BGC0002238 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002238 (Aspergillus oryzae RIB40)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	11,066	2,4'-dihydroxy-3'-methoxypropiophenone	PKS	100%

BGC0002238 - Region 1 - T1PKS

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Location: 1 - 11,066 nt. (total: 11,066 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 11,067
Label		BGC0002238

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002238	1.00	Polyketide	2,4'-dihydroxy-3'-methoxypropiophenone	Aspergillus oryzae RIB40
BGC0001998	0.20	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001400	0.19	Polyketide	citreoviridin	Aspergillus terreus NIH2624
BGC0002171	0.19	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275	0.19	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0001273	0.18	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276	0.18	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275	0.18	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.18	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000107	0.17	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002238	1.00	Polyketide	2,4'-dihydroxy-3'-methoxypropiophenone	Aspergillus oryzae RIB40
BGC0001998	0.52	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001400	0.51	Polyketide	citreoviridin	Aspergillus terreus NIH2624
BGC0002171	0.50	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275	0.50	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0001273	0.50	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276	0.50	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275	0.50	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.49	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000107	0.49	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 11066:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AO090102000165

AMP-binding (13..454): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YGVYCGATVK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

AO090102000166

PKS_AT (557..870): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 58.3%; Benzoyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 71.2
Methoxymalonyl-CoA: 56.8
Malonyl-CoA: 51.9
Isobutyryl-CoA: 51.0
Ethylmalonyl-CoA: 46.7
Benzoyl-CoA: 39.9
2-Methylbutyryl-CoA: 29.7
Acetyl-CoA: 24.2
trans-1,2-CPDA: 22.1
Propionyl-CoA: 21.7
fatty_acid: 21.6
inactive: 19.9
CHC-CoA: 14.1
3-Methylbutyryl-CoA: 11.3