LOCUS       BGC0002271              8963 bp    DNA     linear   CON 26-JUL-2016
DEFINITION  Aspergillus terreus NIH2624 scaffold_1 genomic scaffold, whole
            genome shotgun sequence.
ACCESSION   BGC0002271
VERSION     BGC0002271
KEYWORDS    .
SOURCE      Aspergillus terreus NIH2624
  ORGANISM  Aspergillus terreus NIH2624
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:14:07
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8963
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8963
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5057:6466]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5058..6466
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     protocluster    1..8963
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:2889]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1..2889
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="2"
     cand_cluster    1..8963
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="neighbouring"
                     /product="indole"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..8963
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002271"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8963
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="indole"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(<1..>2889)
                     /locus_tag="ATEG_00700"
     mRNA            complement(<1..>2889)
                     /locus_tag="ATEG_00700"
                     /product="conserved hypothetical protein"
     CDS             complement(1..2889)
                     /NRPS_PKS="Domain: AMP-binding (45-462). E-value: 1.7e-60.
                     Score: 196.6. Matches aSDomain:
                     nrpspksdomains_ATEG_00700_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (599-668). E-value: 2.5e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ATEG_00700_PP-binding.1"
                     /NRPS_PKS="Domain: Thioesterase (693-953). E-value:
                     8.3e-31. Score: 100.0. Matches aSDomain:
                     nrpspksdomains_ATEG_00700_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     221.4; E-value: 3e-67)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ATEG_00700"
                     /product="conserved hypothetical protein"
                     /protein_id="EAU39346.1"
                     /sec_met_domain="AMP-binding (E-value: 4.1e-64, bitscore:
                     204.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTEILSNGHAEPASNGMVQYPFDNVVDALRAAANTTEGIIAYQ
                     TNNSGSETTPAQHISYKELLRTAEANAALLQSKHLTTPKQPVVVHSDNAVDSMIWYWSV
                     LLTGAIPTMTGPGMFSQDAVERKKHLLHLHRTLDAPLCLTRRALMGPFNENAGLLQCLA
                     FEDLSPSPDGSNASLPPSINPSPMDVAALMLTSGSSGTAKAVPITHQQVLAALRGKTAV
                     AQLSHPTSPFLSWVHMDHVANLVHCHLFAIVAGVSQVQVPAANVLVDPMQLLNLLSRHR
                     VSRTFAPNFLFAKLRRQFDAGRTDSLDADLNLAALYLDTGGEANVIDVCAGLQPILARY
                     GAPADVFKPSFGMTETCAGCIFNSHCPSYDQARLHEFASLGTPMPGVRMRISRLDGSGE
                     AAPGERGHLEITGEAIFHGYYNNPTATADAFTADGWFRTGDLAYIDAGGHLHLDGRTKE
                     MVNINGVKYLPHELDAALEQAEIPGATPTYFCCFGTRTAAMDTEVVAVLYLPAYDEADD
                     AARFDAQSSIIRLISMYTHSRPRVVPLRREDMPKTTLGKLSRAKLQAALEAGQFAAYEA
                     ANEAAIRRHRDTMRGEPASAEEATILSIIREQLEIPEADDFGVTDSILSMGATSMDLVA
                     IMQRVNRQLQLRKTLALTDMLNYATARGLCQRIAATSGTGRKHVYDPVVVLQPHGRKTP
                     LWLVHPGVGEVLVFVNLAHHITDRPVYAFRAKGFNAAEGETPFTSLEEVFETYKAAMKA
                     RQPQGPYAIAGYSFGGMVAFEIAKRLEAEGDEVRYCGSWNLPPHIKWRMKQLLWDECII
                     HLFYFVDLMDEETAYTHKPKLCELERQGRRLEAVRYLRQHSNPARWDELGLSEEYYLLW
                     VNLASNMQGMATEYEPSGNVKHLDVFVADPLTHVARTREEWVNGLLAAWKDFVREGVRY
                     HHVEGAHYTMLKPEYVANFAKTLRTVLRERGV"
     aSDomain        complement(31..810)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_00700_Thioesterase.1"
                     /evalue="8.30E-31"
                     /label="ATEG_00700_Thioesterase.1"
                     /locus_tag="ATEG_00700"
                     /protein_end="953"
                     /protein_start="693"
                     /score="100.0"
                     /tool="antismash"
                     /translation="PLWLVHPGVGEVLVFVNLAHHITDRPVYAFRAKGFNAAEGETPFT
                     SLEEVFETYKAAMKARQPQGPYAIAGYSFGGMVAFEIAKRLEAEGDEVRYCGSWNLPPH
                     IKWRMKQLLWDECIIHLFYFVDLMDEETAYTHKPKLCELERQGRRLEAVRYLRQHSNPA
                     RWDELGLSEEYYLLWVNLASNMQGMATEYEPSGNVKHLDVFVADPLTHVARTREEWVNG
                     LLAAWKDFVREGVRYHHVEGAHYTMLKPEYVANFAKTL"
     aSModule        complement(31..2754)
                     /complete
                     /domains="nrpspksdomains_ATEG_00700_AMP-binding.1"
                     /domains="nrpspksdomains_ATEG_00700_PP-binding.1"
                     /domains="nrpspksdomains_ATEG_00700_Thioesterase.1"
                     /final_module
                     /locus_tags="ATEG_00700"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(553..627)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_00700_0003"
                     /evalue="1.20E-13"
                     /label="NRPS-te1"
                     /locus_tag="ATEG_00700"
                     /protein_end="779"
                     /protein_start="754"
                     /score="43.2"
                     /tool="antismash"
                     /translation="QPQGPYAIAGYSFGGMVAFEIAKRL"
     aSDomain        complement(886..1092)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_00700_PP-binding.1"
                     /evalue="2.50E-10"
                     /label="ATEG_00700_PP-binding.1"
                     /locus_tag="ATEG_00700"
                     /protein_end="668"
                     /protein_start="599"
                     /score="32.6"
                     /tool="antismash"
                     /translation="TILSIIREQLEIPEADDFGVTDSILSMGATSMDLVAIMQRVNRQL
                     QLRKTLALTDMLNYATARGLCQRI"
     aSDomain        complement(1504..2754)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_00700_AMP-binding.1"
                     /evalue="1.70E-60"
                     /label="ATEG_00700_AMP-binding.1"
                     /locus_tag="ATEG_00700"
                     /protein_end="462"
                     /protein_start="45"
                     /score="196.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="TNNSGSETTPAQHISYKELLRTAEANAALLQSKHLTTPKQPVVVH
                     SDNAVDSMIWYWSVLLTGAIPTMTGPGMFSQDAVERKKHLLHLHRTLDAPLCLTRRALM
                     GPFNENAGLLQCLAFEDLSPSPDGSNASLPPSINPSPMDVAALMLTSGSSGTAKAVPIT
                     HQQVLAALRGKTAVAQLSHPTSPFLSWVHMDHVANLVHCHLFAIVAGVSQVQVPAANVL
                     VDPMQLLNLLSRHRVSRTFAPNFLFAKLRRQFDAGRTDSLDADLNLAALYLDTGGEANV
                     IDVCAGLQPILARYGAPADVFKPSFGMTETCAGCIFNSHCPSYDQARLHEFASLGTPMP
                     GVRMRISRLDGSGEAAPGERGHLEITGEAIFHGYYNNPTATADAFTADGWFRTGDLAYI
                     DAGGHLHLDGRTKEMVNI"
     CDS_motif       complement(1600..1686)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_00700_0002"
                     /evalue="3.20E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="ATEG_00700"
                     /protein_end="430"
                     /protein_start="401"
                     /score="16.4"
                     /tool="antismash"
                     /translation="PGERGHLEITGEAIFHGYYNNPTATADAF"
     CDS_motif       complement(2263..2319)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_00700_0001"
                     /evalue="2.30E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="ATEG_00700"
                     /protein_end="209"
                     /protein_start="190"
                     /score="14.1"
                     /tool="antismash"
                     /translation="ALMLTSGSSGTAKAVPITH"
     gene            <3810..>4844
                     /locus_tag="ATEG_00701"
     mRNA            <3810..>4844
                     /locus_tag="ATEG_00701"
                     /product="predicted protein"
     CDS             3810..4844
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 73.6; E-value: 2.6e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ATEG_00701"
                     /product="predicted protein"
                     /protein_id="EAU39347.1"
                     /transl_table=11
                     /translation="MTAPMRRALLSLTQGRPQTLAKAFFHSSPSLAMKVARVTAWDSPP
                     EYVSAPDPPAPSPTQLQLSVVAAGVPRVVRARAAGKHPSAMRASLPYDPSIDGVGRDAT
                     GELYFINSLAAPVFAERANVERSQLIKLPAGVDPATIAGLANPTASSWLALRCRAIGGC
                     AGRTVAILGATSASGRIAANVARQLGAARVIGLARNEAALAAVDGLDARVRLQDPLVLP
                     ADLGPVHIVLDYVGGPAAVQLLQALHPPPPGENIQYILVGGLAGYEHMDLPMRLVNVKP
                     IIIMGSGVGSLTREDLDREMPGVVNALAKMGPIGVDVFAVPMAEIQTAWDSEEAQTKRM
                     VIMP"
     gene            complement(<5058..>6466)
                     /locus_tag="ATEG_00702"
     mRNA            complement(join(<5058..5193,5264..5737,5802..>6466))
                     /locus_tag="ATEG_00702"
                     /product="predicted protein"
     CDS             complement(join(5058..5193,5264..5737,5802..6466))
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /locus_tag="ATEG_00702"
                     /product="predicted protein"
                     /protein_id="EAU39348.1"
                     /sec_met_domain="dmat (E-value: 2.7e-111, bitscore: 360.6,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIHAKHPQDTPSPALLAFWSQHMRSVIGPLMKATGYPPAAQEAN
                     LRFLDEHIAPTLGPHPKDPHPNYVAPCAVVGTPFNPSFNVSGTGAPKVRFDYDLLPPLH
                     RAASDDPWGERDARAVLRRLAAALGANTQWLEYFMDRLYLSPAEAQALLAIVPHEVVIP
                     SAMVGVMFDGAQPRLKAWVPTMRRAMVEGRSSNAVALEALRGLRPLGEAIAPAVDVLEA
                     WITSTTQDARLMLMGMDCGAPHDSRLKIYLVTPQNAWATVRDVMTMGGRLDDAPARKRV
                     ALLRTIWPYLINEPDDARIVADEHWCKPERMPRLGFSGLMYSIEIKPGRPVPEAKLYVP
                     LFQYAESSAVAERNMEAALALLDIEWGSSGRYRRTMEETFGKGKEYGQIFAAYSYSERT
                     GGYINSYVSMPIEDVQVHPLLGDYV"
     gene            <7610..>8963
                     /locus_tag="ATEG_00703"
     mRNA            join(<7610..7750,7809..7926,7976..8099,8149..8540,
                     8644..>8963)
                     /locus_tag="ATEG_00703"
                     /product="predicted protein"
     CDS             join(7610..7750,7809..7926,7976..8099,8149..8540,
                     8644..8963)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 91.4; E-value:
                     1.1e-27)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ATEG_00703"
                     /product="predicted protein"
                     /protein_id="EAU39349.1"
                     /transl_table=11
                     /translation="MEELLTQVQIFASSADEPTRSRLITALHDLSISLEGPEESIQRIA
                     VALHVAKIARDLELFERLSASPSALSVQTLAEATGADVVLLRRLMRYLASEKIVDETGV
                     DVFAANNVTRALGTPQGRSYIDCYYELIIPVCHKLPETFARTHYANPTDATKVALQDAF
                     DIDGDVWAFFKAFPKYGAMFDWHMQMQRAALTDWARIATMMKERGAARDDEVVFVDIGG
                     GNGHECLRLQAAYPELTGKLVLQDLPEVIARAPEIPAARFYYMRGVLHDFPDHKSREIL
                     RNTAAAMGPESVLLLDEMVLPDQGVHWMAASMDLQMLAWLASQERTRTQWEELLKSAGM
                     EIVDVYAHRPSAYESLIVVRVANE"
ORIGIN
        1 ctacacccct cgctccctca acaccgtccg cagtgtcttg gcgaagttcg ccacatactc
       61 cggcttcagc atcgtgtaat gcgccccctc cacatggtgg tatcgcactc cctcccgcac
      121 aaagtccttc cacgccgcca acagcccgtt cacccactcc tcgcgcgtcc gggccacatg
      181 cgtcaacgga tccgccacaa acacatccag atgcttcaca ttccctgacg gctcgtactc
      241 ggtcgccatg ccctgcatgt tggaggccag gttcacccac agcaggtagt actcctccga
      301 gagccccagc tcatcccacc gcgccgggtt gctgtgttgc cgcaggtacc gcaccgcctc
      361 cagccgccgc ccctgccgct ccaactcgca cagcttgggc ttgtgcgtgt acgccgtctc
      421 ctcgtccatc aggtcgacaa agtagaacag gtggatgatg cactcgtccc acagcagctg
      481 tttcatgcgc cacttgatgt gcggcggcag gttccagctt ccgcagtacc gcacctcgtc
      541 tccctccgcc tccagccgct tcgcaatctc aaaggccacc atcccgccaa acgaatagcc
      601 cgcgatcgcg tacggcccct ggggctgccg cgccttcatc gccgccttgt acgtctcaaa
      661 cacctcctcc agcgacgtga atggcgtctc gccctcggcc gcgttgaacc ccttggcccg
      721 gaacgcgtac accggccgat ccgtgatgtg gtgcgccagg ttcacaaaca ccagcacctc
      781 gcctaccccc gggtgcacca gccacagcgg cgtcttgcgt ccgtgcggct gcaacaccac
      841 caccgggtca tacacatgct tccgtcccgt gccgctggtc gccgcgatgc gctggcacaa
      901 tccgcgcgcc gtcgcatagt tgagcatgtc cgtcagcgcc agcgtcttgc gcagttgcag
      961 ctgccggttg acccgctgca taatggccac caggtccatg gacgtggcgc ccatcgacag
     1021 gatcgagtcg gtcacgccaa agtcgtccgc ctccgggatt tccagctgct cgcggatgat
     1081 ggacaggatg gtcgcctcct ccgccgacgc cggctcgccg cgcatcgtgt cgcggtgccg
     1141 ccggatggcc gcctcgttag ccgcttcgta ggctgcaaac tggcccgcct ccagcgccgc
     1201 ctgcagcttg gcccgcgaca gcttgcccag cgtcgtcttg ggcatgtcct cgcgccgcag
     1261 cggcaccacc cgcggccgcg agtgcgtgta catgctgatc agccggatga tgctgctctg
     1321 cgcgtcgaac cgcgccgcgt cgtccgcctc gtcgtacgcc ggcaggtaca gcaccgccac
     1381 cacctccgtg tccatcgccg ccgtgcgcgt accgaagcag caaaagtacg tcggcgtggc
     1441 gccgggaatc tccgcctgct ccagcgccgc gtccagctcg tgcgggaggt acttgacccc
     1501 gttgatgttg accatctcct tggtgcggcc gtcgaggtgc aagtggccac ccgcgtcgat
     1561 gtacgccaaa tcccccgtgc gaaaccagcc gtccgccgtg aaggcgtccg ccgtggcggt
     1621 cgggttgttg tagtagccgt ggaagatggc ctcgccggtg atttcgaggt gaccgcgctc
     1681 gccgggggcg gcctcgcccg acccgtccag tcggctgatg cgcatccgca cgcccggcat
     1741 cggagtgccc agcgacgcga actcgtgcag ccgggcctgg tcgtagctgg gacagtggct
     1801 gttgaagatg cagccggcgc aggtctcggt catgccgaag gagggcttga agacgtcggc
     1861 cggggcgccg tagcgggcga ggatgggctg cagaccggca cagacgtcga tcacattcgc
     1921 ctcgccgccg gtgtcgaggt acagggccgc gaggttgagg tcagcgtcga gcgagtcggt
     1981 gcggccggcg tcgaattggc ggcgcagctt ggcgaagagg aagttgggtg caaaggtgcg
     2041 cgagacgcgg tgccggctga gcaggttgag cagctgcatc ggatcgacga gtacgttggc
     2101 cgcggggacc tgcacctgcg acacgcccgc cacgatggca aagaggtggc agtgcacgag
     2161 gttggcgacg tggtccatgt gcacccacga gaggaacggg ctggtcggat gcgacagctg
     2221 ggccaccgcc gtcttgccgc ggagcgctgc cagcacctgc tggtgcgtga tgggcaccgc
     2281 tttggccgtg ccgctgctgc cggaagtgag catcagggcg gccacgtcca tgggggaggg
     2341 gttgatggac ggcggcaagg aggcgttgct tccgtcaggg ctagggctga ggtcttcaaa
     2401 cgccagacat tgcagcagac cggcgttctc attgaacggc cccatgaggg cgcgccgcgt
     2461 gagacacagc ggggcatcta acgtgcggtg cagatggagg agatgtttct tccgctcgac
     2521 ggcgtcctgg ctgaacatgc cgggccccgt catggtggga atggccccgg tcaggagcac
     2581 agaccagtac cagatcatgc tgtcgacggc attgtcggag tggacgacga ccggctgctt
     2641 gggcgtggtc aagtgtttgc tctggagcag ggcggcgttg gcctcggcgg tccgcagcag
     2701 ttccttgtag gagatgtgct gcgccggagt ggtctcgctg ccactgttgt tggtctggta
     2761 ggcgatgatg ccttcggtgg tgttggccgc tgcgcgcagg gcatcgacga cattgtcaaa
     2821 ggggtattgg accatgccgt tcgacgccgg ctcggcatgg ccgttagaga ggatctccgt
     2881 gcgagtcata tcgacgcgga tgagtgtgga caaggtttag ggaactggca tgaaatgaaa
     2941 tgcgtaacaa caacgaacga gggatagtgc gccaatgtcc gctcaatcga gacgccgttc
     3001 agctcgtggg catcgaagtt cctaaatagg attccactct gcccagcatc ggcacatggg
     3061 cgacggcgca cgagtgcatc ggcagcaggt tgtctgccta cattcctgtc tcgcttgatg
     3121 ctgccgggtg gtgctccgtg tggcagcact gcatgcgcct gtgtcccctt gattcaggtt
     3181 ggatgcacgg aggaaacctt cggaagctgt tactcgattg tctttggatc ttcagctgga
     3241 tggcgaacag gtctggcacc gcctcgccct gcattcctgg acgtcactgg cttaatgctg
     3301 ccaagtcttc catctacatc ggcaagggat gttacttctg tagtacttgt agactagatt
     3361 gcaatctgga gcaagccacg acaacagcag aaagacattg cgaactcgag acatggacct
     3421 atacctccag actgcttcta gatccaggct gggctggccg gctaccttga tacgggctgt
     3481 cagacaccgc tgacagaaca acctcagcat ccgttggcca gttacatacg agcagcaagg
     3541 ggcaatgcta cgccatatga tacgagaatc tgactcttca cggcatgcaa ttgctgatcg
     3601 gatcgatcga tcgttccccg ggctgcgttg tcttgaacgt tgttgcccga gcctgccgct
     3661 cccagcatca tcctttgttt ggtggctttg tttgtgacct gtatccaact ttcttactcc
     3721 ccgcagaccg agcgatccct ggttgtggct cgctcttcat aagctcatct ccgaactctg
     3781 ccctcgtgtc cttgttttgg ctgctcacca tgaccgctcc catgcgccgc gcactgctct
     3841 ccctgacgca aggccgcccc cagactctcg ccaaagcatt cttccattcc tcaccatccc
     3901 ttgccatgaa ggtcgctcgt gttactgcct gggactcacc ccctgaatac gtctcggcgc
     3961 ctgacccgcc tgccccgtcc ccgacgcagc tccagctgag cgtggtggcc gccggcgtac
     4021 cccgagtggt gcgcgcccgc gcggcgggca agcaccccag cgccatgcgg gcgtcgctgc
     4081 catacgatcc gagcattgac ggggtcggac gcgacgccac gggcgagctg tacttcatca
     4141 atagcctggc ggcgcccgta ttcgcagagc gcgcaaacgt cgagcgcagc cagctcataa
     4201 agctgccggc gggcgtcgac ccggctacta tcgccggcct agccaatccg accgctagta
     4261 gttggctagc gctgcgctgt cgcgccatcg gcggctgcgc tggccgtaca gtagccatcc
     4321 tgggcgcgac cagcgccagt ggccggatcg cggccaacgt cgcccgccag ctgggcgccg
     4381 cgcgggtgat cggacttgca cgcaacgagg ccgccctcgc tgccgtcgac ggcctagacg
     4441 cccgcgtccg cctgcaggac cctctcgttc ttccggccga cctgggcccc gtccacatcg
     4501 tgctcgacta cgtcggcggg ccggccgccg tgcagctgtt gcaggcgttg catccgccgc
     4561 cacccggtga gaacatccag tacattctgg tcggcgggtt agccggatac gagcatatgg
     4621 acctgcctat gcggctggtc aacgtgaagc caatcatcat catggggtct ggcgtgggca
     4681 gtctgacccg ggaggacttg gaccgtgaaa tgccgggggt agtcaacgcc ctggcgaaga
     4741 tggggccgat tggagtagat gtgtttgcgg tcccgatggc ggagatacag actgcatggg
     4801 actcggaaga agcgcagacc aagcggatgg tcattatgcc ttgatggggg ctagtacgac
     4861 attgatttac ataagtgttt tacacagacc ggtagttatc gaaatccgta tgactgaaag
     4921 caattgagaa tgaactatat tgcaactcga cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5041 nnnnnnnnnn naccagccta gacgtagtct cccaaaagcg gatgcacctg cacgtcctca
     5101 atcggcatgc tgacatacga attgatatat ccccccgtgc gctccgagta cgaatacgcc
     5161 gcaaatatct gcccatactc ctttccctta ccgctgcagc cagtcagctc gcgccaccgt
     5221 cacacagagt gcaacacagg ggggaaaagg aagggcaact cacaaagtct cctccatcgt
     5281 ccgccgatac ctcccgctgg acccccactc gatgtccagc agcgccagcg ccgcctccat
     5341 attacgctcc gcgaccgccg agctctcggc gtactgaaac agcggcacgt acagcttggc
     5401 ctcgggcacc ggccggcccg gcttaatctc gatcgagtac attagcccgg agaagccaag
     5461 ccgcggcatc cgctcgggct tgcaccagtg ctcgtcagct acaatacgcg catcgtccgg
     5521 ctcgttaatc agatacggcc agatcgtgcg cagcagcgcg acccgtttgc gcgccggcgc
     5581 gtcgtccagc cgcccgccca tcgtcatgac gtcgcgcacc gtcgcccacg cgttctgcgg
     5641 cgtcacgagg tagatcttca gccgggagtc gtgcggcgcg ccgcagtcca tgcccatcag
     5701 catgaggcgg gcgtcttgcg tggtggatgt gatccagctg ggggcccgga cccggttagc
     5761 aaacatcaga cgtgacgggt gggggggatg gtgggccata cgcttcgagc acgtcgacgg
     5821 cgggcgcaat agcctcgccc agcggtctca gcccgcgcag cgcctccagc gccaccgcgt
     5881 tcgaggaccg cccctcgacc atcgcgcggc gcatcgtcgg cacccacgcc ttcagccgcg
     5941 gctgggcgcc gtcaaacatc acgccgacca tggcggacgg gatgacgacc tcgtggggga
     6001 cgatcgcgag cagcgcctgc gcctccgccg gcgagaggta caggcggtcc atgaagtact
     6061 ccagccactg ggtgttggcg ccgagggcgg cggccagacg gcgcagcacg gcgcgggcgt
     6121 cgcgctcgcc ccatgggtcg tcggatgcgg cgcggtgcag cggcgggagc aggtcgtagt
     6181 cgaagcggac cttgggggcg ccggtgccgg agacgttgaa gctggggttg aagggggtgc
     6241 cgacgacggc gcagggggcg acatagttcg ggtgcgggtc tttggggtgc gggcccagcg
     6301 tcggcgcgat gtgctcgtcg aggaagcgga ggttggcctc ttgcgctgcg ggcgggtagc
     6361 ctgttgcttt catcagtggg ccgatcacgg agcgcatgtg ctggctccag aaggccagca
     6421 gggcgggcga gggcgtgtcc tgggggtgtt tggcgtggat ggtcatgatt gctgggggtg
     6481 gagctgttct cgcgatggcg atggatggtg agcgggttgg gcggctttac tatctatcct
     6541 ggacggctcg tatagtgctc gctcgatcga tgcaaggtct catcggagag gattcgatat
     6601 agttcatcgc tggcgatgtt gcaggcgttg cctgcgactc ggcggatgcc atccggatat
     6661 gactgcatat acgagtggag gcaggcgttg aaacatgtcc atccacctgt atacgcctcc
     6721 tcgaaccttc cgcaagcttt gcggatgaaa cactcggtgg gctcgtgtct ggatccgcca
     6781 catctccaga actctgtcga gtcccttgct tgctggtccg ccgcgtaagg cggcattcag
     6841 ctggacagac gtatcggtct gcttgaagtt agattccgct acgtataggt caagaagcgg
     6901 tgtgtagacg ttctaaacca aggactcggt ggagcgactc gtattgacgt ccgcctggag
     6961 cggtcttgtg tacacgacct ccttgcttca accgccacag ccgttgagag ccgaggtcca
     7021 gcatgccagc gctgcagtag tggtacatgt agcacgacgc atgtctgata acctgatata
     7081 tgaacagacg tcagcaaggg tcgtcttcgt cctgttgtac ggtgcacccg cacaggaggg
     7141 cgactgagtc acttcacttc gtgttatgaa agcggctatg cctcttgcaa ttcgaactac
     7201 aaacccattc atgttgacaa tggttagggc agcactggtc cggaacaaca tatcgctgca
     7261 agatgccttt gcgtgcgaca caaggacacc tacaactact ccgactgtct tctcaacctc
     7321 gcaatgctcg ttcgaacgtc agcatcaaca cctcggccga tggaagcagc tccttgccct
     7381 cgtctaagat agcatccagc agtcagtcag atatcatcgc tatagcaccc ttgaccataa
     7441 aataaacaca agacagcatt acaaaatggc cggaggggtt acacttacac tcaccatcac
     7501 gcgcatcacc aaatggcccg tcgcagtctt atacaaaatg catctcgagg ccaacataac
     7561 ccgcgacttt ccccgctgag cccacacatc cagcatcatc cagaacacca tggaagaact
     7621 cctcacccaa gtgcagatct tcgccagcag cgccgacgaa cccacccgtt ctcggctcat
     7681 aacagccctg cacgatctct ccatctccct cgagggaccc gaagagagca tccagcgaat
     7741 cgctgttgca gtaagcagac cagacgcgcc aagcggaacc aaaactgacc accgcccagc
     7801 cactgcagct gcatgtcgcg aagatcgcgc gggacctgga gctcttcgag cggctgtccg
     7861 cgagtccatc agctctgtcc gtgcagaccc tcgccgaagc aaccggcgct gatgtcgttc
     7921 tcctccgtag gcaacactga ttctccccat catcgcatgc cgttaacacc cacaggccga
     7981 ctgatgcggt acctcgcgtc ggagaagata gtcgacgaga caggcgtgga cgtcttcgcc
     8041 gcgaacaacg tcacccgcgc gctgggcacg ccccagggcc gcagctacat cgactgctag
     8101 tgagtgtccc cttcgccagg acagacgccg ctgacgcgag gctcgcagct acgagttgat
     8161 catcccggtg tgccacaagc tgccggagac gtttgcgcgc acgcactacg cgaacccgac
     8221 ggatgcaacc aaggtggcgc tgcaggacgc attcgacatc gacggcgacg tgtgggcgtt
     8281 tttcaaggcg ttcccgaaat acggcgccat gttcgactgg cacatgcaga tgcagcgcgc
     8341 cgcgctgacg gactgggcgc gcatcgcgac gatgatgaag gagcgcggcg ccgcgcgaga
     8401 cgacgaggtg gtctttgtcg atatcggcgg aggaaacggg cacgagtgtc tccgtctgca
     8461 ggcggcgtat ccggagctga ctgggaagct ggtcttgcag gatctcccgg aggtgattgc
     8521 acgcgcaccg gagattccgg gtgtggagaa catggcgtgt gatattttca agccgcagcc
     8581 tgttcaaggt acagtccgct tatactccgt agatctgttt gatgcgaggt gctgacgtga
     8641 cagcggcccg attctactac atgcgcggtg tcttgcatga cttcccggac cacaagagcc
     8701 gggagatcct gcgtaacacg gcggcggcta tgggacccga gtccgtcctc ctgctggacg
     8761 agatggtctt gcccgaccaa ggcgtgcatt ggatggcggc atcgatggac ctgcagatgc
     8821 tggcgtggct tgcgtcgcag gaacgaaccc gcactcagtg ggaggagctg ctcaagtcgg
     8881 cggggatgga gattgtcgat gtctatgcac accggcctag tgcgtatgag agcctgattg
     8941 tagtgagagt agccaacgag tga
//
