LOCUS       BGC0002257             21661 bp    DNA     linear   PLN 28-JUL-2020
DEFINITION  Xylaria schweinitzii strain BCC 1337 cytochrome P450 (shwC),
            O-methyltransferase (shwM2), O-methyltransferase (shwM1),
            hypothetical protein (shwD), EthD superfamily protein (shwE),
            metallo-beta-lactamase (shwB), and polyketide synthase (shwP) genes,
            complete cds.
ACCESSION   BGC0002257
VERSION     BGC0002257
KEYWORDS    .
SOURCE      Xylaria schweinitzii
  ORGANISM  Xylaria schweinitzii
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Xylariomycetidae; Xylariales; Xylariaceae; Xylaria.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:12:52
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21661
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..21661
                     /db_xref="taxon:364010"
                     /mol_type="genomic DNA"
                     /organism="Xylaria schweinitzii"
                     /strain="BCC 1337"
     protocluster    1..21661
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[14645:20720]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      14646..20720
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..21661
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..21661
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002257"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21661
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(<1040..>2931)
                     /gene="shwC"
     mRNA            complement(join(<1040..1384,1438..1705,1764..2073,
                     2143..2532,2623..2692,2750..2842,2914..>2931))
                     /gene="shwC"
                     /product="cytochrome P450"
     CDS             complement(join(1040..1384,1438..1705,1764..2073,
                     2143..2532,2623..2692,2750..2842,2914..2931))
                     /codon_start=1
                     /gene="shwC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 144.1; E-value: 1e-43)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450"
                     /protein_id="QLM00038.1"
                     /sec_met_domain="p450 (E-value: 7.7e-40, bitscore: 125.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVLYGIILIVMGWLLYRIFLDPLSRIPGPFMSKFLPLYYIRMTW
                     NGDHVFALKALHDTYGPVVRLGPNELSFATTTAFDSIYGFAADKTFVTGGSRRSLLVPE
                     RMGEVMLAQSGNKEVRNWLRPVIISTLNELVGSCAERFLNIALATGLEQHQVGQERSIS
                     LSGLNDDWMWDLGSLLARGRHATRSTRIQFDDLINDTEYFMCLLELCACVIHRFTLQRY
                     QEHLHRLWEIVSKLFGHQILRDACIDNVMVESSGCPIAAEDSHSARIQEAIKKAGMEDM
                     AGTYQDFNSLATQFNIYGSMHSALNTTFSYLLKHPRCLRKLEEELLHAFQSYDEVTDSR
                     LAKLPYLNACITESFRIMPPFNAGILERVSMGSTVDGIYVPAGTGVQVDQFTLARSKEH
                     WDAPEEFLPERWLDSSSRKNEKAFRPFLIGSRRCPGKNMAYQIFRLAIGKMFYLYEMEL
                     VNKDYHVNRHGESRLGLSNVKLIVEMNPRVPGVLGYSAS"
     gene            complement(<4610..>5997)
                     /gene="shwM2"
     mRNA            complement(join(<4610..5155,5211..5723,5785..>5997))
                     /gene="shwM2"
                     /product="O-methyltransferase"
     CDS             complement(join(4610..5155,5211..5723,5785..5997))
                     /codon_start=1
                     /gene="shwM2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 218.5; E-value:
                     2.4e-66)"
                     /gene_kind="biosynthetic-additional"
                     /product="O-methyltransferase"
                     /protein_id="QLM00039.1"
                     /transl_table=11
                     /translation="MELSRQITDWADQVATYARLISTHLDQQDGELTGLFAPELAVPRA
                     KLSGAAFELFNAIQDKGGFLAHLTADCQVIFALRWIYHFKIPCYVPLDGTVTHDELAHA
                     TGTPKDLLIRVLRIVMTSRFFDEPQCGVVAHSPLSRQMVSDDNYAHWVRYMSTTIVPLA
                     AKQVEATEKWPNGQLLNNTAHNIAFNHCVSFMEFVSQDPCLSVEFAKTMKAVSSAGFYD
                     ASHLINSYDWLSIGDGLIVDMGGSTGHVSIAIGERFQKPQFIVQDLPDVVRIAEKEFSE
                     RRLPPTLASRIRFQAHTFFESQPVQGASVYLLRHILHDWPDREVVQILGNIIPALGPKS
                     KIVISDVVLPEPGSIPATEERLMRSTDMILHSCANSSERTIEDWKAVIAVASQRLRIQR
                     ISRASGSLLSVMELALVGENTVKQ"
     gene            <8454..>9841
                     /gene="shwM1"
     mRNA            join(<8454..8501,8566..8701,8793..8807,8879..9005,
                     9064..>9841)
                     /gene="shwM1"
                     /product="O-methyltransferase"
     CDS             join(8454..8501,8566..8701,8793..8807,8879..9005,
                     9064..9841)
                     /codon_start=1
                     /gene="shwM1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 91.5; E-value:
                     9.9e-28)"
                     /gene_kind="biosynthetic-additional"
                     /product="O-methyltransferase"
                     /protein_id="QLM00040.1"
                     /transl_table=11
                     /translation="MSFNEAREKFLKTVTIAPALGFVPIAVEFCLFDRLCEIGRPATAQ
                     DICKAHGERDGRNMNLSLQLTDDTLLMMGGIGFLDIVSNGMYQANDVTEFLATTPSSQH
                     GAVHFTSEILLASAFLMKRLVETDFVYPFQECQTPLQYAYKCMGSTYAQEHTYSIMHKT
                     GRLDSFNAFMDGKFGDEENIATRLNNIGYDMSSLITDSLDSKQPTVLVDIAGGRGKRLL
                     ELKDAFPRLGADNLVLQEYNSEIGEVPGVTQMSWNFKDEDQEQPVKGALIYFLCCVLHN
                     LSDVEVVKLFKKVRDAMSSRSRILIKEPVKNTASSTTHGAMIVLYGGRERTSAEWQNLA
                     AGAGLMVAFEVYPQVGECVVEMRIARV"
     gene            complement(<10435..>11078)
                     /gene="shwD"
     mRNA            complement(join(<10435..10868,10952..>11078))
                     /gene="shwD"
                     /product="hypothetical protein"
     CDS             complement(join(10435..10868,10952..11078))
                     /codon_start=1
                     /gene="shwD"
                     /product="hypothetical protein"
                     /protein_id="QLM00041.1"
                     /transl_table=11
                     /translation="MTIGRIEQFIDRGNVVDGVEDPDNSATGLLTVFALTAGCFLSGIM
                     MGASLFSIPAFLEAAHTASQLCTQWTSLHHYGATISSSISVATFLLYASAAIRNWSSHK
                     SNRWSCVLAGMVTATMIPFTWIVMTPTNDKLFTLEAEVKAGHLTASLEHVRALVTEWNL
                     MHMIRSCFPLAGALIGFLVHMRK"
     gene            complement(<11156..>11621)
                     /gene="shwE"
     mRNA            complement(join(<11156..11380,11436..>11621))
                     /gene="shwE"
                     /product="EthD superfamily protein"
     CDS             complement(join(11156..11380,11436..11621))
                     /codon_start=1
                     /gene="shwE"
                     /product="EthD superfamily protein"
                     /protein_id="QLM00042.1"
                     /transl_table=11
                     /translation="MSSSREYQPAVLHSEGQFLCVTICGYKKGNVSDEDFHHYMAQVCA
                     PLGRDLMMKYGIVRFTQRFLHLARQIYNTTEIRAAINQLYDPTLTKLADFDLFSQIVFK
                     KLEDFRKFKQDPIYKTRLTVHHDDFVDTKRSM"
     gene            complement(<12283..>13282)
                     /gene="shwB"
     mRNA            complement(join(<12283..13059,13124..>13282))
                     /gene="shwB"
                     /product="metallo-beta-lactamase"
     CDS             complement(join(12283..13059,13124..13282))
                     /codon_start=1
                     /gene="shwB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     136.6; E-value: 1.3e-41)"
                     /gene_kind="biosynthetic-additional"
                     /product="metallo-beta-lactamase"
                     /protein_id="QLM00043.1"
                     /transl_table=11
                     /translation="MNSVGGYQQINKSLNASAFEDYLSTQFDQLPKLSDVELLSSRVIR
                     VLGQNPGKFTLQGTNTYIIGSGSSRLIIDTGQGTPEWARLIASTLETLEIKLCYVLLTH
                     WHGDHTGGVPDLLKLYPHLSNAIYKNSPADGQREITDGQVFSVEGATVRSLYTPGHSHD
                     HMCFILEEEKAMFTGDNILGHGTAAFEDLDQIMVSWNKMQEEDCLLGYPAHGIVISDLR
                     WKIKREIALKTNRENRVLQALQRLRPGDKGRGESVSIRQLASLMYGEGVSNEVRNQAVE
                     PLTEEVLQKLAEDGKVGFEMRNGEKMWFGF"
     gene            <14646..>20720
                     /gene="shwP"
     mRNA            join(<14646..14679,14759..15053,15142..15448,15700..16958,
                     17146..19324,19410..>20720)
                     /gene="shwP"
                     /product="polyketide synthase"
     CDS             join(14646..14679,14759..15053,15142..15448,15700..16958,
                     17146..19324,19410..20720)
                     /NRPS_PKS="Domain: SAT (31-261). E-value: 1.7e-54. Score:
                     176.8. Matches aSDomain: nrpspksdomains_shwP_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (400-822). E-value:
                     4.8e-131. Score: 429.4. Matches aSDomain:
                     nrpspksdomains_shwP_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (925-1229). E-value: 5.9e-82.
                     Score: 267.2. Matches aSDomain:
                     nrpspksdomains_shwP_PKS_AT.1"
                     /NRPS_PKS="Domain: PT (1312-1631). E-value: 5.2e-107.
                     Score: 349.7. Matches aSDomain: nrpspksdomains_shwP_PT.1"
                     /NRPS_PKS="Domain: ACP (1728-1789). E-value: 2.7e-13.
                     Score: 41.9. Matches aSDomain: nrpspksdomains_shwP_ACP.1"
                     /codon_start=1
                     /gene="shwP"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 170.5; E-value: 1.1e-51)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="QLM00044.1"
                     /sec_met_domain="itr_KS (E-value: 2.2e-140, bitscore:
                     457.0, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 7.4e-83, bitscore: 267.2,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-13, bitscore:
                     40.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRISHLEGCANMRALYFGNELPHERLSSLARHLYLFSRQRAYPTL
                     NKFLASATDVLRAEIRHLPASLQALTPPFDHVLDLVDNEKLRNSPLGSSIDAVFIVVIQ
                     LSILIKYFEDDSRKYYELQSSDAALLGTSLGLLASAAMSLSRCIPDIALVGAHITRLAF
                     RLSFLTYRISQMLEPSEESKSHSSSWASVVPNVSPEDVQAELDCFHAEEKTPNASRIFI
                     SARNHSSVTISGPPSRLKNLSRTSKFFHSRKLVSLPIYGGLCHAPHIYSHQHVLEIMGE
                     LDSEISGLVPTVIPLSTSSGAQFSASCARTLFDEIITEILTREIQWDSVIKSLLRQAKT
                     MSAQKCEVLVFQNSLLVHDLVATFKTQQPNIDVSALELIPLINTGDASDVSAAAGTSAD
                     KIAIVGMACRMPGDATDTEKFWELLEEGLDVHTKIPPDRFDVETHYDPACKATNASHTA
                     YGCFVNNAGLFDAPFFNISPREALETDPMQRLALVTAYEALERSGYVPNRTLATNLHRI
                     GTFYGQASDDYREVNAGQEVGTYFIPGGCRGFGPGRINYFFGFSGPSYSIDTACSSSLA
                     TIQVACAALWNGDVDMALAGGMNILTNSDVFAGLSLGHFLSKTPNACKTWDSEADGMKR
                     LEDAVADKDNILGVILGAATNHSAEAVSITHPDANAQSFLSRKVMRSAGTDPLHVSYVE
                     MHGTGTQAGDREEMKSVTDVFAPAGKRPRKQTLHIGSVKANVGHGEAVAGATALLKVLL
                     MFRKGIIPRHVGIKNCFNPALPQDLDSRQVVIPLTNQPWVSTENGAMRIAVVNNFGASG
                     GNTTIVIQEPPRPRTTVVRDENCGVSYAVAISAKSKVSLRGNMERMIDYIDCNPQSSLA
                     DLSYTTTARRYHYHHRIAVTGSNLSQIRSELVAQLDLADSHTSISLTSKPPVAFMFTGQ
                     GASRKSMNLELLARDSRFSTEVLQLDALARAQGFPSFIPVIDGSCAEDEAHSSVATQIA
                     LVAIEIALARYWSSLGVEPDIVIGHSLGEYAALCVAGVLSASDAIYLVGQRARLLEDKA
                     SLGSYKMMAARASLADIEKLAAVAGLQYEVACINSPKQTVLAGLSADLESIREVLQEAG
                     YRCQDLDVAFAFHSSQTDPILDDFERLSSSAVIFHPPKLPVISPLLGEVVFNGKAFKSN
                     YLRRATRETVNYLAALEAAANIGMVGRDTLWVELGPHPVCLVFLKGTLGSSMTEIAVPS
                     FRRDENNWTTLTQSLAKLHCAGVQINWNEFHRPFEAGLQLLDLPTYAWNNKNYWIMYKG
                     NWVLTKGNDYYKTQEETRQPISSSDFHKTSVQRIVEESFDGAAGRVVMRSNLMDVDLLK
                     AAQGHKMNECGVVTSSIHADIAYTMGSYLCQKLRPDFKDKVGLNILNLVVLKGLVAQKF
                     TTTPQLIQVSISTNDMNAERACLTWQNVDSHGILEGAFATAEVEFGDPTEWLDSWVPYK
                     HLVLGRIGALEELVEKGAATRFSKNMAYLLFANNLVDYSENYRGMQSVVMNGLEAFADV
                     MLTSEKGTGSWTVAPYFIDSVIHLAGFVMNVSDAIDTRTKFCFTPGWKSMRFARPLEPG
                     GKYRSYVKMIQTEDVTVYLGDVYVLQDDTIIGFVGGIKFRKCPRILLSRFFSAPDTPGQ
                     LSATSPTSNSGPSKESTTLLTAMSSKISESNVVSKKLPTATSLDASTSAPDSPPAKTKE
                     SSPSAVQPVHTPATDQVRIEKETVDSRAISLIAREAGLDRSDLRETATFAELGIDSLMS
                     LVISDKFRDELNITVTGSLFLEYPTIGDLRGWLSEYYS"
     aSDomain        join(14818..15053,15142..15448,15700..15846)
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_shwP_SAT.1"
                     /evalue="1.70E-54"
                     /label="shwP_SAT.1"
                     /locus_tag="shwP"
                     /protein_end="261"
                     /protein_start="31"
                     /score="176.8"
                     /tool="antismash"
                     /translation="HLYLFSRQRAYPTLNKFLASATDVLRAEIRHLPASLQALTPPFDH
                     VLDLVDNEKLRNSPLGSSIDAVFIVVIQLSILIKYFEDDSRKYYELQSSDAALLGTSLG
                     LLASAAMSLSRCIPDIALVGAHITRLAFRLSFLTYRISQMLEPSEESKSHSSSWASVVP
                     NVSPEDVQAELDCFHAEEKTPNASRIFISARNHSSVTISGPPSRLKNLSRTSKFFHSRK
                     LVSLPIYG"
     aSDomain        join(16264..16958,17146..17716)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_shwP_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.80E-131"
                     /label="shwP_PKS_KS.1"
                     /locus_tag="shwP"
                     /protein_end="822"
                     /protein_start="400"
                     /score="429.4"
                     /tool="antismash"
                     /translation="IAIVGMACRMPGDATDTEKFWELLEEGLDVHTKIPPDRFDVETHY
                     DPACKATNASHTAYGCFVNNAGLFDAPFFNISPREALETDPMQRLALVTAYEALERSGY
                     VPNRTLATNLHRIGTFYGQASDDYREVNAGQEVGTYFIPGGCRGFGPGRINYFFGFSGP
                     SYSIDTACSSSLATIQVACAALWNGDVDMALAGGMNILTNSDVFAGLSLGHFLSKTPNA
                     CKTWDSEADGMKRLEDAVADKDNILGVILGAATNHSAEAVSITHPDANAQSFLSRKVMR
                     SAGTDPLHVSYVEMHGTGTQAGDREEMKSVTDVFAPAGKRPRKQTLHIGSVKANVGHGE
                     AVAGATALLKVLLMFRKGIIPRHVGIKNCFNPALPQDLDSRQVVIPLTNQPWVSTENGA
                     MRIAVVNNFGASGGNTTIVIQEP"
     aSModule        16264..20702
                     /complete
                     /domains="nrpspksdomains_shwP_PKS_KS.1"
                     /domains="nrpspksdomains_shwP_PKS_AT.1"
                     /domains="nrpspksdomains_shwP_PT.1"
                     /domains="nrpspksdomains_shwP_ACP.1"
                     /iterative
                     /locus_tags="shwP"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       16747..16791
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_shwP_0001"
                     /evalue="7.30E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="shwP"
                     /protein_end="576"
                     /protein_start="561"
                     /score="18.1"
                     /tool="antismash"
                     /translation="GPSYSIDTACSSSLA"
     CDS_motif       16786..16824
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_shwP_0002"
                     /evalue="2.10E+00"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="shwP"
                     /protein_end="587"
                     /protein_start="574"
                     /score="2.3"
                     /tool="antismash"
                     /translation="LATIQVACAALWN"
     CDS_motif       17324..17371
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_shwP_0003"
                     /evalue="1.20E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="shwP"
                     /protein_end="707"
                     /protein_start="691"
                     /score="11.4"
                     /tool="antismash"
                     /translation="YVEMHGTGTQAGDREE"
     CDS_motif       17438..17482
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_shwP_0004"
                     /evalue="1.10E-02"
                     /label="PKSI-KS_m6"
                     /locus_tag="shwP"
                     /protein_end="744"
                     /protein_start="729"
                     /score="8.8"
                     /tool="antismash"
                     /translation="GSVKANVGHGEAVAG"
     aSDomain        18026..18937
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_shwP_PKS_AT.1"
                     /evalue="5.90E-82"
                     /label="shwP_PKS_AT.1"
                     /locus_tag="shwP"
                     /protein_end="1229"
                     /protein_start="925"
                     /score="267.2"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="MFTGQGASRKSMNLELLARDSRFSTEVLQLDALARAQGFPSFIPV
                     IDGSCAEDEAHSSVATQIALVAIEIALARYWSSLGVEPDIVIGHSLGEYAALCVAGVLS
                     ASDAIYLVGQRARLLEDKASLGSYKMMAARASLADIEKLAAVAGLQYEVACINSPKQTV
                     LAGLSADLESIREVLQEAGYRCQDLDVAFAFHSSQTDPILDDFERLSSSAVIFHPPKLP
                     VISPLLGEVVFNGKAFKSNYLRRATRETVNYLAALEAAANIGMVGRDTLWVELGPHPVC
                     LVFLKGTLGSSMTEIAVPSFRRD"
     CDS_motif       18209..18259
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_shwP_0005"
                     /evalue="4.40E-02"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="shwP"
                     /protein_end="1003"
                     /protein_start="986"
                     /score="7.4"
                     /tool="antismash"
                     /translation="QIALVAIEIALARYWSS"
     CDS_motif       18263..18382
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_shwP_0006"
                     /evalue="1.50E-19"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="shwP"
                     /protein_end="1044"
                     /protein_start="1004"
                     /score="62.2"
                     /tool="antismash"
                     /translation="GVEPDIVIGHSLGEYAALCVAGVLSASDAIYLVGQRARLL"
     aSDomain        join(19187..19324,19410..20228)
                     /aSDomain="PT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_shwP_PT.1"
                     /evalue="5.20E-107"
                     /label="shwP_PT.1"
                     /locus_tag="shwP"
                     /protein_end="1631"
                     /protein_start="1312"
                     /score="349.7"
                     /tool="antismash"
                     /translation="TSVQRIVEESFDGAAGRVVMRSNLMDVDLLKAAQGHKMNECGVVT
                     SSIHADIAYTMGSYLCQKLRPDFKDKVGLNILNLVVLKGLVAQKFTTTPQLIQVSISTN
                     DMNAERACLTWQNVDSHGILEGAFATAEVEFGDPTEWLDSWVPYKHLVLGRIGALEELV
                     EKGAATRFSKNMAYLLFANNLVDYSENYRGMQSVVMNGLEAFADVMLTSEKGTGSWTVA
                     PYFIDSVIHLAGFVMNVSDAIDTRTKFCFTPGWKSMRFARPLEPGGKYRSYVKMIQTED
                     VTVYLGDVYVLQDDTIIGFVGGIKFRKCPRILLSRFFS"
     aSDomain        20520..20702
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_shwP_ACP.1"
                     /evalue="2.70E-13"
                     /label="shwP_ACP.1"
                     /locus_tag="shwP"
                     /protein_end="1789"
                     /protein_start="1728"
                     /score="41.9"
                     /tool="antismash"
                     /translation="IAREAGLDRSDLRETATFAELGIDSLMSLVISDKFRDELNITVTG
                     SLFLEYPTIGDLRGWL"
ORIGIN
        1 tcttgtggac ggccgtatcc tgctgccaag aagagcagct cctgagggct gctaatgcca
       61 tgtcctcccc gacaacatgg aagctgaagc acctcgaagc gtatcttata ggtaaacctg
      121 aggcgccatt gcttgttcag gtagaccgtc atgatgacca cgatgaaccg cgtttgttag
      181 tatctgtgag cagaattcga ccagatattc tgtggaggct ctacaggagc gccagctcta
      241 acaaaccaag aagactcaga gagagagggg ctttcaacca gatcgcggag aatgtaatgg
      301 ttctcactag caatagtggg cgatctactt aacttatctt ccaattgcct acctatttac
      361 ttatattgta atactgaatg tcctcccaag tccttcacca caatcgcact gaggaattat
      421 atcataaaaa gaaggctata taagactcac cctccccttt tctcccaaaa atttagaagg
      481 gactaataat attgaatctt tacccctata cctacccagt gactcactgg tgacccaact
      541 tcagtccaga gacaaaaccc catcatggca gcaggttacg ggagagcagc tccattttgg
      601 gttaacatta gttttatacc gactagcatc gatcatttac ctacccccgt cgcaagaatt
      661 agcgaagaac tcacacttaa tgggatagac gctctaaatt atagtcaaat actatttcag
      721 aatactagct caaaaaggta gattatcaaa gttggtaagg aaacggtgcc ccgtatcagg
      781 cggtccccta gctaaactct tcctctcatt tctatgtaaa tgatagttaa actgccgagt
      841 gtaaggaatt atagtggatt tataacactc cttgtgattg taaactcaga aatccagaaa
      901 gtaggtatta aactctggtc acaaactatt gttcataatg caaagagaga gaaaaggaaa
      961 agctggataa aaggaaggga ggaaaggaaa tttagcggct tgtataaggc agaggcacta
     1021 cacatctacc catatcaagt caagatgccg aatacccgag gacgccaggc actcgagggt
     1081 tcatctcgac gatcagcttt acgttcgaca atcccaatcg tgattccccg tggcggttga
     1141 cgtgataatc cttgtttacc aattccattt cgtacaggta aaacatctta ccaatcgcca
     1201 gccgaaagat ttgataagcc atgtttttac ctggacatcg tcgagatccg atcagaaatg
     1261 gccgaaatgc cttctcgttc tttctactac tagagtcaag ccacctctcg ggaaggaact
     1321 cttcgggtgc atcccagtgc tctttcgagc gtgccaaggt gaactggtcc acttggacgc
     1381 cggtctgtag gtaaaatgtt aactaggatt gcccattaat atcaaaaccg gacttacccc
     1441 ggcggggacg tatattccat ccacagtcga gcccatagat accctctcta gaataccagc
     1501 attgaatggc ggcatgattc gaaagctttc ggtaatacac gcattgaggt aggggagctt
     1561 ggcaaggcgc gaatctgtga cttcatcata tgattggaat gcgtgtagca attcctcctc
     1621 cagcttcctt agacatcgag ggtgtttcaa caaataggag aaagtagtat tgagtgcaga
     1681 gtgcatgctc ccataaatgt tgaatctaat tagggttggt cagtcggata tttaagactc
     1741 ttgatataga aaaagtcgct tactgtgtgg cgagactgtt aaaatcttgg tatgtgccag
     1801 ccatatcttc cattcctgct tttttaatag cttcctgtat ccgagcggag tgagagtcct
     1861 ccgccgcaat agggcagcca ctggactcaa ccataacatt atctatacag gcatccctca
     1921 gaatctgatg tccgaaaagc tttgagacta tttcccacag ccgatgtaag tgttcttggt
     1981 aacgctgaag tgtaaagcga tggatgacgc aggcgcatag ctccaataga cacataaagt
     2041 attcggtgtc gttgataagg tcatcgaatt gtacttgaga cggttaataa ctgtgctcct
     2101 ctgtccacgt tcttttgacg gaaaggaaag acgggcactt acttcgggta gaacgtgtcg
     2161 catgtctgcc acgcgcaagc aaagacccaa gatcccacat ccaatcatca ttcaaaccag
     2221 agaggctgat ggaccgttcc tggccaactt gatgctgttc caggccggtt gcaagcgcta
     2281 tattcaagaa ccgctccgcg cacgatccga caagctcatt cagagttgaa atgataactg
     2341 gtctcagcca attacggacc tccttgttac cggattgggc gagcatcacc tctcccattc
     2401 tttcgggaac caggagactt cttcggcttc ccccagtcac gaaagtcttg tcggccgcga
     2461 atccgtatat ggagtcaaaa gctgtggtag tggcaaacga caactcgttt ggtcctaagc
     2521 gaaccacagg gcctattcta gttagtgttg aatcagatga tctttttttt ttcattcttc
     2581 cccctttctt tctccccacc ccgttgatat agcgaaacgt accataagtg tcgtgtagtg
     2641 ctttcaaagc gaatacgtga tcgccattcc aggtcattcg aatgtagtag agctgtataa
     2701 ttcagacgaa ttctgagatc taggatgctg atttcatgcg aaaactcacc ggcaggaact
     2761 tggacatgaa cggaccgggt attcttgata gggggtctaa gaagatccgg tatagtagcc
     2821 atcccattac tatgaggatg atcttaaact tatcaacaca atgtcgaaga agagagagaa
     2881 gagagactga atctgggatg aggtcaaaca tacaccgtaa agaaccagca ttgtggcgtg
     2941 atatctcgcc ttgaacaagg agcgagattt aactttgtat gacttcagag aatgctgcag
     3001 tagtcaacaa actctggtaa caatgggtaa tatctagaaa gttatttgag tgcttgcaga
     3061 ataggactgg gaaagagacg agattatata tccgagacat cccagggctc aagctacaac
     3121 gcaggcccaa aataaccttg aatcttctgc tgaaagcgct atgcggtata ctaacatttg
     3181 ctttcggggc aaatatccaa ttatgctatc ggggcccccg atcgttatct tgagaaactc
     3241 tctcggtgtt gaacaacgag cggcaagaaa ctaacagttg tacaaagtgt caccatgagt
     3301 agataattgg ctcaaacaag cgaataatcg tacaattact cagttcaggt tacattgctc
     3361 aagttatgtg acatcgataa tacagccgag acctctcgta aaaccgcgct gccgtgttgg
     3421 tgttcttcaa aagaaagaga caagatgagt ttagcggggt ggctccatgt atcgtagcta
     3481 gccgagattc cgtcctagta ggtagacgct catacaaatt gatgatccct tgagatgatg
     3541 aaaccacccc gctgtgtcct ggctctccgt ggaagtagag aggtgcatat actatccaag
     3601 tgcctagata ataagctctc tggagtctaa tactacataa ggcaagcgca gctaacacta
     3661 acttaagagc tcgtctcctc agggaccagg tgacgaaggt tggagccgtt gacgagggat
     3721 catggattat ttgccgccgt catccgcaga gaatccatgc tctccgtaat caaaagtctt
     3781 atgtatcaat tatagaagaa aaaaagagcg agaagatcct ttatgaatcc cgttacttaa
     3841 ttattggcaa cccgatttta ggcgtatatt atgatagaac cattttgact aagtctcttt
     3901 gggccattaa caacatttaa tggttatgca ataacatttt ccctccagta cctattagtt
     3961 acacgaaccc aagcgttagg gacactcact gggtacccgc accaaggggc tgtctgagaa
     4021 tcgaggaaat gttgtaatta cgcatgtatt aaaggggaat atcacatcaa tataagggga
     4081 actgcttgat caaagagagc ggaattcatt cataccaaaa aaaacaaaga aaagttaacg
     4141 tgatgatgat aggtaccgta ctaacaacag tagcccttgc cccctatttt atcctcccca
     4201 aatattcgca tagccataat aagccgcgta cacacataaa gcatatatta tactacctac
     4261 cccctagaaa gaaagggggt cgcccgctct gccgcactac ccgacgggtt gcacccgatc
     4321 ccaacgggcc accgtaccca caatcatatg cgtacggcaa actgcctgag tcaatccgat
     4381 ctaagatagc ctacaaaaca gggcaatagt ctgcgacaaa gttgtccaag gctattcgag
     4441 catcaagtct aacagctcgt ctgcttagtt aaaatagtta gagagattta tagagcccct
     4501 tggctatatg aatgattatt atacaaattg aatatcattc caagcctttg atcctaagtc
     4561 cttgttaacc catcaggcag ccatgtaagg ttaccaagat ctacgtttac tactgcttca
     4621 cagtgttctc tcccaccagg gcgagctcca taacggacag caaacttccg gaggctctgg
     4681 atattcgttg gatccgtaat ctctggctgg cgacggcaat gaccgccttc caatcttcaa
     4741 tagttctctc ggaggagttg gcacatgaat gaagtatcat gtcggtcgac ctcatcaatc
     4801 gctcctcggt ggcaggaatt gagccgggtt ctgggagaac cacatctgaa atgacgattt
     4861 tgcttttcgg gcctaatgcg gggatgatgt tccctaggat ttggacgact tcacggtccg
     4921 gccagtcgtg gagtatatgg cggagcaggt agacagacgc gccctgcaca ggttgagatt
     4981 cgaagaaggt gtgcgcttgg aaccggatcc gcgaggccag cgtcgggggt agtcgccgct
     5041 ctgaaaattc tttctcggcg atgcgaacta catccggaag atcctgcact atgaattgag
     5101 gcttctggaa tctctcccca atcgcgatgg agacatgtcc ggttgatccg cccatctggc
     5161 actattagca cgcatcgcta agggcagggg tgcattgcag gtaaacctac atcaacaatg
     5221 aggccgtcac caatcgataa ccagtcgtaa ctatttatga gatgcgaggc gtcataaaag
     5281 cccgcgctcg acaccgcttt cattgtcttc gcaaactcga cgctcaaaca tgggtcctgg
     5341 gaaacaaact ccatgaatga cacacaatga ttaaatgcaa tgttatgtgc tgtgttgttg
     5401 agtagctgcc catttggcca cttctcggta gcttcaacct gcttagccgc aaggggcaca
     5461 attgtggtgg acatgtagcg aacccagtgc gcatagttgt cgtctgaaac catctgtcgt
     5521 gacaacggac tgtgggcgac cactccgcat tgaggttcgt cgaagaatcg actggtcata
     5581 acaattcgga ggactcttat gaggagatct tttggagttc cagtagcatg agccagctcg
     5641 tcgtgggtga ctgtgccgtc aagtggaaca taacaaggga tcttgaagtg ataaatccat
     5701 ctcaatgcaa atatgacctg gcactgcgct cttggtcagc tcacttgtga agtgctggtg
     5761 atataaatgg acggaagaac aaacatcagc agtcaggtga gccaagaagc cccctttgtc
     5821 ctgaatagca ttgaacagtt caaaggcagc ccctgagagt ttcgctcgag gcacggccaa
     5881 ctcgggggca aataggcctg taagttcgcc atcttgttga tccaggtgag tggaaataag
     5941 tcgggcgtaa gtcgcaactt gatcagccca gtccgtaatt tgacgtgaca attccatttt
     6001 ctcaggtaca cttgtgcaga tgaaggcagt tgataggctg ctgtaataga agtaggcaga
     6061 gtatgcgagg tttgggtgcg gaatggattt aagagcgata cacatatatt gatcctaatt
     6121 tatcatttat aatgtaatga tgacaaactc aatgtagatt agcaacctga gactcctagg
     6181 aagtatctgt cgagtggtac ggtcctcgaa gtgccaagta gtctataagg tggtttggaa
     6241 atggacggga gttacttagt tagcgtctca caatcaatat attgattaat gagcctccca
     6301 agatcggatg gggcccgtct cttcttatca gaatcgagtt cttaatacca ccctaggtct
     6361 aggtaagtaa gagcccacgc ttcgacatat ccgatagctt ccgttgatag cagagaaaat
     6421 tctattcatg agcagctatg agagatgttg tccagaatac actgagggag atggtttaga
     6481 acaagaccca cgatgatgtt tcttttacta tacctataac cacatcagtg gtctctatac
     6541 ttcttatgcc ctatcaacgt cattataacg acatattcta gaataatggt tcttactctg
     6601 gttcattaat ttcttaaata atttcagttt tcaatggact tatagttata taaccaacaa
     6661 gcttttaacg gttccatata atgaactatt atactctgca agatttttat tctttatcta
     6721 ggtcttttgt atgcttagtt cgctataacg ttattttatc ccgtctatta ttatatatag
     6781 aatttaatat attccgcata aaattaaaaa tatataacta tgtgctccag agtgcggcag
     6841 ccctacaata cgggttttcc cggcacccat agattataga tgctagggcc cgggctgttg
     6901 ctccacaaac gggatcagaa taaccaaggt ggcagacttg ccccccttgt ggtccacagc
     6961 cagtagatag cttcttaggg tattgtcttc tttccctaag gccccgttcc cctgcacctg
     7021 tgatactatg ttactgctgc ttctaccttg cgcggtccct aggcgatttg ctaacatctg
     7081 gttctgtacg tcaacttagc ctacccattg cgttcccgat atcgcttccc ttgttgtaaa
     7141 acatggagac aaactacccg cacctagtat acacagcaat cgggttgcgc tgtgctctgg
     7201 taacaatgcc gtggttgttt attcggaaaa cactaaaagt gataataccc gagcgcgccg
     7261 caggagggtg cttagccagt gcttcttttc cgtttggccg agatgatgaa agacacgtat
     7321 ctcttggctt gtctaagtat aacagtaata ggaaaaaata acgaagtagt cgatctcatt
     7381 tttcgttcga ccaagattat aaaacacacg tatctcttgg ctcatacaag tataacatta
     7441 tcccgagaag atgacgatgt aacttatctt atttttattt gaccgagatt gtgaaagaca
     7501 cgtatctccc ggtctgtaca agtgaaacac tagctagata agatgacgac gcaactggtt
     7561 tcatttttta tttaaccgag attgcgaaag actgtaacaa gtactttgaa tcgagtcgtt
     7621 ggaacgatat tcgatttgtg taataattat ctatgcaact aaggggctat atagatctct
     7681 ttagcagcct taactaaata gacaagctcc tagtcttgat gcttaaatag tctcgcttaa
     7741 agttgctgac tttcgtagac tattatcgtc ctttgtacac tgttttagat cggattaatt
     7801 taggtagttt gccgtacgta tacaattatt tacataatat cgggtgcgcc tacccgtcgg
     7861 gtacgggcgt ccctatacct taggtccgtg tgaaaaaggc ccgtatctcc tgactcgtac
     7921 aagtgcaacg gcagccaggg aggattacga ggcggcttat ctggggtttt ctgtctgaca
     7981 cgatcgtgtg cccatgtcga tggagataga tcccgatgct tgcatccata gcaccatccc
     8041 atcgggttaa atgttcaata gccaatgaat gggcttttgg gagtgactgt cttgtttgtc
     8101 tgtttacggc atacaacacg caaaagttcc aagtagggcc ttctaaagca ccgcaactgt
     8161 ttgacacata caacacccaa aagttccaac aattgaacct tctaacgcgc caacaagatg
     8221 attagtaatg attgtatgac gaacgggtca accatggcgt ggcttgtaac ttgtcagtta
     8281 ttatagacta caggccattc taaatatcta ctactccgac acgagttcag gcccaatttg
     8341 caacccttgt cccctcagcc gggacgaatt acttcatttg actccaagtt tgtggatgag
     8401 aagatccata cattcttgtg tgtgtcttat ttccacatca accaccttct gccatgtcgt
     8461 tcaacgaagc gcgagagaaa ttcttaaaaa cggtgacaat agtaagtttc ttatgctatc
     8521 atcagctcta tcgcttataa ttcgacctaa tgaggctcta aataggctcc cgctctggga
     8581 ttcgtgccta tcgcggtcga gttctgtctc tttgaccgtc tttgcgagat tgggagacca
     8641 gcaactgcgc aggatatatg taaggctcat ggagagaggg atggtagaaa tatgaatctc
     8701 tgtaggttag cccaaatata gtatggattt ttctcaacaa gcattatcaa aaggcggctg
     8761 aaagatacat actaacagat atcgtgttga agcattacaa ttgaccggtg agcatagatc
     8821 ccatcttttt aggagattag gccgtgttca atggtcggct actgacgata actcatagat
     8881 gacactctac tgatgatggg cggcattggg ttcctggata tcgtatcaaa tggaatgtac
     8941 caagcaaatg atgtgaccga attcttagct acgaccccct cttctcagca cggggcagtt
     9001 catttgtagg tcagagaatg ggtaccgctg gactccagat gctaaagata catatcaccg
     9061 cagtacctca gagatcttgt tggcatcagc attcctaatg aagcggctcg tcgaaaccga
     9121 cttcgtttat cccttccaag aatgccaaac accgctgcaa tacgcctaca agtgcatggg
     9181 tagcacgtat gcccaggagc acacgtactc aatcatgcac aagacaggac gactcgacag
     9241 ctttaacgcc ttcatggacg ggaagtttgg cgatgaagag aacatagcta ctcgactgaa
     9301 taatatcggt tacgacatga gtagtttgat cactgacagc cttgattcca aacaaccgac
     9361 cgtgctggtc gacattgctg gtggacgagg caagcgcctc ctagagctga aggacgcgtt
     9421 tccgcggctc ggggccgaca acctcgtgct gcaggaatac aattctgaga ttggtgaggt
     9481 gcctggagtg actcaaatgt cgtggaattt caaagatgaa gatcaagagc aaccagtaaa
     9541 gggggcactt atatatttcc tatgctgtgt tctgcataac ctctcagacg tcgaagttgt
     9601 caagcttttc aagaaggttc gcgacgccat gtcatcccga tcaagaattc tgatcaagga
     9661 gcctgtgaag aatacggcta gttctacaac tcacggagct atgattgttc tatatggtgg
     9721 gcgggaacga acaagcgcgg aatggcagaa cctagcagct ggggctgggc taatggttgc
     9781 ctttgaggtg tacccgcaag tgggagaatg cgtggtagaa atgcgcatag ctcgtgtcta
     9841 actgcagctc cggtatgtgg ataactcgga taaccttgca tggatatatg cttcaacagt
     9901 gtatattgtt tctttaagct cgcttaggaa tttcaggaat atatgcgccg ttattgccct
     9961 atatggtctt atcgttcgag aaccgactcg ctcccatagg tgacatagaa aattgaataa
    10021 taaaccaggc cgcgtatacg taatgagtgt aggcctgatg aagggaggta atcattgata
    10081 tacgcatcca ttctaaagca aattcactga aataataggg gaacgccttg ttcgtaagga
    10141 acgcaatata ttcataccac aacatagaaa cagaatacga taatcctcta ttataatact
    10201 acgactacaa gcaagctacc cccttttctc tctagtataa cctcaaatat aatccatata
    10261 agtcataatt gccccttata tcaagccacc cgtaccacct ctataatcac agggaccgat
    10321 ggaaggcaga tatcgcgact aaatgcagaa gcgtatagac tagaatttga tgtattgcga
    10381 tcgttgaatt gatatgaaat atcaaacata agcttagagc ccgaatccgc catactactt
    10441 cctcatatgc accaaaaacc caatcagagc tccggccaag ggaaagcaag accttatcat
    10501 atgcatcaag ttccattcgg tcacaagcgc acgaacatgt tccaagcttg ctgttagatg
    10561 accggccttg acttcggctt ccagtgtaaa aagcttgtca tttgtcggcg tcatgacaat
    10621 ccaagtgaag gggatcatgg tggctgtcac cataccggct agcacgcaag accacctatt
    10681 agacttgtga gaggaccaat tcctgatagc agcggaagca tacagcagga atgttgcaac
    10741 tgaaatgctg gacgagattg tagcgccata gtgatgaagg cttgtccact gagtgcatag
    10801 ttggctcgct gtatgtgcgg cctcgagaaa cgcggggatt gagaaaagag acgcgcccat
    10861 catgatacct gtgaagtaaa atgagcgttg aaatttcgcc aatattgcca accttgttct
    10921 ccagctaagc tcgggattat gctagtctta ccagacagga aacagcctgc ggtcaaagcg
    10981 aaaacagtca gaagacctgt tgccgagttg tcgggatctt caaccccgtc gacgacatta
    11041 cccctgtcaa tgaattgttc gatccgcccg atagtcatcc tgtacgggaa gtgaaactca
    11101 tgtcaggtta ctggtccttg ttcgattgag ctcttcaagg gctcaagaga aaaccttaca
    11161 tgctcctctt cgtatctaca aagtcgtcgt gatgcaccgt caatcgtgtc ttgtagatgg
    11221 ggtcttgctt gaatttcctg aagtcctcta gtttcttgaa gactatttgg ctgaaaagat
    11281 caaaatcggc cagctttgtc aacgtcgggt cgtaaagctg gttgatcgcg gctcgtatct
    11341 cggtagtatt ataaatctgt cgggccagat gtaagaatct ctataattaa cgggtatttt
    11401 tcttttcatt acttctcgcc tgtatactaa cttacctggg tgaatcttac gatgccgtac
    11461 ttcatcatca agtcccttcc aagcggcgcg cagacttggg ccatgtagtg atggaagtcc
    11521 tcgtcgctga cgttcccttt cttgtagccg caaattgtta cacagagaaa ttggccttcg
    11581 gaatgaagta cggcgggttg atattccctt gatgaggaca tctcggtgaa atgtgttggt
    11641 ctgaatgatg gatagaattg taatctggcg aatgtgatga tggagaagga agagtggcat
    11701 ttggatggca tccaggccgt gacctctctc aataacatgt acaggtaggt gtgtaacaca
    11761 agatcgtgac gtgagacacc taagaggatg tagttcgccg tatctcggaa gctagatgaa
    11821 cacctaacac tttgtccttg attatttggt tttgctacac agcagtgtgt tagtagaagg
    11881 tcagacaacg cgaattcctt aaaaatcctt ggtcacaaac cttggtcaca ataatccggg
    11941 caaagcgccg aggacatggg ttaaatttat gctatcgggg taccctggct gcgtagttat
    12001 tggcccacat agggtgcttg catgctgtct caatcgagct cttactttac ccggcacaag
    12061 cctctccggt gcaatcaagg attgctcaag acatggggcg gtcactcact atagatccca
    12121 agttcatcat ctcacatagc tacatgagtg tatcttgata gctagagtga ccataattct
    12181 tagattatga aaaggagata aacaagaaag tgaatagaga gttggtgaaa ggggatagac
    12241 tatggacttc gtcgtctatg gtaggaggca acatacatag aactaaaatc caaaccacat
    12301 cttttcgccg ttgcgcatct caaatccaac ctttccatcc tctgccagtt tttgcagtac
    12361 ttcctctgtc aatggctcca ccgcttggtt tctaacttcg ttgcttaccc cttcaccata
    12421 catcaatgac gcgagttgac gaatgctcac gctctcgccc cgccccttgt ctccgggtcg
    12481 caagcgctgt agtgcctgca atacccgatt ttcccgattg gtcttcaatg ctatttctct
    12541 cttgatcttc caccggagat ctgaaatcac aatgccgtgg gcaggatagc ctagtaggca
    12601 atcttcctct tgcatcttgt tccaggatac catgatttga tcaagatcct cgaaagcggc
    12661 ggtgccatgg cccagtatgt tatctcccgt aaacatggcc ttctcctctt ccaggataaa
    12721 gcacatatga tcgtgagagt gccctggagt atagagtgac cggacggtag caccctcgac
    12781 ggaaaagact tgaccgtcgg tgatctctct ttgaccgtcg gccggcgagt tcttatatat
    12841 ggcatttgaa agatggggat atagcttcaa caggtctggc acaccaccgg tgtgatcccc
    12901 atgccaatgg gtaaggagaa catagcaaag tttaatttct aacgtctcaa gagttgacgc
    12961 gatcaaacga gcccattccg gagttccttg gccagtgtcg atgataagcc tggatgagcc
    13021 cgagccaata atgtacgtgt ttgtcccttg aagcgtaaac tttacaagtc ctgcgttagc
    13081 tgagcaaggt ggcagatgtc aaatttacga aagtttcgct caccttcccc ggattctggc
    13141 ctagaaccct aataacgcgt gaactgagga gctctacatc agagagttta gggagttggt
    13201 caaactgcgt tgatagatag tcctcgaacg cgctggcatt caaggatttg ttgatctgct
    13261 ggtacccgcc cacgctgttc atgctgaact aggggtacta gggtaaagaa gcaaaggaat
    13321 gtttggattc tcggatctct ggtcacttcg tctcgaaatc cttcaggtaa tcgatgacat
    13381 tgcttgtcaa gaggtaaata tcaatactcc atggtgggca cgaataattc tgggacctac
    13441 cttcaaagag atatgatacg agtaacacgc gcccgcaagt ggtagttggg caagtacatt
    13501 agcacttatg cgtcatgtct ttttgctccc cataatatgt gacatggtga tttattcgta
    13561 cattaaatcc tgtgttaacc tgtacgattg ttccattagt cataccgctt ttttgtcatg
    13621 tcttccgact taaattaact ctagaattcg ttccgtaaga cggcctaaat atattagcac
    13681 ttatgcccgt aattttctat ctaatccata agatgtgata tcgtgtttta gttacactgt
    13741 caatcctgtg ctgacgtgta cgttattccg ttaattacac tagtaccgcg tctatgtcag
    13801 gtaatacgac ttgagttaag cctagatttt aagcctacag ttaggtcggt aagacggtct
    13861 aagatattgg cacttatgca tgtgatatgg tgttttagtc acacggttaa tcccgtgttg
    13921 attaggtcag tacgcttatt cagttacact ggtaccgctt ttgcgttatg tattacgact
    13981 ttggtggtgt ttgtgtggta tttacggtgt atgaggtgta tgaggggtgt gggtgtgtgg
    14041 tgagagaaga ttccgaggac acatacaatc gccggcattg ctgccgtctt aaatagctgc
    14101 aatctgccgt atgtttcact cgccggcttg ctagaattga aggctttgat ggtgtttagc
    14161 tcgccgcaag ggttgcgaag accttgatgg caggggtagg ttcacggctt tccgattgat
    14221 gcagtaattg agaagtgaaa ggtgtgcccc tggcaaaagt aaattgtgtc tcgccacggg
    14281 agctttcatg cctttttggg taacgaagaa accaaaatat cggatacaac ccggaggcgt
    14341 tattagctgt gggggttgac ggggactatt cgacattaac tgtagacagt aaaaataata
    14401 ctagcttcta tggatatcgt gggccgcctg ttaattttct ataagaggac tcttgagttc
    14461 ccgccccggt cagattctgg atgtatagtg ttgcacgtac tctctatggt cactctgaaa
    14521 tcaaaggcaa atattcatta tagaagatcc cagtacccat tagacatcga gattgtattg
    14581 atccaagata acatcttcgc ctcgcgcaaa tcgtttttta cacagtcacg gacggactcc
    14641 ttctaatgcg aatttcccat ctggagggct gtgccaacag tacgcacgat tttgtttatt
    14701 tattacgctt ctagatatac ctgtgaatta aaccaagctg ctgactatag gagcgtagtg
    14761 agggcattat actttggcaa tgaactacct cacgaacgcc tttcatccct cgcgcgccac
    14821 ctgtatctat tcagcagaca acgagcatac ccaacactca ataagtttct cgccagcgcc
    14881 actgacgtcc tccgggccga aattaggcac ttacctgcct cacttcaagc cctcacccca
    14941 ccatttgatc atgttttgga ccttgtggac aatgagaagc tccgcaatag ccctctgggg
    15001 tcctcaattg acgccgtctt catcgttgtg attcagttaa gtatactgat taagtgagcc
    15061 tcagtcgccc caagttccac atttagtaaa ctacagaatg tccagagatg attcctgacg
    15121 aatacaccta ccaccttcta ggtattttga agatgactca cgtaaatact acgaattaca
    15181 atcttccgac gctgcactct taggcacgag tctgggccta ctggcatctg cggccatgtc
    15241 actgtctcgt tgcattcccg acattgccct ggtcggtgcg cacataacga ggctcgcttt
    15301 ccgcctaagt ttcttgacgt atcgaatctc ccaaatgctt gagccctctg aagaatccaa
    15361 atctcattca agttcttggg cttctgtggt tccgaatgtt tcaccagagg atgtgcaagc
    15421 agaactcgac tgttttcacg ccgaagaggt aggacgccct cgtgctcttt tatccgtccc
    15481 cctctaaaca atcgattata ctgtgatttc atgtatcaag ttatcaagcg aatctgcgca
    15541 tatgtggtgg aatattaatg acatcataag cctcggatcg agtatcgatt tgtcaccctg
    15601 cgtccaagtc ttgcgttgaa acactgaacc gatgctttat tgaatgcgtt attggggagt
    15661 agctgttgaa gaaatggttc tgatatacat ctaacacaga aaacaccgaa tgcctcgaga
    15721 atattcatca gtgcccggaa ccattcctca gtcaccatca gcgggcctcc ttcgagactg
    15781 aaaaatctct cgcggacctc aaagttcttc cactctcgca aattggtcag cctccctatc
    15841 tatggaggat tatgccacgc tccacatata tatagccatc aacatgttct cgagatcatg
    15901 ggcgagctgg attcggaaat ctccgggcta gtccccaccg tgataccatt atcgacctcc
    15961 tcgggtgctc agttctcggc atcctgtgcc aggactctct ttgacgagat aatcacggag
    16021 atattgacac gagagatcca atgggattct gttatcaaaa gcctgctacg gcaggccaaa
    16081 acaatgtcgg ctcaaaagtg tgaagtcctc gtctttcaga attctctcct cgtccacgac
    16141 ctggtagcta ccttcaagac tcagcagccc aatatcgatg tcagtgcttt ggaacttata
    16201 ccattgatca acaccggtga tgctagtgac gtatcggcgg ccgcgggaac cagcgcggac
    16261 aaaattgcaa tcgtgggtat ggcgtgtcga atgcctggcg atgcaacaga tacagagaaa
    16321 ttctgggagt tgcttgaaga gggtttggac gtccacacga aaatcccacc tgatcgtttc
    16381 gatgtcgaga cacattatga ccctgcgtgt aaagctacta acgccagcca cacggcgtat
    16441 ggctgtttcg tcaataacgc cggtttgttt gacgctccat ttttcaatat atcgcctcgc
    16501 gaagccttgg agaccgatcc catgcagcgg ttggcgctag ttaccgcata tgaggctctc
    16561 gagagatctg gatatgttcc taatcgaaca ctggcgacta acctccaccg aattgggacc
    16621 ttttacggcc aggcaagcga tgattatcgc gaggtcaatg ccggtcagga agttggcacc
    16681 tacttcatac ccggcggttg caggggtttt ggaccggggc gtatcaacta cttttttgga
    16741 ttttcaggcc ctagctatag cattgatacg gcttgctcgt cctccctggc tacaatccaa
    16801 gtagcctgcg cagctttgtg gaacggagac gtcgatatgg ctttggccgg gggaatgaac
    16861 attctaacga attcagacgt gttcgctggc cttagcctcg gtcactttct cagcaagact
    16921 cctaacgcct gtaaaacgtg ggactcggag gcggacgggt attgtcgcgc tgatggcatt
    16981 gtatctatcg tggtacgtat ctaagtatcc ctcgctgacg tttccttcct tgtcgctttc
    17041 tccccttcct tctttatatt aggcaacact gactgctccc tagtatgtca caaatacccc
    17101 aaactagtac tggaagatac taatcatttt aactccacat catagaatga aacgtcttga
    17161 agatgctgtt gccgataagg acaacattct tggtgtaatc ctcggcgcag caacgaatca
    17221 ctccgcagag gccgtctcta taacgcatcc tgacgctaat gctcagtcct tcttgtcaag
    17281 aaaggtgatg cgttcagcgg gaactgatcc tctccatgtt agttatgtgg aaatgcatgg
    17341 cacaggcaca caggcgggtg atagagagga gatgaaatca gtcaccgacg tattcgcacc
    17401 ggccgggaag aggccacgaa aacagacgct gcacattggt agcgtaaagg caaatgtcgg
    17461 tcacggcgag gccgtcgccg gcgctacagc gctcttgaag gttctgctca tgtttcggaa
    17521 gggaatcatt ccacgtcatg ttggcatcaa aaactgcttc aacccggcac tccctcagga
    17581 tcttgatagt cgccaagttg tgatccctct cactaatcag ccttgggtta gcactgaaaa
    17641 tggagcaatg cgaattgcag tggtaaacaa cttcggcgcg tcggggggaa atacgaccat
    17701 tgttatccag gaaccgccgc ggccgaggac tactgttgtc cgggatgaaa attgtggggt
    17761 gtcatacgcc gtcgccatct ctgccaagag caaggtctcg ctgcgtggca atatggaacg
    17821 gatgatcgat tacattgatt gtaatccaca gagctcgttg gctgacttgt cgtatacgac
    17881 gaccgcgcga cgataccact accatcacag gatagcagtc acgggttcta acttgtctca
    17941 aatcagatcc gaactcgtag cgcaactcga cttagccgac tcacacacgt cgataagtct
    18001 tacttcaaag cctcctgtgg cattcatgtt caccgggcaa ggggcttcgc gcaagtccat
    18061 gaacctggag ctcctcgccc gggattcaag gttcagtacc gaagtcctgc aattggacgc
    18121 cttggctcgc gcccaaggct tcccatcttt tatccccgtc attgatggca gctgtgccga
    18181 agatgaagcc cactctagtg ttgcgactca aatcgccctg gtcgccatcg agatagccct
    18241 ggccagatat tggtcctctt taggcgtcga gccagatatc gtaattggcc atagcttggg
    18301 cgaatacgcg gcgctctgtg tggcaggagt tctctctgct agtgacgcga tctacttagt
    18361 gggtcaaaga gcgagacttc tagaagacaa ggcaagtctc ggaagctata aaatgatggc
    18421 ggcacgggcc tcattggcgg atatcgagaa gttggctgct gtcgcaggac tgcagtacga
    18481 agtggcttgc ataaacagcc ccaagcagac ggtcctcgcc gggttatctg ccgatctcga
    18541 gagtattcgt gaggtgctgc aagaggccgg gtacaggtgt caagaccttg atgtggcatt
    18601 tgcctttcac tcgtcccaaa ccgatcctat cttggacgac ttcgagcggc taagtagttc
    18661 agccgttatt tttcacccgc ccaagctacc tgtcatctcg cctttactcg gcgaagttgt
    18721 gttcaatgga aaggctttca aatcaaatta cctgagacga gcgacccgcg agacggtcaa
    18781 ttacctggca gcgctggaag cggcggctaa tataggcatg gtgggtaggg acactttgtg
    18841 ggtcgagtta ggaccgcatc ctgtctgcct tgtctttctc aagggcactc tgggaagttc
    18901 gatgaccgaa atcgcggtgc catcgtttcg cagagacgaa aataactgga ccactttgac
    18961 ccaaagtttg gcaaaacttc actgcgctgg agttcagatc aactggaatg agtttcatcg
    19021 accatttgag gctggacttc agttgctcga tctccccact tacgcctgga ataataagaa
    19081 ctactggatt atgtacaaag ggaactgggt tctgaccaag ggtaacgact actacaaaac
    19141 ccaggaggaa acgcgccaac ccatttcgtc ttccgacttc cacaagacgt ctgtgcagag
    19201 aattgtcgag gagagctttg acggtgcggc tgggagggtg gtaatgcgat ccaacttgat
    19261 ggatgtggat ttactcaagg cagctcaagg ccacaaaatg aatgaatgcg gcgtagttac
    19321 ttcagtaagt caagtttccc acctacccgt cccgatgtct ggttatcttt gtgctttact
    19381 aacaagtgtc attgccacca ccctgttagt cgattcatgc cgatattgct tatactatgg
    19441 ggtcttattt atgtcagaag ctgagacccg acttcaagga caaggttgga ctgaatatct
    19501 taaacttggt agtcttgaag ggtctggttg ctcaaaaatt caccacgacc ccgcagctca
    19561 tacaggtgtc tatctcgaca aatgatatga atgcggagag agcttgctta acatggcaga
    19621 acgtcgactc acatgggatt ctagaggggg catttgcaac cgcagaggtg gaatttgggg
    19681 accccacgga atggcttgat tcatgggtgc cgtacaagca cttggttctt ggccgtattg
    19741 gagccctcga ggaattggta gagaaaggtg cggccacccg tttctcgaaa aacatggcct
    19801 atctgctttt tgccaataac ctggtcgact attcggagaa ctaccgcggg atgcaatcgg
    19861 tggttatgaa cggtctcgag gcattcgctg acgttatgtt aacttccgag aaaggaacgg
    19921 gtagttggac cgtggcccct tatttcatcg acagcgtgat acatctcgcc ggattcgtta
    19981 tgaatgtatc ggatgccata gatacacgta ccaaattttg ctttaccccg ggatggaagt
    20041 ctatgagatt tgcccgaccg ttggagccgg gtggcaaata tcgatcgtac gtgaagatga
    20101 tacaaacgga ggatgtcaca gtttacctcg gcgacgtcta cgtgctccag gacgacacta
    20161 tcattggatt tgttggcgga atcaaatttc gcaagtgtcc tcgcattctc ctaagccgct
    20221 tcttctccgc tcccgatacg cctggccagt tatcagcgac ctcgccgacc tccaattccg
    20281 gaccctccaa ggagtcgacc acgctattga cagccatgtc atcgaaaata tctgagtcta
    20341 atgtggtgtc aaagaaattg ccgacagcga catctttaga tgccagcacc agcgcgccag
    20401 actcaccacc agcgaaaacg aaagaatctt cgcctagcgc ggttcaacca gtccacaccc
    20461 ccgccacaga ccaagtcagg atcgagaaag agactgtaga ctctcgggct atctctctta
    20521 tagcgcgaga agctgggctt gataggagtg acctgcggga aacggcgacc ttcgccgagc
    20581 ttggcatcga cagcctgatg agccttgtga tatcggataa attccgcgac gagttgaaca
    20641 tcacggtaac tggaagcctc ttccttgaat atccgaccat cggagacctc cggggttggc
    20701 tttcagagta ctattcttaa tgcatatcgt tctgtccagg caattggatg atactcgatt
    20761 cagtccgacc ggtttttgag gttgtcataa cccttgctgc tggcctttct ttcaagtcct
    20821 agttctagct catatgataa tttgagattg atttttatat aataagatgc agaaaagttt
    20881 gctttagact gatttattcg tataagcgga agtcaacttg tcgtcaggac ggatactttc
    20941 tttttaagct caacaccacg ctggacttgc ctacggcatt caggggactt tcttcgcccg
    21001 tttcttcact cctttcaacg acaaaaggta accgacccgt cggctttcct gactatttcg
    21061 tataggcctt ataagggtaa gcagcttcat gacttagcaa ttatcacgag ccgcacgaag
    21121 aacgcgtctg gtggtggaaa cacgggtgtc gattagctcg accaggcttg cttcaccgcc
    21181 cccgcccccg agtgatttat agagtccaca ccgacgtata atcatgtaaa catcaaaggt
    21241 agctgccaga gtgcgccgat ggacacgcag cacacaggga cggttggatg cgccctggag
    21301 gtcacacaca tccaccacac tcatcacaat ggtaggtcat tccagtacgg aagtagagac
    21361 tctccggact atgctttgac cacgatcctg ttggcaatgc tcacaaaaga aaaagcgaac
    21421 aatatcgaca cctcttatct agaaactagg actcatcctt caaagacctc tggcgacaca
    21481 agggcaaaag caacagcaac acatgtagca gcgaccagca aatgccacag taacagcgtc
    21541 agtcccgagc cggtcgtaag catcacgcca gttgctgtgg accctgcacg ctgaactccc
    21601 aagatcgctc caacagtcac cccatgtgat cctagtagct ggcccagaac ccgtcacatt
    21661 c
//
