BGC0002254 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002254 (Aspergillus sp. FM242)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,indole	1	46,989	High	notoamide F/(+)-semivioxanthin/waikikiamide B/waikikiamide C/notoamide A/waikikiamide A	PKS

BGC0002254 - Region 1 - NRPS,indole

Download region GenBank file

Download region SVG

Location: 1 - 46,989 nt. (total: 46,989 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
indole: (indsynth or dmat or indole_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,990
Label		BGC0002254

Tailoring functions

Oxidoreductases: oxidase oxygenase

NotD: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

NotG: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

NotH: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

WaiD: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: ligase

NotE: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002254.3	1.71	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001249.5	0.86	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.77	NRPS	AM-toxin	Alternaria alternata
BGC0002164.2	0.70	NRPS	peramine	Epichloe festucae
BGC0000342.4	0.70	NRPS	enniatin	Fusarium equiseti
BGC0000818.5	0.70	NRPS	notoamide A	Aspergillus versicolor
BGC0001240.4	0.69	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.65	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002254.3	0.97	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001249.5	0.74	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0002164.2	0.68	NRPS	peramine	Epichloe festucae
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001240.4	0.67	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.66	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.66	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 44993:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

NotE: Pro - X

Search NORINE for peptide: strict or relaxed

AMP-binding (71..475): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVMLVGAVNK
Nearest Stachelhaus code(s):: Pro DVMLVGAVNK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1163..1577): X

nrpys: Trp, Trp, Pro

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVYFVGGICK
Nearest Stachelhaus code(s):: Trp DVYFVGGICK (97% 8Å match); Trp or Pro DVYFVGGICK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor