BGC0002275 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002275 (Aspergillus niger CBS 101883 (Aspergillus lacticoffeatus CBS 101883))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS-like,T1PKS	1	48,576	High	pyrophen/campyrone B	NRPS:Type I+PKS

BGC0002275 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 48,576 nt. (total: 48,576 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 48,577
Label		BGC0002275

Tailoring functions

Ligases: ligase

BO96DRAFT_451379: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002275.2	2.00	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002171.2	2.00	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0001284.4	0.64	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.60	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.60	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.59	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001275.3	0.59	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002175.3	0.59	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002275.2	1.00	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002171.2	1.00	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 48576:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BO96DRAFT_451379: X - mal

AMP-binding (24..423): X

nrpys: Phe, D-Phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMFVVGLASK
Nearest Stachelhaus code(s):: Phe or D-Phe DMFVVGLASK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

PKS_AT (1161..1455): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 162.6
inactive: 74.8
Methoxymalonyl-CoA: 73.9
Methylmalonyl-CoA: 66.3
Isobutyryl-CoA: 42.7
Propionyl-CoA: 37.3
Acetyl-CoA: 31.3
Ethylmalonyl-CoA: 30.8
Benzoyl-CoA: 29.8
trans-1,2-CPDA: 28.8
CHC-CoA: 27.6
fatty_acid: 18.8
2-Methylbutyryl-CoA: 17.4
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor