BGC0002266 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002266 (Aspergillus calidoustus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	19,248	calidoustene A/calidoustene B/calidoustene C	terpene+PKS	100%

BGC0002266 - Region 1 - T1PKS

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Location: 1 - 19,248 nt. (total: 19,248 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,249
Label		BGC0002266

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002266	1.00	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002731	0.45	Polyketide	nanangenine A, nanangenine B, nanangenine C	Aspergillus nanangensis
BGC0002736	0.31	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002227	0.31	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0001124	0.31	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0002729	0.29	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001749	0.28	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0000046	0.26	Polyketide	depudecin	Alternaria brassicicola
BGC0001913	0.26	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001264	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002266	1.00	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002731	0.76	Polyketide	nanangenine A, nanangenine B, nanangenine C	Aspergillus nanangensis
BGC0002736	0.65	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002227	0.65	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0001124	0.64	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0002729	0.63	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001749	0.62	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0000046	0.60	Polyketide	depudecin	Alternaria brassicicola
BGC0001913	0.60	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001264	0.59	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae

Similar known gene clusters from MIBiG 4.0

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19248:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPCAL02977

PKS_AT (555..866): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; 2-Methylbutyryl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 68.4
Methoxymalonyl-CoA: 57.0
Malonyl-CoA: 50.3
Propionyl-CoA: 36.3
Isobutyryl-CoA: 33.3
fatty_acid: 28.8
trans-1,2-CPDA: 19.4
Ethylmalonyl-CoA: 18.6
Benzoyl-CoA: 16.2
2-Methylbutyryl-CoA: 11.6
CHC-CoA: 10.5
3-Methylbutyryl-CoA: 8.3
inactive: 0.0
Acetyl-CoA: -0.4