BGC0002254 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002254 (Aspergillus sp. FM242)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,indole	1	46,989	notoamide F/(+)-semivioxanthin/waikikiamide B/waikikiamide C/notoamide A/waikikiamide A	PKS	100%

BGC0002254 - Region 1 - NRPS,indole

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Location: 1 - 46,989 nt. (total: 46,989 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,990
Label		BGC0002254

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002254	1.77	Polyketide	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0000818	0.72	NRP	notoamide A	Aspergillus versicolor
BGC0002157	0.70	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002226	0.67	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001249	0.67	NRP	dimethylcoprogen	Alternaria alternata
BGC0000687	0.66	Terpene	phyllocladan-16α-ol	Diaporthe amygdali
BGC0000900	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0001893	0.64	Other	abscisic acid	Botrytis cinerea B05.10
BGC0001084	0.63	NRP, Terpene, Alkaloid	notoamide A	Aspergillus sp. MF297-2
BGC0002736	0.63	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002254	0.98	Polyketide	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001893	0.68	Other	abscisic acid	Botrytis cinerea B05.10
BGC0002157	0.68	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002226	0.67	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001249	0.67	NRP	dimethylcoprogen	Alternaria alternata
BGC0001528	0.67	Terpene	betaestacin	Phoma betae
BGC0000818	0.66	NRP	notoamide A	Aspergillus versicolor
BGC0000687	0.66	Terpene	phyllocladan-16α-ol	Diaporthe amygdali
BGC0000677	0.66	Terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 44993:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

NotE

Search NORINE for peptide: strict or relaxed

AMP-binding (71..475): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVMLVGAVNK
Nearest Stachelhaus code(s):: Pro DVMLVGAVNK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1163..1577): X

nrpys: Trp, Trp, Pro

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVYFVGGICK
Nearest Stachelhaus code(s):: Trp DVYFVGGICK (97% 8Å match); Trp or Pro DVYFVGGICK (97% 8Å match)
Stachelhaus code match:: 100% (strong)