BGC0002253 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002253 (Aspergillus sp. FM242)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	33,994	High	waikikiamide A/waikikiamide B/waikikiamide C/(+)-semivioxanthin/semivioxanthin	PKS

BGC0002253 - Region 1 - T1PKS

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Location: 1 - 33,994 nt. (total: 33,994 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,995
Label		BGC0002253

Tailoring functions

Oxidoreductases: dehydrogenase

SvioC: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

SvioM: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

SvioA: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002253.3	1.00	PKS	waikikiamide A, waikikiamide B, waikikiamide C, (+)-semivioxanthin, semivioxanthin	Aspergillus sp. FM242
BGC0000107.3	0.69	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.68	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.68	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002253.3	1.00	PKS	waikikiamide A, waikikiamide B, waikikiamide C, (+)-semivioxanthin, semivioxanthin	Aspergillus sp. FM242
BGC0000107.3	0.69	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.68	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.68	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.68	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33994:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SvioA: mal

PKS_AT (818..1116): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 58.3%; Methoxymalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 95.0
Methoxymalonyl-CoA: 58.7
Methylmalonyl-CoA: 55.9
inactive: 33.3
Propionyl-CoA: 27.5
fatty_acid: 25.4
Isobutyryl-CoA: 17.2
Ethylmalonyl-CoA: 15.1
2-Methylbutyryl-CoA: 14.6
CHC-CoA: 10.9
Benzoyl-CoA: 9.2
trans-1,2-CPDA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor