BGC0002239 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002239 (Acremonium sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,T1PKS	1	32,747	High	GKK1032 A2/pyrrocidine A/pyrrocidine B	PKS+NRPS:Type I

BGC0002239 - Region 1 - NRPS,T1PKS

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Location: 1 - 32,747 nt. (total: 32,747 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,748
Label		BGC0002239

Tailoring functions

Oxidoreductases: dehydrogenase

pydC: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

pydE: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Ligases: synthase

pydA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002239.2	2.00	NRPS, PKS	GKK1032 A2, pyrrocidine A, pyrrocidine B	Acremonium sp.
BGC0002192.3	0.95	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.91	PKS	ACT-Toxin II	Alternaria alternata
BGC0002505.3	0.87	NRPS, PKS	xenoacremone A	Xenoacremonium sp. BF-2018a
BGC0002538.3	0.85	PKS	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0001268.4	0.82	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002139.3	0.43	PKS	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0001305.4	0.41	PKS	fujikurin A, fujikurin B, fujikurin C, fujikurin D	Fusarium fujikuroi IMI 58289
BGC0002230.2	0.41	NRPS, PKS	tolypyridone C	Tolypocladium sp. 49Y

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002239.2	1.00	NRPS, PKS	GKK1032 A2, pyrrocidine A, pyrrocidine B	Acremonium sp.
BGC0002192.3	0.77	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.76	PKS	ACT-Toxin II	Alternaria alternata
BGC0002505.3	0.74	NRPS, PKS	xenoacremone A	Xenoacremonium sp. BF-2018a
BGC0002538.3	0.74	PKS	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0001268.4	0.72	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002139.3	0.54	PKS	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0001305.4	0.53	PKS	fujikurin A, fujikurin B, fujikurin C, fujikurin D	Fusarium fujikuroi IMI 58289
BGC0002230.2	0.53	NRPS, PKS	tolypyridone C	Tolypocladium sp. 49Y

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 32747:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk - Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pydA: pk - Tyr

Search NORINE for peptide: strict or relaxed

PKS_AT (564..880): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 78.9
Methoxymalonyl-CoA: 68.2
Ethylmalonyl-CoA: 39.2
Malonyl-CoA: 37.5
Isobutyryl-CoA: 27.8
fatty_acid: 18.2
Propionyl-CoA: 18.2
Benzoyl-CoA: 17.2
CHC-CoA: 15.7
trans-1,2-CPDA: 10.6
2-Methylbutyryl-CoA: 8.9
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

AMP-binding (3055..3467): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMNSTGALSK
Nearest Stachelhaus code(s):: Tyr DMNSTGALSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor