LOCUS       BGC0002274              2779 bp    DNA     linear   CON 26-JUL-2016
DEFINITION  Aspergillus terreus NIH2624 scaffold_3 genomic scaffold, whole
            genome shotgun sequence.
ACCESSION   BGC0002274
VERSION     BGC0002274
KEYWORDS    .
SOURCE      Aspergillus terreus NIH2624
  ORGANISM  Aspergillus terreus NIH2624
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:14:27
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(<1..>2779)
                     /locus_tag="ATEG_02004"
     mRNA            complement(join(<1..795,827..>2779))
                     /locus_tag="ATEG_02004"
                     /product="predicted protein"
     protocluster    1..2779
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:2779]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..2779
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..2779
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..2779
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002274"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..2779
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(join(1..795,827..2779))
                     /NRPS_PKS="Domain: AMP-binding (12-436). E-value: 5.8e-59.
                     Score: 191.5. Matches aSDomain:
                     nrpspksdomains_ATEG_02004_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (572-639). E-value: 9e-11.
                     Score: 34.1. Matches aSDomain:
                     nrpspksdomains_ATEG_02004_PP-binding.1"
                     /NRPS_PKS="Domain: Thioesterase (652-905). E-value: 2e-30.
                     Score: 98.7. Matches aSDomain:
                     nrpspksdomains_ATEG_02004_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     245.5; E-value: 1.5e-74)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ATEG_02004"
                     /product="predicted protein"
                     /protein_id="EAU36966.1"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-69, bitscore:
                     220.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.6e-12, bitscore:
                     34.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLNNLQALLRRVAAREDSGHVVVYGMGNTKAFKSYSYQDLLRVA
                     IKASVALRKTSDLHPGSVILLHFDNHWDNIVWFWAASFAGCLPAISASFSNDASQRTAH
                     IERLSTTLMHPLCLTNERIMADFAGQDAVQPLAVETLVLNGDVSFEALPQEHPEPSLSD
                     DALLLFTSGSSGNSKGVCLSHGQILASISGKYAVRPLPDNTSFLNWVGLDHVAAIVEIH
                     LQAMYALKTQVHVPAADILSSPATFLQLLEKHRVSRTFAPNFFLAKLRDLLQENDSLPE
                     PRRWDLRSLEYVASGGEANVTKTCDRLSEYLVAFGAPKDVIVPGFGMTETCAGSIFNTR
                     CPEYDKSRSAEFASVGTCMPGISMRVTDLSNNALPSGEIGHLQLTGPVVFKRYFNNTSA
                     TQEAFTPDGWFKTGDMGCIDENGCLTLTGRAKENMIINGVNHSPHEIETALDKIPGLTP
                     SYSCCFSFFPSGGETEEICVVYLPTYSPDDLAARAQTADAISKTVLMSTGSRPHVLPLE
                     REALPKSSLGKLSRAKIKAAYEKGEYATYQNANNELMRRYRESTRAEPQNDLEKTLLEV
                     FTRSLSITDDAFDVKTPIFDVGINSVELIRLKRDIEDHLGMAASAIPMIMLMTHSTVRD
                     LATALEKLQGPREYDPNPLWLVHPGAGEVLVFINLAQYIVDRPVYALRARGFNDGEQPF
                     ETIEEATASYYNGIRSRQPHGPYALAGYCYGSMLAFEVAKMLESHGEEVRFLGSFNLPP
                     HIKMRMRELDWKECLLHLAYFLDLVSQERSREMSVELAGLSHDEILDSVIQNANMERYA
                     ELSLNRPLLVRWADVAYELHRMAFDYDPAGCVAGMDVFFSIPLAIAAASKTEWRNVHLS
                     QWEDFTRTVPKFHDVAGEHYSMIGPDHVFSFQKTLRKALDERGM"
     aSDomain        complement(34..792)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_02004_Thioesterase.1"
                     /evalue="2.00E-30"
                     /label="ATEG_02004_Thioesterase.1"
                     /locus_tag="ATEG_02004"
                     /protein_end="905"
                     /protein_start="652"
                     /score="98.7"
                     /tool="antismash"
                     /translation="PLWLVHPGAGEVLVFINLAQYIVDRPVYALRARGFNDGEQPFETI
                     EEATASYYNGIRSRQPHGPYALAGYCYGSMLAFEVAKMLESHGEEVRFLGSFNLPPHIK
                     MRMRELDWKECLLHLAYFLDLVSQERSREMSVELAGLSHDEILDSVIQNANMERYAELS
                     LNRPLLVRWADVAYELHRMAFDYDPAGCVAGMDVFFSIPLAIAAASKTEWRNVHLSQWE
                     DFTRTVPKFHDVAGEHYSMIGPDHVFSFQKT"
     aSModule        complement(34..2743)
                     /complete
                     /domains="nrpspksdomains_ATEG_02004_AMP-binding.1"
                     /domains="nrpspksdomains_ATEG_02004_PP-binding.1"
                     /domains="nrpspksdomains_ATEG_02004_Thioesterase.1"
                     /final_module
                     /locus_tags="ATEG_02004"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(541..615)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_02004_0003"
                     /evalue="1.90E-11"
                     /label="NRPS-te1"
                     /locus_tag="ATEG_02004"
                     /protein_end="736"
                     /protein_start="711"
                     /score="36.3"
                     /tool="antismash"
                     /translation="QPHGPYALAGYCYGSMLAFEVAKML"
     aSDomain        complement(863..1063)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_02004_PP-binding.1"
                     /evalue="9.00E-11"
                     /label="ATEG_02004_PP-binding.1"
                     /locus_tag="ATEG_02004"
                     /protein_end="639"
                     /protein_start="572"
                     /score="34.1"
                     /tool="antismash"
                     /translation="LLEVFTRSLSITDDAFDVKTPIFDVGINSVELIRLKRDIEDHLGM
                     AASAIPMIMLMTHSTVRDLATA"
     aSDomain        complement(1472..2743)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_02004_AMP-binding.1"
                     /evalue="5.80E-59"
                     /label="ATEG_02004_AMP-binding.1"
                     /locus_tag="ATEG_02004"
                     /protein_end="436"
                     /protein_start="12"
                     /score="191.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VAAREDSGHVVVYGMGNTKAFKSYSYQDLLRVAIKASVALRKTSD
                     LHPGSVILLHFDNHWDNIVWFWAASFAGCLPAISASFSNDASQRTAHIERLSTTLMHPL
                     CLTNERIMADFAGQDAVQPLAVETLVLNGDVSFEALPQEHPEPSLSDDALLLFTSGSSG
                     NSKGVCLSHGQILASISGKYAVRPLPDNTSFLNWVGLDHVAAIVEIHLQAMYALKTQVH
                     VPAADILSSPATFLQLLEKHRVSRTFAPNFFLAKLRDLLQENDSLPEPRRWDLRSLEYV
                     ASGGEANVTKTCDRLSEYLVAFGAPKDVIVPGFGMTETCAGSIFNTRCPEYDKSRSAEF
                     ASVGTCMPGISMRVTDLSNNALPSGEIGHLQLTGPVVFKRYFNNTSATQEAFTPDGWFK
                     TGDMGCIDENGCLTLTGRAKENMII"
     CDS_motif       complement(1568..1657)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_02004_0002"
                     /evalue="5.40E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="ATEG_02004"
                     /protein_end="404"
                     /protein_start="374"
                     /score="15.6"
                     /tool="antismash"
                     /translation="PSGEIGHLQLTGPVVFKRYFNNTSATQEAF"
     CDS_motif       complement(2228..2287)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_02004_0001"
                     /evalue="3.40E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="ATEG_02004"
                     /protein_end="184"
                     /protein_start="164"
                     /score="19.7"
                     /tool="antismash"
                     /translation="ALLLFTSGSSGNSKGVCLSH"
ORIGIN
        1 tcacattcct cgctcatcca gcgcttttcg caaagtcttc tggaagctga aaacatggtc
       61 cgggccgatc atgctgtaat gctcgccggc cacatcgtgg aacttgggta cagtcctggt
      121 gaaatcctcc cactggctca ggtgcacatt acgccactcc gtcttcgagg cggccgcgat
      181 ggcgagcgga atagagaaga acacatccat tcccgccacg cagccagcag gatcgtagtc
      241 gaaggccatg cgatgcagct cgtacgcaac atcggcccat cgcaccagca agggccggtt
      301 cagcgagagc tcggcgtacc gctccatgtt cgcgttctgg atcacactgt ccaggatttc
      361 atcgtgacta aggcccgcaa gctccaccga catctctcgc gagcgctcct gcgagaccag
      421 atccaggaag tacgccaggt ggagcaggca ttccttccag tccagctcgc gcatgcgcat
      481 tttgatatga ggcgggaggt tgaacgagcc caggaagcgg acttcctcgc cgtgcgattc
      541 gagcatcttc gcgacctcaa acgccagcat agatccatag caatacccgg ccagcgcgta
      601 gggcccgtgt ggctggcgcg acctgatgcc attgtagtag ctggccgtgg cctcttcgat
      661 agtctcaaag ggctgttctc catcgttaaa cccgcgtgcg cgcagcgcgt acactggccg
      721 gtcaacgata tactgggcga ggttgatgaa gaccagcact tcgcctgcgc cggggtggac
      781 cagccacagc gggttcttgt ggccgtggct ttggagcgtc acccaccgga tcgtactcgc
      841 gcgggccctg cagtttttcc aaagcagtgg ctagatctct gacggtgctg tgcgtcatca
      901 gcatgatcat ggggattgct gacgcagcca tgccgagatg gtcttcgatg tctcttttca
      961 gacggatcaa ctcgaccgag ttgattccca catcgaaaat aggggttttc acatcgaatg
     1021 cgtcgtctgt gatgctcagc gagcgcgtga agacttccag cagcgttttc tcgaggtcgt
     1081 tctgcggctc cgcgcgagtg ctctcccggt atcgtcgcat cagctcgtta ttggcgttct
     1141 ggtaggtcgc atactccccc ttctcgtacg ccgccttgat tttggctcgc gacagctttc
     1201 ccaacgagga tttgggaagg gcctctcttt cgagcggcag tacatgcggc cgcgaacccg
     1261 tactcatgag gactgtcttt gaaattgcat cggccgtctg ggctcgtgca gccaggtcgt
     1321 cagggctgta tgtgggtaga tacaccacac agatctcctc ggtctcccct cccgatggga
     1381 agaaagagaa gcaacagctg tagctcggag tgagtccggg aatcttgtcg agggcagtct
     1441 cgatctcatg gggactatgg ttgacaccgt tgatgatcat attctctttt gcacgcccgg
     1501 taagtgttag acacccgttc tcatcaatgc agcccatgtc tcctgtctta aaccagccat
     1561 cgggggtaaa ggcctcctgt gtggcgctcg tattgttgaa atatctcttg aagacgaccg
     1621 ggcccgtcag ttgcagatga ccaatctccc cggaaggcaa ggcattgtta gagaggtcag
     1681 tcactctcat ggagatacca ggcatgcagg tcccaactga agcaaactcc gctgaccggc
     1741 tcttatcgta ctccggacag cgggtattga agatagaccc agcacaagtc tccgtcattc
     1801 caaacccagg aacgatcaca tccttcgggg ctccgaatgc aaccaagtac tctgacagac
     1861 gatcacaagt cttggtcacg tttgcttcgc cccccgaagc gacgtattcc agagaacgga
     1921 gatcccagcg tcgcggctca ggcagggagt cattctcctg caagaggtct cgaagtttgg
     1981 cgaggaagaa gttcggggcg aatgtcctgg aaacccggtg cttctcgagt aactggagga
     2041 aagtggctgg gctagacaaa atgtctgcgg ctggcacgtg gacctgcgtc ttcagtgcgt
     2101 acatcgcctg gaggtggatt tcgacaatcg cggcgacatg gtccagcccc acccagttga
     2161 ggaatgaagt gttgtccggc aacggacgga cggcgtattt accagagatg ctcgccagga
     2221 tctgtccatg gctcagacat acgcccttgg agttccccga gctgcctgaa gtgaagagaa
     2281 gaagggcatc gtcgctgagg cttggctccg gatgttcttg ggggagggct tcgaacgaga
     2341 catccccgtt caagacgagg gtttcaacgg caagtggctg gaccgcatcc tgcccggcaa
     2401 agtccgccat gattctttca ttggtcaagc agagcggatg catgagcgtt gtcgacagac
     2461 gctcaatgtg tgccgtgcgt tgggacgcgt cgttcgagaa agaagctgag atagcaggaa
     2521 gacatcccgc aaaggacgcc gcccaaaacc agacgatgtt atcccagtga ttgtcaaaat
     2581 gaagcaagat aacggatcca gggtgcaggt cacttgtctt gcggagagcc acagacgcct
     2641 ttatggccac ccgcagcaag tcttggtagg agtaagactt gaaggctttg gtgttcccca
     2701 tgccatacac taccacatgg ccactgtcct ctcttgcggc cactcgtctc aggagtgcct
     2761 gtaggttgtt caaagtcat
//
