BGC0002257 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002257 (Xylaria schweinitzii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	21,661	High	rufoschweinitzin	PKS

BGC0002257 - Region 1 - T1PKS

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Location: 1 - 21,661 nt. (total: 21,661 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 21,662
Label		BGC0002257

Tailoring functions

Oxidoreductases: oxygenase

shwC: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: acylase methyltransferase

shwM1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

shwM2: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

shwP: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

shwB: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 61.20%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydrolase

shwB: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 61.20%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002257.2	1.00	PKS	rufoschweinitzin	Xylaria schweinitzii
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.75	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000156.5	0.63	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002257.2	1.00	PKS	rufoschweinitzin	Xylaria schweinitzii
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.75	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.75	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000156.5	0.63	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 21661:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

shwP: mal

PKS_AT (925..1229): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 106.9
inactive: 61.4
Methylmalonyl-CoA: 53.7
Methoxymalonyl-CoA: 46.2
Propionyl-CoA: 35.8
Benzoyl-CoA: 27.1
2-Methylbutyryl-CoA: 22.3
Ethylmalonyl-CoA: 21.7
Isobutyryl-CoA: 21.4
CHC-CoA: 19.2
Acetyl-CoA: 18.6
fatty_acid: 17.0
trans-1,2-CPDA: 11.4
3-Methylbutyryl-CoA: 9.5

Link to PARAS substrate predictor