BGC0002270: swainsonine biosynthetic gene cluster from Metarhizium robertsii ARSEF 23
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Location: 6,738,325 - 6,782,169 nt. (total: 43,845 nt).
This entry is originally from NCBI GenBank ADNJ02000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002270
Short description swainsonine biosynthetic gene cluster from Metarhizium robertsii ARSEF 23
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
ADNJ02000001.1
6738325 - 6782169
via Knock-out studies
Compounds
  • swainsonine
Species Metarhizium robertsii ARSEF 23 [taxonomy]
References
Chemical products information
swainsonine Evidence:
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Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MAA_08628
  • EFY95975.1
 6738325 - 6739152 (-) Crotonase, core
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    • MAA_08627
    • EFY95974.1
    		 6746674 - 6747453 (-) hypothetical protein
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      • MAA_08626
      • EFY95973.1
      		 6749128 - 6750352 (+) Protein kinase-like protein
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        • MAA_08625
        • EFY95972.1
        		 6750794 - 6751558 (+) Emopamil-binding protein
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          • MAA_08624
          • EFY95971.2
          		 6752243 - 6753727 (+) protein kinase domain protein
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            • MAA_08623
            • EFY95970.1
            		 6754767 - 6755820 (-) phytanoyl-CoA dioxygenase
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              • MAA_08622
              • EFY95969.1
              		 6757524 - 6764990 (+) polyketide synthase
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                • MAA_08621
                • EFY95968.1
                		 6765432 - 6766349 (-) f420-dependent NADP reductase
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                  • MAA_08620
                  • EFY95967.1
                  		 6767205 - 6768336 (+) nmrA-like family protein
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                    • MAA_08619
                    • EFY95966.2
                    		 6768583 - 6770073 (-) choline transport protein
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                      • MAA_08618
                      • EFY95965.1
                      		 6771233 - 6772221 (+) Phytanoyl-CoA dioxygenase PhyH
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                        • MAA_08617
                        • EFY95964.2
                        		 6772598 - 6774094 (-) aromatic amino acid aminotransferase
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                          • MAA_08616
                          • EFY95963.1
                          		 6775338 - 6780252 (-) WD40 repeat-like-containing domain protein
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                            • MAA_08615
                            • EFY95962.2
                            		 6781618 - 6782169 (-) flavoprotein oxygenase
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              MAA_08622
                              Substrates
                              pipecolic acid (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Entry added
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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