BGC0002235: 12,13-dihydroxymagnaporthepyrone biosynthetic gene cluster from Pyricularia oryzae 70-15
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Location: 7,566,458 - 7,674,280 nt. (total: 107,823 nt).
This entry is originally from NCBI GenBank CM001232.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0002235
Short description | 12,13-dihydroxymagnaporthepyrone biosynthetic gene cluster from Pyricularia oryzae 70-15
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Unknown)
- NRPS (Type I)

Loci
CM001232.1
7585850 - 7659361
via Heterologous expression
Compounds

- 12,13-dihydroxymagnaporthepyrone
- 10,11-dihydroxymagnaporthepyrone
- Unknown amide 8

Species Pyricularia oryzae 70-15 [taxonomy]
References

- [1] Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae. Song, Z et al., Chemical Science (2015) DOI:10.1039/c4sc03707c
- [2] A Putative Polyketide Synthase/Peptide Synthetase fromMagnaporthe griseaSignals Pathogen Attack to Resistant Rice[W]. Böhnert, H et al., The Plant Cell (2004) DOI:10.1105/tpc.104.022715
- [3] Magnaporthe griseaavirulence geneACE1belongs to an infection‐specific gene cluster involved in secondary metabolism. Collemare, J et al., New Phytologist (2008) DOI:10.1111/j.1469-8137.2008.02459.x
- [4] A putative polyketide synthase/peptide synthetase from Magnaporthe grisea signals pathogen attack to resistant rice. Böhnert HU et al., Plant Cell (2004) PMID:15319478
- [5] Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi. Khaldi N et al., Genome Biol (2008) PMID:18218086
- [6] Magnaporthe grisea avirulence gene ACE1 belongs to an infection-specific gene cluster involved in secondary metabolism. Collemare J et al., New Phytol (2008) PMID:18433432
- [7] Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering. Nielsen ML et al., PLoS One (2016) PMID:27551732
- [8] Heterologous expression of the avirulence gene . Song Z et al., Chem Sci (2015) PMID:29142718

Chemical products information
12,13-dihydroxymagnaporthepyrone Evidence: NMR [1]
Copy SMILES
C16H20O5
10,11-dihydroxymagnaporthepyrone Evidence: NMR [1]
Copy SMILES
C16H20O5
Unknown amide 8 Evidence: NMR [1]
Copy SMILES
C30H43N1O4
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
MGG_12447 EHA55860.1 | 7586458 - 7598810 (-) | polyketide synthase/peptide synthetase |  |  | copy AA seq copy Nt seq
MGG_08391 EHA55861.1 | 7600595 - 7601743 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_08390 EHA55862.1 | 7603974 - 7605248 (-) | dipeptidyl aminopeptidase/acylaminoacyl peptidase |  |  | copy AA seq copy Nt seq
MGG_08389 EHA55863.1 | 7606089 - 7607239 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_15096 EHA55864.1 | 7607293 - 7607948 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_08387 EHA55865.1 | 7608307 - 7610221 (+) | cytochrome P450 oxidoreductase GliF |  |  | copy AA seq copy Nt seq
MGG_08386 EHA55866.1 | 7610820 - 7612124 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_15927 EHA55867.1 | 7615104 - 7616858 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_15928 EHA55868.1 | 7617293 - 7619366 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_08384 EHA55869.1 | 7621151 - 7622983 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_08381 EHA55870.1 | 7627558 - 7628721 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_08380 EHA55871.1 | 7629292 - 7630440 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_08379 EHA55872.1 | 7632939 - 7634904 (+) | cytochrome P450 |  |  | copy AA seq copy Nt seq
MGG_08378 EHA55873.1 | 7637917 - 7639654 (+) | cytochrome P450 oxidoreductase GliF |  |  | copy AA seq copy Nt seq
MGG_15929 EHA55874.1 | 7640243 - 7640604 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
MGG_15097 EHA55875.1 | 7641419 - 7654280 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
MGG_08377 EHA55876.1 | 7657050 - 7658947 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2024-05-21
MIBiG v4 annotathon

- (ID: 7DA2QLBWQP4AXXNZI5PHTAAU)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Entry added

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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