-ketoacyl synthase

Hydrolases: hydrolase

zopQ: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthase

zopA: Hydroxylation, Other

MITE: MITE0000120Hydroxylation, Other (identity: 100.00%)
smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002222.2	1.00	PKS	zopfiellin	Diffractella curvata
BGC0002191.2	0.76	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001268.4	0.61	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002155.3	0.53	PKS	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002222.2	1.00	PKS	zopfiellin	Diffractella curvata
BGC0002191.2	0.76	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001268.4	0.61	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002155.3	0.53	PKS	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 40991:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

zopA: pk

PKS_AT (617..933): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 72.6
Methoxymalonyl-CoA: 66.7
Malonyl-CoA: 60.6
Ethylmalonyl-CoA: 48.1
Isobutyryl-CoA: 33.6
2-Methylbutyryl-CoA: 32.2
Propionyl-CoA: 28.3
Benzoyl-CoA: 22.1
trans-1,2-CPDA: 11.6
3-Methylbutyryl-CoA: 9.5
fatty_acid: 6.0
inactive: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0

Link to PARAS substrate predictor