LOCUS BGC0002224 38870 bp DNA linear PLN 28-MAR-2021 DEFINITION Diffractella curvata strain CBS 591.74 zopfiellin biosynthetic gene cluster, partial sequence. ACCESSION BGC0002224 VERSION BGC0002224 KEYWORDS . SOURCE Diffractella curvata ORGANISM Diffractella curvata Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Lasiosphaeriaceae; Diffractella. REFERENCE 1 (bases 1 to 38870) AUTHORS de Mattos-Shipley,K.M.J., Spencer,C., Greco,C., Heard,D.M., O'Flynn,D.E., Dao,T.T., Song,Z., Mulholland,N.P., Vincent,J.L., Simpson,T.J., Cox,R.R., Bailey,A.M. and Willis,C.L. TITLE Uncovering biosynthetic relationships between antifungal nonadrides and octadrides JOURNAL Chem Sci 11, 11570-11578 (2020) REFERENCE 2 (bases 1 to 38870) AUTHORS de Mattos-Shipley,K.M.J., Spencer,C., Greco,C., Heard,D.M., O'Flynn,D.E., Dao,T.T., Song,Z., Mulholland,N.P., Vincent,J.L., Simpson,T.J., Cox,R.R., Bailey,A.M. and Willis,C.L. TITLE Direct Submission JOURNAL Submitted (02-JUL-2020) Life Sciences, University of Bristol, Life Sciences Building, Bristol, UK BS8 1TQ, United Kingdom COMMENT ##Assembly-Data-START## Assembly Method :: Newbler v. 2.9 Sequencing Technology :: Illumina ##Assembly-Data-END## ##antiSMASH-Data-START## Version :: False Run date :: 2026-04-13 15:33:23 NOTE :: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 38870 ##antiSMASH-Data-END## FEATURES Location/Qualifiers source 1..38870 /culture_collection="CBS:591.74" /db_xref="taxon:2819868" /mol_type="genomic DNA" /organism="Diffractella curvata" /strain="CBS 591.74" misc_feature <1..>38870 /note="zopfiellin biosynthetic gene cluster" region 1..38870 /candidate_cluster_numbers="1" /contig_edge="True" /product="T1PKS" /region_number="1" /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /subregion_numbers="1" /tool="antismash" subregion 1..38870 /aStool="mibig" /contig_edge="True" /label="PKS" /subregion_number="1" /tool="antismash" mRNA complement(join(<686..1084,1229..1367,1422..1599, 1712..1808,1902..>1934)) /gene="zopL9" /product="ZopL9" gene complement(<686..>1934) /gene="zopL9" CDS complement(join(686..1084,1229..1367,1422..1599,1712..1808, 1902..1934)) /codon_start=1 /gene="zopL9" /note="hypothetical protein" /product="ZopL9" /protein_id="QTE75983.1" /transl_table=11 /translation="MATATVTTAPTVVRTTADYYDAPPVLKIHTYTRESYEEQFGNKSV IHHPINLKDIRAANINLQNNGFQLIKLQSKLTNPDDYLDEETVKRVYIPELAEAVKKLT GATEVRVLNPKVRDSSTEKDGFENNWGKNNGAVRRIHIDLAPGGVEEALYPIFGEEYMK SIAGRWRLINAWKPTRPVERDPLAVCDRVPDEDLVPLQRVVPGKALMEQRYHLKTGKKD HDWYYASNQQPDEVLLFTQYSDFPNRNTADRVPHVSVKLPGQEDKPRRTSVDARCLVVW " mRNA complement(<3212..>4009) /gene="zopL8" /product="ZopL8" gene complement(<3212..>4009) /gene="zopL8" CDS complement(3212..4009) /codon_start=1 /gene="zopL8" /note="hypothetical protein" /product="ZopL8" /protein_id="QTE75984.1" /transl_table=11 /translation="MSAPSRIPSSSSNRLILASEPPLENLHSVRTPTLHLVPEVFPKVI LPILAIRSACNTPSSVYLNPRANPYLQGPGTPASCVHINPLVSLSHTIQSNPTFHFSSV INLFARLATTWAAVTSCPHCRYDRHALLLMPALAEQILGVYEAAGVAYGVISFTFPSVD DDASAWIDIGTTGKEVAAAITCEKSGMRLGELELEDEETKLLARAVLRRGVMKLGKLLE ELRDAIGELSGEGWAQRTGTLKAVEHRVEGVMERLVGLLGMLR" mRNA <5476..>6888 /gene="zopL7" /product="ZopL7" gene <5476..>6888 /gene="zopL7" CDS 5476..6888 /codon_start=1 /gene="zopL7" /note="putative transcription factor" /product="ZopL7" /protein_id="QTE75985.1" /transl_table=11 /translation="MSSQSPPPSAPKDTNGSKQPKLRSTCDACQDAKVRCSHDNPRCRR CQAHKIKCVYSLSRRMGRPRRLQTNGNEPKQQKNKSSNVLNGSSGSMELEVTPPLIAIS EAEPAQPTSFQDALATLSWDKSASITAIDPFDTNFSSPECVDFSSSSDGSRVRSDSSFS FPSLSLWDHTALSEERVINAFSPQALLYTNSHAIFPGDLSVNHSTNTTSSQGIMDITLD FQSPRNEPQRQQQEPFKMSELMDETDANKSTSPPEAKNRTCDCYASVLGELSNLDQTKV DNQDSSIDIVLRVEKGVQKHAANILSCELCAGNRSGLLLLLVMVIDHVVRVLGNISSGA KTIPPQRKSSSDRNGNNSKDDNSNDIPLSPRMAMKTSSESRRGESPGGLTTAWNCKLLV GEQEIVGPDKVEFMKLLVQGRLSRLCSTLRRLKRDMQDNPQDSNSKAGNIMVIEIHRRL QSVIGRLELWDG" mRNA complement(join(<7415..8719,8780..>9022)) /gene="zopL6" /product="ZopL6" gene complement(<7415..>9022) /gene="zopL6" CDS complement(join(7415..8719,8780..9022)) /codon_start=1 /gene="zopL6" /gene_functions="transport (smcogs) SMCOG1005: Drug resistance transporter, EmrB/QacA" /gene_kind="transport" /note="MFS transporter" /product="ZopL6" /protein_id="QTE75986.1" /transl_table=11 /translation="MVADKLEVLDGSTGPPMAGNTEEEPYSTFTVGQKRWIIGMVSFAG FFSPLSSSIYFPALPTIAKDLSVTSAQINLTVTTYLIIQGVAPMVVASFSDVAGRRPAY ILCFALYLAANLGLSLQNSYPALLGLRCLQSAGSSGTISLANGVVSDLVTSSERGKFIS LASAGTILGPTLAPIIGGLLTQYLEWHWLFWLLFILAGAFAIPFLLFTPETSRVIVGNG SISPPFLNSCLTDVFRRRKLAKTEHRIRKPERPRMQVPNLLKSLSVIANLETVLVLLPA GFSSAALQAVLTDASKEFTETYRYNTLQVSLMFIPIGVGGLLSVLFTGKLVDWNYRRHA KRLGLSVNRNKSQDMADFPLERARLELSIPIFILLSVLVIVYGWIMTQHVNISGPIIIL FILGYAMIAVYQILSVLLVDIHPGQAATASAANNLIRCELGAAFAAFIAPMIDGIGTGW SYTILALAVMATVPGLLVTMRCGILWRKQKAARETEKQGEKDGQSARVTTQSDENTA" mRNA join(<9900..10236,10299..>11440) /gene="zopL5" /product="ZopL5" CDS join(9900..10236,10299..11440) /codon_start=1 /gene="zopL5" /note="2-methylcitrate dehydratase" /product="ZopL5" /protein_id="QTE75987.1" /transl_table=11 /translation="MPLPPFDSVIVGIAAYVYHYPVSPTSHPKAWQYARIALMDAMGCA IEAISKSEDCRAMFGPVVPGTVTPNGFKLPGTSHQLDPLKGAFDMGTAIRFLDHNDAIA GADWGHPSDNLGAILAVMDWLGRSSANGKLEHHGPALTIDTLLQATIKSYEIQGCFLLR NAFNAHGLDHVILVKLASTAVVSWLLGLTEQQCHAAISHVWMDGQPLRVYRSGVNTIPR KGWAAGDACMKAVHLSLLTRAGQPGSPTVLTVPRWGFYATSFGNKEFEFPKKYGTWVIE HIFFKLMPVEGHGVSAAEAALIHSATLRARGFNPIQNVAKVEIRTNAAADLIINKKGPL SNAADRDHCMQYIVALVLLKGDIPAAQDFQDNSPWATSPELAALRKKIDIRPDEQLTRD YMDLEKRSLAAGITIYLNDGSSLNEVLIEFPVGHVQSPKTLASLEQKYKRNMGLMFSEA EMARARKAVENNGDMPVSDFLDMFTRETPILVKL" gene <9900..>11441 /gene="zopL5" mRNA complement(join(<12081..12400,12466..>12937)) /gene="zopL4" /product="ZopL4" gene complement(<12081..>12937) /gene="zopL4" CDS complement(join(12081..12400,12466..12937)) /codon_start=1 /gene="zopL4" /note="Maleidride dimerase" /product="ZopL4" /protein_id="QTE75988.1" /transl_table=11 /translation="MVAIRYLLVALPVLVVGKPLNFNHDTHQRPLSHNPVGWVHPDIEE AERDGFYFENPEMDCKYVSQPFVYKAFKTLEKDMGSLFTLINKDVHFTIVGNHPGAGVY HDLMHFYVNALRRVALVGSDHPENFRIIPKAIHGGCDQEWSVQEMNFQGISNSGTLFDI INVWVTRWSSDRKQMIEVRTYIDSMKVSQLLHENENWWNSTRHIHHYEWMPGPNGMPNL SELYALMPEQDRPKGRAPGEGLEGRVLGYMPAEWEGGPGNE" mRNA <13598..>15103 /gene="zopL3" /product="ZopL3" gene <13598..>15103 /gene="zopL3" CDS 13598..15103 /codon_start=1 /gene="zopL3" /gene_functions="transport (smcogs) SMCOG1106: major facilitator transporter" /gene_kind="transport" /note="MFS transporter" /product="ZopL3" /protein_id="QTE75989.1" /transl_table=11 /translation="MESPSAARVSPTRPKTPSETTPLLNAATGGDPERYSAFGESQKKF IILTAALASTFSPFSSNIYYPAINSIADDLQVSIPMVNMTITAYMIFQGLAPTFMGNLS DTAGRRPVYVLCFTIYILANIGIALQHSFVGLLLLRCLQSSGSSATIALSNAVAADTVT SSERGMYLGIASLGSILGPALGPLLGGLLSQYLNWRSIFWFLAAAATLVFVPLVLFYPE TCRAIVGDGSISPPAWNKSLLNYLNETKSHSVQNKAMVIKPKIRFPNPLTTLRLLFTLP TGLILLCNGVGYAAHFAVTSSMPSQFNEIYGLNDLQIGLTFIPISLGTILSAFANGYLL DWNFRRIARQEGLPILKGKKQDVSNFPIERARLQIALPMLFSAAALIVAYGWLLDMQLP IFAPLVLLFLIGSSITACYNVFNVLIVDLNYSTPATATAANNLVRCMLGAASTAVVAPI LERFGRGWTYTFVAGAWLAATPAALLVYRYGFAWRRRDRCEES" mRNA complement(<15346..>15906) /gene="zopL2" /product="ZopL2" gene complement(<15346..>15906) /gene="zopL2" CDS complement(15346..15906) /codon_start=1 /gene="zopL2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1027: isochorismatase" /gene_kind="biosynthetic-additional" /note="Isochorismatase-like enzyme" /product="ZopL2" /protein_id="QTE75990.1" /transl_table=11 /translation="MAKTALLVMDVQGAFVPRLAQSSDYLPRLAKTIAAARPSVVKVIY TRVAFRPGHPEISPSNPTFSAAVKSKSFVEGSPETLIDPSIAPQEGDVLVDKKRVSAFS GSGLDIILSSLGIETVVLAGMSTGGVVLSTVLEASDKDFGVVVLKDLCVDADETLHNTL MDKIFTKRGQVVEAEKWLETLKA" mRNA join(<16901..17060,17112..>17569) /gene="zopL1" /product="ZopL1" gene <16901..>17569 /gene="zopL1" CDS join(16901..17060,17112..17569) /codon_start=1 /gene="zopL1" /note="PEBP-like enzyme" /product="ZopL1" /protein_id="QTE75991.1" /transl_table=11 /translation="MYASTRLVLSIFLLGLSIAQTPPGFTPSCDQNLGVTYPNKASIII PGSRLLASDTAIQPRLSAASDVLKEDGKYLLVMLDPDVQFPKQPTTTILHWMEPGFQYN KTSLALTPVSDPEAESVASYAGPHPPIGQIHRYILLLFWQPEDYRLPKEFKSFIPADIP HRIDFDVVRFVEAAELGKPIAASYFIAEGLRSNMKDELRRVV" cand_cluster 18235..26211 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /kind="single" /product="T1PKS" /protoclusters="1" /tool="antismash" protocluster complement(18235..26211) /aStool="rule-based-clusters" /category="PKS" /contig_edge="True" /core_location="[18234:26211](-)" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" /tool="antismash" proto_core complement(18235..26211) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" mRNA complement(join(<18235..19065,19128..25407,25460..>26211)) /gene="zopPKS" /product="ZopPKS" gene complement(<18235..>26211) /gene="zopPKS" CDS complement(join(18235..19065,19128..25407,25460..26211)) /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (35-461). E-value: 6.2e-183. Score: 600.4. Matches aSDomain: nrpspksdomains_zopPKS_PKS_KS.1" /NRPS_PKS="Domain: PKS_AT (617-933). E-value: 9.4e-97. Score: 315.9. Matches aSDomain: nrpspksdomains_zopPKS_PKS_AT.1" /NRPS_PKS="Domain: PKS_DH (1011-1202). E-value: 9.1e-28. Score: 89.6. Matches aSDomain: nrpspksdomains_zopPKS_PKS_DH.1" /NRPS_PKS="Domain: cMT (1487-1688). E-value: 8.1e-55. Score: 177.5. Matches aSDomain: nrpspksdomains_zopPKS_cMT.1" /NRPS_PKS="Domain: PKS_ER (1915-2227). E-value: 1.7e-108. Score: 354.4. Matches aSDomain: nrpspksdomains_zopPKS_PKS_ER.1" /NRPS_PKS="Domain: PKS_KR (2252-2429). E-value: 2.9e-56. Score: 182.2. Matches aSDomain: nrpspksdomains_zopPKS_PKS_KR.1" /NRPS_PKS="Domain: PKS_PP (2528-2609). E-value: 2.3e-13. Score: 42.3. Matches aSDomain: nrpspksdomains_zopPKS_PKS_PP.1" /codon_start=1 /gene="zopPKS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: itr_KS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_KS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: hyb_KS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: tra_KS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_AT" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: mod_KS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: ene_KS" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_N" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_zinc_N" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (MITE) MITE0000120: Hydroxylation, Other (100% identity)" /gene_functions="biosynthetic-additional (smcogs) SMCOG1093: Beta-ketoacyl synthase" /gene_kind="biosynthetic" /note="Zopfiellin polyketide synthase" /product="ZopPKS" /protein_id="QTE75992.1" /sec_met_domain="mod_KS (E-value: 2.5e-154, bitscore: 504.0, seeds: 217, tool: rule-based-clusters)" /sec_met_domain="hyb_KS (E-value: 5.4e-159, bitscore: 519.4, seeds: 33, tool: rule-based-clusters)" /sec_met_domain="itr_KS (E-value: 1.3e-184, bitscore: 603.7, seeds: 96, tool: rule-based-clusters)" /sec_met_domain="tra_KS (E-value: 3.7e-145, bitscore: 473.8, seeds: 44, tool: rule-based-clusters)" /sec_met_domain="ketoacyl-synt (E-value: 5e-76, bitscore: 245.4, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="PKS_KS (E-value: 1.5e-183, bitscore: 600.4, seeds: 2284, tool: rule-based-clusters)" /sec_met_domain="ene_KS (E-value: 2.4e-53, bitscore: 171.1, seeds: 19, tool: rule-based-clusters)" /sec_met_domain="PKS_AT (E-value: 2.2e-97, bitscore: 315.9, seeds: 1682, tool: rule-based-clusters)" /sec_met_domain="ADH_N (E-value: 7.6e-09, bitscore: 25.4, seeds: 66, tool: rule-based-clusters)" /sec_met_domain="ADH_zinc_N (E-value: 1.1e-15, bitscore: 47.8, seeds: 86, tool: rule-based-clusters)" /sec_met_domain="adh_short (E-value: 2.9e-48, bitscore: 154.1, seeds: 230, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 4e-10, bitscore: 30.1, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MAPYLNGHHDEVLSLPSGSPTSNPALTISEDRSMPIAVVGMGMRG PADATNVEGLWKLVSEAREGWSKIPKERWNNDAFYHPDSNRNGTTNVTAGHFMTQDLAC FDAPFFNMTNAEAAALDPQQRLLLECTYEALENAGTPLAEIQGSKTSCFVGSFCGDYTD MLMRDPETVPMYQCTNSGHSRAILANRLSYFFNLQGPSVTIDTACSASLVALHLGCQSL RTGDATRAVVAGANVILSHEIMITMSMMRFMSPDGRCYTFDDRANGYARGEGVGCVILR PLADALRDGDTIRAVIRGTGSNQDGKTSGITLPSGAAQESLIRNVYESAGLDPLETSYV EAHGTGTPAGDPLETAALSRVFGPGRSLDQPLRIGSIKTNIGHLEGASGIAGVIKTVLM LENKILLPNRNFETPNPRIPFYDWKLKVNTLVEPWVVDGPHRASVNSFGYGGSNAHAIL ESAEDYLSIRGLHGSIRTAKSILTPELDKITPNSNGFANGSTNGHLSGHANGHPNGHPN GSANGERNGKLSSERQRLFVISGFDQDACKRQAKMFSDYLESRQDLDDGYLDNLAYTLG ERRTEFIWKAAISASSKSDLSKALLGDIKFSKANKKPTLGFVFTGQGAQWCGMGKELLP AYPVFRNTIAKIGSYLTTLGAPFDVTEELTKDPKTSDIGLALYSQPLCSAVQIAIVDLL ASWGIKPASVTGHSSGEIASAYAMGALSWEDAMAVAYYRGVSSSNVRSTNPISGAMMAV GMSKGDALPYLSSLTKGKAGVACVNSPSSITVSGDATAIDELQSLFEEKKLFSRKLAVD VAYHSHHMALIAEEYGNAISGIKIRETGEVEFYSSVFGRRAEASELGPSYWVANMLGEV KFADSLRMLCLETSSSSGKKTRKRASAPTVNTIVEIGPHSALAGPIKQILQADDKLKEA GIGYASALIRKVDAVTTTLDLASKLVLGGYPVNLSALNRPTGAESHSVLVDLPPYPWNH SNSYWAEPRLSKVFRQRTFPRTDLLGALDRNSNPLEPRWRNHIRASEIPWVKDHKIQSN VVYPAAGYIVMAIEAAFQRATEKSLTITGYKLREISIGSALVIPEQSDGVETLVSFKPH TESIRAPSDLWDEFCVYSVTDDNRWTEHCRGLIAVQTPQRSINIIDGDVQAVAEMNHYT RIIVEAEDKCHIDVDVKEFYQQLTQLGIEYGDTFANVTKARAARNSCIATVAIADTAAV MPQHFQFPCILHPSTLDAIFHPIFVALAAEAGPLKDPAVPVFIEEIYVSSNITSQPGDE LVVYAGTKKKDDKYLTASMTILDGSRLNSEPVLTIRDLTCTTLAREIAQESGEETKRVA YNFQWRADVDLLSKNGISELCDNAPLSLQETATIRGLEQTAYYYMEWALAEVAPAELPI MEPHLQKMYALMEKLVKDVREDKFNIPTASWLAAGGAERAKLRHAIRDSGPEGHLLCFM GRNLPAIMKKEVDPWNLLIGEQRLEAYFKDSPRIARTYLAAAEYFDLLGHKSPHLSILE IGVGTGGATFPILKSLGGADGDLPRFQKYDCTDVNSTLFDSLKERAAPWKDLVTFKELN IDNDPVAQGFTAESYDVIFAAYALHTSKSLHTALGNARKLLKPGGKLVILDVTREHMAS SLIFGTLPSWWAAEEKNRQASPVLSEGDWEAALLASRFSGLEGVVWDVPNGPDHQSSVM VSTALHKKETAHISDVLVIAEEDDSDVILNDLLERLTSLNIGFEVTPFSKAKPVGKICI VLSELTRSIMIDPSLEQFEVVKDIFIKSDGVLWVTRGGTLSFSNPTSNLVTGFARTARS ENGGTIIATLDLDSRKSKSPSSSASEAIFTLFRHLFLLSHMLPNEVDTEYAERDGQILI SRLVENSKLSKKILASSSRPVPELQPFHQSGRPLVMHVGQPGLLDTIHFIDDERMVQPL SDDQVEIEVKATGLNFKDVMMGLGQIQTETLGGECAGVVTAVGKNARGLAIGDRVSTYG FGTFCNFYREKWTAFQKIPDDMSFEMGAALPVTYGTAYYSVYHLARVEKRDSVLVHAAT GGLGQAIIELCQLIGAEIYATVGTQEKKKLLMDCFGIPEDHIFYSRDGSFAKGVMRMTM GRGADVVFNSLAGEALRLSWNCVADYGRFIELGARDITVNTRLEMGNFIKNPMFAAFNL VYLIRARREVGDKVWADVMDLFRKKSIKGPTPLHVHRLSKIEDALRIMQTGKHMGKLVA VAEPDEMVQAVPRDTSKNLFRPDASYLLVGGLGGIGRATALWMVDHGAKNLIFANRSGL ASKEAKETIDALKSKGALAVVYGCDVSNSEAVAELVAESSKSMPPIRGVIQGAMVLRDG LLEKMPLTDYMSVIRPKVQGTWNLHKNLPENMDFFLMLSSVSGIIGNATQAAYAAGSTF MDAFAAYRSNLGLPAVTLDLGVITEVGYLAEKDKELAAGMQRQGFEGTNKAKLLALIQS AIADPRREDLLSHVVTGLGTWQEGKSLAIYDLPVFSHFRRQALKKDSGAADGKARVRDV LKAATTLEEATEQICNALVDKISDRSNIPADNISRDNPMTDYGIDSLVAVEMRNWIVRE MDSTMPILELLANQSLQQLSAKIAQRSGLVSLKVVEKE" aSDomain complement(18271..18513) /aSDomain="PKS_PP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_zopPKS_PKS_PP.1" /evalue="2.30E-13" /label="zopPKS_PKS_PP.1" /locus_tag="zopPKS" /protein_end="2609" /protein_start="2528" /score="42.3" /tool="antismash" /translation="TLEEATEQICNALVDKISDRSNIPADNISRDNPMTDYGIDSLVAV EMRNWIVREMDSTMPILELLANQSLQQLSAKIAQRS" aSModule complement(18271..26106) /complete /domains="nrpspksdomains_zopPKS_PKS_KS.1" /domains="nrpspksdomains_zopPKS_PKS_AT.1" /domains="nrpspksdomains_zopPKS_PKS_DH.1" /domains="nrpspksdomains_zopPKS_cMT.1" /domains="nrpspksdomains_zopPKS_PKS_ER.1" /domains="nrpspksdomains_zopPKS_PKS_KR.1" /domains="nrpspksdomains_zopPKS_PKS_PP.1" /iterative /locus_tags="zopPKS" /tool="antismash" /type="pks" CDS_motif complement(18802..18822) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0016" /evalue="3.70E+01" /label="PKSI-ER_m2" /locus_tag="zopPKS" /protein_end="2432" /protein_start="2425" /score="-1.7" /tool="antismash" /translation="GVITEVG" aSDomain complement(join(18811..19065,19128..19403)) /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_zopPKS_PKS_KR.1" /evalue="2.90E-56" /label="zopPKS_PKS_KR.1" /locus_tag="zopPKS" /protein_end="2429" /protein_start="2252" /score="182.2" /tool="antismash" /translation="SYLLVGGLGGIGRATALWMVDHGAKNLIFANRSGLASKEAKETID ALKSKGALAVVYGCDVSNSEAVAELVAESSKSMPPIRGVIQGAMVLRDGLLEKMPLTDY MSVIRPKVQGTWNLHKNLPENMDFFLMLSSVSGIIGNATQAAYAAGSTFMDAFAAYRSN LGLPAVTLDLGVIT" CDS_motif complement(18859..18966) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0015" /evalue="8.00E-19" /label="PKSI-KR_m4" /locus_tag="zopPKS" /protein_end="2413" /protein_start="2377" /score="60.2" /tool="antismash" /translation="MDFFLMLSSVSGIIGNATQAAYAAGSTFMDAFAAYR" CDS_motif complement(18985..19014) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0014" /evalue="6.10E-04" /label="PKSI-KR_m3" /locus_tag="zopPKS" /protein_end="2371" /protein_start="2361" /score="13.1" /tool="antismash" /translation="PKVQGTWNLH" CDS_motif complement(19305..19403) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0013" /evalue="4.60E-16" /label="PKSI-KR_m1" /locus_tag="zopPKS" /protein_end="2285" /protein_start="2252" /score="51.3" /tool="antismash" /translation="SYLLVGGLGGIGRATALWMVDHGAKNLIFANRS" CDS_motif complement(19479..19523) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0012" /evalue="4.60E-05" /label="PKSI-ER_m9" /locus_tag="zopPKS" /protein_end="2227" /protein_start="2212" /score="16.4" /tool="antismash" /translation="ALRIMQTGKHMGKLV" aSDomain complement(19479..20414) /aSDomain="PKS_ER" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_zopPKS_PKS_ER.1" /evalue="1.70E-108" /label="zopPKS_PKS_ER.1" /locus_tag="zopPKS" /protein_end="2227" /protein_start="1915" /score="354.4" /tool="antismash" /translation="GLLDTIHFIDDERMVQPLSDDQVEIEVKATGLNFKDVMMGLGQIQ TETLGGECAGVVTAVGKNARGLAIGDRVSTYGFGTFCNFYREKWTAFQKIPDDMSFEMG AALPVTYGTAYYSVYHLARVEKRDSVLVHAATGGLGQAIIELCQLIGAEIYATVGTQEK KKLLMDCFGIPEDHIFYSRDGSFAKGVMRMTMGRGADVVFNSLAGEALRLSWNCVADYG RFIELGARDITVNTRLEMGNFIKNPMFAAFNLVYLIRARREVGDKVWADVMDLFRKKSI KGPTPLHVHRLSKIEDALRIMQTGKHMGKLV" CDS_motif complement(19914..19964) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0011" /evalue="3.70E-07" /label="PKSI-ER_m6" /locus_tag="zopPKS" /protein_end="2082" /protein_start="2065" /score="22.5" /tool="antismash" /translation="GAEIYATVGTQEKKKLL" CDS_motif complement(19974..20033) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0010" /evalue="1.60E-08" /label="PKSI-ER_m5" /locus_tag="zopPKS" /protein_end="2062" /protein_start="2042" /score="26.9" /tool="antismash" /translation="DSVLVHAATGGLGQAIIELC" CDS_motif complement(20064..20102) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0009" /evalue="9.60E-04" /label="PKSI-ER_m4" /locus_tag="zopPKS" /protein_end="2032" /protein_start="2019" /score="12.7" /tool="antismash" /translation="AALPVTYGTAYYS" CDS_motif complement(20232..20270) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0008" /evalue="6.20E-04" /label="PKSI-ER_m2" /locus_tag="zopPKS" /protein_end="1976" /protein_start="1963" /score="12.7" /tool="antismash" /translation="LGGECAGVVTAVG" aSDomain complement(21096..21698) /aSDomain="MT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_zopPKS_cMT.1" /domain_subtypes="cMT" /evalue="8.10E-55" /label="zopPKS_cMT.1" /locus_tag="zopPKS" /protein_end="1688" /protein_start="1487" /score="177.5" /tool="antismash" /translation="YFKDSPRIARTYLAAAEYFDLLGHKSPHLSILEIGVGTGGATFPI LKSLGGADGDLPRFQKYDCTDVNSTLFDSLKERAAPWKDLVTFKELNIDNDPVAQGFTA ESYDVIFAAYALHTSKSLHTALGNARKLLKPGGKLVILDVTREHMASSLIFGTLPSWWA AEEKNRQASPVLSEGDWEAALLASRFSGLEGVVWDVPN" aSDomain complement(22554..23126) /aSDomain="PKS_DH" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_zopPKS_PKS_DH.1" /evalue="9.10E-28" /label="zopPKS_PKS_DH.1" /locus_tag="zopPKS" /protein_end="1202" /protein_start="1011" /score="89.6" /tool="antismash" /translation="DLLGALDRNSNPLEPRWRNHIRASEIPWVKDHKIQSNVVYPAAGY IVMAIEAAFQRATEKSLTITGYKLREISIGSALVIPEQSDGVETLVSFKPHTESIRAPS DLWDEFCVYSVTDDNRWTEHCRGLIAVQTPQRSINIIDGDVQAVAEMNHYTRIIVEAED KCHIDVDVKEFYQQLTQLGIEYGDTFAN" CDS_motif complement(22968..23045) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0007" /evalue="2.80E-12" /label="PKSI-DH_m2" /locus_tag="zopPKS" /protein_end="1064" /protein_start="1038" /score="39.0" /tool="antismash" /translation="WVKDHKIQSNVVYPAAGYIVMAIEAA" aSDomain complement(23361..24308) /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_zopPKS_PKS_AT.1" /evalue="9.40E-97" /label="zopPKS_PKS_AT.1" /locus_tag="zopPKS" /protein_end="933" /protein_start="617" /score="315.9" /tool="antismash" /translation="VFTGQGAQWCGMGKELLPAYPVFRNTIAKIGSYLTTLGAPFDVTE ELTKDPKTSDIGLALYSQPLCSAVQIAIVDLLASWGIKPASVTGHSSGEIASAYAMGAL SWEDAMAVAYYRGVSSSNVRSTNPISGAMMAVGMSKGDALPYLSSLTKGKAGVACVNSP SSITVSGDATAIDELQSLFEEKKLFSRKLAVDVAYHSHHMALIAEEYGNAISGIKIRET GEVEFYSSVFGRRAEASELGPSYWVANMLGEVKFADSLRMLCLETSSSSGKKTRKRASA PTVNTIVEIGPHSALAGPIKQILQADDKLKEAGIG" CDS_motif complement(23967..24068) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0006" /evalue="2.40E-10" /label="PKSI-AT-mM_m3" /locus_tag="zopPKS" /protein_end="731" /protein_start="697" /score="32.8" /tool="antismash" /translation="GIKPASVTGHSSGEIASAYAMGALSWEDAMAVAY" CDS_motif complement(24258..24311) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0005" /evalue="6.80E-07" /label="PKSI-AT-mM_m1" /locus_tag="zopPKS" /protein_end="634" /protein_start="616" /score="21.5" /tool="antismash" /translation="FVFTGQGAQWCGMGKELL" aSDomain complement(join(24777..25407,25460..26106)) /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_zopPKS_PKS_KS.1" /domain_subtypes="Iterative-KS" /evalue="6.20E-183" /label="zopPKS_PKS_KS.1" /locus_tag="zopPKS" /protein_end="461" /protein_start="35" /score="600.4" /tool="antismash" /translation="IAVVGMGMRGPADATNVEGLWKLVSEAREGWSKIPKERWNNDAFY HPDSNRNGTTNVTAGHFMTQDLACFDAPFFNMTNAEAAALDPQQRLLLECTYEALENAG TPLAEIQGSKTSCFVGSFCGDYTDMLMRDPETVPMYQCTNSGHSRAILANRLSYFFNLQ GPSVTIDTACSASLVALHLGCQSLRTGDATRAVVAGANVILSHEIMITMSMMRFMSPDG RCYTFDDRANGYARGEGVGCVILRPLADALRDGDTIRAVIRGTGSNQDGKTSGITLPSG AAQESLIRNVYESAGLDPLETSYVEAHGTGTPAGDPLETAALSRVFGPGRSLDQPLRIG SIKTNIGHLEGASGIAGVIKTVLMLENKILLPNRNFETPNPRIPFYDWKLKVNTLVEPW VVDGPHRASVNSFGYGGSNAHAILESA" CDS_motif complement(24993..25037) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0004" /evalue="1.80E-03" /label="PKSI-KS_m6" /locus_tag="zopPKS" /protein_end="389" /protein_start="374" /score="11.0" /tool="antismash" /translation="GSIKTNIGHLEGASG" CDS_motif complement(25098..25145) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0003" /evalue="6.70E-04" /label="PKSI-KS_m5" /locus_tag="zopPKS" /protein_end="354" /protein_start="338" /score="12.0" /tool="antismash" /translation="YVEAHGTGTPAGDPLE" CDS_motif complement(25338..25376) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0002" /evalue="4.80E-04" /label="PKSI-KS_m4" /locus_tag="zopPKS" /protein_end="274" /protein_start="261" /score="13.2" /tool="antismash" /translation="FDDRANGYARGEG" CDS_motif complement(25570..25617) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_zopPKS_0001" /evalue="4.30E-06" /label="PKSI-KS_m3" /locus_tag="zopPKS" /protein_end="214" /protein_start="198" /score="18.7" /tool="antismash" /translation="GPSVTIDTACSASLVA" mRNA complement(join(<27481..28095,28161..>28211)) /gene="zopR1" /product="ZopR1" gene complement(<27481..>28211) /gene="zopR1" CDS complement(join(27481..28095,28161..28211)) /codon_start=1 /gene="zopR1" /note="DUF341 hydrolase" /product="ZopR1" /protein_id="QTE75993.1" /transl_table=11 /translation="MPTLKFLCLHGAGTNAQILGSQLGPLMRELGKDNSAIFHLVEGDV GSPPGPGIEGFYEGPFFSYYKWPRTFNDNDESIMEAYDMLYEVIEEEGPFDGILGFSHG GTLATGFLAHHATLNPYDPPLFRCAVFFSSLAPFRMNDDETPVFEEGLEGKIKIPTLHV MGTKDFIYSYSLHLFNLCDVKSSAILVHDRGHEIPSDGKTLARMAAAFRDLGTRSMFL" mRNA complement(join(<29207..29247,29308..29673,29722..>30019)) /gene="zopR2" /product="ZopR2" gene complement(<29207..>30019) /gene="zopR2" CDS complement(join(29207..29247,29308..29673,29722..30019)) /NRPS_PKS="Domain: ECH (40-208). E-value: 3.6e-10. Score: 31.5. Matches aSDomain: nrpspksdomains_zopR2_ECH.1" /codon_start=1 /gene="zopR2" /note="Enoyl CoA hydratase-like enzyme" /product="ZopR2" /protein_id="QTE75994.1" /transl_table=11 /translation="MSQDQSRAVHTRLGVDFRGNYVAIVEVKCSRTPDAELDLALKRLL EYLSQDSKLRVIIIAVGKDDSALAFNTDSNTEVYTETTKEKFRSYMIAPLKCNTAIISV LHGICTKLALDIACGSDIRICTSNARFLLGDATQKNTSLEAAMTEMPPAVLTMDGASVF REMLMSGGAFVAQDAHRMEFVSSVSETMDEAIFDALRLAESIAQSTARIQKVRPVNYTS HGQVRQPSFNKL" aSDomain complement(join(29348..29673,29722..29899)) /aSDomain="ECH" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_zopR2_ECH.1" /evalue="3.60E-10" /label="zopR2_ECH.1" /locus_tag="zopR2" /protein_end="208" /protein_start="40" /score="31.5" /tool="antismash" /translation="LKRLLEYLSQDSKLRVIIIAVGKDDSALAFNTDSNTEVYTETTKE KFRSYMIAPLKCNTAIISVLHGICTKLALDIACGSDIRICTSNARFLLGDATQKNTSLE AAMTEMPPAVLTMDGASVFREMLMSGGAFVAQDAHRMEFVSSVSETMDEAIFDALRLAE SIAQS" mRNA join(<30541..30746,30803..31003,31063..31818,31914..>32073) /gene="zopR3" /product="ZopR3" gene <30541..>32073 /gene="zopR3" CDS join(30541..30746,30803..31003,31063..31818,31914..32073) /codon_start=1 /gene="zopR3" /note="Citrate synthase" /product="ZopR3" /protein_id="QTE75995.1" /transl_table=11 /translation="MAHPTNGTLFVRDSRTKQEYEIPIVDNAVLAVDFKNIRGYSDGSK MRGLLLYDPGLQNTAIKRSQISSSDARGLPMIRGYSVEQLYSLQSDFEDLFHLMVLGKY PTPEEKEILRHTFAQEMINVPDTVVAAIKAFPPSSTGMSMMLAGLSAYLASYDHAIPAK QGGNLYHNNPRLANKAAIKTTAAYAVVLGLTISHRKGIPFAPAQANKSFYENLFNMMGM ADPITKLPNPLYIDVFRRAAILNADNGMTHSTFLTLVAGSALPDPLSCLISATSAAYGP LHYGAQEATWNNLIEIETKENVPAFLEQVKRRERRLFGYGHRVHKTEDPRLAIIKGLLK ELNVSPATIPLMEIAYEIDRLAALDQYFTSRGLSANADFYFGFLIHAFGFDPDMITLAN LAMRILGLMAHWREAMDQEIKLFRPLHIYTGPKQRITAARL" mRNA join(<35687..35831,35904..36175,36241..36350,36431..36447, 36526..36569,36652..36783,36864..37208,37295..37417, 37485..>37748) /gene="zopR4" /product="ZopR4" gene <35687..>37748 /gene="zopR4" CDS join(35687..35831,35904..36175,36241..36350,36431..36447, 36526..36569,36652..36783,36864..37208,37295..37417, 37485..37748) /codon_start=1 /gene="zopR4" /gene_functions="biosynthetic-additional (smcogs) SMCOG1138: FAD linked oxidase domain protein" /gene_kind="biosynthetic-additional" /note="FAD-dependant oxidoreductase" /product="ZopR4" /protein_id="QTE75996.1" /transl_table=11 /translation="MTRIPPFSIGVIATIMFCFVYESNCANVTNTCAVIGRDISSASAI IYPSDTIAFTTDTSHFTESSNQIPTCVLEVGSAQDVAVALKIIGATKTPFAIMSGGHSS NQKFSSTTGIHISLIRLRQVVFSADKSTVEIGMGITWAEVYQILDGTGYNVVGGRTFGP GVGGFTLGGGYSWKTNQYGLTCDTVRSYNLVLPNGTITTASKRINPDLFFALKGGLNRF GIVTSAVFETHAQVPLIYGGQVFYSTDDIPAVINATLEFYKLADIKTQIMYIIATTPTQ ESVILLAFHDGPNRPSSLSVFDNITPLSSTLSTLSFSDFVHSIQDKPRIRGTADTISTT GITTGFIKAVSDQIAALREAAVSHGAASIAFDIEPFTDYGKHATDSAYPHTRSQLPLGL DFSWVSADDDEFWHDTAKNAIAKLKVVAAQEGIYNPKEAAYPNYSAASKTALQLYGEEN TERLKRIRAQIDPYNVMKLAGGFDL" ORIGIN 1 atccttcgtt ctagtttcat ccaacttcga gtcgcacaaa aatgctcacc aagaccaaca 61 cggctgaggc gaaaaggata ggaaagagcg atgaagatga gtcaacacta gtcttagcaa 121 gacaccgggt gggtactaga gtcaaattga gcgatataat ggattgtatt gccttaggat 181 tgggaatgta cctctagtag agactacagg aagaaaggta atattagctg tttcagtcgg 241 atgactaatg ggtagttatt ttctctttca agttgaaagg ggtatagcta aatacaccac 301 aatatctcgc attaggggga aagggcccaa gcatgtttat tagtttaaag ggcgttgttg 361 ggggctattt ttcttgccgg tgattggctc cactaaattt ctatcaagac tataggaagt 421 gttaaccaca acactcttaa ctggtccaat aaaaagtctt cgccgcggca tgggtcgcaa 481 ttgttgtaat agcacacaaa gcttagtcaa gatattcatc gtctttctca ttgacctctt 541 gttgaaagaa atctaatggt agaacacgca aactagctaa agacaaatgt accagatccg 601 gagataagag cccaccgtac tatgatcggc tccctacctt tgctgcctgg ttgcagaaca 661 gcgacaaggt ttccgtcagg cccacttacc acacgacaag gcacctagca tcaacgcttg 721 ttcgcctggg cttatcctct tgccctggaa gcttcacgct tacgtgaggg acccggtcgg 781 cggtgttacg atttggaaag tcggaatact gggtgaaaag caaaacctcg tctggttgct 841 ggttggaagc gtagtaccag tcgtggtctt tctttcccgt cttgagatgg tatcgctgtt 901 ccatcaaagc cttgcctggt acgacacgct ggagcggtac gagatcttcg tccggaaccc 961 tgtcacaaac agccagggga tctcgctcca caggacgggt tggcttccac gcattgatga 1021 gcctccatcg acccgcaata gacttcatat attcttcccc aaaaatgggg tagagtgctt 1081 cctcctgctc ggaatattag ccttgcaact agaaagcctg agtaatggaa acacagtaga 1141 gagatcgaca acaccatagc tagctcagcc agctcctgtc ctggtaggac aacctgactc 1201 gcacgatcac caaggggtat aagcttacta cgccgccagg agcaagatca atatggattc 1261 gacggactgc cccgttattt ttgccccagt tgttctcaaa gccatccttc tccgtgcttg 1321 aatcacggac tttggggtta agaacacgga cttccgtggc gccagtgctt tttgcaaatc 1381 aattagcgat cagctggtct tggcggaaaa ataagacata cagcttcttc acagcctctg 1441 caagttcagg gatgtacacc cttttcacag tctcttcgtc gagatagtca tccgggtttg 1501 tcaatttaga ttggagctta atcagctgga acccgttgtt ctggaggttg atgttcgccg 1561 cccggatgtc tttcagattt atgggatggt gaataacacc tatagagcgt caacgcttag 1621 tttctgtgat tccctttcat ggtatatatc ggacttccat agatatctag cttcagttat 1681 aaggcagggg gtaatcttaa aaaatacata ctcttatttc caaattgttc ttcgtagctc 1741 tcacgcgtgt acgtgtgtat cttaaggaca ggtggggcgt cgtaatagtc cgcagtggtg 1801 cgaactacct attatctaaa gtcagcaacg gggacacttg catatagttg cctcaaagat 1861 ggttggggat gggaacatct gattttgggc gtcaaactca cggtcggtgc cgtggtaaca 1921 gtcgcggtag ccatcttctc tttgataagt tgcttaaggg ttcttgtgac ttgtgttctt 1981 ttgtttaccg taatgtttgg ctcttgttat ttaattaggt ttgcctcact tgagacttta 2041 taaatcacta attaagctat gtttgaatta tttcctcacg tttgaactat ctcggtgact 2101 tgttctatga ttcggaagcc tctcggcgac ttgttataaa ttcccgcatt gtccagcagt 2161 tttacggact gcaagatcgg gaacaaaaag ccagataagg ccgaaagctc ctagctaact 2221 gcatacgatt aagatatccc aatatatccg accattcagc tcggaatccg agtgtgtgta 2281 ccgacatttt gttgagtgtg actaatttac ggatggttga ccaaataaaa tgtaactcta 2341 acagactctc aaaagtatct aatgatgtaa gtctttataa acttaactac aggagttaag 2401 catcggactg acataattcc ataaggaatt aactcctcgg taaaactacg atagaatcta 2461 cccattgcca acgtacgata ctttgtatac tgctgactgt gctgtagctc ggggacacag 2521 aattaatccg ccgtagagga tagctagcaa actcggatcc tggttcgctc tacgcctcca 2581 tgcatggcac tcagttgtgt cacatgcttg ccaatgctcg gtccgagtgc gacagcaaca 2641 ctgcagctac aggtaactca taaaattctt ggtcacggcc ttagcaactt ccgttccaaa 2701 attccgccag caccttgcat acaagtatct actaatcatg catctaacca tcttgaccgg 2761 aaattgcatc gttatgcatg gtcatatttt agcaagggtc ttattcccac ctcatgtttc 2821 cccaacactg tgattacgtg gctacctacc tatttatgtt tccgaacacg ataaagtagc 2881 aacgaaattt aactctcgaa acttgctcag cttaaaactc gcattctaaa agtgacgccc 2941 gggacttcga gcgtacgcct atcctactcc cgatgtggct tatttgggat cctgtcgcta 3001 atccctcatc cgacatccca tatccggggc tacactacat aacacttcac atagtctgcg 3061 tgttaggatc acctaacctt acaatcaacc ttatctagaa gtttaaacag aactatgacc 3121 tcattgatat agaatatgtc ttctattaga cctttatacc ctgtattcta attcattcgc 3181 ttttatgtcg agcctggttg ggcctgctag atcaacgcaa catccccaat aagccaacta 3241 atctctccat cacgccttct accctatgct ccacagcctt caatgtccct gttctttgcg 3301 cccacccctc tcccgaaagc tcaccgatcg cgtctcttaa ctcctctaat agctttccta 3361 gcttcataac cccccttcgt aacacggctc gcgctaatag ctttgtttct tcatcctcaa 3421 gttctaactc cccaagccgc atccctgatt tttcacacgt aatagcggcc gcgacctcct 3481 tgcccgtagt tcctatatca atccaagcgc tcgcatcatc atcaacagac gggaaagtga 3541 aagaaataac cccgtaagct acgccagcag cctcataaac gccaaggatt tgttcggcca 3601 gagcaggcat cagaagcaga gcgtggcgat catagcggca atgggggcac gatgttacgg 3661 cggcccacgt ggtggcgagg cgggcaaaga ggttgataac agatgagaag tggaaggtcg 3721 ggtttgattg aatggtgtgc gagaggctga cgagggggtt aatatgcacg caggaagccg 3781 gcgtccccgg gccctgcagg taggggttag ctcgggggtt aagatagact gaagatggcg 3841 tgttacaggc gctacgtatt gcaaggattg gcaagatgac tttcgggaag acctccggga 3901 caagatgcaa agtaggggtt cttaccgaat ggagattctc gagggggggc tcgcttgcca 3961 gtatgagccg attggaggag gatgacggga tgcgcgaggg agcggacatg gttaggtagt 4021 tctctagtgg aggagtggaa tggggagaaa ggtttaaaac aacgtttgtg aattcaacgt 4081 aaaaaagacg acagtagcca aaataataaa tagcaatatg ggttggtgtt cactgtcgtc 4141 tgaaaaagga aaaatatata tagttaataa ggaaaggaga atagagtttt gatatcatta 4201 ataatataat aactattcgc gctccaaaga aaattaataa gaaacgacag ggaattatcg 4261 atcggctacg ggcttacctt atatttacct tccttagtaa aacaagttgg tagattttta 4321 gatattagct tttacactaa taaatataaa catcttgact tctcgctttc cgggtttaca 4381 cgtcatattt tgactttgtg tcgtaaccaa aagagatttg agatatagaa aaagccgtta 4441 atcgatatta tacaaaaagg gtgcggaagg aatgcggaag gagggaatat gcatccatca 4501 aagctacggg aggagtaaca ttcaagaagc gttacggaag gtgtgttttc ggcaagctac 4561 ttaaatctta gaggtctgag cgtttcgcag tgggccatta atcctccgaa cttttctgtc 4621 atcttatagg tagcgacggt tagctcgcgc cacaaagtag cacagggtag cacataagta 4681 tgcagtcaga cggcgctatc ggtattggta atcggttgat ctaccgtcac tgcctctttt 4741 ggagaaaacc accggctttt tatcggacaa gatgcgactg ttacgatggt acttatgaga 4801 cataacgctt agagttcaga cggctatgct tttcgaccct aagcttattt ttatagttat 4861 taagaatcgt ataatattta attatgtggg ctatactaca attttgtaaa ttatttaata 4921 taattaaagt tctttaatta ttatatttag tatgtgatta gaaataagcc aaatgctagg 4981 aatattaaaa tatcatacgt atccactctt tgactaataa gggatttttc taaagttaaa 5041 gccttgagtt agtagcttcc gtatacgagt gtccatggtc agacgggtaa atcacccccg 5101 caccacctct aagaacttgc aggtgtttat cagctatgtt aaagccctgt gattcgctaa 5161 cgataaccga tgcaataagc ttaccaggat aggttcccat taacttgaaa cgataacatt 5221 ctgctttgct aatcctgcaa cctggtcctt gaagtgttgt tgtgtaggca gtatatcttg 5281 tgccgatagc ttgcacgaaa gctgccacaa ataagattaa aataagctct ggtattaatg 5341 aagaggcgct cttggtactg atctctccac acttggcgct gacctctggg cacttggcat 5401 tgttctctag atacttggca ttgttcttca gactatagag tgccgactga gccccggctg 5461 acatgaatca tggagatgtc ctcgcaatct cccccaccat cagcgccgaa ggatacaaac 5521 gggtcgaaac agccaaagct tcgttcgacc tgtgacgctt gtcaagatgc gaaagtccgc 5581 tgcagtcacg ataatcctcg ctgccgtcgg tgtcaagcac acaaaatcaa gtgtgtatac 5641 agtctctcac ggcgcatggg tagacctcgg cgactccaga caaacggaaa tgagccaaaa 5701 caacagaaga acaaaagcag taatgtcctc aacggttcta gtggcagcat ggagctagag 5761 gttacaccgc ccttaattgc catctcagag gcagaacccg ctcagccaac atcctttcaa 5821 gacgcattgg caactctaag ctgggacaag tcagcatcta ttaccgccat agaccccttc 5881 gacaccaact tcagctcacc cgaatgtgtt gacttcagca gcagcagtga tgggtcgagg 5941 gttcggtcag attccagctt cagtttccct agtttatcgc tttgggacca cactgccctt 6001 tcggaggaga gagtgatcaa tgcgttcagt ccacaggcat tgttgtacac gaatagtcac 6061 gccatctttc ctggagactt gtcggtcaac cattcaacca atacgactag tagccaagga 6121 atcatggaca tcaccctgga tttccaatcc ccgcgtaacg agcctcaacg gcagcagcag 6181 gagccattta agatgagcga gctcatggac gaaaccgacg ccaataaatc cacgtcacct 6241 cccgaggcca agaatcggac atgcgactgc tatgcctcag tcctaggcga gctctcaaac 6301 ttggaccaaa cgaaggtaga taatcaagat tccagcatag atatcgttct tcgagtcgaa 6361 aagggtgtac agaagcatgc cgccaatatt ctttcatgcg agctctgcgc cggcaaccgc 6421 tctggtctct tgctcctcct ggtcatggtg attgaccacg tcgtgcgggt gcttgggaac 6481 atctccagtg gcgcaaaaac cataccgccg caacgaaaat catccagtga ccgcaacggc 6541 aacaatagca aggacgataa ctccaatgac atccccttgt cgccccgaat ggcaatgaag 6601 actagtagcg agagccgtag aggagagagc ccaggtggct tgacgacggc gtggaattgt 6661 aagttgcttg ttggcgagca ggaaatcgtg gggccggata aagtggagtt tatgaaacta 6721 ctagttcaag ggagactaag ccggttgtgc tccacattgc ggcggttaaa gagagacatg 6781 caagacaatc ctcaagattc gaactcgaaa gccgggaaca tcatggtgat tgagatccac 6841 cggcggctac agtctgttat cggtaggctt gagctctggg acggctaaga gttcatatga 6901 ggataggcag cgtgccttga tattcaaaac catctctcca tacctgtcac cttagagtag 6961 agcaactctt tctaccactt gatctttaga tagttctcag ggacttcaca gtggtgtggg 7021 tgatctcgta gttgaaatat agtgggctta aggtgaacta agcgtaaaaa taataactgc 7081 aaagaggagg cgtgacttaa gtttatggat tgagaatgca tacgactata tagagatata 7141 tcttccagca cctgttgttt gcaaatgatc tgatgaccat catatatgaa agcaggatag 7201 aggaagctac ggtttcagtg cagtgacacg gacggtatta ggggcgggga atcgggtttc 7261 caaccacatc tagattatat taatcttaat attatatggc agtacggtaa tggcattgaa 7321 ggtaaattaa tagcggcagt gttacccggc tgtatcattt ggtcgaccta actaatagta 7381 cattggtatt cagggggggt gggggggggg gcttttacgc cgtgttttcg tcggactgcg 7441 tagttactct cgcgctttgt ccatctttct cgccctgttt ctctgtctcc ctcgccgcct 7501 tttgcttccg ccagagaatt ccacagcgca tagttaccag taatcccgga acagtagcca 7561 taacagccag ggctaagatg gtataggacc accctgttcc aataccgtcg atcattggag 7621 cgataaaagc cgcaaatgca gcaccaagct cgcagcgtat gagattgttt gctgcagagg 7681 ctgtggccgc ctggcctggg tgtatatcga ccaacagcac actgagaatc tgataaacgg 7741 ctatcatggc atacccaaga atgaagagga tgattatcgg cccagatata ttgacatgct 7801 gggtcatgat ccagccgtag acaatgacca acacgcttag gaggataaag atgggaatac 7861 tgagctctag tcgtgcgcgt tcgaggggga agtcagccat atcttgactc ttgttgcggt 7921 ttactgataa accaaggcgt tttgcatgac gccggtagtt ccagtcaacc aactttccag 7981 taaacaaaac tgagagaagg cctcccacac ctatcggaat aaacattagg gagacctgta 8041 gggtattgta cctgtatgtc tccgtaaact ccttggatgc atccgtcaga acagcttgca 8101 atgctgcaga cgagaaacct gcaggaagaa gaacaagtac tgtctcgagg ttcgcgataa 8161 cagaaagtga tttgagtaga ttggggacct gcatcctggg tctttcgggt tttctgatac 8221 ggtgctctgt cttggctagt tttcggcggc gaaaaacatc ggtaagacaa gagttcagaa 8281 aaggcggtga tatactacca ttcccaacaa tgactcgact ggtctccggg gtgaatagaa 8341 ggaagggaat ggcgaaagct ccggctaaga tgaagaggag ccagaagagc caatgccatt 8401 ccagatactg ggtcaacagc ccgccgatga ttggtgctaa tgtaggacct aagattgtgc 8461 ctgctgaggc taaggaaata aattttcctc tctctgaaga cgtgacaagg tcgctgacaa 8521 caccgttcgc gagagaaatg gttccactgc ttcctgcact ctggagacac ctcaagccta 8581 gcagcgccgg gtagctattc tgcaagctca agcccaggtt agcggcaagg tatagggcaa 8641 aacagaggat gtatgctggt ctgcgtccgg ccacatcact gaagcttgct accaccatgg 8701 gtgccacgcc ttggatgatc tagatacatt ctgtcagcca cgccatatca ttcggccttg 8761 atatacgctg aataaatacc agataagttg taacggtcag attgatctgc gcgctcgtca 8821 cactcaagtc ttttgctatg gttggaagag ctgggaagta gatagaggac gacagcgggg 8881 agaaaaatcc ggcgaacgag accatcccaa tgatccatcg tttctggcca acggtgaaag 8941 ttgaataggg ctcttcttcc gtatttccag ccatgggagg cccggtactg ccgtctagaa 9001 cctctagttt gtccgcgacc atggtgacat ctgttggaga agtgccgttt tagaactgtg 9061 ggttcccgtt ctcgtttctg gactcatcca tcatgagcac aggaatctta tcctattaag 9121 ggccaactaa agagctagat tctattctgt gtaccgtgat tttagtgaag ccagttgcga 9181 tgctgagttg acgtcatttc tcctagcctg agagtgtagc tcaaaaacga gccaaggcta 9241 ggtaagcgaa ccggtcccga gccaaggagc taagccctaa ttaagtccgg gtaaaacgcc 9301 actgacgaaa cttgtcttgg aatggaaagc agctatcaaa acaggttaag tgcggctact 9361 cgatagggaa taagatgtgg ctatcacacc ctgcatttct aatggtggtc agaccaggcc 9421 ctggagctaa cccaaagtcc ggatgaaaca cgacacggaa agagctgcag aacaatcaca 9481 tctcggcggg tttgacagga accgatgaag cgatatgcac ctgtgcggct gcggccgacg 9541 ccacctcttt tactatgtac atttcctgct ggatgcaact cacgacagac gctgtttata 9601 tcctatttcc gggttacgct cgattttcaa aatcacccga gacgcaagct gactttaaca 9661 aggcaataag ttgtaattga cctcactacc gaccaggcat caattaagtc gccgatggtg 9721 ataaagcgtg tatcgttata acgataacag ccttgcaatc tttcaactca gatactcggc 9781 gtgtttccct accagtagtc ctcaaacgat gctcatatac tctgatatca ttgcagctcc 9841 aagatccatc aattggcgat gagaggtcta tccttgcccg ttcatgtgcc ccactcaaaa 9901 tgcctctccc accatttgac agtgtaattg ttggcattgc cgcatacgtc taccactacc 9961 cggtatcccc cacctcacac ccaaaggcct ggcaatatgc ccgtatcgcg cttatggacg 10021 ccatgggttg cgcgattgag gctatatcca aaagcgaaga ctgtcgagct atgttcggac 10081 ctgtggtacc agggaccgtg acccccaacg gctttaaatt acctggcaca tcgcatcaac 10141 tcgacccttt gaagggcgct tttgacatgg gtacagcgat taggttcctg gatcacaatg 10201 atgccatcgc gggtgcagat tgggggcatc cgtctggtat gaatcatgta tctcaaccga 10261 atcggaacgg ctttgatagt ctaactattg tcacgtagat aacctaggtg ctatacttgc 10321 cgtcatggac tggctcggtc gctcatctgc caatggcaag ctggagcacc acggcccggc 10381 cttgacaatt gacacgctgc tgcaagcaac catcaaatct tacgaaatcc aaggttgttt 10441 cctcctccgc aatgctttca atgcccacgg actcgaccac gtaattctcg tcaaactcgc 10501 ctcgacggca gttgtttctt ggctgctcgg cttgacggag caacaatgtc acgccgccat 10561 ctcccatgtc tggatggacg gccaacctct ccgtgtgtat cgctctggtg taaatactat 10621 accacgaaaa ggttgggcag ccggcgacgc gtgcatgaaa gccgtgcatc tcagcctcct 10681 caccagggcc gggcagccgg gctctcctac ggtactgaca gtgccccgtt ggggctttta 10741 tgcgacgtca tttggaaaca aggagtttga gtttccgaag aaatatggga catgggtcat 10801 cgagcacatt ttctttaaac tcatgcctgt cgagggccat ggcgtctccg cagcagaagc 10861 ggcgctaatt catagtgcga cattacgagc gagaggcttt aatccgatac agaacgttgc 10921 caaggtcgag atccgcacca atgccgcggc ggacctgatc attaacaaaa aaggcccact 10981 cagcaatgct gcggatcgcg atcactgcat gcagtacatt gttgccctcg ttttgcttaa 11041 gggtgatatc cccgcggccc aggacttcca ggacaatagt ccgtgggcga caagtccaga 11101 gctagcagca ctacgaaaaa agattgatat ccgccccgac gagcaactta cacgtgacta 11161 catggacttg gaaaagagaa gcttggcagc tggcataact atatatctga atgacgggag 11221 ttcattgaac gaggtgctta tagagttccc cgttggccat gtgcagagtc ccaagacgct 11281 tgcaagtctg gaacaaaagt acaagagaaa tatgggctta atgttttcag aggcggagat 11341 ggcgcgcgct aggaaagcag tggaaaataa cggcgacatg cctgtctctg actttctaga 11401 catgtttacc cgagagactc caatattggt aaagttataa gctaatgcca tttttggtat 11461 ttcaatgcat agctagccaa acattaaata atatactctg ttaactaaag tcaaaaaacg 11521 gagtgcttga ctttcatcgc ttgacggagg tgatttacta gattttaggt atcccgaatg 11581 caaggtatag taatgaaacc atttagtgat gaagctattt attaataatt tcgtttaata 11641 atgaatccat ttacattccg aggggccgaa tgcgaacatc ttcatatcaa tagattgtta 11701 cttttgggtc atagttctct cacaagccat gaccttatcg cgaacatgga atatcgaact 11761 catgagagaa caagagaaca tgcctgaagt attgccagag atccaaagca ttcagtaaag 11821 cagggctgca ccctcgtctt tggtttatgc ttagttatgt gaaatgacct tgtatacggg 11881 taatgcgttc tagagaggct taatcactgt tctacagcct gaatcttcta ataccgccca 11941 ttttagtcca tcctttaccc attcgaataa ttgatattcc acgggcttct tcttcatcat 12001 gttatacttt cgctgctcaa ttccactttg ttcatccttc agctactggc agcccactgg 12061 tactatggct gccagagagt ctactcgttc cctggcccgc cttcccactc agctggcata 12121 tagccaagaa ccctcccctc gagcccttcg ccgggcgcgc gaccctttgg tctgtcttgc 12181 tcgggcataa gggcatatag ctctgaaaga tttggcatac cattcggacc aggcatccac 12241 tcataatggt ggatatgacg ggttgaattc caccagttct cgttttcatg caagagttgg 12301 gagactttca tagaatcgat atacgtccgc acttcaatca tctgcttcct atcggatgac 12361 cagcgggtca cccagacgtt gatgatatcg aagagggttc cttttgatca ttccctgtta 12421 gtattgtaac atgtccgtcc tgaaggaaag agaatggtga ccgaccgcta ttcgaaatgc 12481 cctgaaagtt catttcctgc accgaccact cctgatcaca gcccccgtga atggccttcg 12541 ggatgattcg gaaattttct ggatggtcgc tcccaacgag ggcgactcgt ctcaaggcgt 12601 tgacgtagaa gtgcattaaa tcgtgataaa cgccggcacc tggatgattg ccaacaatgg 12661 taaagtgcac gtctttgttg atgagggtaa ataagctgcc catgtccttt tccagggtct 12721 tgaaagcttt gtagacaaaa ggctgtgaca catatttgca atccatttct gggttctcga 12781 agtaaaaccc gtcgcgctcg gcctcttcaa tatctggatg cacccagcca acagggttat 12841 ggctaagagg gcgttggtgg gtatcatggt tgaagttgag gggtttgccc accactagga 12901 cgggcagcgc gacgagcaga tatcgaatgg caaccatgtt ggacgtcggg ttggtgttga 12961 ggatgaggat ggacttggag acgtaaaggt gaggggcttg gtttatgact gttgaataac 13021 gccgaagtaa ctgacgcacg agtcgctgtc tagacttgat agaactatcg ctccatcccg 13081 gaatacatac cattggtaga aacggttgac taaagatctg cttagtgccc gttcagttgt 13141 atgtcggcaa cctaggaagt agggaggcgg acggtctcga ccacttttga ttggctcaaa 13201 ccgccccatt gaatctccat gtctctcttc tgctctctaa gtccgaaacg aggggagtct 13261 attcccgttc gataaaagcc atgcaatttt catccagcca ataattcgaa gactatacct 13321 accgataatt aagcggactt agagaccagc ctcgtcgtgg ccacacagct atgtagcatc 13381 gacgaacttc atgcctatct cactatatac ttacatacct atatgagcga gtttcttggg 13441 aaggccgaga tctctccatt acgtctgtaa taaaccaatg atgaacactt atatacaaaa 13501 gacgaagtaa ataccttgaa catttaatgt gccaccagga cacaagctgt aacagggacc 13561 tcccgcaatc ccgcttccct ctgacccaaa ctccgccatg gagagtcctt ctgccgctag 13621 ggtgagccca actcggccca aaactcccag cgaaacaaca cccttactca atgcggctac 13681 cggaggagat ccggagcggt actcagcttt tggcgaaagc cagaaaaagt tcatcattct 13741 caccgccgct ctagcatcca cattctcccc cttctccagc aacatttact acccagccat 13801 caactccatc gccgatgact tacaagtcag catccctatg gtcaacatga ccatcactgc 13861 ctacatgatt tttcaaggtc tcgcccccac tttcatgggt aacctctcgg atacggccgg 13921 gcgcaggcca gtttatgtcc tatgtttcac catctatatt ctggccaata ttggcattgc 13981 cctacagcac agcttcgtgg gtctccttct cctacgctgt ctccaatcat caggatcctc 14041 tgccacaatc gctctctcca acgccgtggc agccgatacc gttaccagct ccgaaagggg 14101 catgtatctc ggcattgcgt ctctgggttc tatcctgggt cctgctcttg gccccctgct 14161 aggcggtcta ctcagccaat acctcaactg gagatccatc ttctggttcc tcgccgcagc 14221 cgcaacactg gttttcgtcc cgctcgtact tttctacccc gagacctgcc gcgctattgt 14281 gggtgacggg tcaatttccc cgcccgcttg gaataaatcc ctcctcaact atctaaatga 14341 aacaaagagc cactcggtgc agaataaagc gatggtcata aagcctaaga tcaggtttcc 14401 aaaccctcta acaacactac gacttctatt cacactcccc acgggcctca tcctgctctg 14461 caatggcgta ggctacgccg cccactttgc cgtgacatcg tcgatgccta gccagttcaa 14521 tgaaatctac ggcctcaacg acctgcaaat tggactgacc tttatcccaa tcagcctcgg 14581 taccatcctc tcggccttcg caaatggcta tctcctcgac tggaatttcc ggcgtatagc 14641 gcgacaagag ggtcttccca tcctcaaggg caagaagcaa gacgtgtcta atttccccat 14701 tgagcgagcc cgacttcaaa tcgcgcttcc tatgttgttt tctgccgccg cgttgatcgt 14761 cgcatatggc tggctgctag atatgcagct ccccattttc gcgccgctgg tcttgctgtt 14821 tctcatcggc tcgtctatca cggcatgcta taatgtgttt aacgtactga ttgttgatct 14881 caactattcg actccagcta ccgctaccgc agcaaacaat cttgtgaggt gtatgttggg 14941 agccgcatct accgccgtgg ttgcgccgat cttggagagg tttggtaggg gctggacata 15001 tacctttgtg gccggggcgt ggctggctgc tacgccagcc gccctgctgg tctataggta 15061 tgggttcgcg tggcggagga gggatcgatg cgaagagagc taagtgagtc gacaagaagt 15121 gagttaacaa gatgtggaag aatgcgttct accagagact aggtactcaa tcaaacccat 15181 tgtgccccca cacatgtttc gacaacgtgc aagtgaggga aagttgagca gctactacta 15241 tggttgccta aacctgttgc tgttgtattg agggaagaga aaaccgcacc tctgacaaaa 15301 tctagttggg tacctcgggc aatgccactc tagacaaaag cttaattaag ccttcaacgt 15361 ctccaaccat ttctcagcct ccactacctg gccccttttc gtgaatatct tgtccatcag 15421 agtattgtgc aacgtctcat cagcatccac acacagatcc ttcagcacca caacgccgaa 15481 gtccttgtct gatgcctcta gaacggtcga cagcaccact ccccctgtac tcatgcccgc 15541 caagacgacg gtctcaatgc ccaagctact caggataatg tccagcccac tcccactgaa 15601 tgcactcacg cgcttcttgt cgacaagaac gtcaccctct tgcggagcga tagatgggtc 15661 gattaaagtt tctggagaac cctcgacgaa ggattttgac ttcacggcgg cgctgaaggt 15721 aggatttgaa ggcgagatct cgggatggcc ggggcggaag gcgactcttg tgtaaatcac 15781 tttgacgacg gacgggcgtg cggcggcaat ggtctttgcg agacggggaa ggtaatctga 15841 cgattgagct aggcggggca cgaatgcgcc ctgcacgtcc atgaccagga gggccgtttt 15901 cgccattttg actcggagtt atcgtagaag tcttggagat tgcttgaagc gtcgcaaatg 15961 gattaaagaa cgatactgag atcttggcgg aagaggaaat aaaatggtag taaagaaccg 16021 atatcctttt gcgatatggt tttataaggt tgtatgcatg tgatcgatct gcacggcgat 16081 ttgaaacagg gatgcggagt tactcggagt ttaatttgct aacagatcat aagtgaccga 16141 aagatttggc aggggcgtcg aatgttgccg accacggcca aatgacccgg gccaactgca 16201 agcggttaac tccgacatgg actccaacct gtcaaggggt ctggtccgta cgcttgtctc 16261 ctaattactt gtggtttcaa ttttggcgaa aactgtagtg gggtgcgatc cgcagaccag 16321 cactcaaatc aacaacgtac ctgttatctc cgaaatctca tgattggcag gttagtcgat 16381 gctctcattt ctccttctga atctcattgt taaacaagac aggattattt gcatcctatt 16441 tctccagtgt gcgcgcgact acggagaagg caacccgcgc ggtcgggcaa tgcgctcggc 16501 gatctgtgga cctgcgcact agcaacgccg ggtactaaca acgcgaatgc gcggctttct 16561 aaggtcgcac tacggaaatt aacgctcacg gctttgtctc actggcacac tgcggacgcc 16621 atactctgtc actaatgggt ttgtaaatgg caggcaggaa aagaagtagt gcatagaggg 16681 ctgtagatgg aaaaatctca actgtaaatc ctcgagctga tctttgcctg ataatttttt 16741 cccagcattc ttcgaagggg tagtccatgt cagactaaac aagggacaga gaataaacta 16801 tattgactac agcaccaatt agccaacgag cggtgatcat aaaggaggca aaatttacag 16861 acaatattgt tcccctcaag ttccattctc agcgcccaag atgtacgcaa gcacacgtct 16921 cgttctctcc atcttcctgc ttggcctctc catcgcgcaa accccgcctg ggttcactcc 16981 gtcttgtgac caaaacttgg gtgtcacata tccaaacaag gcatctatca ttatccccgg 17041 ttcacgtctg ctagcttcag gtatacatat agtctttttc tctcccagtt cgccgacctg 17101 acgtcaagca gataccgcta tccaaccccg cctctctgcc gcctccgatg tattgaaaga 17161 agatggaaaa tatttactcg tcatgttgga tccagacgtt caatttccga agcaacccac 17221 gactacaatt ctgcactgga tggagccggg cttccaatac aacaagacct ctctcgctct 17281 cacacccgta tctgaccccg aagctgagag tgtagctagc tatgctgggc ctcatccacc 17341 aattggccag atccaccgtt atattttgct tttgttttgg caaccggaag attacagact 17401 cccgaaagag tttaagagtt tcattcctgc agacattccg cataggattg attttgatgt 17461 ggtcaggttt gtggaagcgg ccgagctggg gaagcctatt gcggcgagct atttcatcgc 17521 ggaagggcta aggtcaaata tgaaggacga gctcaggagg gtggtgtaat tagtgataat 17581 tattgccaaa ataacccttt tccctgtatt tttgtgactg aatggcttgt aggtttatat 17641 tcacctaggt gctgctgtga tcacagaata cagagctctc tctaggagct ggatattcgt 17701 tgtgaaggtt gcaatttttt gattctaatc cgaaaggaag gcgggattga aggtcctgcc 17761 cagtagaggt ttatatagcc ctgatcacag ggagcagggt atttaggaga gccagtctcg 17821 tgtgtaggca cgtggctggc tggctggctg gcctactgtt tacactctct ccctacgggc 17881 gcagtgcaga gagtgcgctg cccgctctct acgttccagc tgcgttaccg cggctccctg 17941 gctccctggc tccctggcta ttattatacc aacaggctat tttccgagca gtaactttct 18001 tgactcgctt gatattgagg tttatagcac tacacggtgg cccaaccttg attgctacag 18061 tgttctagaa actggtcaac ttgatcccaa ctcccgttac aaggactaaa gaggtacaga 18121 ggaggatttt atgtagtgta tgtatgagac acaatcgatt gaggagatgt atgctggcaa 18181 taataattgc aatctagagt ctacacagcc tagtaatgaa ataaactaaa ctagttactc 18241 cttctcaact acctttaagg aaactaaacc gctcctttgc gcaatcttag cacttagctg 18301 ctgtaaactc tggttcgcaa gcaactccag aattggcatt gtgctatcca tctccctcac 18361 aatccaattt cgcatctcta ccgccacgag cgagtcaatg ccatagtccg tcattggatt 18421 atctcgggat atattgtcag ccggtatgtt agatctgtcg ctgatcttgt caactaaggc 18481 gttgcagatc tgctcggtcg cttcctcgag agttgtggcg gccttgagaa catctcgaac 18541 tcgagctttg ccgtcagcag caccactgtc cttcttcaat gcctggcgtc taaagtggct 18601 aaacaccggg aggtcgtaaa tagcaagcga cttgccctct tgccacgtgc ctaggcctgt 18661 aaccacgtgc gacagaagat cctcgcgtct cgggtcggca atggccgact gaatgagtgc 18721 gagtagtttc gccttgtttg tgccctcgaa gccttgtcgc tgcatgccgg cggcgagctc 18781 cttgtccttc tcagctagat aaccgacttc ggtgatgaca ccgagatcga gcgtcaccgc 18841 gggaaggccg agattgctgc gatatgctgc gaaagcatcc atgaacgtag atccggcggc 18901 gtaagcagcc tgcgtggcat tcccgataat gccactgacc gaagagagca tgaggaagaa 18961 gtccatattt tctgggaggt tcttatgaag attccaggtt ccttggacct tgggacgaat 19021 gacggacata tagtcggtga gaggcatctt ctcgaggagg ccgtcctgtc atgatatgtt 19081 agcatattct gaataaggga gctgaggagt tacttgatga cgcttaccct taggaccata 19141 gctccttgaa taacgccgcg aattggtggc atagacttgc tgctttccgc aaccaactcg 19201 gcaactgcct cgctgttgct aacatcgcag ccatagacga cagccaaggc gccctttgat 19261 ttaagagcgt cgatggtttc cttcgcttcc ttcgaagcta gaccgctccg gttggcaaag 19321 atgaggttct tagcgccgtg atcaaccatc cacaatgcag ttgctcgtcc aataccgcct 19381 aggccgccca caagtaggta agacgcatcc ggccggaata ggttcttgct cgtatcccgt 19441 ggaactgctt gtaccatctc atcgggctcg gccactgcaa ccaacttacc catgtgcttt 19501 ccggtttgca taatccggag ggcatcctcg atctttgaaa ggcggtggac gtgcaatggc 19561 gtcggcccct tgatggactt cttgcgaaac agatccatca cgtcggccca gactttatct 19621 ccaacctcac gcctagctct gatcaagtaa accaagttga atgccgcaaa catggggttc 19681 ttgatgaagt tacccatctc caaccgcgta ttgacagtaa tgtcacgggc gccaagctcg 19741 atgaagcgcc cataatcagc aacacaattc cagctaagcc ggagagcttc tccagcaagg 19801 gaattaaaca caacatcagc acctctgccc attgtcatcc tcatgacacc tttggcaaag 19861 ctgccatcgc ggctgtagaa gatatggtcc tcggggatcc caaaacaatc cattagtagc 19921 tttttcttct cttgtgtccc cacagtagcg tatatttccg cgccgatgag ttggcaaagc 19981 tcaatgatgg cctggccgag gccgccagtt gcagcgtgaa caagtacaga gtccctcttc 20041 tccactctgg cgaggtggta gactgagtag tatgctgtcc cgtaggtgac aggaagggcg 20101 gctcccattt caaacgacat gtcgtcgggg atcttctgga aggcagtcca cttctcgcgg 20161 tagaagttac aaaaagtgcc gaatccatac gtagagacgc gatcaccgat ggcgaggcct 20221 cgggcattct tgcccacagc ggttaccaca cctgcacact cgcctccgag agtctccgtc 20281 tggatctgac ccagacccat catgacgtct ttaaaattga gacctgttgc cttgacttcg 20341 atctctactt gatcatctga tagaggctga accatcctct catcgtcgat gaagtgaatc 20401 gtgtccagga gaccgggttg gccaacatgc atgaccagag gtctgccaga ttggtggaat 20461 ggctgcagct caggaactgg cctgctagac gatgccaaga ttttcttgct cagtttgctg 20521 ttctcaacaa gtcgggaaat caggatttgc ccgtcccttt cggcatactc tgtgtcaacc 20581 tcgttgggca acatatggct cagcagaaaa aggtgccgga atagagtgaa gatggcttct 20641 gatgctgagg agcttgggga cttcgacttt ctggaatcaa gatcgagtgt agcaatgatg 20701 gttcccccat tctctgagcg ggccgtccgg gcgaaaccag tcacgagatt tgaggtagga 20761 ttagaaaacg agagcgtccc tccccgggta acccaaagaa caccatcact cttgataaat 20821 atgtccttga cgacctcgaa ttgctccaga gagggatcga tcatgataga cctggtaagc 20881 tcgctgagga caatgcatat ttttccgaca ggctttgctt tactgaaagg cgttacctca 20941 aagccgatat tgaggctagt cagacgttca agcaggtcat tcagaataac gtcgctatca 21001 tcctcttcgg caataacaag gacgtctgag atgtgggcag tttccttctt gtgaagagca 21061 gtagaaacca tcaccgagct ttggtggtca ggtccattag ggacgtccca gacaaccccc 21121 tccaggccgg agaagcggct ggccaagagg gcagcctccc agtcgccttc ggataggact 21181 ggacttgctt gccgattttt ttcttcggca gcccaccagc tgggaagggt gccgaagatc 21241 aaagaagaag ccatatgctc ccttgtcaca tcgagaatca ccaacttgcc gccgggcttc 21301 aatagcttgc gagcattgcc taaggcggta tgcagtgact tgctcgtgtg aagggcgtag 21361 gcggcaaaaa tcacatcgta agactctgca gtaaaccctt gcgcaaccgg gtcgttgtca 21421 atattaagct ctttgaaggt aactagatct ttccagggcg cggctctctc cttgagcgag 21481 tcgaacaagg tactgttgac atcagtgcaa tcatacttct ggaagcgtgg gaggtcgccg 21541 tccgcaccgc cgagcgactt taggatcgga aaagtggccc caccggtgcc gacaccaatt 21601 tcgagaatgg acaggtgcgg actcttgtgg ccgaggaggt caaaatattc agccgcggcg 21661 aggtaggttc gagcaattcg agggctgtcc ttgaaataag cttctagcct ttgctcaccg 21721 ataagcaaat tccatggatc gacttctttt ttcataattg cggggagatt ccgtcccatg 21781 aagcataaga ggtggccctc tggcccggaa tcccggatgg catgtctcaa cttcgccctt 21841 tcagccccac ctgcagctag ccacgacgca gttgggatat tgaacttatc ttctcgaaca 21901 tccttgacca acttctccat aagagcatac atcttctgga gatggggctc catgatgggc 21961 agctccgctg gcgcgacctc agccagggcc cactccatat agtagtacgc cgtctgctcc 22021 aatcctcgga tagtggctgt ctcttgtagt gacaagggag cgttgtcaca gagctcagaa 22081 atgccattct tagacaggag atcaacatcg gctctccatt ggaagttgta ggcgacgcgc 22141 ttggtttcct cgcctgattc ctgggcaatc tccctcgcaa gtgtggtgca ggtaaggtca 22201 cggattgtga gcaccggctc gctgttcagt cggctcccat ccaaaatcgt catggacgct 22261 gtcaggtact tgtcgtcttt tttcttagtt ccggcgtaga ccactaattc gtcccctggt 22321 tgggaggtga tgttgctcga cacgtagatc tcctcgataa acaccggaac ggctgggtcc 22381 ttcaaaggcc cagcttcagc ggctaaagcg acaaaaatgg gatggaagat ggcgtcaaga 22441 gtggaagggt gcaagatgca ggggaattgg aagtgctgcg gcatgacggc agctgtatcg 22501 gcaatggcca cagtcgcaat acatgagttg cgagcagcac gggccttggt cacatttgca 22561 aatgtatcgc cgtactcaat ccctagctgg gtgagttgtt ggtagaactc cttcacatca 22621 acatcgatat ggcacttgtc ctcggcttcg acgatgattc gggtgtagtg gttcatctcg 22681 gcgaccgcct ggacatcacc atcaatgatg ttgatactcc tctgcggcgt ctggacagca 22741 atcaaacctc tgcagtgctc cgtccaccgg ttgtcatcgg taacagagta gacacaaaat 22801 tcgtcccaca agtctgatgg cgcgcgaata ctctccgtat gtggcttgaa gctcacaagt 22861 gtttccacac cgtcggactg ttctgggatg acaagagcag atccaatcga gatctcccgg 22921 agcttgtagc cagtgattgt gagcgatttt tcagtcgcac gctggaatgc cgcctcaatt 22981 gccatgacta tatagccagc agcagggtac acgacgttgg attgaatctt gtggtctttg 23041 acccacggga tctcagatgc acggatatga ttacgccacc gcggttcgag cgggtttgag 23101 ttccgatcca acgcaccaag caaatcggtt cggggaaaag ttctttgacg gaagaccttg 23161 ctcaacctcg gctccgccca gtagctattg gaatgattcc atgggtaggg tgggagatca 23221 actagaacgc tgtggctttc tgccccggtt gggcggttga gagcagacaa attcaccgga 23281 tatccgccaa ggactagctt tgatgcgaga tccagagtag ttgtgacggc gtcaaccttg 23341 cggatgagag cggaggcata gccgatgcct gcctctttca atttgtcatc ggcttgcaaa 23401 atctgcttga tcggcccggc aagtgctgag tgcggtccaa tttcaacaat agtgttgacg 23461 gttggggcag aggcacgctt ccgagttttc ttcccgctgc tcgatgatgt ttcaagacac 23521 aacatccgta gagagtcggc aaacttgacc tctcccagca tattagctac ccagtatgaa 23581 ggaccaagct ccgaagcttc ggccctccgg ccgaaaaccg acgaatagaa ttcaacttcc 23641 ccagtctctc gaattttgat tccagagata gcattgccgt actcttcggc gattagtgcc 23701 atgtgatggg aatggtacgc gacgtccacc gctagctttc gcgagaacag cttcttctct 23761 tcgaataatg attggagctc gtcaatcgcc gtagcgtctc ccgagaccgt gatactggat 23821 ggactgttaa cgcaggcaac gcccgcctta cccttcgtca aactagatag gtaaggtagg 23881 gcatctccct tagacatccc tacagccatc atggctccag aaattgggtt tgtgcttcgc 23941 acgttacttg acgaaacgcc acggtagtag gctacagcca tcgcgtcctc ccagctcagc 24001 gcacccatag cataagcgga ggcgatctca ccactcgagt gtccggtaac cgatgcgggt 24061 ttgattcccc acgaggcgag aaggtcgaca attgcaatct ggaccgctga gcataacggc 24121 tgactatata atgctagccc gatatcagat gtcttggggt ctttcgtaag ctcctctgtc 24181 acatcgaatg gtgccccaag agtcgtcaag tatgaaccta tctttgcgat ggtgtttcga 24241 aatactggat aagcgggcag tagctctttg cccatgccac accactgagc tccctggccg 24301 gtgaagacaa acccaagcgt tggctttttg tttgcttttg agaatttgat atcgcctaac 24361 aaagctttgc tcaagtcgct ttttgaggag gcagatatcg cggctttcca gataaactct 24421 gttcgtcgtt cacccagagt atatgcaagg ttatccaggt agccgtcgtc caagtcctgc 24481 ctggactcaa ggtagtcact gaacatcttc gcctgccgtt tgcaagcatc ttgatcaaag 24541 ccagagatga cgaagagcct ctgacgctcg cttgagagtt tgccattcct ctcgccattg 24601 gcggatccat tggggtgccc attagggtgc ccgtttgcat gtccgcttaa atgcccgttc 24661 gtagacccgt tcgcaaatcc gttgctgtta ggagtaatct tgtccaactc gggagtgagg 24721 atggatttcg cggttctaat cgatccatgt agcccgcgta tagaaaggta gtcttctgcg 24781 ctctcaagaa tagcatgagc atttgagccg ccatagccga agctattcac agatgctcga 24841 tgcgggccat cgacaaccca aggctccaca agagtattaa cttttaactt ccagtcgtaa 24901 aacgggatgc gaggatttgg ggtttcgaag tttcgattag ggagcaatat cttattctca 24961 agcatgagaa ctgtcttgat aacacctgcg attccgctag ccccctccaa gtgtccaatg 25021 ttggtcttta tcgacccaat gcgcagaggt tggtcaaggg agcggccagg accaaagacc 25081 cttgagagag cggcggtctc cagagggtca ccagcaggag taccggtccc gtgagcttca 25141 acataactag tctcaagggg atcaaggccg gcgctttcgt agacgtttct gataagtgac 25201 tcttgtgcag cgccgcttgg gagggtgatt ccagacgtct tgccgtcttg atttgagcca 25261 gtgccccgga tcacggcgcg gattgtatcg ccgtccctga gagcgtcggc gagaggcctg 25321 aggatgacac aacctacgcc ctcacctcgc gcatacccat ttgctctatc atcgaacgta 25381 taacaacgcc catctgggga catgaatctg aagtcatatt agccaaatgt tctctaatat 25441 tatcttgatc tctccatacc tcatcatact catagtaatc atgatctcgt ggctcaatat 25501 gacgtttgcg cctgcaacaa ctgctctcgt cgcatcgccc gttcgcaagc tctgacagcc 25561 tagatggaga gccaccagac tagccgaaca ggccgtgtcg attgtgacac tagggccttg 25621 gaggttgaaa aaataagaga gacgattggc gagaatggct cgcgaatgtc cgctattagt 25681 gcattggtac attggcaccg tttccgggtc tcgcatcaac atatcggtgt agtcgccaca 25741 gaacgacccg acaaaacaag acgtcttgct tccttggatt tctgcaagcg gtgttcccgc 25801 attttccagc gcttcgtagg tgcattctag caacaatcgt tgttgggggt cgagcgctgc 25861 ggcttcggca ttcgtcatgt tgaaaaacgg tgcatcaaag catgcgagat cttgtgtcat 25921 gaagtgacca gccgtgacat tggttgtccc attcctgttc gaatctgggt ggtaaaaagc 25981 atcgttgttc cacctctcct tggggatctt gctccagccc tcccgcgctt cggagactag 26041 tttccataga ccctcaacgt tggtagcatc tgccgggcct cgcataccca ttcccacaac 26101 ggcgatgggc atggaccggt cttctgagat agtaagggcg ggattggagg tgggtgaccc 26161 agaaggtaga cttagcacct cgtcatggtg cccgttaagg tagggagcca tggtggaggt 26221 ctggcggcga ataagttcag cctgtgctgc ctggctggcg agtatactcg tcttatgaaa 26281 tatgttcttg cttagagaaa ggtttgacca tgtgagcatc taatatttcg tagaatagga 26341 tgtcggtttt tactttcgtt ttcaaaaggg gctcgagaac catttagaga caacttcggc 26401 tcttggagcg cccaaatggt ggtacttgaa gctcggattc tttcaatcca aagcggacat 26461 cgttttgccg cttataggca tattgatcat agcaacaagc gctatgtcac cgagcgcgtc 26521 aaaaacctca ctacgaaaaa gggcaactga tattttatgg attactaagg accggtcata 26581 ttttaatttc aagcttagag ggaggtggtg taggccgaat gcgtgtgcaa tccaacccaa 26641 aaaccgctaa ttgcaaaata gaccgaacta ccgtatggat cgcggagaat ttgcccagat 26701 aacaggaaaa taaatcaatt aagcaatgta taattaggtt tttttcttcg ttgacgattt 26761 atcgatactt tattacaaaa ttgctggcaa caactttgta ttctctgtag cgtaaaacgt 26821 tggtaattac cccagagggc atggtttaag aaattcaggt cgattaatta actacccaac 26881 ttgggtaact ctttattctt aaaaacgcta taattagccc attactagat cctccaatcc 26941 ctcgccaatc agaccatgag ctatgtagta cacggagaga tcttgtaaaa aaaaatacac 27001 cgaaatccaa aattcaccgg gcggtttttt gccggtccca acttccctaa ccgtaacgtt 27061 ccaaagctac tgtgctaaag gcaacttccg aaggtttaga tctgctattt ttattagttt 27121 ctgagctgtt tcaattaatt agaccttgaa gtttgttcct tcaagctcaa tagatatgtt 27181 tcattgatgg tatggcctaa gtctgccgga gataacgtct tcatgaacgc gatgcctctg 27241 ggctagatca tgtcaacatc ctaggtgcaa tataattgat gatgagaaaa cgtaagtact 27301 atatgcaata tgaacaagta aaaccagagc atcgacaata cacatatatc tcttattgat 27361 gagggttggt tattcattta ttacgcgtct ttaactgtct tgatatttac gtaagtggaa 27421 ttaaagttgc cttcccagct ttgctaaaaa ctataagccg ccttctggta tctattagca 27481 ctacagaaac atagacctcg tccctagatc tctaaatgca gcggccattc tagccaacgt 27541 ctttccgtcc gatgggatct cgtgtcccct atcatgcacc aaaatcgctg acgatttcac 27601 atcgcacaag ttgaaaaggt ggagtgagta actgtaaatg aaatccttag ttcccataac 27661 atgaagcgtt gggatcttga ttttgccctc taatccctct tcgaaaactg gagtttcgtc 27721 atcattcatc cggaatggag caagcgagct gaagaacacc gcgcaccgaa aaagtggtgg 27781 gtcataaggg ttcagggtgg cgtggtgggc gagaaagccg gttgctaggg ttccgccgtg 27841 ggaaaagccg aggatgccat caaacggtcc ttcttcttcg attacctcgt atagcatatc 27901 atatgcttcc attatagact cgtcgttatc attaaatgtt cgcggccatt tgtagtagct 27961 gaagaacggg ccttcgtaga atccttcaat gccagggccc ggtggcgacc caacatctcc 28021 ttccactaaa tggaaaatag cgctattgtc tttcccgagt tctcgcataa ggggtccgag 28081 ttgggagccg agaatctgcc cgggttatcc ccaagtcaga atatgtaaat ggtgggggca 28141 tgcctagtgg cgatactcac ttgtgcgttt gttcccgcac catgaagaca gagaaatttc 28201 agcgtgggca ttttccaggt ctgcgaatga gaggttattc tgttcgttga gatctgtggg 28261 tcgcagtgtc tcaaaaataa atgtgtccaa agaggagttt ataaaatgct acgccggatg 28321 tttataagct cccgattata aggtgaatga atatgcttgt ctaggaagct gagatgctca 28381 gatgatatct gccggctcct aatgcttccg tgcatcataa gccaatgaga cctgataccg 28441 tatgcaagta catgcaaggg taggtatgaa aatatctgga ggcttatctc ggggtgaagg 28501 ctgcgtgcct gttcaaacac tcagttcaat gctattatgt gcatgagtca aatggcatgg 28561 cagctatcta ctctactcgg gcatcttgca aacaatcctt tccatgtcgt ttttaggaag 28621 gttgcattct tctccctaca taccccaccc agtcactcct gtttaagccg ctgtcaactt 28681 gatttgatag gcttgaaatg gggcttcata ccccttttta aaatgcagcc ggaaaaagga 28741 gccgctaaat gggtttgcca agctttgata ggacgtggaa atatatgaaa agtgtttctc 28801 ggactccggc aatgaccctg gagtagaaaa ttacgggcgg attattacta atgtccgtag 28861 attaccttaa acatctacct tcgaattggt tgcccgggct ggttccgaag tttaatatcc 28921 taagaatata agtttttcgt attatactct tatgaggcca tgctgtttta ttattgggta 28981 cttgcgctct cgggtgacaa ttgctactct caaactatat gcacgctaag tatctatgat 29041 cggcctggtc aaccatcgat ctgttgcatc tgctcccacg gtatattgca tgcataggtc 29101 aagtgttatg ttaaagtttt aggctcgtcc gctgttgtta ttctactatt cccagatccc 29161 tccatgccgc gagccaagcc ccaaattcga cggtctcatt tattctctac agtttattga 29221 agctcggttg cctaacttgg ccgtggccta tgtaatgaag ttagtgatat cgtttcgagc 29281 ggacggaaag ctagtgcgat gacttactgg tgtaattcac cggtcggact ttctgtatac 29341 gtgcagtaga ctgtgcaata gattccgcga gtcttagggc gtcaaaaatg gcctcgtcca 29401 ttgtttctga tacactggaa acaaattcca ttctgtgtgc gtcttgggca acgaatgctc 29461 ctccagacat aagcatttcc cggaatacac tagcgccgtc catagtcaac actgcaggtg 29521 gcatctccgt cattgctgcc tcaagagagg tgtttttctg cgtcgcgtct ccaagcaaaa 29581 acctcgcgtt tgatgtgcag atgcgtatgt ctgagccaca ggcaatatcc aacgccagtt 29641 ttgtgcagat gccgtgtaag actgatatga tagctttttg atgtgttaac ggccatccaa 29701 atccatggtg gcagaactca ccagtattgc atttcaacgg ggcaatcatg tatgacctga 29761 acttttcttt tgtcgtctcc gtatatacct ctgtgtttga gtccgtgttg aaagcaaggg 29821 cgctatcatc tttaccaacg gcaattataa taacccgcag cttggaatcc tgggagaggt 29881 attcaagcaa tctcttcaac gccaaatcta attctgcatc aggtgttcga gaacacttca 29941 cctcgacaat agcaacgtaa ttgccccgga aatcaacacc cagtcttgta tgtacagctc 30001 ttgactggtc ttgagacata atggaaagag tggccgctga aaagtccaaa ctaatagagt 30061 gatggtgagc tagctaccct atgagcagga tacgactact taaaaatggt agaatacgtg 30121 ttactattag atgctggtta ttggcatcta ggtgggggaa ggtatttgcc taaaaggtag 30181 ccgataagtg gtgccttgcg ccgaaatgtt accgataagt tcccgccata atcttcggtg 30241 ggctgttgat tagttcccgc accgggtaga tcgtgtcgat cccatttgag aggtcatcgg 30301 atggttatac aaagcgaggg ttacttacat aagcctgaag taacattctc atacaattct 30361 ttctttgccg agacatttta gtcctagctg gaccttttgg taaaggttgc ccaaaagctt 30421 gaaaattgaa gatccaaaag atttttgaat acattcaaac gaaccgaaaa ctcccgaatt 30481 gaccaccttg ggtgcgacaa gagacactcc cttcctctcg tggcctcaga gctgttcaca 30541 atggcgcatc ctaccaacgg cactttgttt gtgcgagact cacgtactaa gcaggagtac 30601 gagataccaa tagttgacaa tgcagttttg gccgtggatt tcaaaaacat caggggttat 30661 tcggatggat cgaagatgcg aggattgtta ctttacgacc ctgggctaca gaatacagcc 30721 atcaaaagat cgcaaataag ttcctcgtaa gaactccgaa gctttattct tgccaaaata 30781 ttaatttacc ctatggggac agagatgcac gaggattgcc catgattcgt ggttattcag 30841 tcgagcaact ttactcgttg caaagcgact tcgaggacct gtttcatcta atggttcttg 30901 gaaaataccc cacaccagaa gagaaggaaa tactgcgtca tacctttgca caagagatga 30961 tcaatgtgcc cgacacggtt gttgctgcaa tcaaagcttt tccgtaagtc ccaccccatg 31021 ctaaacaaat ggagtcactc tgacctcttc actcgtttgt agaccatcaa gcacaggaat 31081 gtcaatgatg ctagcggggc tatcagcgta ccttgcctca tacgaccacg caataccggc 31141 gaaacagggg ggaaacctat atcacaataa cccacgactg gccaacaaag ctgccatcaa 31201 aaccaccgcg gcttatgcag tagtcttggg tctaacgata agccatcgga aaggcatccc 31261 atttgcccca gcccaagcta acaaatcatt ttatgaaaat ctctttaaca tgatgggtat 31321 ggcagatccc atcaccaaac ttcccaatcc actctacatc gatgtcttcc gccgcgcagc 31381 aatattgaat gcggataacg gcatgacgca ttcgactttt ttgacacttg tggctggctc 31441 ggcccttccc gatccgttat cctgtctcat tagcgccact tctgccgcct acggcccgct 31501 acactatggg gcacaggaag ctacatggaa taatcttatt gagatcgaga cgaaagagaa 31561 tgtcccggcg ttcctggagc aggtcaaaag gcgtgagcgg agactatttg ggtacggaca 31621 ccgtgtccac aaaacggaag acccaaggct agccattatt aaaggcttgc ttaaggagtt 31681 gaacgtttca cccgcaacta tcccgttgat ggagattgcg tatgaaatcg acagattggc 31741 tgcgttggat caatatttca cgtcaagggg tttaagcgcc aatgcagatt tttattttgg 31801 cttcttgatt catgctttgt aagatcagac actccatcct gattctcgat ttttacaata 31861 ttccaaaagc caaaatcacg aagaagcgaa ctacgaactg actgacatca cagtggattt 31921 gatcctgaca tgatcacgtt agcaaatctc gccatgagga tactcggcct aatggctcat 31981 tggcgtgagg caatggatca agaaattaaa ctgttccgcc cacttcacat ctacacagga 32041 ccaaaacaaa ggataaccgc agccaggcta taggatatgg gtataggatt actttagaag 32101 gcagatataa ggtatcagtc gttgttgtta ctactcgtac atgtcatagc tttgagagca 32161 aaggaattta caacgaactc ctaaagacaa agtaaacacg tagctttcca atgtagtaac 32221 actatctaca cttaaagcca gtacgtagtc tacttaagca tcttagtatt cttgagctat 32281 tcgtgccaga tagtattgcc acctactaac ttcatgtttt ttatacgtat catgagccta 32341 catgcccgag aagtgttgag agtgttagca gcccgttttt aaaccaccgg cgccactcgt 32401 ataacctgcc tatatgtaga cctgacagat ttgaacgcga aggcctcaat agagctttta 32461 tttatttgta acatacttag ttcttccaaa tgtaccctct gagctagtag caaatatatc 32521 ttccacagaa gcggtccaga gtaggagatc ctcagcaata atatattagc tgtcgtctag 32581 ttcgagatat agttcaattt actaaggctg ttatagaggt gtcgtcataa gttaactata 32641 tcctcaaacg tcactgaaat tagttaagtg aagttattta tagcatgacg agatgaatca 32701 actctacggc gctggttatt atctactagg cctttaacgt cattttacac cgtctaaggg 32761 attactgaga ttctctccct attcgaagag ataatctttg cgctatcatt acgtatttag 32821 cttcataaaa ttgagttttg gatatcgata ttagctgcgt atttatctca ctcgagtaag 32881 agagccagaa gtctcgagag ccattaatcg ttttcgttta acgtacatta taagtgagcg 32941 gtgggtataa gcgagcggtg gccgctccac tactccaact ataattacct cagaaacagc 33001 tgaatcagat gattctgcgg cctcctggca agtaagctac cgctcgcttg taatgtacgt 33061 tataccactt ttaagtacac cgtttgattg taatccttac tctactagga aaacccaagc 33121 cccatagcca gtttacaata ccacagcata tacaccgaac aagggaccga tgggcccgcc 33181 caggccaact aaaacaaaac agtgaaaaag aaggtttagg agaaaacggt aacaagaagg 33241 accagcctgc caccaaggaa gtagtagtca ctgcagttat tctctcgaac ccgagactcg 33301 cggaacccac acgtaatcac actgacaaag tagacaaaat caataacgaa ttagtacgta 33361 accagtatct aggggataac aaagcgaatc acgaatatgt cgaaagccct gggtgatcac 33421 ccaggtctac gtgcataagc gagttttaac agcttcagag ctgtaaggac aaaagagtat 33481 aataaagttg attgattaaa gctgcgaagt aaataaaaga aaaagggttt gggcggtata 33541 taggcgaacc aggcgaaaga gtgtagattg tgagcgacta ctgcacaaat gctaaaaaga 33601 gaccctgttc cctacctgac ctggtggaag tgagggtacc tcggtctaat catgatcctg 33661 agcttacagc tcaacaaggg gcagaaaaaa gttgaacaag ggcagggggc cctaaccctg 33721 caaaacgctc aacaagggta gaccaactct acacttgttg agctttttat atatgcttgg 33781 catatgccta ttaaataaat aaatactcaa cacctatcct tagcatataa aaaggtacat 33841 tagggcttcg agagctgcgc atatggcccg catatgtatc gcacgtgaga tttttgtatt 33901 taataaaatt taaaatagtt gggagagaaa atattacaca tttgctagta attaaagcaa 33961 cgaatagaat gaaaataatg aagtatgatt gaaaggatat ttgtacatat gcacggtgcc 34021 acgtgggcgt atgcagcgta taccctgtgt actgtacgtg ctattttaat acgggccgtg 34081 tacggcatat gcgggccgca aaacgcaact ctcgaagcct taatgacctt tttatatgcc 34141 aaggataggt gttggcagct tagtatttat ttatttaata ggcatatgcc aagcatatac 34201 aaaaagctca acaagtgtag agttggtcta tccttgttca gctgcacccc cacccgatcc 34261 tgcctaagga ctaatatata tagtcaagct tcaatttata ttgcttgcca atgactccca 34321 ttgtagtcct ttagcggggc actactagct ggacttttta tgtagctagg atcgctattt 34381 ttggtgtttc tgcacatatc tgatgcattc gtagcgggga gacttgttgt cccagaccta 34441 ggcgagaaag gggtggaaca tgactaagtt tgacgaccgg ttaactgggg tcctgagagg 34501 gaaggcacag agacggcttg gcaggtggta accgttggca tacgatagtg attaggatca 34561 ctatcacaat gtaagggtcg aagtagccaa tggtacccta cacaagactg gtgtatctgc 34621 agttctgtag agtaatactt caattgttta ttgccctccg agggaagact gctatctggg 34681 ccgtagatac ggcgtgatat atatgtaact tccctagcca ataaggcccc cgctcggtgc 34741 tgctttgtgt gctcggtgtt agtcctcgcc gattccaccg agcagcttcc tgctggctgt 34801 acctatccct ggctgagcag cctcaggccg cgggcctggt accgagcact aagcataaga 34861 tcgtaacgcc agcgcttccg attggtcgct ggctaaaatt agatccctct tggtctgcgc 34921 tttaagccat agcttgtaca ttggtaagtt acttgaggat ccgtgaagag cccaagagcg 34981 aacctccact ttagttacac cacggggtgg cgcctttgcg cttgcacctc tttggacttc 35041 gtacgtagtc cttcgacatt tgcccattgc cgaaagtcga tctcacatga ttattataaa 35101 acgacaacta tcataataag gaagtaatgt cctatagtaa aataggtttt cattcactcc 35161 ctaaaatata ataactctaa acatgtaata gaaagttaaa aaatatttct ttaatgtcta 35221 ttctaagctt tagtatccga gcttagctct cggtatccga actttacact atcggtatct 35281 aaaacctaaa ttacgcgaac ggaaataaat atacttatat atgggggctg atattactaa 35341 tatttctaat ccctctttct ctttgggggc tataaaggaa taccaatggg ggaaatttaa 35401 gtgggtcggg attgtcaaca tctatgttaa taccgaaata ttcggtgtgt ttttttttct 35461 gttacacatg caggaacggg gtggggctcc ctccgcgtac tactattatc tcggtccact 35521 tacatgtctt cccgtgtagt tatatataaa gctcttcttt attttcattt tttcaccttt 35581 ctaattcatg agaagtttat taggcatgca attccctttg tgaataaacg aataggacac 35641 acgaagattg ttcccattgt cgttctctca cttcattact gccatcatga ctaggattcc 35701 gccattttcg atcggagtga tcgcaacgat catgttttgt tttgtgtacg agtccaactg 35761 cgcaaatgta accaatacat gcgccgtaat cggtcgagat atttcatctg ccagcgccat 35821 catatacccg agtgagcatc taaaccttat ccaactcctt cttagatttg gtggcaattt 35881 cgctaacgta ctaatcaata caggcgatac tattgccttc acgaccgaca ccagtcactt 35941 tacggaatcg tcgaaccaga tacccacctg tgtgctcgaa gtcggatcgg ctcaagatgt 36001 tgcagtagcg ctaaagatca ttggtgccac taagaccccg tttgctatca tgtccggtgg 36061 ccattcgtcc aaccagaaat tctccagcac gacgggcatc cacatctccc ttattcgcct 36121 aagacaagtc gtcttctcgg cagataagtc tactgtcgag attggcatgg gcattgtacg 36181 tcgaatcgtc acccataagc tagttaacgt tgagcgctga ttcgcttttc attcttcaag 36241 acatgggctg aggtttacca aatccttgac ggcaccggtt ataacgtggt agggggtagg 36301 actttcgggc ccggcgtggg tggattcaca cttggtggtg gctattcatg gtaatttttc 36361 actttaatat atccctttac taacctgtta actttttaag cttattataa attctaactt 36421 cgccgcctag gaaaactaac caatatggta cgctatgcct agactataag aactcggtca 36481 aagcaccaga tagttatatt atctctaaca ttgcttacat tacaggctta acctgcgaca 36541 ccgttagaag ttataacctt gtgcttccgg ttcgtatttc tactctaaat tttgcccgcg 36601 tgtagtttac actttaaaac ctatttttac gtactaacta aagcccgcta gaatggaact 36661 attacgaccg cctctaagag gataaacccc gatttatttt ttgcgcttaa aggtggttta 36721 aaccgctttg gcatagtcac ctcggccgta ttcgagactc atgcacaggt ccctctaatt 36781 tatgtaagct tctttctttt caaccccttc ccgtagatgc tacttccttc gactagactt 36841 aaagatatta acaaaatgaa taggggggtc aagtatttta cagtacagac gatattccag 36901 cagttattaa cgccaccctt gagttctaca aacttgccga tattaaaacg caaatcatgt 36961 acataatcgc aactacgcct acccaggaat cagttatcct cttagcgttc cacgacggtc 37021 ctaatcgacc atcgagcctt tccgtattcg ataacatcac acctctatcc agcacgctta 37081 gcaccttgtc gttctccgat ttcgttcata gcatccaaga taagccccgt attagaggta 37141 cagctgatac tatatcgaca acggggataa caacgggctt tataaaagct gttagcgacc 37201 aaattgcggt acgtgagatg ttcacgcatg aaaatggcgt acaacattaa atgacgcaaa 37261 ctaatgcggt tattttaata tatacatatt ataggcccta cgtgaagcag ccgtctctca 37321 tggcgctgcg tccattgcgt tcgatatcga accgtttact gactacggca aacacgctac 37381 tgatagcgcc tacccacaca cgcgctctca actaccggta agtcctctga cttagcacca 37441 atgatacatc gtctacttag tgactaacat acgcggactc ctagctcggt ctagacttct 37501 cctgggtctc ggctgatgac gacgagttct ggcacgacac agctaagaac gcaattgcta 37561 agcttaaagt agtggccgct caggaaggca tctataatcc taaggaggcc gcttacccta 37621 attattccgc agccagcaag acggccttgc agctatatgg ggaagagaat acggagcgtc 37681 ttaaaagaat tcgtgcccag atagacccct ataacgtaat gaagctcgca ggtggatttg 37741 acctttaaag tatattatag ttttaatttt actttattgt gggcatccct acttataaac 37801 tataaagtat gagaaattaa agataaaaac ttaggattag aatatataca gttcaacgaa 37861 aataaatttc ttaatactac ttataggtta ggacctttca ccgccttcca gtgtacccaa 37921 cacgtcgcta taccacttcg ctgcgctggc agcactgcat gcactggctg ccgtaggctg 37981 tgagctttag aaaccgagct aggtttggaa attaagctgg ttgcagaaac caagctagga 38041 ttattaaatt tggctctgcg tatctagctc gcagccatag atatataaat acgcgagaag 38101 gggacttctt taaatcctct aatattctat attgccccag tcaccaggct catttagcag 38161 agcagtccag aaggtctcgt ccaactccct aaccgagagc aaggggttat tcacttccat 38221 ggattgtgca gcgagtgacc aagccgtgct ttgggacagt atggcggtcg tttgcttggc 38281 ctctgctgaa cgtgttgctg tagacaattt tgccatatac catgttcgaa tccacatgat 38341 cttgacgtga taggcagcca agacagatgc atcgacgcca ttgtcaaatc tcctccgtcg 38401 ccccagggat tacactaacc gatcggcctg gtcaaaacag tcggcaagag tctggcacat 38461 ggccgcaaag ccgaaattaa gccgcgccag tgtcaggcgc ggaggtcgga ttttccctgg 38521 gccgtataat tgagaggccg catctaggat ctgcgcgcgg ggtatctaca gtcgggattg 38581 cttacccggc aaaagcgggg ataacctgcc ggcatcgtgg cgaccacgcc gctcccacgc 38641 ggggttcgtg tacataaaag gaaggctctc aggccttaag attgagaagg ccagagttca 38701 atgaaagtca tccccaaccc ctactattgt actcaagagc cctgtcttcg cagcgtgtga 38761 gccgtaattg taccccagca ctccagcata tcaccccttg gaccaacggt cctgacagcc 38821 aggcttacgt cccagtccag atcgtcaact agtagaattc gacttgaagt //