BGC0002267 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002267 (Aspergillus terreus NIH2624)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	50,173	azasperpyranone A/azasperpyranone B/azasperpyranone C/azasperpyranone D/azasperpyranone E/azasperpyranone F/azasperpyranone G/azasperpyranone H	PKS	100%

BGC0002267 - Region 1 - T1PKS

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Location: 1 - 50,173 nt. (total: 50,173 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 50,174
Label		BGC0002267

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002267	1.00	Polyketide	azasperpyranone A, azasperpyranone B, azasperpyranone C, azasperpyranone D, azasperpyranone E, azasperpyranone F, azasperpyranone G, azasperpyranone H	Aspergillus terreus NIH2624
BGC0000022	0.48	Polyketide	asperfuranone	Aspergillus nidulans FGSC A4
BGC0000099	0.37	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002155	0.33	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001252	0.33	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002515	0.33	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002194	0.32	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002429	0.32	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0002191	0.32	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001606	0.32	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002267	1.00	Polyketide	azasperpyranone A, azasperpyranone B, azasperpyranone C, azasperpyranone D, azasperpyranone E, azasperpyranone F, azasperpyranone G, azasperpyranone H	Aspergillus terreus NIH2624
BGC0000022	0.78	Polyketide	asperfuranone	Aspergillus nidulans FGSC A4
BGC0000099	0.70	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002155	0.66	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001252	0.66	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002515	0.66	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002194	0.66	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002429	0.65	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0002191	0.65	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001606	0.65	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 47136:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: ATEG_07659 + ATEG_07661

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ATEG_07659

PKS_AT (537..896): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 76.6
Methoxymalonyl-CoA: 72.7
Malonyl-CoA: 65.2
Isobutyryl-CoA: 47.9
Ethylmalonyl-CoA: 44.0
Propionyl-CoA: 31.4
Benzoyl-CoA: 24.8
2-Methylbutyryl-CoA: 20.6
trans-1,2-CPDA: 17.3
fatty_acid: 11.1
CHC-CoA: 9.1
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ATEG_07661

PKS_AT (967..1263): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 58.3%; Methoxymalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 65.3
Methoxymalonyl-CoA: 57.5
Methylmalonyl-CoA: 54.8
inactive: 47.9
Ethylmalonyl-CoA: 41.2
CHC-CoA: 28.7
Propionyl-CoA: 24.7
2-Methylbutyryl-CoA: 23.1
Isobutyryl-CoA: 22.7
trans-1,2-CPDA: 20.9
Benzoyl-CoA: 19.6
Acetyl-CoA: 16.8
fatty_acid: 13.7
3-Methylbutyryl-CoA: 9.4