LOCUS       BGC0002224             38870 bp    DNA     linear   PLN 28-MAR-2021
DEFINITION  Diffractella curvata strain CBS 591.74 zopfiellin biosynthetic gene
            cluster, partial sequence.
ACCESSION   BGC0002224
VERSION     BGC0002224
KEYWORDS    .
SOURCE      Diffractella curvata
  ORGANISM  Diffractella curvata
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Sordariomycetidae; Sordariales; Lasiosphaeriaceae;
            Diffractella.
REFERENCE   1  (bases 1 to 38870)
  AUTHORS   de Mattos-Shipley,K.M.J., Spencer,C., Greco,C., Heard,D.M.,
            O'Flynn,D.E., Dao,T.T., Song,Z., Mulholland,N.P., Vincent,J.L.,
            Simpson,T.J., Cox,R.R., Bailey,A.M. and Willis,C.L.
  TITLE     Uncovering biosynthetic relationships between antifungal nonadrides
            and octadrides
  JOURNAL   Chem Sci 11, 11570-11578 (2020)
REFERENCE   2  (bases 1 to 38870)
  AUTHORS   de Mattos-Shipley,K.M.J., Spencer,C., Greco,C., Heard,D.M.,
            O'Flynn,D.E., Dao,T.T., Song,Z., Mulholland,N.P., Vincent,J.L.,
            Simpson,T.J., Cox,R.R., Bailey,A.M. and Willis,C.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2020) Life Sciences, University of Bristol, Life
            Sciences Building, Bristol, UK BS8 1TQ, United Kingdom
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: Newbler v. 2.9
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            ##antiSMASH-Data-START##
            Version               :: 8.dev-5707d64f
            Run date              :: 2026-04-13 15:33:33
            NOTE :: This is a single region extracted from a larger record!
            Orig. start           :: 0
            Orig. end             :: 38870
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..38870
                     /culture_collection="CBS:591.74"
                     /db_xref="taxon:2819868"
                     /mol_type="genomic DNA"
                     /organism="Diffractella curvata"
                     /strain="CBS 591.74"
     misc_feature    <1..>38870
                     /note="zopfiellin biosynthetic gene cluster"
     region          1..38870
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..38870
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002224"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..38870
                     /SMILES="C([*])C(-O)(C)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..38870
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[18234:26211](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(18235..26211)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     mRNA            complement(join(<686..1084,1229..1367,1422..1599,
                     1712..1808,1902..>1934))
                     /gene="zopL9"
                     /product="ZopL9"
     gene            complement(<686..>1934)
                     /gene="zopL9"
     CDS             complement(join(686..1084,1229..1367,1422..1599,1712..1808,
                     1902..1934))
                     /codon_start=1
                     /gene="zopL9"
                     /note="hypothetical protein"
                     /product="ZopL9"
                     /protein_id="QTE75983.1"
                     /transl_table=11
                     /translation="MATATVTTAPTVVRTTADYYDAPPVLKIHTYTRESYEEQFGNKSV
                     IHHPINLKDIRAANINLQNNGFQLIKLQSKLTNPDDYLDEETVKRVYIPELAEAVKKLT
                     GATEVRVLNPKVRDSSTEKDGFENNWGKNNGAVRRIHIDLAPGGVEEALYPIFGEEYMK
                     SIAGRWRLINAWKPTRPVERDPLAVCDRVPDEDLVPLQRVVPGKALMEQRYHLKTGKKD
                     HDWYYASNQQPDEVLLFTQYSDFPNRNTADRVPHVSVKLPGQEDKPRRTSVDARCLVVW
                     "
     mRNA            complement(<3212..>4009)
                     /gene="zopL8"
                     /product="ZopL8"
     gene            complement(<3212..>4009)
                     /gene="zopL8"
     CDS             complement(3212..4009)
                     /codon_start=1
                     /gene="zopL8"
                     /note="hypothetical protein"
                     /product="ZopL8"
                     /protein_id="QTE75984.1"
                     /transl_table=11
                     /translation="MSAPSRIPSSSSNRLILASEPPLENLHSVRTPTLHLVPEVFPKVI
                     LPILAIRSACNTPSSVYLNPRANPYLQGPGTPASCVHINPLVSLSHTIQSNPTFHFSSV
                     INLFARLATTWAAVTSCPHCRYDRHALLLMPALAEQILGVYEAAGVAYGVISFTFPSVD
                     DDASAWIDIGTTGKEVAAAITCEKSGMRLGELELEDEETKLLARAVLRRGVMKLGKLLE
                     ELRDAIGELSGEGWAQRTGTLKAVEHRVEGVMERLVGLLGMLR"
     mRNA            <5476..>6888
                     /gene="zopL7"
                     /product="ZopL7"
     gene            <5476..>6888
                     /gene="zopL7"
     CDS             5476..6888
                     /codon_start=1
                     /gene="zopL7"
                     /note="putative transcription factor"
                     /product="ZopL7"
                     /protein_id="QTE75985.1"
                     /transl_table=11
                     /translation="MSSQSPPPSAPKDTNGSKQPKLRSTCDACQDAKVRCSHDNPRCRR
                     CQAHKIKCVYSLSRRMGRPRRLQTNGNEPKQQKNKSSNVLNGSSGSMELEVTPPLIAIS
                     EAEPAQPTSFQDALATLSWDKSASITAIDPFDTNFSSPECVDFSSSSDGSRVRSDSSFS
                     FPSLSLWDHTALSEERVINAFSPQALLYTNSHAIFPGDLSVNHSTNTTSSQGIMDITLD
                     FQSPRNEPQRQQQEPFKMSELMDETDANKSTSPPEAKNRTCDCYASVLGELSNLDQTKV
                     DNQDSSIDIVLRVEKGVQKHAANILSCELCAGNRSGLLLLLVMVIDHVVRVLGNISSGA
                     KTIPPQRKSSSDRNGNNSKDDNSNDIPLSPRMAMKTSSESRRGESPGGLTTAWNCKLLV
                     GEQEIVGPDKVEFMKLLVQGRLSRLCSTLRRLKRDMQDNPQDSNSKAGNIMVIEIHRRL
                     QSVIGRLELWDG"
     mRNA            complement(join(<7415..8719,8780..>9022))
                     /gene="zopL6"
                     /product="ZopL6"
     gene            complement(<7415..>9022)
                     /gene="zopL6"
     CDS             complement(join(7415..8719,8780..9022))
                     /codon_start=1
                     /gene="zopL6"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /note="MFS transporter"
                     /product="ZopL6"
                     /protein_id="QTE75986.1"
                     /transl_table=11
                     /translation="MVADKLEVLDGSTGPPMAGNTEEEPYSTFTVGQKRWIIGMVSFAG
                     FFSPLSSSIYFPALPTIAKDLSVTSAQINLTVTTYLIIQGVAPMVVASFSDVAGRRPAY
                     ILCFALYLAANLGLSLQNSYPALLGLRCLQSAGSSGTISLANGVVSDLVTSSERGKFIS
                     LASAGTILGPTLAPIIGGLLTQYLEWHWLFWLLFILAGAFAIPFLLFTPETSRVIVGNG
                     SISPPFLNSCLTDVFRRRKLAKTEHRIRKPERPRMQVPNLLKSLSVIANLETVLVLLPA
                     GFSSAALQAVLTDASKEFTETYRYNTLQVSLMFIPIGVGGLLSVLFTGKLVDWNYRRHA
                     KRLGLSVNRNKSQDMADFPLERARLELSIPIFILLSVLVIVYGWIMTQHVNISGPIIIL
                     FILGYAMIAVYQILSVLLVDIHPGQAATASAANNLIRCELGAAFAAFIAPMIDGIGTGW
                     SYTILALAVMATVPGLLVTMRCGILWRKQKAARETEKQGEKDGQSARVTTQSDENTA"
     mRNA            join(<9900..10236,10299..>11440)
                     /gene="zopL5"
                     /product="ZopL5"
     CDS             join(9900..10236,10299..11440)
                     /codon_start=1
                     /gene="zopL5"
                     /note="2-methylcitrate dehydratase"
                     /product="ZopL5"
                     /protein_id="QTE75987.1"
                     /transl_table=11
                     /translation="MPLPPFDSVIVGIAAYVYHYPVSPTSHPKAWQYARIALMDAMGCA
                     IEAISKSEDCRAMFGPVVPGTVTPNGFKLPGTSHQLDPLKGAFDMGTAIRFLDHNDAIA
                     GADWGHPSDNLGAILAVMDWLGRSSANGKLEHHGPALTIDTLLQATIKSYEIQGCFLLR
                     NAFNAHGLDHVILVKLASTAVVSWLLGLTEQQCHAAISHVWMDGQPLRVYRSGVNTIPR
                     KGWAAGDACMKAVHLSLLTRAGQPGSPTVLTVPRWGFYATSFGNKEFEFPKKYGTWVIE
                     HIFFKLMPVEGHGVSAAEAALIHSATLRARGFNPIQNVAKVEIRTNAAADLIINKKGPL
                     SNAADRDHCMQYIVALVLLKGDIPAAQDFQDNSPWATSPELAALRKKIDIRPDEQLTRD
                     YMDLEKRSLAAGITIYLNDGSSLNEVLIEFPVGHVQSPKTLASLEQKYKRNMGLMFSEA
                     EMARARKAVENNGDMPVSDFLDMFTRETPILVKL"
     gene            <9900..>11441
                     /gene="zopL5"
     mRNA            complement(join(<12081..12400,12466..>12937))
                     /gene="zopL4"
                     /product="ZopL4"
     gene            complement(<12081..>12937)
                     /gene="zopL4"
     CDS             complement(join(12081..12400,12466..12937))
                     /codon_start=1
                     /gene="zopL4"
                     /note="Maleidride dimerase"
                     /product="ZopL4"
                     /protein_id="QTE75988.1"
                     /transl_table=11
                     /translation="MVAIRYLLVALPVLVVGKPLNFNHDTHQRPLSHNPVGWVHPDIEE
                     AERDGFYFENPEMDCKYVSQPFVYKAFKTLEKDMGSLFTLINKDVHFTIVGNHPGAGVY
                     HDLMHFYVNALRRVALVGSDHPENFRIIPKAIHGGCDQEWSVQEMNFQGISNSGTLFDI
                     INVWVTRWSSDRKQMIEVRTYIDSMKVSQLLHENENWWNSTRHIHHYEWMPGPNGMPNL
                     SELYALMPEQDRPKGRAPGEGLEGRVLGYMPAEWEGGPGNE"
     mRNA            <13598..>15103
                     /gene="zopL3"
                     /product="ZopL3"
     gene            <13598..>15103
                     /gene="zopL3"
     CDS             13598..15103
                     /codon_start=1
                     /gene="zopL3"
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /note="MFS transporter"
                     /product="ZopL3"
                     /protein_id="QTE75989.1"
                     /transl_table=11
                     /translation="MESPSAARVSPTRPKTPSETTPLLNAATGGDPERYSAFGESQKKF
                     IILTAALASTFSPFSSNIYYPAINSIADDLQVSIPMVNMTITAYMIFQGLAPTFMGNLS
                     DTAGRRPVYVLCFTIYILANIGIALQHSFVGLLLLRCLQSSGSSATIALSNAVAADTVT
                     SSERGMYLGIASLGSILGPALGPLLGGLLSQYLNWRSIFWFLAAAATLVFVPLVLFYPE
                     TCRAIVGDGSISPPAWNKSLLNYLNETKSHSVQNKAMVIKPKIRFPNPLTTLRLLFTLP
                     TGLILLCNGVGYAAHFAVTSSMPSQFNEIYGLNDLQIGLTFIPISLGTILSAFANGYLL
                     DWNFRRIARQEGLPILKGKKQDVSNFPIERARLQIALPMLFSAAALIVAYGWLLDMQLP
                     IFAPLVLLFLIGSSITACYNVFNVLIVDLNYSTPATATAANNLVRCMLGAASTAVVAPI
                     LERFGRGWTYTFVAGAWLAATPAALLVYRYGFAWRRRDRCEES"
     mRNA            complement(<15346..>15906)
                     /gene="zopL2"
                     /product="ZopL2"
     gene            complement(<15346..>15906)
                     /gene="zopL2"
     CDS             complement(15346..15906)
                     /codon_start=1
                     /gene="zopL2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /note="Isochorismatase-like enzyme"
                     /product="ZopL2"
                     /protein_id="QTE75990.1"
                     /transl_table=11
                     /translation="MAKTALLVMDVQGAFVPRLAQSSDYLPRLAKTIAAARPSVVKVIY
                     TRVAFRPGHPEISPSNPTFSAAVKSKSFVEGSPETLIDPSIAPQEGDVLVDKKRVSAFS
                     GSGLDIILSSLGIETVVLAGMSTGGVVLSTVLEASDKDFGVVVLKDLCVDADETLHNTL
                     MDKIFTKRGQVVEAEKWLETLKA"
     mRNA            join(<16901..17060,17112..>17569)
                     /gene="zopL1"
                     /product="ZopL1"
     gene            <16901..>17569
                     /gene="zopL1"
     CDS             join(16901..17060,17112..17569)
                     /codon_start=1
                     /gene="zopL1"
                     /note="PEBP-like enzyme"
                     /product="ZopL1"
                     /protein_id="QTE75991.1"
                     /transl_table=11
                     /translation="MYASTRLVLSIFLLGLSIAQTPPGFTPSCDQNLGVTYPNKASIII
                     PGSRLLASDTAIQPRLSAASDVLKEDGKYLLVMLDPDVQFPKQPTTTILHWMEPGFQYN
                     KTSLALTPVSDPEAESVASYAGPHPPIGQIHRYILLLFWQPEDYRLPKEFKSFIPADIP
                     HRIDFDVVRFVEAAELGKPIAASYFIAEGLRSNMKDELRRVV"
     mRNA            complement(join(<18235..19065,19128..25407,25460..>26211))
                     /gene="zopPKS"
                     /product="ZopPKS"
     gene            complement(<18235..>26211)
                     /gene="zopPKS"
     CDS             complement(join(18235..19065,19128..25407,25460..26211))
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (35-461). E-value:
                     6.2e-183. Score: 600.4. Matches aSDomain:
                     nrpspksdomains_zopPKS_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (617-933). E-value: 9.4e-97.
                     Score: 315.9. Matches aSDomain:
                     nrpspksdomains_zopPKS_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (1011-1202). E-value: 9.1e-28.
                     Score: 89.6. Matches aSDomain:
                     nrpspksdomains_zopPKS_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1487-1688). E-value: 8.1e-55.
                     Score: 177.5. Matches aSDomain:
                     nrpspksdomains_zopPKS_cMT.1"
                     /NRPS_PKS="Domain: PKS_ER (1915-2227). E-value: 1.7e-108.
                     Score: 354.4. Matches aSDomain:
                     nrpspksdomains_zopPKS_PKS_ER.1"
                     /NRPS_PKS="Domain: PKS_KR (2252-2429). E-value: 2.9e-56.
                     Score: 182.2. Matches aSDomain:
                     nrpspksdomains_zopPKS_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2528-2609). E-value: 2.3e-13.
                     Score: 42.3. Matches aSDomain:
                     nrpspksdomains_zopPKS_PKS_PP.1"
                     /codon_start=1
                     /gene="zopPKS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     ene_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000120: Hydroxylation, Other (100% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /note="Zopfiellin polyketide synthase"
                     /product="ZopPKS"
                     /protein_id="QTE75992.1"
                     /sec_met_domain="mod_KS (E-value: 2.5e-154, bitscore:
                     504.0, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 5.4e-159, bitscore:
                     519.4, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.3e-184, bitscore:
                     603.7, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 3.7e-145, bitscore:
                     473.8, seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 5e-76, bitscore:
                     245.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 1.5e-183, bitscore:
                     600.4, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 2.4e-53, bitscore: 171.1,
                     seeds: 19, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 2.2e-97, bitscore: 315.9,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_N (E-value: 7.6e-09, bitscore: 25.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-15, bitscore:
                     47.8, seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.9e-48, bitscore:
                     154.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4e-10, bitscore:
                     30.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPYLNGHHDEVLSLPSGSPTSNPALTISEDRSMPIAVVGMGMRG
                     PADATNVEGLWKLVSEAREGWSKIPKERWNNDAFYHPDSNRNGTTNVTAGHFMTQDLAC
                     FDAPFFNMTNAEAAALDPQQRLLLECTYEALENAGTPLAEIQGSKTSCFVGSFCGDYTD
                     MLMRDPETVPMYQCTNSGHSRAILANRLSYFFNLQGPSVTIDTACSASLVALHLGCQSL
                     RTGDATRAVVAGANVILSHEIMITMSMMRFMSPDGRCYTFDDRANGYARGEGVGCVILR
                     PLADALRDGDTIRAVIRGTGSNQDGKTSGITLPSGAAQESLIRNVYESAGLDPLETSYV
                     EAHGTGTPAGDPLETAALSRVFGPGRSLDQPLRIGSIKTNIGHLEGASGIAGVIKTVLM
                     LENKILLPNRNFETPNPRIPFYDWKLKVNTLVEPWVVDGPHRASVNSFGYGGSNAHAIL
                     ESAEDYLSIRGLHGSIRTAKSILTPELDKITPNSNGFANGSTNGHLSGHANGHPNGHPN
                     GSANGERNGKLSSERQRLFVISGFDQDACKRQAKMFSDYLESRQDLDDGYLDNLAYTLG
                     ERRTEFIWKAAISASSKSDLSKALLGDIKFSKANKKPTLGFVFTGQGAQWCGMGKELLP
                     AYPVFRNTIAKIGSYLTTLGAPFDVTEELTKDPKTSDIGLALYSQPLCSAVQIAIVDLL
                     ASWGIKPASVTGHSSGEIASAYAMGALSWEDAMAVAYYRGVSSSNVRSTNPISGAMMAV
                     GMSKGDALPYLSSLTKGKAGVACVNSPSSITVSGDATAIDELQSLFEEKKLFSRKLAVD
                     VAYHSHHMALIAEEYGNAISGIKIRETGEVEFYSSVFGRRAEASELGPSYWVANMLGEV
                     KFADSLRMLCLETSSSSGKKTRKRASAPTVNTIVEIGPHSALAGPIKQILQADDKLKEA
                     GIGYASALIRKVDAVTTTLDLASKLVLGGYPVNLSALNRPTGAESHSVLVDLPPYPWNH
                     SNSYWAEPRLSKVFRQRTFPRTDLLGALDRNSNPLEPRWRNHIRASEIPWVKDHKIQSN
                     VVYPAAGYIVMAIEAAFQRATEKSLTITGYKLREISIGSALVIPEQSDGVETLVSFKPH
                     TESIRAPSDLWDEFCVYSVTDDNRWTEHCRGLIAVQTPQRSINIIDGDVQAVAEMNHYT
                     RIIVEAEDKCHIDVDVKEFYQQLTQLGIEYGDTFANVTKARAARNSCIATVAIADTAAV
                     MPQHFQFPCILHPSTLDAIFHPIFVALAAEAGPLKDPAVPVFIEEIYVSSNITSQPGDE
                     LVVYAGTKKKDDKYLTASMTILDGSRLNSEPVLTIRDLTCTTLAREIAQESGEETKRVA
                     YNFQWRADVDLLSKNGISELCDNAPLSLQETATIRGLEQTAYYYMEWALAEVAPAELPI
                     MEPHLQKMYALMEKLVKDVREDKFNIPTASWLAAGGAERAKLRHAIRDSGPEGHLLCFM
                     GRNLPAIMKKEVDPWNLLIGEQRLEAYFKDSPRIARTYLAAAEYFDLLGHKSPHLSILE
                     IGVGTGGATFPILKSLGGADGDLPRFQKYDCTDVNSTLFDSLKERAAPWKDLVTFKELN
                     IDNDPVAQGFTAESYDVIFAAYALHTSKSLHTALGNARKLLKPGGKLVILDVTREHMAS
                     SLIFGTLPSWWAAEEKNRQASPVLSEGDWEAALLASRFSGLEGVVWDVPNGPDHQSSVM
                     VSTALHKKETAHISDVLVIAEEDDSDVILNDLLERLTSLNIGFEVTPFSKAKPVGKICI
                     VLSELTRSIMIDPSLEQFEVVKDIFIKSDGVLWVTRGGTLSFSNPTSNLVTGFARTARS
                     ENGGTIIATLDLDSRKSKSPSSSASEAIFTLFRHLFLLSHMLPNEVDTEYAERDGQILI
                     SRLVENSKLSKKILASSSRPVPELQPFHQSGRPLVMHVGQPGLLDTIHFIDDERMVQPL
                     SDDQVEIEVKATGLNFKDVMMGLGQIQTETLGGECAGVVTAVGKNARGLAIGDRVSTYG
                     FGTFCNFYREKWTAFQKIPDDMSFEMGAALPVTYGTAYYSVYHLARVEKRDSVLVHAAT
                     GGLGQAIIELCQLIGAEIYATVGTQEKKKLLMDCFGIPEDHIFYSRDGSFAKGVMRMTM
                     GRGADVVFNSLAGEALRLSWNCVADYGRFIELGARDITVNTRLEMGNFIKNPMFAAFNL
                     VYLIRARREVGDKVWADVMDLFRKKSIKGPTPLHVHRLSKIEDALRIMQTGKHMGKLVA
                     VAEPDEMVQAVPRDTSKNLFRPDASYLLVGGLGGIGRATALWMVDHGAKNLIFANRSGL
                     ASKEAKETIDALKSKGALAVVYGCDVSNSEAVAELVAESSKSMPPIRGVIQGAMVLRDG
                     LLEKMPLTDYMSVIRPKVQGTWNLHKNLPENMDFFLMLSSVSGIIGNATQAAYAAGSTF
                     MDAFAAYRSNLGLPAVTLDLGVITEVGYLAEKDKELAAGMQRQGFEGTNKAKLLALIQS
                     AIADPRREDLLSHVVTGLGTWQEGKSLAIYDLPVFSHFRRQALKKDSGAADGKARVRDV
                     LKAATTLEEATEQICNALVDKISDRSNIPADNISRDNPMTDYGIDSLVAVEMRNWIVRE
                     MDSTMPILELLANQSLQQLSAKIAQRSGLVSLKVVEKE"
     aSDomain        complement(18271..18513)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_zopPKS_PKS_PP.1"
                     /evalue="2.30E-13"
                     /label="zopPKS_PKS_PP.1"
                     /locus_tag="zopPKS"
                     /protein_end="2609"
                     /protein_start="2528"
                     /score="42.3"
                     /tool="antismash"
                     /translation="TLEEATEQICNALVDKISDRSNIPADNISRDNPMTDYGIDSLVAV
                     EMRNWIVREMDSTMPILELLANQSLQQLSAKIAQRS"
     aSModule        complement(18271..26106)
                     /complete
                     /domains="nrpspksdomains_zopPKS_PKS_KS.1"
                     /domains="nrpspksdomains_zopPKS_PKS_AT.1"
                     /domains="nrpspksdomains_zopPKS_PKS_DH.1"
                     /domains="nrpspksdomains_zopPKS_cMT.1"
                     /domains="nrpspksdomains_zopPKS_PKS_ER.1"
                     /domains="nrpspksdomains_zopPKS_PKS_KR.1"
                     /domains="nrpspksdomains_zopPKS_PKS_PP.1"
                     /iterative
                     /locus_tags="zopPKS"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(18802..18822)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0016"
                     /evalue="3.70E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="zopPKS"
                     /protein_end="2432"
                     /protein_start="2425"
                     /score="-1.7"
                     /tool="antismash"
                     /translation="GVITEVG"
     aSDomain        complement(join(18811..19065,19128..19403))
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_zopPKS_PKS_KR.1"
                     /evalue="2.90E-56"
                     /label="zopPKS_PKS_KR.1"
                     /locus_tag="zopPKS"
                     /protein_end="2429"
                     /protein_start="2252"
                     /score="182.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="SYLLVGGLGGIGRATALWMVDHGAKNLIFANRSGLASKEAKETID
                     ALKSKGALAVVYGCDVSNSEAVAELVAESSKSMPPIRGVIQGAMVLRDGLLEKMPLTDY
                     MSVIRPKVQGTWNLHKNLPENMDFFLMLSSVSGIIGNATQAAYAAGSTFMDAFAAYRSN
                     LGLPAVTLDLGVIT"
     CDS_motif       complement(18859..18966)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0015"
                     /evalue="8.00E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="zopPKS"
                     /protein_end="2413"
                     /protein_start="2377"
                     /score="60.2"
                     /tool="antismash"
                     /translation="MDFFLMLSSVSGIIGNATQAAYAAGSTFMDAFAAYR"
     CDS_motif       complement(18985..19014)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0014"
                     /evalue="6.10E-04"
                     /label="PKSI-KR_m3"
                     /locus_tag="zopPKS"
                     /protein_end="2371"
                     /protein_start="2361"
                     /score="13.1"
                     /tool="antismash"
                     /translation="PKVQGTWNLH"
     CDS_motif       complement(19305..19403)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0013"
                     /evalue="4.60E-16"
                     /label="PKSI-KR_m1"
                     /locus_tag="zopPKS"
                     /protein_end="2285"
                     /protein_start="2252"
                     /score="51.3"
                     /tool="antismash"
                     /translation="SYLLVGGLGGIGRATALWMVDHGAKNLIFANRS"
     CDS_motif       complement(19479..19523)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0012"
                     /evalue="4.60E-05"
                     /label="PKSI-ER_m9"
                     /locus_tag="zopPKS"
                     /protein_end="2227"
                     /protein_start="2212"
                     /score="16.4"
                     /tool="antismash"
                     /translation="ALRIMQTGKHMGKLV"
     aSDomain        complement(19479..20414)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_zopPKS_PKS_ER.1"
                     /evalue="1.70E-108"
                     /label="zopPKS_PKS_ER.1"
                     /locus_tag="zopPKS"
                     /protein_end="2227"
                     /protein_start="1915"
                     /score="354.4"
                     /tool="antismash"
                     /translation="GLLDTIHFIDDERMVQPLSDDQVEIEVKATGLNFKDVMMGLGQIQ
                     TETLGGECAGVVTAVGKNARGLAIGDRVSTYGFGTFCNFYREKWTAFQKIPDDMSFEMG
                     AALPVTYGTAYYSVYHLARVEKRDSVLVHAATGGLGQAIIELCQLIGAEIYATVGTQEK
                     KKLLMDCFGIPEDHIFYSRDGSFAKGVMRMTMGRGADVVFNSLAGEALRLSWNCVADYG
                     RFIELGARDITVNTRLEMGNFIKNPMFAAFNLVYLIRARREVGDKVWADVMDLFRKKSI
                     KGPTPLHVHRLSKIEDALRIMQTGKHMGKLV"
     CDS_motif       complement(19914..19964)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0011"
                     /evalue="3.70E-07"
                     /label="PKSI-ER_m6"
                     /locus_tag="zopPKS"
                     /protein_end="2082"
                     /protein_start="2065"
                     /score="22.5"
                     /tool="antismash"
                     /translation="GAEIYATVGTQEKKKLL"
     CDS_motif       complement(19974..20033)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0010"
                     /evalue="1.60E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="zopPKS"
                     /protein_end="2062"
                     /protein_start="2042"
                     /score="26.9"
                     /tool="antismash"
                     /translation="DSVLVHAATGGLGQAIIELC"
     CDS_motif       complement(20064..20102)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0009"
                     /evalue="9.60E-04"
                     /label="PKSI-ER_m4"
                     /locus_tag="zopPKS"
                     /protein_end="2032"
                     /protein_start="2019"
                     /score="12.7"
                     /tool="antismash"
                     /translation="AALPVTYGTAYYS"
     CDS_motif       complement(20232..20270)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0008"
                     /evalue="6.20E-04"
                     /label="PKSI-ER_m2"
                     /locus_tag="zopPKS"
                     /protein_end="1976"
                     /protein_start="1963"
                     /score="12.7"
                     /tool="antismash"
                     /translation="LGGECAGVVTAVG"
     aSDomain        complement(21096..21698)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_zopPKS_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="8.10E-55"
                     /label="zopPKS_cMT.1"
                     /locus_tag="zopPKS"
                     /protein_end="1688"
                     /protein_start="1487"
                     /score="177.5"
                     /tool="antismash"
                     /translation="YFKDSPRIARTYLAAAEYFDLLGHKSPHLSILEIGVGTGGATFPI
                     LKSLGGADGDLPRFQKYDCTDVNSTLFDSLKERAAPWKDLVTFKELNIDNDPVAQGFTA
                     ESYDVIFAAYALHTSKSLHTALGNARKLLKPGGKLVILDVTREHMASSLIFGTLPSWWA
                     AEEKNRQASPVLSEGDWEAALLASRFSGLEGVVWDVPN"
     aSDomain        complement(22554..23126)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_zopPKS_PKS_DH.1"
                     /evalue="9.10E-28"
                     /label="zopPKS_PKS_DH.1"
                     /locus_tag="zopPKS"
                     /protein_end="1202"
                     /protein_start="1011"
                     /score="89.6"
                     /tool="antismash"
                     /translation="DLLGALDRNSNPLEPRWRNHIRASEIPWVKDHKIQSNVVYPAAGY
                     IVMAIEAAFQRATEKSLTITGYKLREISIGSALVIPEQSDGVETLVSFKPHTESIRAPS
                     DLWDEFCVYSVTDDNRWTEHCRGLIAVQTPQRSINIIDGDVQAVAEMNHYTRIIVEAED
                     KCHIDVDVKEFYQQLTQLGIEYGDTFAN"
     CDS_motif       complement(22968..23045)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0007"
                     /evalue="2.80E-12"
                     /label="PKSI-DH_m2"
                     /locus_tag="zopPKS"
                     /protein_end="1064"
                     /protein_start="1038"
                     /score="39.0"
                     /tool="antismash"
                     /translation="WVKDHKIQSNVVYPAAGYIVMAIEAA"
     aSDomain        complement(23361..24308)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_zopPKS_PKS_AT.1"
                     /evalue="9.40E-97"
                     /label="zopPKS_PKS_AT.1"
                     /locus_tag="zopPKS"
                     /protein_end="933"
                     /protein_start="617"
                     /score="315.9"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFTGQGAQWCGMGKELLPAYPVFRNTIAKIGSYLTTLGAPFDVTE
                     ELTKDPKTSDIGLALYSQPLCSAVQIAIVDLLASWGIKPASVTGHSSGEIASAYAMGAL
                     SWEDAMAVAYYRGVSSSNVRSTNPISGAMMAVGMSKGDALPYLSSLTKGKAGVACVNSP
                     SSITVSGDATAIDELQSLFEEKKLFSRKLAVDVAYHSHHMALIAEEYGNAISGIKIRET
                     GEVEFYSSVFGRRAEASELGPSYWVANMLGEVKFADSLRMLCLETSSSSGKKTRKRASA
                     PTVNTIVEIGPHSALAGPIKQILQADDKLKEAGIG"
     CDS_motif       complement(23967..24068)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0006"
                     /evalue="2.40E-10"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="zopPKS"
                     /protein_end="731"
                     /protein_start="697"
                     /score="32.8"
                     /tool="antismash"
                     /translation="GIKPASVTGHSSGEIASAYAMGALSWEDAMAVAY"
     CDS_motif       complement(24258..24311)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0005"
                     /evalue="6.80E-07"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="zopPKS"
                     /protein_end="634"
                     /protein_start="616"
                     /score="21.5"
                     /tool="antismash"
                     /translation="FVFTGQGAQWCGMGKELL"
     aSDomain        complement(join(24777..25407,25460..26106))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_zopPKS_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.20E-183"
                     /label="zopPKS_PKS_KS.1"
                     /locus_tag="zopPKS"
                     /protein_end="461"
                     /protein_start="35"
                     /score="600.4"
                     /tool="antismash"
                     /translation="IAVVGMGMRGPADATNVEGLWKLVSEAREGWSKIPKERWNNDAFY
                     HPDSNRNGTTNVTAGHFMTQDLACFDAPFFNMTNAEAAALDPQQRLLLECTYEALENAG
                     TPLAEIQGSKTSCFVGSFCGDYTDMLMRDPETVPMYQCTNSGHSRAILANRLSYFFNLQ
                     GPSVTIDTACSASLVALHLGCQSLRTGDATRAVVAGANVILSHEIMITMSMMRFMSPDG
                     RCYTFDDRANGYARGEGVGCVILRPLADALRDGDTIRAVIRGTGSNQDGKTSGITLPSG
                     AAQESLIRNVYESAGLDPLETSYVEAHGTGTPAGDPLETAALSRVFGPGRSLDQPLRIG
                     SIKTNIGHLEGASGIAGVIKTVLMLENKILLPNRNFETPNPRIPFYDWKLKVNTLVEPW
                     VVDGPHRASVNSFGYGGSNAHAILESA"
     CDS_motif       complement(24993..25037)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0004"
                     /evalue="1.80E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="zopPKS"
                     /protein_end="389"
                     /protein_start="374"
                     /score="11.0"
                     /tool="antismash"
                     /translation="GSIKTNIGHLEGASG"
     CDS_motif       complement(25098..25145)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0003"
                     /evalue="6.70E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="zopPKS"
                     /protein_end="354"
                     /protein_start="338"
                     /score="12.0"
                     /tool="antismash"
                     /translation="YVEAHGTGTPAGDPLE"
     CDS_motif       complement(25338..25376)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0002"
                     /evalue="4.80E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="zopPKS"
                     /protein_end="274"
                     /protein_start="261"
                     /score="13.2"
                     /tool="antismash"
                     /translation="FDDRANGYARGEG"
     CDS_motif       complement(25570..25617)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_zopPKS_0001"
                     /evalue="4.30E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="zopPKS"
                     /protein_end="214"
                     /protein_start="198"
                     /score="18.7"
                     /tool="antismash"
                     /translation="GPSVTIDTACSASLVA"
     mRNA            complement(join(<27481..28095,28161..>28211))
                     /gene="zopR1"
                     /product="ZopR1"
     gene            complement(<27481..>28211)
                     /gene="zopR1"
     CDS             complement(join(27481..28095,28161..28211))
                     /codon_start=1
                     /gene="zopR1"
                     /note="DUF341 hydrolase"
                     /product="ZopR1"
                     /protein_id="QTE75993.1"
                     /transl_table=11
                     /translation="MPTLKFLCLHGAGTNAQILGSQLGPLMRELGKDNSAIFHLVEGDV
                     GSPPGPGIEGFYEGPFFSYYKWPRTFNDNDESIMEAYDMLYEVIEEEGPFDGILGFSHG
                     GTLATGFLAHHATLNPYDPPLFRCAVFFSSLAPFRMNDDETPVFEEGLEGKIKIPTLHV
                     MGTKDFIYSYSLHLFNLCDVKSSAILVHDRGHEIPSDGKTLARMAAAFRDLGTRSMFL"
     mRNA            complement(join(<29207..29247,29308..29673,29722..>30019))
                     /gene="zopR2"
                     /product="ZopR2"
     gene            complement(<29207..>30019)
                     /gene="zopR2"
     CDS             complement(join(29207..29247,29308..29673,29722..30019))
                     /NRPS_PKS="Domain: ECH (40-208). E-value: 3.6e-10. Score:
                     31.5. Matches aSDomain: nrpspksdomains_zopR2_ECH.1"
                     /codon_start=1
                     /gene="zopR2"
                     /note="Enoyl CoA hydratase-like enzyme"
                     /product="ZopR2"
                     /protein_id="QTE75994.1"
                     /transl_table=11
                     /translation="MSQDQSRAVHTRLGVDFRGNYVAIVEVKCSRTPDAELDLALKRLL
                     EYLSQDSKLRVIIIAVGKDDSALAFNTDSNTEVYTETTKEKFRSYMIAPLKCNTAIISV
                     LHGICTKLALDIACGSDIRICTSNARFLLGDATQKNTSLEAAMTEMPPAVLTMDGASVF
                     REMLMSGGAFVAQDAHRMEFVSSVSETMDEAIFDALRLAESIAQSTARIQKVRPVNYTS
                     HGQVRQPSFNKL"
     aSDomain        complement(join(29348..29673,29722..29899))
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_zopR2_ECH.1"
                     /evalue="3.60E-10"
                     /label="zopR2_ECH.1"
                     /locus_tag="zopR2"
                     /protein_end="208"
                     /protein_start="40"
                     /score="31.5"
                     /tool="antismash"
                     /translation="LKRLLEYLSQDSKLRVIIIAVGKDDSALAFNTDSNTEVYTETTKE
                     KFRSYMIAPLKCNTAIISVLHGICTKLALDIACGSDIRICTSNARFLLGDATQKNTSLE
                     AAMTEMPPAVLTMDGASVFREMLMSGGAFVAQDAHRMEFVSSVSETMDEAIFDALRLAE
                     SIAQS"
     mRNA            join(<30541..30746,30803..31003,31063..31818,31914..>32073)
                     /gene="zopR3"
                     /product="ZopR3"
     gene            <30541..>32073
                     /gene="zopR3"
     CDS             join(30541..30746,30803..31003,31063..31818,31914..32073)
                     /codon_start=1
                     /gene="zopR3"
                     /note="Citrate synthase"
                     /product="ZopR3"
                     /protein_id="QTE75995.1"
                     /transl_table=11
                     /translation="MAHPTNGTLFVRDSRTKQEYEIPIVDNAVLAVDFKNIRGYSDGSK
                     MRGLLLYDPGLQNTAIKRSQISSSDARGLPMIRGYSVEQLYSLQSDFEDLFHLMVLGKY
                     PTPEEKEILRHTFAQEMINVPDTVVAAIKAFPPSSTGMSMMLAGLSAYLASYDHAIPAK
                     QGGNLYHNNPRLANKAAIKTTAAYAVVLGLTISHRKGIPFAPAQANKSFYENLFNMMGM
                     ADPITKLPNPLYIDVFRRAAILNADNGMTHSTFLTLVAGSALPDPLSCLISATSAAYGP
                     LHYGAQEATWNNLIEIETKENVPAFLEQVKRRERRLFGYGHRVHKTEDPRLAIIKGLLK
                     ELNVSPATIPLMEIAYEIDRLAALDQYFTSRGLSANADFYFGFLIHAFGFDPDMITLAN
                     LAMRILGLMAHWREAMDQEIKLFRPLHIYTGPKQRITAARL"
     mRNA            join(<35687..35831,35904..36175,36241..36350,36431..36447,
                     36526..36569,36652..36783,36864..37208,37295..37417,
                     37485..>37748)
                     /gene="zopR4"
                     /product="ZopR4"
     gene            <35687..>37748
                     /gene="zopR4"
     CDS             join(35687..35831,35904..36175,36241..36350,36431..36447,
                     36526..36569,36652..36783,36864..37208,37295..37417,
                     37485..37748)
                     /codon_start=1
                     /gene="zopR4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /note="FAD-dependant oxidoreductase"
                     /product="ZopR4"
                     /protein_id="QTE75996.1"
                     /transl_table=11
                     /translation="MTRIPPFSIGVIATIMFCFVYESNCANVTNTCAVIGRDISSASAI
                     IYPSDTIAFTTDTSHFTESSNQIPTCVLEVGSAQDVAVALKIIGATKTPFAIMSGGHSS
                     NQKFSSTTGIHISLIRLRQVVFSADKSTVEIGMGITWAEVYQILDGTGYNVVGGRTFGP
                     GVGGFTLGGGYSWKTNQYGLTCDTVRSYNLVLPNGTITTASKRINPDLFFALKGGLNRF
                     GIVTSAVFETHAQVPLIYGGQVFYSTDDIPAVINATLEFYKLADIKTQIMYIIATTPTQ
                     ESVILLAFHDGPNRPSSLSVFDNITPLSSTLSTLSFSDFVHSIQDKPRIRGTADTISTT
                     GITTGFIKAVSDQIAALREAAVSHGAASIAFDIEPFTDYGKHATDSAYPHTRSQLPLGL
                     DFSWVSADDDEFWHDTAKNAIAKLKVVAAQEGIYNPKEAAYPNYSAASKTALQLYGEEN
                     TERLKRIRAQIDPYNVMKLAGGFDL"
ORIGIN
        1 atccttcgtt ctagtttcat ccaacttcga gtcgcacaaa aatgctcacc aagaccaaca
       61 cggctgaggc gaaaaggata ggaaagagcg atgaagatga gtcaacacta gtcttagcaa
      121 gacaccgggt gggtactaga gtcaaattga gcgatataat ggattgtatt gccttaggat
      181 tgggaatgta cctctagtag agactacagg aagaaaggta atattagctg tttcagtcgg
      241 atgactaatg ggtagttatt ttctctttca agttgaaagg ggtatagcta aatacaccac
      301 aatatctcgc attaggggga aagggcccaa gcatgtttat tagtttaaag ggcgttgttg
      361 ggggctattt ttcttgccgg tgattggctc cactaaattt ctatcaagac tataggaagt
      421 gttaaccaca acactcttaa ctggtccaat aaaaagtctt cgccgcggca tgggtcgcaa
      481 ttgttgtaat agcacacaaa gcttagtcaa gatattcatc gtctttctca ttgacctctt
      541 gttgaaagaa atctaatggt agaacacgca aactagctaa agacaaatgt accagatccg
      601 gagataagag cccaccgtac tatgatcggc tccctacctt tgctgcctgg ttgcagaaca
      661 gcgacaaggt ttccgtcagg cccacttacc acacgacaag gcacctagca tcaacgcttg
      721 ttcgcctggg cttatcctct tgccctggaa gcttcacgct tacgtgaggg acccggtcgg
      781 cggtgttacg atttggaaag tcggaatact gggtgaaaag caaaacctcg tctggttgct
      841 ggttggaagc gtagtaccag tcgtggtctt tctttcccgt cttgagatgg tatcgctgtt
      901 ccatcaaagc cttgcctggt acgacacgct ggagcggtac gagatcttcg tccggaaccc
      961 tgtcacaaac agccagggga tctcgctcca caggacgggt tggcttccac gcattgatga
     1021 gcctccatcg acccgcaata gacttcatat attcttcccc aaaaatgggg tagagtgctt
     1081 cctcctgctc ggaatattag ccttgcaact agaaagcctg agtaatggaa acacagtaga
     1141 gagatcgaca acaccatagc tagctcagcc agctcctgtc ctggtaggac aacctgactc
     1201 gcacgatcac caaggggtat aagcttacta cgccgccagg agcaagatca atatggattc
     1261 gacggactgc cccgttattt ttgccccagt tgttctcaaa gccatccttc tccgtgcttg
     1321 aatcacggac tttggggtta agaacacgga cttccgtggc gccagtgctt tttgcaaatc
     1381 aattagcgat cagctggtct tggcggaaaa ataagacata cagcttcttc acagcctctg
     1441 caagttcagg gatgtacacc cttttcacag tctcttcgtc gagatagtca tccgggtttg
     1501 tcaatttaga ttggagctta atcagctgga acccgttgtt ctggaggttg atgttcgccg
     1561 cccggatgtc tttcagattt atgggatggt gaataacacc tatagagcgt caacgcttag
     1621 tttctgtgat tccctttcat ggtatatatc ggacttccat agatatctag cttcagttat
     1681 aaggcagggg gtaatcttaa aaaatacata ctcttatttc caaattgttc ttcgtagctc
     1741 tcacgcgtgt acgtgtgtat cttaaggaca ggtggggcgt cgtaatagtc cgcagtggtg
     1801 cgaactacct attatctaaa gtcagcaacg gggacacttg catatagttg cctcaaagat
     1861 ggttggggat gggaacatct gattttgggc gtcaaactca cggtcggtgc cgtggtaaca
     1921 gtcgcggtag ccatcttctc tttgataagt tgcttaaggg ttcttgtgac ttgtgttctt
     1981 ttgtttaccg taatgtttgg ctcttgttat ttaattaggt ttgcctcact tgagacttta
     2041 taaatcacta attaagctat gtttgaatta tttcctcacg tttgaactat ctcggtgact
     2101 tgttctatga ttcggaagcc tctcggcgac ttgttataaa ttcccgcatt gtccagcagt
     2161 tttacggact gcaagatcgg gaacaaaaag ccagataagg ccgaaagctc ctagctaact
     2221 gcatacgatt aagatatccc aatatatccg accattcagc tcggaatccg agtgtgtgta
     2281 ccgacatttt gttgagtgtg actaatttac ggatggttga ccaaataaaa tgtaactcta
     2341 acagactctc aaaagtatct aatgatgtaa gtctttataa acttaactac aggagttaag
     2401 catcggactg acataattcc ataaggaatt aactcctcgg taaaactacg atagaatcta
     2461 cccattgcca acgtacgata ctttgtatac tgctgactgt gctgtagctc ggggacacag
     2521 aattaatccg ccgtagagga tagctagcaa actcggatcc tggttcgctc tacgcctcca
     2581 tgcatggcac tcagttgtgt cacatgcttg ccaatgctcg gtccgagtgc gacagcaaca
     2641 ctgcagctac aggtaactca taaaattctt ggtcacggcc ttagcaactt ccgttccaaa
     2701 attccgccag caccttgcat acaagtatct actaatcatg catctaacca tcttgaccgg
     2761 aaattgcatc gttatgcatg gtcatatttt agcaagggtc ttattcccac ctcatgtttc
     2821 cccaacactg tgattacgtg gctacctacc tatttatgtt tccgaacacg ataaagtagc
     2881 aacgaaattt aactctcgaa acttgctcag cttaaaactc gcattctaaa agtgacgccc
     2941 gggacttcga gcgtacgcct atcctactcc cgatgtggct tatttgggat cctgtcgcta
     3001 atccctcatc cgacatccca tatccggggc tacactacat aacacttcac atagtctgcg
     3061 tgttaggatc acctaacctt acaatcaacc ttatctagaa gtttaaacag aactatgacc
     3121 tcattgatat agaatatgtc ttctattaga cctttatacc ctgtattcta attcattcgc
     3181 ttttatgtcg agcctggttg ggcctgctag atcaacgcaa catccccaat aagccaacta
     3241 atctctccat cacgccttct accctatgct ccacagcctt caatgtccct gttctttgcg
     3301 cccacccctc tcccgaaagc tcaccgatcg cgtctcttaa ctcctctaat agctttccta
     3361 gcttcataac cccccttcgt aacacggctc gcgctaatag ctttgtttct tcatcctcaa
     3421 gttctaactc cccaagccgc atccctgatt tttcacacgt aatagcggcc gcgacctcct
     3481 tgcccgtagt tcctatatca atccaagcgc tcgcatcatc atcaacagac gggaaagtga
     3541 aagaaataac cccgtaagct acgccagcag cctcataaac gccaaggatt tgttcggcca
     3601 gagcaggcat cagaagcaga gcgtggcgat catagcggca atgggggcac gatgttacgg
     3661 cggcccacgt ggtggcgagg cgggcaaaga ggttgataac agatgagaag tggaaggtcg
     3721 ggtttgattg aatggtgtgc gagaggctga cgagggggtt aatatgcacg caggaagccg
     3781 gcgtccccgg gccctgcagg taggggttag ctcgggggtt aagatagact gaagatggcg
     3841 tgttacaggc gctacgtatt gcaaggattg gcaagatgac tttcgggaag acctccggga
     3901 caagatgcaa agtaggggtt cttaccgaat ggagattctc gagggggggc tcgcttgcca
     3961 gtatgagccg attggaggag gatgacggga tgcgcgaggg agcggacatg gttaggtagt
     4021 tctctagtgg aggagtggaa tggggagaaa ggtttaaaac aacgtttgtg aattcaacgt
     4081 aaaaaagacg acagtagcca aaataataaa tagcaatatg ggttggtgtt cactgtcgtc
     4141 tgaaaaagga aaaatatata tagttaataa ggaaaggaga atagagtttt gatatcatta
     4201 ataatataat aactattcgc gctccaaaga aaattaataa gaaacgacag ggaattatcg
     4261 atcggctacg ggcttacctt atatttacct tccttagtaa aacaagttgg tagattttta
     4321 gatattagct tttacactaa taaatataaa catcttgact tctcgctttc cgggtttaca
     4381 cgtcatattt tgactttgtg tcgtaaccaa aagagatttg agatatagaa aaagccgtta
     4441 atcgatatta tacaaaaagg gtgcggaagg aatgcggaag gagggaatat gcatccatca
     4501 aagctacggg aggagtaaca ttcaagaagc gttacggaag gtgtgttttc ggcaagctac
     4561 ttaaatctta gaggtctgag cgtttcgcag tgggccatta atcctccgaa cttttctgtc
     4621 atcttatagg tagcgacggt tagctcgcgc cacaaagtag cacagggtag cacataagta
     4681 tgcagtcaga cggcgctatc ggtattggta atcggttgat ctaccgtcac tgcctctttt
     4741 ggagaaaacc accggctttt tatcggacaa gatgcgactg ttacgatggt acttatgaga
     4801 cataacgctt agagttcaga cggctatgct tttcgaccct aagcttattt ttatagttat
     4861 taagaatcgt ataatattta attatgtggg ctatactaca attttgtaaa ttatttaata
     4921 taattaaagt tctttaatta ttatatttag tatgtgatta gaaataagcc aaatgctagg
     4981 aatattaaaa tatcatacgt atccactctt tgactaataa gggatttttc taaagttaaa
     5041 gccttgagtt agtagcttcc gtatacgagt gtccatggtc agacgggtaa atcacccccg
     5101 caccacctct aagaacttgc aggtgtttat cagctatgtt aaagccctgt gattcgctaa
     5161 cgataaccga tgcaataagc ttaccaggat aggttcccat taacttgaaa cgataacatt
     5221 ctgctttgct aatcctgcaa cctggtcctt gaagtgttgt tgtgtaggca gtatatcttg
     5281 tgccgatagc ttgcacgaaa gctgccacaa ataagattaa aataagctct ggtattaatg
     5341 aagaggcgct cttggtactg atctctccac acttggcgct gacctctggg cacttggcat
     5401 tgttctctag atacttggca ttgttcttca gactatagag tgccgactga gccccggctg
     5461 acatgaatca tggagatgtc ctcgcaatct cccccaccat cagcgccgaa ggatacaaac
     5521 gggtcgaaac agccaaagct tcgttcgacc tgtgacgctt gtcaagatgc gaaagtccgc
     5581 tgcagtcacg ataatcctcg ctgccgtcgg tgtcaagcac acaaaatcaa gtgtgtatac
     5641 agtctctcac ggcgcatggg tagacctcgg cgactccaga caaacggaaa tgagccaaaa
     5701 caacagaaga acaaaagcag taatgtcctc aacggttcta gtggcagcat ggagctagag
     5761 gttacaccgc ccttaattgc catctcagag gcagaacccg ctcagccaac atcctttcaa
     5821 gacgcattgg caactctaag ctgggacaag tcagcatcta ttaccgccat agaccccttc
     5881 gacaccaact tcagctcacc cgaatgtgtt gacttcagca gcagcagtga tgggtcgagg
     5941 gttcggtcag attccagctt cagtttccct agtttatcgc tttgggacca cactgccctt
     6001 tcggaggaga gagtgatcaa tgcgttcagt ccacaggcat tgttgtacac gaatagtcac
     6061 gccatctttc ctggagactt gtcggtcaac cattcaacca atacgactag tagccaagga
     6121 atcatggaca tcaccctgga tttccaatcc ccgcgtaacg agcctcaacg gcagcagcag
     6181 gagccattta agatgagcga gctcatggac gaaaccgacg ccaataaatc cacgtcacct
     6241 cccgaggcca agaatcggac atgcgactgc tatgcctcag tcctaggcga gctctcaaac
     6301 ttggaccaaa cgaaggtaga taatcaagat tccagcatag atatcgttct tcgagtcgaa
     6361 aagggtgtac agaagcatgc cgccaatatt ctttcatgcg agctctgcgc cggcaaccgc
     6421 tctggtctct tgctcctcct ggtcatggtg attgaccacg tcgtgcgggt gcttgggaac
     6481 atctccagtg gcgcaaaaac cataccgccg caacgaaaat catccagtga ccgcaacggc
     6541 aacaatagca aggacgataa ctccaatgac atccccttgt cgccccgaat ggcaatgaag
     6601 actagtagcg agagccgtag aggagagagc ccaggtggct tgacgacggc gtggaattgt
     6661 aagttgcttg ttggcgagca ggaaatcgtg gggccggata aagtggagtt tatgaaacta
     6721 ctagttcaag ggagactaag ccggttgtgc tccacattgc ggcggttaaa gagagacatg
     6781 caagacaatc ctcaagattc gaactcgaaa gccgggaaca tcatggtgat tgagatccac
     6841 cggcggctac agtctgttat cggtaggctt gagctctggg acggctaaga gttcatatga
     6901 ggataggcag cgtgccttga tattcaaaac catctctcca tacctgtcac cttagagtag
     6961 agcaactctt tctaccactt gatctttaga tagttctcag ggacttcaca gtggtgtggg
     7021 tgatctcgta gttgaaatat agtgggctta aggtgaacta agcgtaaaaa taataactgc
     7081 aaagaggagg cgtgacttaa gtttatggat tgagaatgca tacgactata tagagatata
     7141 tcttccagca cctgttgttt gcaaatgatc tgatgaccat catatatgaa agcaggatag
     7201 aggaagctac ggtttcagtg cagtgacacg gacggtatta ggggcgggga atcgggtttc
     7261 caaccacatc tagattatat taatcttaat attatatggc agtacggtaa tggcattgaa
     7321 ggtaaattaa tagcggcagt gttacccggc tgtatcattt ggtcgaccta actaatagta
     7381 cattggtatt cagggggggt gggggggggg gcttttacgc cgtgttttcg tcggactgcg
     7441 tagttactct cgcgctttgt ccatctttct cgccctgttt ctctgtctcc ctcgccgcct
     7501 tttgcttccg ccagagaatt ccacagcgca tagttaccag taatcccgga acagtagcca
     7561 taacagccag ggctaagatg gtataggacc accctgttcc aataccgtcg atcattggag
     7621 cgataaaagc cgcaaatgca gcaccaagct cgcagcgtat gagattgttt gctgcagagg
     7681 ctgtggccgc ctggcctggg tgtatatcga ccaacagcac actgagaatc tgataaacgg
     7741 ctatcatggc atacccaaga atgaagagga tgattatcgg cccagatata ttgacatgct
     7801 gggtcatgat ccagccgtag acaatgacca acacgcttag gaggataaag atgggaatac
     7861 tgagctctag tcgtgcgcgt tcgaggggga agtcagccat atcttgactc ttgttgcggt
     7921 ttactgataa accaaggcgt tttgcatgac gccggtagtt ccagtcaacc aactttccag
     7981 taaacaaaac tgagagaagg cctcccacac ctatcggaat aaacattagg gagacctgta
     8041 gggtattgta cctgtatgtc tccgtaaact ccttggatgc atccgtcaga acagcttgca
     8101 atgctgcaga cgagaaacct gcaggaagaa gaacaagtac tgtctcgagg ttcgcgataa
     8161 cagaaagtga tttgagtaga ttggggacct gcatcctggg tctttcgggt tttctgatac
     8221 ggtgctctgt cttggctagt tttcggcggc gaaaaacatc ggtaagacaa gagttcagaa
     8281 aaggcggtga tatactacca ttcccaacaa tgactcgact ggtctccggg gtgaatagaa
     8341 ggaagggaat ggcgaaagct ccggctaaga tgaagaggag ccagaagagc caatgccatt
     8401 ccagatactg ggtcaacagc ccgccgatga ttggtgctaa tgtaggacct aagattgtgc
     8461 ctgctgaggc taaggaaata aattttcctc tctctgaaga cgtgacaagg tcgctgacaa
     8521 caccgttcgc gagagaaatg gttccactgc ttcctgcact ctggagacac ctcaagccta
     8581 gcagcgccgg gtagctattc tgcaagctca agcccaggtt agcggcaagg tatagggcaa
     8641 aacagaggat gtatgctggt ctgcgtccgg ccacatcact gaagcttgct accaccatgg
     8701 gtgccacgcc ttggatgatc tagatacatt ctgtcagcca cgccatatca ttcggccttg
     8761 atatacgctg aataaatacc agataagttg taacggtcag attgatctgc gcgctcgtca
     8821 cactcaagtc ttttgctatg gttggaagag ctgggaagta gatagaggac gacagcgggg
     8881 agaaaaatcc ggcgaacgag accatcccaa tgatccatcg tttctggcca acggtgaaag
     8941 ttgaataggg ctcttcttcc gtatttccag ccatgggagg cccggtactg ccgtctagaa
     9001 cctctagttt gtccgcgacc atggtgacat ctgttggaga agtgccgttt tagaactgtg
     9061 ggttcccgtt ctcgtttctg gactcatcca tcatgagcac aggaatctta tcctattaag
     9121 ggccaactaa agagctagat tctattctgt gtaccgtgat tttagtgaag ccagttgcga
     9181 tgctgagttg acgtcatttc tcctagcctg agagtgtagc tcaaaaacga gccaaggcta
     9241 ggtaagcgaa ccggtcccga gccaaggagc taagccctaa ttaagtccgg gtaaaacgcc
     9301 actgacgaaa cttgtcttgg aatggaaagc agctatcaaa acaggttaag tgcggctact
     9361 cgatagggaa taagatgtgg ctatcacacc ctgcatttct aatggtggtc agaccaggcc
     9421 ctggagctaa cccaaagtcc ggatgaaaca cgacacggaa agagctgcag aacaatcaca
     9481 tctcggcggg tttgacagga accgatgaag cgatatgcac ctgtgcggct gcggccgacg
     9541 ccacctcttt tactatgtac atttcctgct ggatgcaact cacgacagac gctgtttata
     9601 tcctatttcc gggttacgct cgattttcaa aatcacccga gacgcaagct gactttaaca
     9661 aggcaataag ttgtaattga cctcactacc gaccaggcat caattaagtc gccgatggtg
     9721 ataaagcgtg tatcgttata acgataacag ccttgcaatc tttcaactca gatactcggc
     9781 gtgtttccct accagtagtc ctcaaacgat gctcatatac tctgatatca ttgcagctcc
     9841 aagatccatc aattggcgat gagaggtcta tccttgcccg ttcatgtgcc ccactcaaaa
     9901 tgcctctccc accatttgac agtgtaattg ttggcattgc cgcatacgtc taccactacc
     9961 cggtatcccc cacctcacac ccaaaggcct ggcaatatgc ccgtatcgcg cttatggacg
    10021 ccatgggttg cgcgattgag gctatatcca aaagcgaaga ctgtcgagct atgttcggac
    10081 ctgtggtacc agggaccgtg acccccaacg gctttaaatt acctggcaca tcgcatcaac
    10141 tcgacccttt gaagggcgct tttgacatgg gtacagcgat taggttcctg gatcacaatg
    10201 atgccatcgc gggtgcagat tgggggcatc cgtctggtat gaatcatgta tctcaaccga
    10261 atcggaacgg ctttgatagt ctaactattg tcacgtagat aacctaggtg ctatacttgc
    10321 cgtcatggac tggctcggtc gctcatctgc caatggcaag ctggagcacc acggcccggc
    10381 cttgacaatt gacacgctgc tgcaagcaac catcaaatct tacgaaatcc aaggttgttt
    10441 cctcctccgc aatgctttca atgcccacgg actcgaccac gtaattctcg tcaaactcgc
    10501 ctcgacggca gttgtttctt ggctgctcgg cttgacggag caacaatgtc acgccgccat
    10561 ctcccatgtc tggatggacg gccaacctct ccgtgtgtat cgctctggtg taaatactat
    10621 accacgaaaa ggttgggcag ccggcgacgc gtgcatgaaa gccgtgcatc tcagcctcct
    10681 caccagggcc gggcagccgg gctctcctac ggtactgaca gtgccccgtt ggggctttta
    10741 tgcgacgtca tttggaaaca aggagtttga gtttccgaag aaatatggga catgggtcat
    10801 cgagcacatt ttctttaaac tcatgcctgt cgagggccat ggcgtctccg cagcagaagc
    10861 ggcgctaatt catagtgcga cattacgagc gagaggcttt aatccgatac agaacgttgc
    10921 caaggtcgag atccgcacca atgccgcggc ggacctgatc attaacaaaa aaggcccact
    10981 cagcaatgct gcggatcgcg atcactgcat gcagtacatt gttgccctcg ttttgcttaa
    11041 gggtgatatc cccgcggccc aggacttcca ggacaatagt ccgtgggcga caagtccaga
    11101 gctagcagca ctacgaaaaa agattgatat ccgccccgac gagcaactta cacgtgacta
    11161 catggacttg gaaaagagaa gcttggcagc tggcataact atatatctga atgacgggag
    11221 ttcattgaac gaggtgctta tagagttccc cgttggccat gtgcagagtc ccaagacgct
    11281 tgcaagtctg gaacaaaagt acaagagaaa tatgggctta atgttttcag aggcggagat
    11341 ggcgcgcgct aggaaagcag tggaaaataa cggcgacatg cctgtctctg actttctaga
    11401 catgtttacc cgagagactc caatattggt aaagttataa gctaatgcca tttttggtat
    11461 ttcaatgcat agctagccaa acattaaata atatactctg ttaactaaag tcaaaaaacg
    11521 gagtgcttga ctttcatcgc ttgacggagg tgatttacta gattttaggt atcccgaatg
    11581 caaggtatag taatgaaacc atttagtgat gaagctattt attaataatt tcgtttaata
    11641 atgaatccat ttacattccg aggggccgaa tgcgaacatc ttcatatcaa tagattgtta
    11701 cttttgggtc atagttctct cacaagccat gaccttatcg cgaacatgga atatcgaact
    11761 catgagagaa caagagaaca tgcctgaagt attgccagag atccaaagca ttcagtaaag
    11821 cagggctgca ccctcgtctt tggtttatgc ttagttatgt gaaatgacct tgtatacggg
    11881 taatgcgttc tagagaggct taatcactgt tctacagcct gaatcttcta ataccgccca
    11941 ttttagtcca tcctttaccc attcgaataa ttgatattcc acgggcttct tcttcatcat
    12001 gttatacttt cgctgctcaa ttccactttg ttcatccttc agctactggc agcccactgg
    12061 tactatggct gccagagagt ctactcgttc cctggcccgc cttcccactc agctggcata
    12121 tagccaagaa ccctcccctc gagcccttcg ccgggcgcgc gaccctttgg tctgtcttgc
    12181 tcgggcataa gggcatatag ctctgaaaga tttggcatac cattcggacc aggcatccac
    12241 tcataatggt ggatatgacg ggttgaattc caccagttct cgttttcatg caagagttgg
    12301 gagactttca tagaatcgat atacgtccgc acttcaatca tctgcttcct atcggatgac
    12361 cagcgggtca cccagacgtt gatgatatcg aagagggttc cttttgatca ttccctgtta
    12421 gtattgtaac atgtccgtcc tgaaggaaag agaatggtga ccgaccgcta ttcgaaatgc
    12481 cctgaaagtt catttcctgc accgaccact cctgatcaca gcccccgtga atggccttcg
    12541 ggatgattcg gaaattttct ggatggtcgc tcccaacgag ggcgactcgt ctcaaggcgt
    12601 tgacgtagaa gtgcattaaa tcgtgataaa cgccggcacc tggatgattg ccaacaatgg
    12661 taaagtgcac gtctttgttg atgagggtaa ataagctgcc catgtccttt tccagggtct
    12721 tgaaagcttt gtagacaaaa ggctgtgaca catatttgca atccatttct gggttctcga
    12781 agtaaaaccc gtcgcgctcg gcctcttcaa tatctggatg cacccagcca acagggttat
    12841 ggctaagagg gcgttggtgg gtatcatggt tgaagttgag gggtttgccc accactagga
    12901 cgggcagcgc gacgagcaga tatcgaatgg caaccatgtt ggacgtcggg ttggtgttga
    12961 ggatgaggat ggacttggag acgtaaaggt gaggggcttg gtttatgact gttgaataac
    13021 gccgaagtaa ctgacgcacg agtcgctgtc tagacttgat agaactatcg ctccatcccg
    13081 gaatacatac cattggtaga aacggttgac taaagatctg cttagtgccc gttcagttgt
    13141 atgtcggcaa cctaggaagt agggaggcgg acggtctcga ccacttttga ttggctcaaa
    13201 ccgccccatt gaatctccat gtctctcttc tgctctctaa gtccgaaacg aggggagtct
    13261 attcccgttc gataaaagcc atgcaatttt catccagcca ataattcgaa gactatacct
    13321 accgataatt aagcggactt agagaccagc ctcgtcgtgg ccacacagct atgtagcatc
    13381 gacgaacttc atgcctatct cactatatac ttacatacct atatgagcga gtttcttggg
    13441 aaggccgaga tctctccatt acgtctgtaa taaaccaatg atgaacactt atatacaaaa
    13501 gacgaagtaa ataccttgaa catttaatgt gccaccagga cacaagctgt aacagggacc
    13561 tcccgcaatc ccgcttccct ctgacccaaa ctccgccatg gagagtcctt ctgccgctag
    13621 ggtgagccca actcggccca aaactcccag cgaaacaaca cccttactca atgcggctac
    13681 cggaggagat ccggagcggt actcagcttt tggcgaaagc cagaaaaagt tcatcattct
    13741 caccgccgct ctagcatcca cattctcccc cttctccagc aacatttact acccagccat
    13801 caactccatc gccgatgact tacaagtcag catccctatg gtcaacatga ccatcactgc
    13861 ctacatgatt tttcaaggtc tcgcccccac tttcatgggt aacctctcgg atacggccgg
    13921 gcgcaggcca gtttatgtcc tatgtttcac catctatatt ctggccaata ttggcattgc
    13981 cctacagcac agcttcgtgg gtctccttct cctacgctgt ctccaatcat caggatcctc
    14041 tgccacaatc gctctctcca acgccgtggc agccgatacc gttaccagct ccgaaagggg
    14101 catgtatctc ggcattgcgt ctctgggttc tatcctgggt cctgctcttg gccccctgct
    14161 aggcggtcta ctcagccaat acctcaactg gagatccatc ttctggttcc tcgccgcagc
    14221 cgcaacactg gttttcgtcc cgctcgtact tttctacccc gagacctgcc gcgctattgt
    14281 gggtgacggg tcaatttccc cgcccgcttg gaataaatcc ctcctcaact atctaaatga
    14341 aacaaagagc cactcggtgc agaataaagc gatggtcata aagcctaaga tcaggtttcc
    14401 aaaccctcta acaacactac gacttctatt cacactcccc acgggcctca tcctgctctg
    14461 caatggcgta ggctacgccg cccactttgc cgtgacatcg tcgatgccta gccagttcaa
    14521 tgaaatctac ggcctcaacg acctgcaaat tggactgacc tttatcccaa tcagcctcgg
    14581 taccatcctc tcggccttcg caaatggcta tctcctcgac tggaatttcc ggcgtatagc
    14641 gcgacaagag ggtcttccca tcctcaaggg caagaagcaa gacgtgtcta atttccccat
    14701 tgagcgagcc cgacttcaaa tcgcgcttcc tatgttgttt tctgccgccg cgttgatcgt
    14761 cgcatatggc tggctgctag atatgcagct ccccattttc gcgccgctgg tcttgctgtt
    14821 tctcatcggc tcgtctatca cggcatgcta taatgtgttt aacgtactga ttgttgatct
    14881 caactattcg actccagcta ccgctaccgc agcaaacaat cttgtgaggt gtatgttggg
    14941 agccgcatct accgccgtgg ttgcgccgat cttggagagg tttggtaggg gctggacata
    15001 tacctttgtg gccggggcgt ggctggctgc tacgccagcc gccctgctgg tctataggta
    15061 tgggttcgcg tggcggagga gggatcgatg cgaagagagc taagtgagtc gacaagaagt
    15121 gagttaacaa gatgtggaag aatgcgttct accagagact aggtactcaa tcaaacccat
    15181 tgtgccccca cacatgtttc gacaacgtgc aagtgaggga aagttgagca gctactacta
    15241 tggttgccta aacctgttgc tgttgtattg agggaagaga aaaccgcacc tctgacaaaa
    15301 tctagttggg tacctcgggc aatgccactc tagacaaaag cttaattaag ccttcaacgt
    15361 ctccaaccat ttctcagcct ccactacctg gccccttttc gtgaatatct tgtccatcag
    15421 agtattgtgc aacgtctcat cagcatccac acacagatcc ttcagcacca caacgccgaa
    15481 gtccttgtct gatgcctcta gaacggtcga cagcaccact ccccctgtac tcatgcccgc
    15541 caagacgacg gtctcaatgc ccaagctact caggataatg tccagcccac tcccactgaa
    15601 tgcactcacg cgcttcttgt cgacaagaac gtcaccctct tgcggagcga tagatgggtc
    15661 gattaaagtt tctggagaac cctcgacgaa ggattttgac ttcacggcgg cgctgaaggt
    15721 aggatttgaa ggcgagatct cgggatggcc ggggcggaag gcgactcttg tgtaaatcac
    15781 tttgacgacg gacgggcgtg cggcggcaat ggtctttgcg agacggggaa ggtaatctga
    15841 cgattgagct aggcggggca cgaatgcgcc ctgcacgtcc atgaccagga gggccgtttt
    15901 cgccattttg actcggagtt atcgtagaag tcttggagat tgcttgaagc gtcgcaaatg
    15961 gattaaagaa cgatactgag atcttggcgg aagaggaaat aaaatggtag taaagaaccg
    16021 atatcctttt gcgatatggt tttataaggt tgtatgcatg tgatcgatct gcacggcgat
    16081 ttgaaacagg gatgcggagt tactcggagt ttaatttgct aacagatcat aagtgaccga
    16141 aagatttggc aggggcgtcg aatgttgccg accacggcca aatgacccgg gccaactgca
    16201 agcggttaac tccgacatgg actccaacct gtcaaggggt ctggtccgta cgcttgtctc
    16261 ctaattactt gtggtttcaa ttttggcgaa aactgtagtg gggtgcgatc cgcagaccag
    16321 cactcaaatc aacaacgtac ctgttatctc cgaaatctca tgattggcag gttagtcgat
    16381 gctctcattt ctccttctga atctcattgt taaacaagac aggattattt gcatcctatt
    16441 tctccagtgt gcgcgcgact acggagaagg caacccgcgc ggtcgggcaa tgcgctcggc
    16501 gatctgtgga cctgcgcact agcaacgccg ggtactaaca acgcgaatgc gcggctttct
    16561 aaggtcgcac tacggaaatt aacgctcacg gctttgtctc actggcacac tgcggacgcc
    16621 atactctgtc actaatgggt ttgtaaatgg caggcaggaa aagaagtagt gcatagaggg
    16681 ctgtagatgg aaaaatctca actgtaaatc ctcgagctga tctttgcctg ataatttttt
    16741 cccagcattc ttcgaagggg tagtccatgt cagactaaac aagggacaga gaataaacta
    16801 tattgactac agcaccaatt agccaacgag cggtgatcat aaaggaggca aaatttacag
    16861 acaatattgt tcccctcaag ttccattctc agcgcccaag atgtacgcaa gcacacgtct
    16921 cgttctctcc atcttcctgc ttggcctctc catcgcgcaa accccgcctg ggttcactcc
    16981 gtcttgtgac caaaacttgg gtgtcacata tccaaacaag gcatctatca ttatccccgg
    17041 ttcacgtctg ctagcttcag gtatacatat agtctttttc tctcccagtt cgccgacctg
    17101 acgtcaagca gataccgcta tccaaccccg cctctctgcc gcctccgatg tattgaaaga
    17161 agatggaaaa tatttactcg tcatgttgga tccagacgtt caatttccga agcaacccac
    17221 gactacaatt ctgcactgga tggagccggg cttccaatac aacaagacct ctctcgctct
    17281 cacacccgta tctgaccccg aagctgagag tgtagctagc tatgctgggc ctcatccacc
    17341 aattggccag atccaccgtt atattttgct tttgttttgg caaccggaag attacagact
    17401 cccgaaagag tttaagagtt tcattcctgc agacattccg cataggattg attttgatgt
    17461 ggtcaggttt gtggaagcgg ccgagctggg gaagcctatt gcggcgagct atttcatcgc
    17521 ggaagggcta aggtcaaata tgaaggacga gctcaggagg gtggtgtaat tagtgataat
    17581 tattgccaaa ataacccttt tccctgtatt tttgtgactg aatggcttgt aggtttatat
    17641 tcacctaggt gctgctgtga tcacagaata cagagctctc tctaggagct ggatattcgt
    17701 tgtgaaggtt gcaatttttt gattctaatc cgaaaggaag gcgggattga aggtcctgcc
    17761 cagtagaggt ttatatagcc ctgatcacag ggagcagggt atttaggaga gccagtctcg
    17821 tgtgtaggca cgtggctggc tggctggctg gcctactgtt tacactctct ccctacgggc
    17881 gcagtgcaga gagtgcgctg cccgctctct acgttccagc tgcgttaccg cggctccctg
    17941 gctccctggc tccctggcta ttattatacc aacaggctat tttccgagca gtaactttct
    18001 tgactcgctt gatattgagg tttatagcac tacacggtgg cccaaccttg attgctacag
    18061 tgttctagaa actggtcaac ttgatcccaa ctcccgttac aaggactaaa gaggtacaga
    18121 ggaggatttt atgtagtgta tgtatgagac acaatcgatt gaggagatgt atgctggcaa
    18181 taataattgc aatctagagt ctacacagcc tagtaatgaa ataaactaaa ctagttactc
    18241 cttctcaact acctttaagg aaactaaacc gctcctttgc gcaatcttag cacttagctg
    18301 ctgtaaactc tggttcgcaa gcaactccag aattggcatt gtgctatcca tctccctcac
    18361 aatccaattt cgcatctcta ccgccacgag cgagtcaatg ccatagtccg tcattggatt
    18421 atctcgggat atattgtcag ccggtatgtt agatctgtcg ctgatcttgt caactaaggc
    18481 gttgcagatc tgctcggtcg cttcctcgag agttgtggcg gccttgagaa catctcgaac
    18541 tcgagctttg ccgtcagcag caccactgtc cttcttcaat gcctggcgtc taaagtggct
    18601 aaacaccggg aggtcgtaaa tagcaagcga cttgccctct tgccacgtgc ctaggcctgt
    18661 aaccacgtgc gacagaagat cctcgcgtct cgggtcggca atggccgact gaatgagtgc
    18721 gagtagtttc gccttgtttg tgccctcgaa gccttgtcgc tgcatgccgg cggcgagctc
    18781 cttgtccttc tcagctagat aaccgacttc ggtgatgaca ccgagatcga gcgtcaccgc
    18841 gggaaggccg agattgctgc gatatgctgc gaaagcatcc atgaacgtag atccggcggc
    18901 gtaagcagcc tgcgtggcat tcccgataat gccactgacc gaagagagca tgaggaagaa
    18961 gtccatattt tctgggaggt tcttatgaag attccaggtt ccttggacct tgggacgaat
    19021 gacggacata tagtcggtga gaggcatctt ctcgaggagg ccgtcctgtc atgatatgtt
    19081 agcatattct gaataaggga gctgaggagt tacttgatga cgcttaccct taggaccata
    19141 gctccttgaa taacgccgcg aattggtggc atagacttgc tgctttccgc aaccaactcg
    19201 gcaactgcct cgctgttgct aacatcgcag ccatagacga cagccaaggc gccctttgat
    19261 ttaagagcgt cgatggtttc cttcgcttcc ttcgaagcta gaccgctccg gttggcaaag
    19321 atgaggttct tagcgccgtg atcaaccatc cacaatgcag ttgctcgtcc aataccgcct
    19381 aggccgccca caagtaggta agacgcatcc ggccggaata ggttcttgct cgtatcccgt
    19441 ggaactgctt gtaccatctc atcgggctcg gccactgcaa ccaacttacc catgtgcttt
    19501 ccggtttgca taatccggag ggcatcctcg atctttgaaa ggcggtggac gtgcaatggc
    19561 gtcggcccct tgatggactt cttgcgaaac agatccatca cgtcggccca gactttatct
    19621 ccaacctcac gcctagctct gatcaagtaa accaagttga atgccgcaaa catggggttc
    19681 ttgatgaagt tacccatctc caaccgcgta ttgacagtaa tgtcacgggc gccaagctcg
    19741 atgaagcgcc cataatcagc aacacaattc cagctaagcc ggagagcttc tccagcaagg
    19801 gaattaaaca caacatcagc acctctgccc attgtcatcc tcatgacacc tttggcaaag
    19861 ctgccatcgc ggctgtagaa gatatggtcc tcggggatcc caaaacaatc cattagtagc
    19921 tttttcttct cttgtgtccc cacagtagcg tatatttccg cgccgatgag ttggcaaagc
    19981 tcaatgatgg cctggccgag gccgccagtt gcagcgtgaa caagtacaga gtccctcttc
    20041 tccactctgg cgaggtggta gactgagtag tatgctgtcc cgtaggtgac aggaagggcg
    20101 gctcccattt caaacgacat gtcgtcgggg atcttctgga aggcagtcca cttctcgcgg
    20161 tagaagttac aaaaagtgcc gaatccatac gtagagacgc gatcaccgat ggcgaggcct
    20221 cgggcattct tgcccacagc ggttaccaca cctgcacact cgcctccgag agtctccgtc
    20281 tggatctgac ccagacccat catgacgtct ttaaaattga gacctgttgc cttgacttcg
    20341 atctctactt gatcatctga tagaggctga accatcctct catcgtcgat gaagtgaatc
    20401 gtgtccagga gaccgggttg gccaacatgc atgaccagag gtctgccaga ttggtggaat
    20461 ggctgcagct caggaactgg cctgctagac gatgccaaga ttttcttgct cagtttgctg
    20521 ttctcaacaa gtcgggaaat caggatttgc ccgtcccttt cggcatactc tgtgtcaacc
    20581 tcgttgggca acatatggct cagcagaaaa aggtgccgga atagagtgaa gatggcttct
    20641 gatgctgagg agcttgggga cttcgacttt ctggaatcaa gatcgagtgt agcaatgatg
    20701 gttcccccat tctctgagcg ggccgtccgg gcgaaaccag tcacgagatt tgaggtagga
    20761 ttagaaaacg agagcgtccc tccccgggta acccaaagaa caccatcact cttgataaat
    20821 atgtccttga cgacctcgaa ttgctccaga gagggatcga tcatgataga cctggtaagc
    20881 tcgctgagga caatgcatat ttttccgaca ggctttgctt tactgaaagg cgttacctca
    20941 aagccgatat tgaggctagt cagacgttca agcaggtcat tcagaataac gtcgctatca
    21001 tcctcttcgg caataacaag gacgtctgag atgtgggcag tttccttctt gtgaagagca
    21061 gtagaaacca tcaccgagct ttggtggtca ggtccattag ggacgtccca gacaaccccc
    21121 tccaggccgg agaagcggct ggccaagagg gcagcctccc agtcgccttc ggataggact
    21181 ggacttgctt gccgattttt ttcttcggca gcccaccagc tgggaagggt gccgaagatc
    21241 aaagaagaag ccatatgctc ccttgtcaca tcgagaatca ccaacttgcc gccgggcttc
    21301 aatagcttgc gagcattgcc taaggcggta tgcagtgact tgctcgtgtg aagggcgtag
    21361 gcggcaaaaa tcacatcgta agactctgca gtaaaccctt gcgcaaccgg gtcgttgtca
    21421 atattaagct ctttgaaggt aactagatct ttccagggcg cggctctctc cttgagcgag
    21481 tcgaacaagg tactgttgac atcagtgcaa tcatacttct ggaagcgtgg gaggtcgccg
    21541 tccgcaccgc cgagcgactt taggatcgga aaagtggccc caccggtgcc gacaccaatt
    21601 tcgagaatgg acaggtgcgg actcttgtgg ccgaggaggt caaaatattc agccgcggcg
    21661 aggtaggttc gagcaattcg agggctgtcc ttgaaataag cttctagcct ttgctcaccg
    21721 ataagcaaat tccatggatc gacttctttt ttcataattg cggggagatt ccgtcccatg
    21781 aagcataaga ggtggccctc tggcccggaa tcccggatgg catgtctcaa cttcgccctt
    21841 tcagccccac ctgcagctag ccacgacgca gttgggatat tgaacttatc ttctcgaaca
    21901 tccttgacca acttctccat aagagcatac atcttctgga gatggggctc catgatgggc
    21961 agctccgctg gcgcgacctc agccagggcc cactccatat agtagtacgc cgtctgctcc
    22021 aatcctcgga tagtggctgt ctcttgtagt gacaagggag cgttgtcaca gagctcagaa
    22081 atgccattct tagacaggag atcaacatcg gctctccatt ggaagttgta ggcgacgcgc
    22141 ttggtttcct cgcctgattc ctgggcaatc tccctcgcaa gtgtggtgca ggtaaggtca
    22201 cggattgtga gcaccggctc gctgttcagt cggctcccat ccaaaatcgt catggacgct
    22261 gtcaggtact tgtcgtcttt tttcttagtt ccggcgtaga ccactaattc gtcccctggt
    22321 tgggaggtga tgttgctcga cacgtagatc tcctcgataa acaccggaac ggctgggtcc
    22381 ttcaaaggcc cagcttcagc ggctaaagcg acaaaaatgg gatggaagat ggcgtcaaga
    22441 gtggaagggt gcaagatgca ggggaattgg aagtgctgcg gcatgacggc agctgtatcg
    22501 gcaatggcca cagtcgcaat acatgagttg cgagcagcac gggccttggt cacatttgca
    22561 aatgtatcgc cgtactcaat ccctagctgg gtgagttgtt ggtagaactc cttcacatca
    22621 acatcgatat ggcacttgtc ctcggcttcg acgatgattc gggtgtagtg gttcatctcg
    22681 gcgaccgcct ggacatcacc atcaatgatg ttgatactcc tctgcggcgt ctggacagca
    22741 atcaaacctc tgcagtgctc cgtccaccgg ttgtcatcgg taacagagta gacacaaaat
    22801 tcgtcccaca agtctgatgg cgcgcgaata ctctccgtat gtggcttgaa gctcacaagt
    22861 gtttccacac cgtcggactg ttctgggatg acaagagcag atccaatcga gatctcccgg
    22921 agcttgtagc cagtgattgt gagcgatttt tcagtcgcac gctggaatgc cgcctcaatt
    22981 gccatgacta tatagccagc agcagggtac acgacgttgg attgaatctt gtggtctttg
    23041 acccacggga tctcagatgc acggatatga ttacgccacc gcggttcgag cgggtttgag
    23101 ttccgatcca acgcaccaag caaatcggtt cggggaaaag ttctttgacg gaagaccttg
    23161 ctcaacctcg gctccgccca gtagctattg gaatgattcc atgggtaggg tgggagatca
    23221 actagaacgc tgtggctttc tgccccggtt gggcggttga gagcagacaa attcaccgga
    23281 tatccgccaa ggactagctt tgatgcgaga tccagagtag ttgtgacggc gtcaaccttg
    23341 cggatgagag cggaggcata gccgatgcct gcctctttca atttgtcatc ggcttgcaaa
    23401 atctgcttga tcggcccggc aagtgctgag tgcggtccaa tttcaacaat agtgttgacg
    23461 gttggggcag aggcacgctt ccgagttttc ttcccgctgc tcgatgatgt ttcaagacac
    23521 aacatccgta gagagtcggc aaacttgacc tctcccagca tattagctac ccagtatgaa
    23581 ggaccaagct ccgaagcttc ggccctccgg ccgaaaaccg acgaatagaa ttcaacttcc
    23641 ccagtctctc gaattttgat tccagagata gcattgccgt actcttcggc gattagtgcc
    23701 atgtgatggg aatggtacgc gacgtccacc gctagctttc gcgagaacag cttcttctct
    23761 tcgaataatg attggagctc gtcaatcgcc gtagcgtctc ccgagaccgt gatactggat
    23821 ggactgttaa cgcaggcaac gcccgcctta cccttcgtca aactagatag gtaaggtagg
    23881 gcatctccct tagacatccc tacagccatc atggctccag aaattgggtt tgtgcttcgc
    23941 acgttacttg acgaaacgcc acggtagtag gctacagcca tcgcgtcctc ccagctcagc
    24001 gcacccatag cataagcgga ggcgatctca ccactcgagt gtccggtaac cgatgcgggt
    24061 ttgattcccc acgaggcgag aaggtcgaca attgcaatct ggaccgctga gcataacggc
    24121 tgactatata atgctagccc gatatcagat gtcttggggt ctttcgtaag ctcctctgtc
    24181 acatcgaatg gtgccccaag agtcgtcaag tatgaaccta tctttgcgat ggtgtttcga
    24241 aatactggat aagcgggcag tagctctttg cccatgccac accactgagc tccctggccg
    24301 gtgaagacaa acccaagcgt tggctttttg tttgcttttg agaatttgat atcgcctaac
    24361 aaagctttgc tcaagtcgct ttttgaggag gcagatatcg cggctttcca gataaactct
    24421 gttcgtcgtt cacccagagt atatgcaagg ttatccaggt agccgtcgtc caagtcctgc
    24481 ctggactcaa ggtagtcact gaacatcttc gcctgccgtt tgcaagcatc ttgatcaaag
    24541 ccagagatga cgaagagcct ctgacgctcg cttgagagtt tgccattcct ctcgccattg
    24601 gcggatccat tggggtgccc attagggtgc ccgtttgcat gtccgcttaa atgcccgttc
    24661 gtagacccgt tcgcaaatcc gttgctgtta ggagtaatct tgtccaactc gggagtgagg
    24721 atggatttcg cggttctaat cgatccatgt agcccgcgta tagaaaggta gtcttctgcg
    24781 ctctcaagaa tagcatgagc atttgagccg ccatagccga agctattcac agatgctcga
    24841 tgcgggccat cgacaaccca aggctccaca agagtattaa cttttaactt ccagtcgtaa
    24901 aacgggatgc gaggatttgg ggtttcgaag tttcgattag ggagcaatat cttattctca
    24961 agcatgagaa ctgtcttgat aacacctgcg attccgctag ccccctccaa gtgtccaatg
    25021 ttggtcttta tcgacccaat gcgcagaggt tggtcaaggg agcggccagg accaaagacc
    25081 cttgagagag cggcggtctc cagagggtca ccagcaggag taccggtccc gtgagcttca
    25141 acataactag tctcaagggg atcaaggccg gcgctttcgt agacgtttct gataagtgac
    25201 tcttgtgcag cgccgcttgg gagggtgatt ccagacgtct tgccgtcttg atttgagcca
    25261 gtgccccgga tcacggcgcg gattgtatcg ccgtccctga gagcgtcggc gagaggcctg
    25321 aggatgacac aacctacgcc ctcacctcgc gcatacccat ttgctctatc atcgaacgta
    25381 taacaacgcc catctgggga catgaatctg aagtcatatt agccaaatgt tctctaatat
    25441 tatcttgatc tctccatacc tcatcatact catagtaatc atgatctcgt ggctcaatat
    25501 gacgtttgcg cctgcaacaa ctgctctcgt cgcatcgccc gttcgcaagc tctgacagcc
    25561 tagatggaga gccaccagac tagccgaaca ggccgtgtcg attgtgacac tagggccttg
    25621 gaggttgaaa aaataagaga gacgattggc gagaatggct cgcgaatgtc cgctattagt
    25681 gcattggtac attggcaccg tttccgggtc tcgcatcaac atatcggtgt agtcgccaca
    25741 gaacgacccg acaaaacaag acgtcttgct tccttggatt tctgcaagcg gtgttcccgc
    25801 attttccagc gcttcgtagg tgcattctag caacaatcgt tgttgggggt cgagcgctgc
    25861 ggcttcggca ttcgtcatgt tgaaaaacgg tgcatcaaag catgcgagat cttgtgtcat
    25921 gaagtgacca gccgtgacat tggttgtccc attcctgttc gaatctgggt ggtaaaaagc
    25981 atcgttgttc cacctctcct tggggatctt gctccagccc tcccgcgctt cggagactag
    26041 tttccataga ccctcaacgt tggtagcatc tgccgggcct cgcataccca ttcccacaac
    26101 ggcgatgggc atggaccggt cttctgagat agtaagggcg ggattggagg tgggtgaccc
    26161 agaaggtaga cttagcacct cgtcatggtg cccgttaagg tagggagcca tggtggaggt
    26221 ctggcggcga ataagttcag cctgtgctgc ctggctggcg agtatactcg tcttatgaaa
    26281 tatgttcttg cttagagaaa ggtttgacca tgtgagcatc taatatttcg tagaatagga
    26341 tgtcggtttt tactttcgtt ttcaaaaggg gctcgagaac catttagaga caacttcggc
    26401 tcttggagcg cccaaatggt ggtacttgaa gctcggattc tttcaatcca aagcggacat
    26461 cgttttgccg cttataggca tattgatcat agcaacaagc gctatgtcac cgagcgcgtc
    26521 aaaaacctca ctacgaaaaa gggcaactga tattttatgg attactaagg accggtcata
    26581 ttttaatttc aagcttagag ggaggtggtg taggccgaat gcgtgtgcaa tccaacccaa
    26641 aaaccgctaa ttgcaaaata gaccgaacta ccgtatggat cgcggagaat ttgcccagat
    26701 aacaggaaaa taaatcaatt aagcaatgta taattaggtt tttttcttcg ttgacgattt
    26761 atcgatactt tattacaaaa ttgctggcaa caactttgta ttctctgtag cgtaaaacgt
    26821 tggtaattac cccagagggc atggtttaag aaattcaggt cgattaatta actacccaac
    26881 ttgggtaact ctttattctt aaaaacgcta taattagccc attactagat cctccaatcc
    26941 ctcgccaatc agaccatgag ctatgtagta cacggagaga tcttgtaaaa aaaaatacac
    27001 cgaaatccaa aattcaccgg gcggtttttt gccggtccca acttccctaa ccgtaacgtt
    27061 ccaaagctac tgtgctaaag gcaacttccg aaggtttaga tctgctattt ttattagttt
    27121 ctgagctgtt tcaattaatt agaccttgaa gtttgttcct tcaagctcaa tagatatgtt
    27181 tcattgatgg tatggcctaa gtctgccgga gataacgtct tcatgaacgc gatgcctctg
    27241 ggctagatca tgtcaacatc ctaggtgcaa tataattgat gatgagaaaa cgtaagtact
    27301 atatgcaata tgaacaagta aaaccagagc atcgacaata cacatatatc tcttattgat
    27361 gagggttggt tattcattta ttacgcgtct ttaactgtct tgatatttac gtaagtggaa
    27421 ttaaagttgc cttcccagct ttgctaaaaa ctataagccg ccttctggta tctattagca
    27481 ctacagaaac atagacctcg tccctagatc tctaaatgca gcggccattc tagccaacgt
    27541 ctttccgtcc gatgggatct cgtgtcccct atcatgcacc aaaatcgctg acgatttcac
    27601 atcgcacaag ttgaaaaggt ggagtgagta actgtaaatg aaatccttag ttcccataac
    27661 atgaagcgtt gggatcttga ttttgccctc taatccctct tcgaaaactg gagtttcgtc
    27721 atcattcatc cggaatggag caagcgagct gaagaacacc gcgcaccgaa aaagtggtgg
    27781 gtcataaggg ttcagggtgg cgtggtgggc gagaaagccg gttgctaggg ttccgccgtg
    27841 ggaaaagccg aggatgccat caaacggtcc ttcttcttcg attacctcgt atagcatatc
    27901 atatgcttcc attatagact cgtcgttatc attaaatgtt cgcggccatt tgtagtagct
    27961 gaagaacggg ccttcgtaga atccttcaat gccagggccc ggtggcgacc caacatctcc
    28021 ttccactaaa tggaaaatag cgctattgtc tttcccgagt tctcgcataa ggggtccgag
    28081 ttgggagccg agaatctgcc cgggttatcc ccaagtcaga atatgtaaat ggtgggggca
    28141 tgcctagtgg cgatactcac ttgtgcgttt gttcccgcac catgaagaca gagaaatttc
    28201 agcgtgggca ttttccaggt ctgcgaatga gaggttattc tgttcgttga gatctgtggg
    28261 tcgcagtgtc tcaaaaataa atgtgtccaa agaggagttt ataaaatgct acgccggatg
    28321 tttataagct cccgattata aggtgaatga atatgcttgt ctaggaagct gagatgctca
    28381 gatgatatct gccggctcct aatgcttccg tgcatcataa gccaatgaga cctgataccg
    28441 tatgcaagta catgcaaggg taggtatgaa aatatctgga ggcttatctc ggggtgaagg
    28501 ctgcgtgcct gttcaaacac tcagttcaat gctattatgt gcatgagtca aatggcatgg
    28561 cagctatcta ctctactcgg gcatcttgca aacaatcctt tccatgtcgt ttttaggaag
    28621 gttgcattct tctccctaca taccccaccc agtcactcct gtttaagccg ctgtcaactt
    28681 gatttgatag gcttgaaatg gggcttcata ccccttttta aaatgcagcc ggaaaaagga
    28741 gccgctaaat gggtttgcca agctttgata ggacgtggaa atatatgaaa agtgtttctc
    28801 ggactccggc aatgaccctg gagtagaaaa ttacgggcgg attattacta atgtccgtag
    28861 attaccttaa acatctacct tcgaattggt tgcccgggct ggttccgaag tttaatatcc
    28921 taagaatata agtttttcgt attatactct tatgaggcca tgctgtttta ttattgggta
    28981 cttgcgctct cgggtgacaa ttgctactct caaactatat gcacgctaag tatctatgat
    29041 cggcctggtc aaccatcgat ctgttgcatc tgctcccacg gtatattgca tgcataggtc
    29101 aagtgttatg ttaaagtttt aggctcgtcc gctgttgtta ttctactatt cccagatccc
    29161 tccatgccgc gagccaagcc ccaaattcga cggtctcatt tattctctac agtttattga
    29221 agctcggttg cctaacttgg ccgtggccta tgtaatgaag ttagtgatat cgtttcgagc
    29281 ggacggaaag ctagtgcgat gacttactgg tgtaattcac cggtcggact ttctgtatac
    29341 gtgcagtaga ctgtgcaata gattccgcga gtcttagggc gtcaaaaatg gcctcgtcca
    29401 ttgtttctga tacactggaa acaaattcca ttctgtgtgc gtcttgggca acgaatgctc
    29461 ctccagacat aagcatttcc cggaatacac tagcgccgtc catagtcaac actgcaggtg
    29521 gcatctccgt cattgctgcc tcaagagagg tgtttttctg cgtcgcgtct ccaagcaaaa
    29581 acctcgcgtt tgatgtgcag atgcgtatgt ctgagccaca ggcaatatcc aacgccagtt
    29641 ttgtgcagat gccgtgtaag actgatatga tagctttttg atgtgttaac ggccatccaa
    29701 atccatggtg gcagaactca ccagtattgc atttcaacgg ggcaatcatg tatgacctga
    29761 acttttcttt tgtcgtctcc gtatatacct ctgtgtttga gtccgtgttg aaagcaaggg
    29821 cgctatcatc tttaccaacg gcaattataa taacccgcag cttggaatcc tgggagaggt
    29881 attcaagcaa tctcttcaac gccaaatcta attctgcatc aggtgttcga gaacacttca
    29941 cctcgacaat agcaacgtaa ttgccccgga aatcaacacc cagtcttgta tgtacagctc
    30001 ttgactggtc ttgagacata atggaaagag tggccgctga aaagtccaaa ctaatagagt
    30061 gatggtgagc tagctaccct atgagcagga tacgactact taaaaatggt agaatacgtg
    30121 ttactattag atgctggtta ttggcatcta ggtgggggaa ggtatttgcc taaaaggtag
    30181 ccgataagtg gtgccttgcg ccgaaatgtt accgataagt tcccgccata atcttcggtg
    30241 ggctgttgat tagttcccgc accgggtaga tcgtgtcgat cccatttgag aggtcatcgg
    30301 atggttatac aaagcgaggg ttacttacat aagcctgaag taacattctc atacaattct
    30361 ttctttgccg agacatttta gtcctagctg gaccttttgg taaaggttgc ccaaaagctt
    30421 gaaaattgaa gatccaaaag atttttgaat acattcaaac gaaccgaaaa ctcccgaatt
    30481 gaccaccttg ggtgcgacaa gagacactcc cttcctctcg tggcctcaga gctgttcaca
    30541 atggcgcatc ctaccaacgg cactttgttt gtgcgagact cacgtactaa gcaggagtac
    30601 gagataccaa tagttgacaa tgcagttttg gccgtggatt tcaaaaacat caggggttat
    30661 tcggatggat cgaagatgcg aggattgtta ctttacgacc ctgggctaca gaatacagcc
    30721 atcaaaagat cgcaaataag ttcctcgtaa gaactccgaa gctttattct tgccaaaata
    30781 ttaatttacc ctatggggac agagatgcac gaggattgcc catgattcgt ggttattcag
    30841 tcgagcaact ttactcgttg caaagcgact tcgaggacct gtttcatcta atggttcttg
    30901 gaaaataccc cacaccagaa gagaaggaaa tactgcgtca tacctttgca caagagatga
    30961 tcaatgtgcc cgacacggtt gttgctgcaa tcaaagcttt tccgtaagtc ccaccccatg
    31021 ctaaacaaat ggagtcactc tgacctcttc actcgtttgt agaccatcaa gcacaggaat
    31081 gtcaatgatg ctagcggggc tatcagcgta ccttgcctca tacgaccacg caataccggc
    31141 gaaacagggg ggaaacctat atcacaataa cccacgactg gccaacaaag ctgccatcaa
    31201 aaccaccgcg gcttatgcag tagtcttggg tctaacgata agccatcgga aaggcatccc
    31261 atttgcccca gcccaagcta acaaatcatt ttatgaaaat ctctttaaca tgatgggtat
    31321 ggcagatccc atcaccaaac ttcccaatcc actctacatc gatgtcttcc gccgcgcagc
    31381 aatattgaat gcggataacg gcatgacgca ttcgactttt ttgacacttg tggctggctc
    31441 ggcccttccc gatccgttat cctgtctcat tagcgccact tctgccgcct acggcccgct
    31501 acactatggg gcacaggaag ctacatggaa taatcttatt gagatcgaga cgaaagagaa
    31561 tgtcccggcg ttcctggagc aggtcaaaag gcgtgagcgg agactatttg ggtacggaca
    31621 ccgtgtccac aaaacggaag acccaaggct agccattatt aaaggcttgc ttaaggagtt
    31681 gaacgtttca cccgcaacta tcccgttgat ggagattgcg tatgaaatcg acagattggc
    31741 tgcgttggat caatatttca cgtcaagggg tttaagcgcc aatgcagatt tttattttgg
    31801 cttcttgatt catgctttgt aagatcagac actccatcct gattctcgat ttttacaata
    31861 ttccaaaagc caaaatcacg aagaagcgaa ctacgaactg actgacatca cagtggattt
    31921 gatcctgaca tgatcacgtt agcaaatctc gccatgagga tactcggcct aatggctcat
    31981 tggcgtgagg caatggatca agaaattaaa ctgttccgcc cacttcacat ctacacagga
    32041 ccaaaacaaa ggataaccgc agccaggcta taggatatgg gtataggatt actttagaag
    32101 gcagatataa ggtatcagtc gttgttgtta ctactcgtac atgtcatagc tttgagagca
    32161 aaggaattta caacgaactc ctaaagacaa agtaaacacg tagctttcca atgtagtaac
    32221 actatctaca cttaaagcca gtacgtagtc tacttaagca tcttagtatt cttgagctat
    32281 tcgtgccaga tagtattgcc acctactaac ttcatgtttt ttatacgtat catgagccta
    32341 catgcccgag aagtgttgag agtgttagca gcccgttttt aaaccaccgg cgccactcgt
    32401 ataacctgcc tatatgtaga cctgacagat ttgaacgcga aggcctcaat agagctttta
    32461 tttatttgta acatacttag ttcttccaaa tgtaccctct gagctagtag caaatatatc
    32521 ttccacagaa gcggtccaga gtaggagatc ctcagcaata atatattagc tgtcgtctag
    32581 ttcgagatat agttcaattt actaaggctg ttatagaggt gtcgtcataa gttaactata
    32641 tcctcaaacg tcactgaaat tagttaagtg aagttattta tagcatgacg agatgaatca
    32701 actctacggc gctggttatt atctactagg cctttaacgt cattttacac cgtctaaggg
    32761 attactgaga ttctctccct attcgaagag ataatctttg cgctatcatt acgtatttag
    32821 cttcataaaa ttgagttttg gatatcgata ttagctgcgt atttatctca ctcgagtaag
    32881 agagccagaa gtctcgagag ccattaatcg ttttcgttta acgtacatta taagtgagcg
    32941 gtgggtataa gcgagcggtg gccgctccac tactccaact ataattacct cagaaacagc
    33001 tgaatcagat gattctgcgg cctcctggca agtaagctac cgctcgcttg taatgtacgt
    33061 tataccactt ttaagtacac cgtttgattg taatccttac tctactagga aaacccaagc
    33121 cccatagcca gtttacaata ccacagcata tacaccgaac aagggaccga tgggcccgcc
    33181 caggccaact aaaacaaaac agtgaaaaag aaggtttagg agaaaacggt aacaagaagg
    33241 accagcctgc caccaaggaa gtagtagtca ctgcagttat tctctcgaac ccgagactcg
    33301 cggaacccac acgtaatcac actgacaaag tagacaaaat caataacgaa ttagtacgta
    33361 accagtatct aggggataac aaagcgaatc acgaatatgt cgaaagccct gggtgatcac
    33421 ccaggtctac gtgcataagc gagttttaac agcttcagag ctgtaaggac aaaagagtat
    33481 aataaagttg attgattaaa gctgcgaagt aaataaaaga aaaagggttt gggcggtata
    33541 taggcgaacc aggcgaaaga gtgtagattg tgagcgacta ctgcacaaat gctaaaaaga
    33601 gaccctgttc cctacctgac ctggtggaag tgagggtacc tcggtctaat catgatcctg
    33661 agcttacagc tcaacaaggg gcagaaaaaa gttgaacaag ggcagggggc cctaaccctg
    33721 caaaacgctc aacaagggta gaccaactct acacttgttg agctttttat atatgcttgg
    33781 catatgccta ttaaataaat aaatactcaa cacctatcct tagcatataa aaaggtacat
    33841 tagggcttcg agagctgcgc atatggcccg catatgtatc gcacgtgaga tttttgtatt
    33901 taataaaatt taaaatagtt gggagagaaa atattacaca tttgctagta attaaagcaa
    33961 cgaatagaat gaaaataatg aagtatgatt gaaaggatat ttgtacatat gcacggtgcc
    34021 acgtgggcgt atgcagcgta taccctgtgt actgtacgtg ctattttaat acgggccgtg
    34081 tacggcatat gcgggccgca aaacgcaact ctcgaagcct taatgacctt tttatatgcc
    34141 aaggataggt gttggcagct tagtatttat ttatttaata ggcatatgcc aagcatatac
    34201 aaaaagctca acaagtgtag agttggtcta tccttgttca gctgcacccc cacccgatcc
    34261 tgcctaagga ctaatatata tagtcaagct tcaatttata ttgcttgcca atgactccca
    34321 ttgtagtcct ttagcggggc actactagct ggacttttta tgtagctagg atcgctattt
    34381 ttggtgtttc tgcacatatc tgatgcattc gtagcgggga gacttgttgt cccagaccta
    34441 ggcgagaaag gggtggaaca tgactaagtt tgacgaccgg ttaactgggg tcctgagagg
    34501 gaaggcacag agacggcttg gcaggtggta accgttggca tacgatagtg attaggatca
    34561 ctatcacaat gtaagggtcg aagtagccaa tggtacccta cacaagactg gtgtatctgc
    34621 agttctgtag agtaatactt caattgttta ttgccctccg agggaagact gctatctggg
    34681 ccgtagatac ggcgtgatat atatgtaact tccctagcca ataaggcccc cgctcggtgc
    34741 tgctttgtgt gctcggtgtt agtcctcgcc gattccaccg agcagcttcc tgctggctgt
    34801 acctatccct ggctgagcag cctcaggccg cgggcctggt accgagcact aagcataaga
    34861 tcgtaacgcc agcgcttccg attggtcgct ggctaaaatt agatccctct tggtctgcgc
    34921 tttaagccat agcttgtaca ttggtaagtt acttgaggat ccgtgaagag cccaagagcg
    34981 aacctccact ttagttacac cacggggtgg cgcctttgcg cttgcacctc tttggacttc
    35041 gtacgtagtc cttcgacatt tgcccattgc cgaaagtcga tctcacatga ttattataaa
    35101 acgacaacta tcataataag gaagtaatgt cctatagtaa aataggtttt cattcactcc
    35161 ctaaaatata ataactctaa acatgtaata gaaagttaaa aaatatttct ttaatgtcta
    35221 ttctaagctt tagtatccga gcttagctct cggtatccga actttacact atcggtatct
    35281 aaaacctaaa ttacgcgaac ggaaataaat atacttatat atgggggctg atattactaa
    35341 tatttctaat ccctctttct ctttgggggc tataaaggaa taccaatggg ggaaatttaa
    35401 gtgggtcggg attgtcaaca tctatgttaa taccgaaata ttcggtgtgt ttttttttct
    35461 gttacacatg caggaacggg gtggggctcc ctccgcgtac tactattatc tcggtccact
    35521 tacatgtctt cccgtgtagt tatatataaa gctcttcttt attttcattt tttcaccttt
    35581 ctaattcatg agaagtttat taggcatgca attccctttg tgaataaacg aataggacac
    35641 acgaagattg ttcccattgt cgttctctca cttcattact gccatcatga ctaggattcc
    35701 gccattttcg atcggagtga tcgcaacgat catgttttgt tttgtgtacg agtccaactg
    35761 cgcaaatgta accaatacat gcgccgtaat cggtcgagat atttcatctg ccagcgccat
    35821 catatacccg agtgagcatc taaaccttat ccaactcctt cttagatttg gtggcaattt
    35881 cgctaacgta ctaatcaata caggcgatac tattgccttc acgaccgaca ccagtcactt
    35941 tacggaatcg tcgaaccaga tacccacctg tgtgctcgaa gtcggatcgg ctcaagatgt
    36001 tgcagtagcg ctaaagatca ttggtgccac taagaccccg tttgctatca tgtccggtgg
    36061 ccattcgtcc aaccagaaat tctccagcac gacgggcatc cacatctccc ttattcgcct
    36121 aagacaagtc gtcttctcgg cagataagtc tactgtcgag attggcatgg gcattgtacg
    36181 tcgaatcgtc acccataagc tagttaacgt tgagcgctga ttcgcttttc attcttcaag
    36241 acatgggctg aggtttacca aatccttgac ggcaccggtt ataacgtggt agggggtagg
    36301 actttcgggc ccggcgtggg tggattcaca cttggtggtg gctattcatg gtaatttttc
    36361 actttaatat atccctttac taacctgtta actttttaag cttattataa attctaactt
    36421 cgccgcctag gaaaactaac caatatggta cgctatgcct agactataag aactcggtca
    36481 aagcaccaga tagttatatt atctctaaca ttgcttacat tacaggctta acctgcgaca
    36541 ccgttagaag ttataacctt gtgcttccgg ttcgtatttc tactctaaat tttgcccgcg
    36601 tgtagtttac actttaaaac ctatttttac gtactaacta aagcccgcta gaatggaact
    36661 attacgaccg cctctaagag gataaacccc gatttatttt ttgcgcttaa aggtggttta
    36721 aaccgctttg gcatagtcac ctcggccgta ttcgagactc atgcacaggt ccctctaatt
    36781 tatgtaagct tctttctttt caaccccttc ccgtagatgc tacttccttc gactagactt
    36841 aaagatatta acaaaatgaa taggggggtc aagtatttta cagtacagac gatattccag
    36901 cagttattaa cgccaccctt gagttctaca aacttgccga tattaaaacg caaatcatgt
    36961 acataatcgc aactacgcct acccaggaat cagttatcct cttagcgttc cacgacggtc
    37021 ctaatcgacc atcgagcctt tccgtattcg ataacatcac acctctatcc agcacgctta
    37081 gcaccttgtc gttctccgat ttcgttcata gcatccaaga taagccccgt attagaggta
    37141 cagctgatac tatatcgaca acggggataa caacgggctt tataaaagct gttagcgacc
    37201 aaattgcggt acgtgagatg ttcacgcatg aaaatggcgt acaacattaa atgacgcaaa
    37261 ctaatgcggt tattttaata tatacatatt ataggcccta cgtgaagcag ccgtctctca
    37321 tggcgctgcg tccattgcgt tcgatatcga accgtttact gactacggca aacacgctac
    37381 tgatagcgcc tacccacaca cgcgctctca actaccggta agtcctctga cttagcacca
    37441 atgatacatc gtctacttag tgactaacat acgcggactc ctagctcggt ctagacttct
    37501 cctgggtctc ggctgatgac gacgagttct ggcacgacac agctaagaac gcaattgcta
    37561 agcttaaagt agtggccgct caggaaggca tctataatcc taaggaggcc gcttacccta
    37621 attattccgc agccagcaag acggccttgc agctatatgg ggaagagaat acggagcgtc
    37681 ttaaaagaat tcgtgcccag atagacccct ataacgtaat gaagctcgca ggtggatttg
    37741 acctttaaag tatattatag ttttaatttt actttattgt gggcatccct acttataaac
    37801 tataaagtat gagaaattaa agataaaaac ttaggattag aatatataca gttcaacgaa
    37861 aataaatttc ttaatactac ttataggtta ggacctttca ccgccttcca gtgtacccaa
    37921 cacgtcgcta taccacttcg ctgcgctggc agcactgcat gcactggctg ccgtaggctg
    37981 tgagctttag aaaccgagct aggtttggaa attaagctgg ttgcagaaac caagctagga
    38041 ttattaaatt tggctctgcg tatctagctc gcagccatag atatataaat acgcgagaag
    38101 gggacttctt taaatcctct aatattctat attgccccag tcaccaggct catttagcag
    38161 agcagtccag aaggtctcgt ccaactccct aaccgagagc aaggggttat tcacttccat
    38221 ggattgtgca gcgagtgacc aagccgtgct ttgggacagt atggcggtcg tttgcttggc
    38281 ctctgctgaa cgtgttgctg tagacaattt tgccatatac catgttcgaa tccacatgat
    38341 cttgacgtga taggcagcca agacagatgc atcgacgcca ttgtcaaatc tcctccgtcg
    38401 ccccagggat tacactaacc gatcggcctg gtcaaaacag tcggcaagag tctggcacat
    38461 ggccgcaaag ccgaaattaa gccgcgccag tgtcaggcgc ggaggtcgga ttttccctgg
    38521 gccgtataat tgagaggccg catctaggat ctgcgcgcgg ggtatctaca gtcgggattg
    38581 cttacccggc aaaagcgggg ataacctgcc ggcatcgtgg cgaccacgcc gctcccacgc
    38641 ggggttcgtg tacataaaag gaaggctctc aggccttaag attgagaagg ccagagttca
    38701 atgaaagtca tccccaaccc ctactattgt actcaagagc cctgtcttcg cagcgtgtga
    38761 gccgtaattg taccccagca ctccagcata tcaccccttg gaccaacggt cctgacagcc
    38821 aggcttacgt cccagtccag atcgtcaact agtagaattc gacttgaagt
//
