BGC0002229 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002229 (Aspergillus aculeatus ATCC 16872)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	45,454	High	6-MSA/aculin A	PKS

BGC0002229 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 45,454 nt. (total: 45,454 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 45,455
Label		BGC0002229

Tailoring functions

Oxidoreductases: oxygenase

ASPACDRAFT_32595: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ASPACDRAFT_45673: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: synthase

ASPACDRAFT_1904397: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002229.2	1.00	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001275.3	0.80	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.80	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.80	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.71	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002229.2	1.00	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001275.3	0.80	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.80	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.80	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.71	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 45250:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPACDRAFT_1904397: pk

PKS_AT (529..822): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 70.8%; CE-Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 106.3
Methoxymalonyl-CoA: 96.3
Ethylmalonyl-CoA: 85.6
Malonyl-CoA: 67.6
Isobutyryl-CoA: 63.1
2-Methylbutyryl-CoA: 44.0
Propionyl-CoA: 43.7
Benzoyl-CoA: 37.2
fatty_acid: 34.5
trans-1,2-CPDA: 34.4
3-Methylbutyryl-CoA: 34.3
Acetyl-CoA: 31.0
CHC-CoA: 15.4
inactive: 0.0

Link to PARAS substrate predictor