BGC0002250 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002250 (Pyrenophora tritici-repentis Pt-1C-BFP)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	42,501	triticone D/triticone E/triticone A/triticone B/triticone F/triticone C	PKS+NRPS:Type I	100%

BGC0002250 - Region 1 - NRPS,T1PKS

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Location: 1 - 42,501 nt. (total: 42,501 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,502
Label		BGC0002250

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002250	1.94	Polyketide, NRP	triticone D, triticone E, triticone A, triticone B, triticone F, triticone C	Pyrenophora tritici-repentis Pt-1C-BFP
BGC0001563	1.10	NRP, Polyketide	curvupallide-B	Cochliobolus pallescens
BGC0001068	0.73	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001924	0.68	Terpene	ascofuranone	Acremonium egyptiacum
BGC0000129	0.63	Polyketide	pyripyropene A	Aspergillus fumigatus Af293
BGC0000996	0.61	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002216	0.58	Terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0000676	0.57	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0000688	0.57	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001445	0.55	NRP, Polyketide	leporin B	Aspergillus flavus NRRL3357

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002250	1.00	Polyketide, NRP	triticone D, triticone E, triticone A, triticone B, triticone F, triticone C	Pyrenophora tritici-repentis Pt-1C-BFP
BGC0001563	0.81	NRP, Polyketide	curvupallide-B	Cochliobolus pallescens
BGC0001068	0.69	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001924	0.67	Terpene	ascofuranone	Acremonium egyptiacum
BGC0000129	0.65	Polyketide	pyripyropene A	Aspergillus fumigatus Af293
BGC0000996	0.64	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002216	0.62	Terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0000676	0.62	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0000688	0.62	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001445	0.61	NRP, Polyketide	leporin B	Aspergillus flavus NRRL3357

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37709:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PTRG_04244

PKS_AT (556..877): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 74.9
Methoxymalonyl-CoA: 62.1
Isobutyryl-CoA: 56.9
Ethylmalonyl-CoA: 54.6
Malonyl-CoA: 40.3
trans-1,2-CPDA: 26.6
fatty_acid: 26.0
Benzoyl-CoA: 24.6
Propionyl-CoA: 17.6
2-Methylbutyryl-CoA: 15.0
Acetyl-CoA: 14.9
3-Methylbutyryl-CoA: 13.5
CHC-CoA: 12.7
inactive: 0.0

AMP-binding (2918..3331): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFDKFGSIAK
Nearest Stachelhaus code(s):: Phe NHDKFGSISK (71% 8Å match); MalAc NHDKFGSISK (68% 8Å match); Ser DFDTFGGILK (65% 8Å match); Tyr DFESFGNIAK (62% 8Å match)
Stachelhaus code match:: 70% (weak)