LOCUS       BGC0002278             28520 bp    DNA     linear   PLN 20-MAY-2015
DEFINITION  Penicillium brasilianum genome assembly Pbras_Allpaths-LG, scaffold
            SCAF3, whole genome shotgun sequence.
ACCESSION   BGC0002278
VERSION     BGC0002278
KEYWORDS    .
SOURCE      Penicillium brasilianum
  ORGANISM  Penicillium brasilianum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:14:55
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             join(1..348,471..920)
                     /NRPS_PKS="Domain: PKS_KR (14-130). E-value: 8e-13. Score:
                     40.5. Matches aSDomain:
                     nrpspksdomains_PMG11_03952_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     204.9; E-value: 2.3e-62)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PMG11_03952"
                     /product="Putative 2-deoxy-D-gluconate 3-dehydrogenase"
                     /protein_id="CEO59270.1"
                     /transl_table=11
                     /translation="MAATVQSLFSLSGRTAVVTGGTRGIGQAMAVALAEAGADIILIQR
                     DESNTATKDDIINRLGRKAHIHVAELSNRKAVKEIIPALVSKGFKPDILLNCAGIQRRH
                     PSEKFPDEDWDEVLEVNLSQVFILCREFGAYLLARDASEFPSGRRGSIINVASLLTFQG
                     GITVPAYAASKGGVGQLTKALSNEWVAKGINVNAIAPGYIATDMNTALINDENRNAGIM
                     ARIPAGRWGQPEDFKGVVVFLASGASSYVSGEIITVDGGWMGR"
     protocluster    1..28520
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[6204:9303]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6205..9303
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..28520
                     /SMILES="NC(Cc1ccccc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..28520
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002278"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..28520
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        join(43..348,471..512)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PMG11_03952_PKS_KR.1"
                     /evalue="8.00E-13"
                     /label="PMG11_03952_PKS_KR.1"
                     /locus_tag="PMG11_03952"
                     /protein_end="130"
                     /protein_start="14"
                     /score="40.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TAVVTGGTRGIGQAMAVALAEAGADIILIQRDESNTATKDDIINR
                     LGRKAHIHVAELSNRKAVKEIIPALVSKGFKPDILLNCAGIQRRHPSEKFPDEDWDEVL
                     EVNLSQVFILCR"
     CDS_motif       49..126
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PMG11_03952_0001"
                     /evalue="2.10E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="PMG11_03952"
                     /protein_end="42"
                     /protein_start="16"
                     /score="23.6"
                     /tool="antismash"
                     /translation="VVTGGTRGIGQAMAVALAEAGADIIL"
     3'UTR           921..1153
                     /locus_tag="PMG11_03952"
     5'UTR           1562..3155
                     /locus_tag="PMG11_03953"
     gene            1562..5178
                     /locus_tag="PMG11_03953"
     mRNA            1562..5178
                     /inference="profile:GO:0006950"
                     /inference="profile:GO:0009628"
                     /inference="profile:GO:0016020"
                     /inference="profile:GO:0016491"
                     /inference="profile:GO:0043231"
                     /inference="profile:GO:0044237"
                     /inference="profile:GO:0044444"
                     /inference="protein motif:InterPro:IPR013112"
                     /inference="protein motif:InterPro:IPR013121"
                     /inference="protein motif:InterPro:IPR013130"
                     /locus_tag="PMG11_03953"
                     /note="Transmembrane protein (predicted by TMHMM Phobius),
                     Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="hypothetical protein"
     CDS             3156..5027
                     /codon_start=1
                     /locus_tag="PMG11_03953"
                     /product="hypothetical protein"
                     /protein_id="CEO59271.1"
                     /transl_table=11
                     /translation="MATPGPQLAARDYGSNETYVYEYSRGLGGVDVPRDVIITRIIYSS
                     VIILAFGVFCGRIALISHAYLRQITSSTANGRQQTYWRRETSSWWSSLKKHILYSPLGK
                     KRHNREIQLSSAVGIGTLPSRFQTILITFYFASQVVYCLYLDYAVNNKAALIAELRGRS
                     GTLAVLNMVPLFLLAARNNPLISILHISFDTYNLLHRWLGRMIVLESVVHTVAWAVNAV
                     DEQGMGDMLSRLRDTPFFTWGLVGTVAMVFLGLHSPSPIRHAFYETFLHLHQLAALLAF
                     LGVWFHLQLDSLPQRSWASGIAVIWIVERSTRLIRLAYLNLSTKHGSTHMTVQALPGEA
                     CRVTFHLPKSVRIDPGCHVFAYIPCVSWWMSHPFSIAWAEASSPNPQSPRYHDSKSPDS
                     LPSPSALEKQSQELDSYFEPTHRPTQVSLIVSARQGMTRRLYNLARSKPDQILRAPGFI
                     EGPYGSHPANASSYGTAVLFSAGAGITHHLMYTRDLVERAATARAATRRVYLIWSVRST
                     DHLTWVSSWMDQILRLPGRRDILIVKVFVSKPRRAADIVSPSATVQMHSGRCRPDVILN
                     ELMPKSVGATFVSVCGPGAFADEVRAAARGRIGKGAVVDFVEEAFTW"
     3'UTR           5028..5178
                     /locus_tag="PMG11_03953"
     3'UTR           complement(6145..6204)
                     /locus_tag="PMG11_03954"
     gene            complement(6145..9303)
                     /locus_tag="PMG11_03954"
     mRNA            complement(6145..9303)
                     /inference="profile:GO:0009058"
                     /inference="profile:GO:0009987"
                     /inference="profile:GO:0016853"
                     /inference="protein motif:InterPro:IPR000873"
                     /inference="protein motif:InterPro:IPR009081"
                     /inference="protein motif:InterPro:IPR010080"
                     /inference="protein motif:InterPro:IPR013120"
                     /inference="protein motif:InterPro:IPR016040"
                     /inference="protein motif:InterPro:IPR020806"
                     /locus_tag="PMG11_03954"
                     /note="Transmembrane protein (predicted by Phobius), Part
                     of predicted secondary metabolite gene cluster cluster12"
                     /product="hypothetical protein"
     CDS             complement(6205..9303)
                     /NRPS_PKS="Domain: AMP-binding (26-430). E-value: 6.3e-76.
                     Score: 247.4. Matches aSDomain:
                     nrpspksdomains_PMG11_03954_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (550-620). E-value: 2.4e-16. Score:
                     51.6. Matches aSDomain: nrpspksdomains_PMG11_03954_PCP.1"
                     /NRPS_PKS="Domain: TD (662-908). E-value: 2.1e-66. Score:
                     215.4. Matches aSDomain: nrpspksdomains_PMG11_03954_TD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     248.2; E-value: 2.1e-75)"
                     /gene_kind="biosynthetic"
                     /locus_tag="PMG11_03954"
                     /product="hypothetical protein"
                     /protein_id="CEO59272.1"
                     /sec_met_domain="AMP-binding (E-value: 9.8e-78, bitscore:
                     251.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.4e-15, bitscore:
                     46.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.3e-56, bitscore:
                     181.1, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSITPSFSDYDEAVSHDQGLGQIFYQRMRENPSAVAIVDEQSQS
                     LTYEELHFKAIELARTLTQGTFDSQERVGIIVQHGLLDAVTQVAIIYAGGTCVPLDPLL
                     PDQQIIDRLKRLGAQRVLVDEANSKRSLPFKLLTVGDLFCQRSRTTGAESSKLPVSTTL
                     THCTHLIHTSGTTSEPKAVQIVARSIVHVAHHAPYEAVHKSDVVGHGNSTSFDVALFDI
                     WGALSRGATIGVLNKATLLDIPALGAAIRRLGITIMAITAPLVNLAATTHPDTFQPLRC
                     VLMGGEAVNLCAMKAILTAGPPKHLINAYGPTECCVYCLTHEITMDDVKAGHVSIGSPV
                     GRNACCVCDEEGCPVAVGEEGELLVGGPGVSPGYVNQAEKNEKTFIYVAGMVDPHTGEP
                     FRMYRTGDIVRLSPDGKHDFLGRRDHQVKVRGYRVELPAVDSALMKTGHFSEGLAMRID
                     SKEEGAGAALVAFVVLQDKAKVNAVDEAMEAMRASLPEYMVPHIEVIPEIPLNAHAKVD
                     RRRLEEMYHQRREKHLCPLYGDLSVKPDSVSTQEHLARLWATILATPAPDYSDDDDFFA
                     LGGTSLQASLLITRIRQQLCTEISLLTLYDHSTLSRLASIIDQNRGTSTQTVRRECDLW
                     VADTKLGDDLELPWGPVVDWRRDTEGRVFLTGATGFVGAFLLAALLALPDVRQVGCLVR
                     ATSAATGLERLRGTLAKYNLWQDTFLPKLLPFPGSLEDSWLGMDGERFHEIAHWASVVF
                     HLGARVNYTQPYSMHRPANVIGTMNIARFAVTGRVKGLHYCSSISCFGPTGFMTGAQTV
                     YEDAPLSAHLDALPYDHGYAQSQWAADELLQRLVKRGFPIAVYRPGFITGDRKTGACNP
                     DDFFSRLIRASVDLRCYPDLPNQRKEFVPVDYVVDAMLHISSSVFSLGHSFHLLPKRAV
                     SVDMTECMELVARASGVVIECVSYEEWIERLSVSSHASLQPLLPMLAEKVHNGLSRWEL
                     YENMPTYDDTNTRRALATYPGGLICPLFDSELMKKYVRYLINI"
     aSDomain        complement(6580..7317)
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PMG11_03954_TD.1"
                     /evalue="2.10E-66"
                     /label="PMG11_03954_TD.1"
                     /locus_tag="PMG11_03954"
                     /protein_end="908"
                     /protein_start="662"
                     /score="215.4"
                     /tool="antismash"
                     /translation="VFLTGATGFVGAFLLAALLALPDVRQVGCLVRATSAATGLERLRG
                     TLAKYNLWQDTFLPKLLPFPGSLEDSWLGMDGERFHEIAHWASVVFHLGARVNYTQPYS
                     MHRPANVIGTMNIARFAVTGRVKGLHYCSSISCFGPTGFMTGAQTVYEDAPLSAHLDAL
                     PYDHGYAQSQWAADELLQRLVKRGFPIAVYRPGFITGDRKTGACNPDDFFSRLIRASVD
                     LRCYPDLPNQRKEFVPVDYVVDAM"
     aSModule        complement(6580..9225)
                     /complete
                     /domains="nrpspksdomains_PMG11_03954_AMP-binding.1"
                     /domains="nrpspksdomains_PMG11_03954_PCP.1"
                     /domains="nrpspksdomains_PMG11_03954_TD.1"
                     /final_module
                     /locus_tags="PMG11_03954"
                     /monomer_pairings="Phe -> Phe"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     aSDomain        complement(7444..7653)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PMG11_03954_PCP.1"
                     /evalue="2.40E-16"
                     /label="PMG11_03954_PCP.1"
                     /locus_tag="PMG11_03954"
                     /protein_end="620"
                     /protein_start="550"
                     /score="51.6"
                     /tool="antismash"
                     /translation="EHLARLWATILATPAPDYSDDDDFFALGGTSLQASLLITRIRQQL
                     CTEISLLTLYDHSTLSRLASIIDQN"
     CDS_motif       complement(7993..8049)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PMG11_03954_0004"
                     /evalue="2.60E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="PMG11_03954"
                     /protein_end="437"
                     /protein_start="418"
                     /score="29.3"
                     /tool="antismash"
                     /translation="FLGRRDHQVKVRGYRVELP"
     aSDomain        complement(8014..9225)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PMG11_03954_AMP-binding.1"
                     /evalue="6.30E-76"
                     /label="PMG11_03954_AMP-binding.1"
                     /locus_tag="PMG11_03954"
                     /protein_end="430"
                     /protein_start="26"
                     /score="247.4"
                     /specificity="substrate consensus: Phe"
                     /tool="antismash"
                     /translation="QRMRENPSAVAIVDEQSQSLTYEELHFKAIELARTLTQGTFDSQE
                     RVGIIVQHGLLDAVTQVAIIYAGGTCVPLDPLLPDQQIIDRLKRLGAQRVLVDEANSKR
                     SLPFKLLTVGDLFCQRSRTTGAESSKLPVSTTLTHCTHLIHTSGTTSEPKAVQIVARSI
                     VHVAHHAPYEAVHKSDVVGHGNSTSFDVALFDIWGALSRGATIGVLNKATLLDIPALGA
                     AIRRLGITIMAITAPLVNLAATTHPDTFQPLRCVLMGGEAVNLCAMKAILTAGPPKHLI
                     NAYGPTECCVYCLTHEITMDDVKAGHVSIGSPVGRNACCVCDEEGCPVAVGEEGELLVG
                     GPGVSPGYVNQAEKNEKTFIYVAGMVDPHTGEPFRMYRTGDIVRLSPDGKHDFLGRRDH
                     QVKVR"
     CDS_motif       complement(8149..8235)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PMG11_03954_0003"
                     /evalue="1.20E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="PMG11_03954"
                     /protein_end="385"
                     /protein_start="356"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VGEEGELLVGGPGVSPGYVNQAEKNEKTF"
     CDS_motif       complement(8752..8799)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PMG11_03954_0002"
                     /evalue="1.20E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="PMG11_03954"
                     /protein_end="184"
                     /protein_start="168"
                     /score="12.0"
                     /tool="antismash"
                     /translation="LIHTSGTTSEPKAVQI"
     CDS_motif       complement(9001..9039)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PMG11_03954_0001"
                     /evalue="5.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="PMG11_03954"
                     /protein_end="101"
                     /protein_start="88"
                     /score="10.4"
                     /tool="antismash"
                     /translation="AIIYAGGTCVPLD"
     gene            10273..11389
                     /locus_tag="PMG11_03955"
     mRNA            join(10273..10527,10584..10734,10794..11389)
                     /inference="profile:GO:0000166"
                     /inference="profile:GO:0005730"
                     /inference="profile:GO:0005737"
                     /inference="profile:GO:0008152"
                     /inference="profile:GO:0050662"
                     /inference="protein motif:InterPro:IPR008030"
                     /inference="protein motif:InterPro:IPR016040"
                     /locus_tag="PMG11_03955"
                     /note="Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="hypothetical protein"
     CDS             join(10273..10527,10584..10734,10794..11389)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 92.2; E-value: 6.6e-28)"
                     /gene_kind="other"
                     /locus_tag="PMG11_03955"
                     /product="hypothetical protein"
                     /protein_id="CEO59273.1"
                     /transl_table=11
                     /translation="MTVSIPLITVFGATGNQGGAVAKSLLQNPSFKVRALTRNPNSAAS
                     QSLLAQGAEIHQANGFSSESMLEAFSGTWGVFVNINSDDKEFKPDGPTEFDMGKTIVDA
                     AVQAGVRHFIFSSGPDCHTLTKGKVKMNAADMKFKIEQYARNIGKFETVSFICAAWFFE
                     NFLSKDIAPIFGGFPYIPDAEGYLTFIAPKWGGKEEVPFISMTDDFGDIVQGMFIDPVR
                     WRDQIVHGCSDICSFEDLVSSFEKLSGRKSRFQPLPSWEDFNTYGIPELDDTKAMFGFT
                     QNNQGRYFGPEPSEKETAGTLKQITAAALGRPKEEQNLTSVEDWFRKHFHFQ"
     gene            11943..13756
                     /locus_tag="PMG11_03956"
     mRNA            join(11943..12064,12128..12289,12351..12689,12754..12940,
                     13004..13026,13080..13208,13263..13680,13745..13756)
                     /inference="profile:GO:0004497"
                     /inference="profile:GO:0006725"
                     /inference="profile:GO:0044248"
                     /inference="protein motif:InterPro:IPR002938"
                     /inference="protein motif:InterPro:IPR003042"
                     /inference="protein motif:InterPro:IPR012336"
                     /inference="protein motif:InterPro:IPR012941"
                     /locus_tag="PMG11_03956"
                     /note="Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="Putative FAD binding domain protein"
     CDS             join(11943..12064,12128..12289,12351..12689,12754..12940,
                     13004..13026,13080..13208,13263..13680,13745..13756)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 225.2; E-value:
                     2.9e-68)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PMG11_03956"
                     /product="Putative FAD binding domain protein"
                     /protein_id="CEO59274.1"
                     /transl_table=11
                     /translation="MRSALTFMLRLAAALYLAQLGIPFRIIDKRSDEPRIGQADGLNPK
                     TMEIFESWGIHNQITQLWEPATHETIWYRGLDGELVRTDRYLNQPPMGVRWTHGTLQQG
                     TVEEIMKKKIYEIADMTVGYHTTLCELNIDITQLTAPGAFPCTTQVQQMKKGSIVTEII
                     TAKYVIGADGGKSLTRTLLDIGMNGEKGASVWGVMDFAGSSDFPDFGATSIIRSATDGS
                     LDFVRREEGLIRMYVELNKGPEGKHICRENITPEAIVQKCQYMIRPYRLDVRRWVWWSA
                     FTATQKLSTALSKFNRVFLVGDAVHTHSPVTGMGMNTSIQDSYNLAWKLAGVIKGQLNP
                     KILATYDTERGIVAKQLLQADRTTLELFDTKFGHETPSLLERAETLRVFLAGRAIRYAD
                     ALLTSPSAQGIGSFQPGECLPDFSITNHATGRSVHIHNALKSNETWNMIVFAGDVSSVT
                     QMTLL"
     gene            14323..15543
                     /locus_tag="PMG11_03957"
     mRNA            join(14323..14405,14459..14584,14640..14762,14820..15543)
                     /inference="profile:GO:0016491"
                     /inference="protein motif:InterPro:IPR002227"
                     /inference="protein motif:InterPro:IPR008922"
                     /locus_tag="PMG11_03957"
                     /note="Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="Putative Tyrosinase central domain protein"
     CDS             join(14323..14405,14459..14584,14640..14762,14820..15543)
                     /codon_start=1
                     /locus_tag="PMG11_03957"
                     /product="Putative Tyrosinase central domain protein"
                     /protein_id="CEO59275.1"
                     /transl_table=11
                     /translation="MLQVWLLLLAVVSAQRCDPNNRAIRREWGSFSRQERLDYIDAVHC
                     LREKPPILPTEQYPGVRHRMDDFAATHINYTLNIHLSGIFFGWHRRFVWLWEKALREEC
                     GYPGYQPYWNWAISANNLSASPLFDGSDTSLSGNGDPAEDQNDTMTLAPTNVTIPTGSG
                     GGCVTNGPFANITLNLPDLDSAPGDVFPENAFAYTPRCLTRNLNNFIAQSFTSQADVDR
                     LLSTPDIVDLQHNMDVSVWPELSEAGIMGPHAAAHMQLGRAMDDFWTAPQEPAFMLHHA
                     MVDRVWTLWQAHDPANRQYALNGTSVMGNPASAPEVDLDTQVTWGPLGQNKTLRDVMST
                     EAYEFCYEYGD"
     gene            16956..18026
                     /locus_tag="PMG11_03958"
     mRNA            16956..18026
                     /inference="protein motif:InterPro:IPR003480"
                     /inference="protein motif:InterPro:IPR023213"
                     /locus_tag="PMG11_03958"
                     /note="Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="hypothetical protein"
     CDS             16956..18026
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transferase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PMG11_03958"
                     /product="hypothetical protein"
                     /protein_id="CEO59276.1"
                     /sec_met_domain="Transferase (E-value: 8.9e-23, bitscore:
                     70.2, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPVHIAASPTDHPVMRSQINVLDDGIIVALFFNHMVIDGTGIGA
                     LLESLAACCNGATFIPCNIECEQNTRENLLVTLERNKMPGHPEIRSPPILEVPTGTGHE
                     EVHDSLLLDYKFFISGTKIKLLREHIQNLGSGFVSEDDILTAILWTCLGRSRPHRLSQR
                     GLPASVCKLQRVVNVRHKLRPHVSPYYVGNCFIMLNEALTTVELGQEASDSETGEQAFA
                     RQIAPVARLLRSRLDKVDDLFIRDYFSHYETASDWANTSVHEPDVAVTSIRRLNIYGEY
                     FGPILGKVEDFEMLPYMNPEGVCTIMPHRRAGDDAWEVGVTLGREDMERLRKNVKWRWL
                     VDRESPLQVFEGHHVV"
     gene            18450..19732
                     /locus_tag="PMG11_03959"
     mRNA            join(18450..18495,18549..19732)
                     /inference="protein motif:InterPro:IPR006593"
                     /inference="protein motif:InterPro:IPR008960"
                     /inference="protein motif:InterPro:IPR015920"
                     /locus_tag="PMG11_03959"
                     /note="Transmembrane protein (predicted by TMHMM Phobius),
                     Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="hypothetical protein"
     CDS             join(18450..18495,18549..19732)
                     /codon_start=1
                     /locus_tag="PMG11_03959"
                     /product="hypothetical protein"
                     /protein_id="CEO59277.1"
                     /transl_table=11
                     /translation="MKQYSWIGLTVAASLFIGIEGQPARFHPSGRNDISFTIATSETSN
                     DPPRGDLLLQIQAPDSIQWIGIGSGNQMAGANIFVVYASSATNVVVSPREGTGHVPPLH
                     NAENHITVLPGTGIANGTITARFKWKNFLDAHWVASNATDSASSWIWAYKNGPPLLSEK
                     VSAPIEYHDAFGRELVDLRRAQSTSNFNIEDGVFTDSSSPEIQNLPYMATAHGYMMALA
                     FVLLFPTFALLVPLSSFITIPVISVHAPLQGLALATAIAGAGLGLKMWIGGNSQPAAHP
                     IIGIIVVATLTFIQPALGWAHHLRFKRNGEKSYFSFGHRWLGRSMLALGVINGGLGFWW
                     EGPVTGSLKTGMVIYAAIAGVVCVVYLILHLFIRAKFASRREHVQCIRLEDASAPSSKR
                     ADSWQVVHGQ"
     CDS             complement(join(20119..20303,20366..20496,20566..20749,
                     20818..21013))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PMG11_03960"
                     /product="hypothetical protein"
                     /protein_id="CEO59278.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 6e-27, bitscore:
                     83.9, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPFTKEQITMTGEYCRKKSSTLPVSILEQIKFTDQLHKDEVVMA
                     PSESQCSWLLSFTRALRPKRILELGTFTGVSALVFYEATKEGTAEIVSMDMSEKYLEFA
                     QDAFRRYGADERIKTVQGPCLDMLPTLTGQFDLVYIDAAEEEYESYTRYILDHKLLSPN
                     GVILVDDVLLEGLVVDSSIARNFPEEIQEPYLAIADKMNAFNRYAAKDPRVTTTMIPLF
                     NGVTQIMWK"
     gene            complement(20119..21023)
                     /locus_tag="PMG11_03960"
     mRNA            complement(join(20119..20303,20366..20496,20566..20749,
                     20818..21023))
                     /inference="profile:GO:0008168"
                     /inference="profile:GO:0009699"
                     /inference="profile:GO:0050896"
                     /inference="protein motif:InterPro:IPR002935"
                     /locus_tag="PMG11_03960"
                     /note="Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="hypothetical protein"
     5'UTR           complement(21014..21023)
                     /locus_tag="PMG11_03960"
     gene            21539..23563
                     /locus_tag="PMG11_03961"
     mRNA            join(21539..21794,21854..21917,21975..22236,22287..22401,
                     22464..22558,22610..22939,22998..23108,23175..23335,
                     23389..23563)
                     /inference="profile:GO:0004497"
                     /inference="profile:GO:0016020"
                     /inference="profile:GO:0016705"
                     /inference="profile:GO:0030282"
                     /inference="profile:GO:0033280"
                     /inference="profile:GO:0034097"
                     /inference="profile:GO:0042359"
                     /inference="profile:GO:0043231"
                     /inference="profile:GO:0044249"
                     /inference="profile:GO:0044444"
                     /inference="profile:GO:0048522"
                     /inference="profile:GO:0048523"
                     /inference="profile:GO:0051341"
                     /inference="profile:GO:0051704"
                     /inference="profile:GO:0070887"
                     /inference="profile:GO:2000026"
                     /inference="protein motif:InterPro:IPR001128"
                     /inference="protein motif:InterPro:IPR002401"
                     /locus_tag="PMG11_03961"
                     /note="Transmembrane protein (predicted by TMHMM Phobius),
                     Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="Putative Benzoate 4-monooxygenase cytochrome
                     P450"
     CDS             join(21539..21794,21854..21917,21975..22236,22287..22401,
                     22464..22558,22610..22939,22998..23108,23175..23335,
                     23389..23563)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 246.3; E-value: 1e-74)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PMG11_03961"
                     /product="Putative Benzoate 4-monooxygenase cytochrome
                     P450"
                     /protein_id="CEO59279.1"
                     /sec_met_domain="p450 (E-value: 2.8e-55, bitscore: 177.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVAISEATSWLGRCWSSFGIGRLLLWSLSILIAHRLIHRLFFH
                     PLRHIPGPWSATLSGWYEFYTNVWQDGQWCKTYPDLHRKYKSPVVRIGPDHVHIKDIEA
                     YEKIFRNGTNYHKDHTFYTCADNDGSIFSLSDCHEHRVRRKALSPRFSKQAAEADAPGI
                     LRQLRRMENFMVKQSALDKTYNINDLFRALEINVVGKTLLGDCGDLVEYQETKPELLET
                     VDGLSAMIPLLRFFPYMAAVNQIIPSVLADKLMPAGVLNFKKTCEDYTKPRMIKSIRTD
                     LDRTRASVIELLVAHSYDVTGNPPNIDYLAAEAFTFIDAGVDTAGRTLAAAVYYVLRNQ
                     EIEKKLVDELNDAKLWCNGTNEADVRTLGRLPYLNAIIKEAHRIWPALPGPLPRVVPSE
                     GLRIGRYFIPAGTIVSATHHSLHFDETIFPEPNNFKPERWLREDRTDLDRYLNPYSRGS
                     RACIGINLAQIKLQLGLADLFYRLDMELCEPIPTALGWKDHFVAEPTSAIYLRARFRKG
                     ISCSE"
     gene            complement(24757..26178)
                     /locus_tag="PMG11_03962"
     mRNA            complement(24757..26178)
                     /inference="protein motif:InterPro:IPR003480"
                     /inference="protein motif:InterPro:IPR023213"
                     /locus_tag="PMG11_03962"
                     /note="Part of predicted secondary metabolite gene cluster
                     cluster12"
                     /product="hypothetical protein"
     CDS             complement(24757..26178)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transferase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PMG11_03962"
                     /product="hypothetical protein"
                     /protein_id="CEO59280.1"
                     /sec_met_domain="Transferase (E-value: 7.2e-16, bitscore:
                     47.4, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTFEAYQLTCFDHLFSLFYGGCALSFHISCPEEAVPILCGGLER
                     LVSHLPFLAGKVSQSGKIAGVHPIPTTTSGSSPPIAVVRHFPKLRLLCKPGSRSQLCRD
                     YIRDESLILAPYELCSLAGTPVARFQINVLADGIILVPWVNHMAIDGIGVDNMTRALSI
                     CCQADNNPLKARQLPTDPSVEADTRAVLANFARSQTNTITNSGTETDGPPTLGEGENNV
                     SSLVDYNFCFAASKVQRLRNCVRSLWPENKDSDQPIPRISCDDIVTVFIWIALTSLRQD
                     GMSINHGTMKSTLTRAVDIRNRFSNPIPSTYFGNCVVLLKESLPLEVPQWRNTLPGDDD
                     QKSCSTLAPVLHRAADVLRSRLQSLDDQYIREIFSSPHLPDADPGPNVFVSSLRHLSSY
                     KHDFGPVLGQANGFHLLPYMRPDGVCTIMPKRPDQDDWEIMVTLNPKDMELLRQDSWFQ
                     WMSQTTTPITLFESL"
     5'UTR           26934..26969
                     /locus_tag="PMG11_03963"
     CDS             join(26970..27144,27207..27406,27463..27536,27607..27755,
                     27811..27922,27988..28109,28173..28251,28322..28348,
                     28406..28520)
                     /NRPS_PKS="Domain: TauD (29-324). E-value: 1.5e-37. Score:
                     121.6. Matches aSDomain: nrpspksdomains_PMG11_03963_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121:dioxygenase, TauD/TfdA (Score: 165.8; E-value:
                     2e-50)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="PMG11_03963"
                     /product="Putative Taurine catabolism dioxygenase TauD,
                     TfdA family protein"
                     /protein_id="CEO59281.1"
                     /sec_met_domain="TauD (E-value: 3.2e-38, bitscore: 121.6,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTAGEPAPCHPLPHRKSGALDNFKYIETSPALGREYPGLQLSSI
                     IDDEEIVRDLAITASERGVLFFDHQDIAPSELKRLILKIGELMGNPKEAGLHRHAFSIK
                     GNEELNIPEVDDPDILILSSAVQNTNFNVALPVGSRKFASWGWHSDESHEKYPPAYTGF
                     KIAKSPPTGGDTLFVSSYGLYEYLSNPWQKFAESLTATHHAAEYLRHKDVGFKFHDNVK
                     RGHPENVDLDFKASHPVVRTNPVTGWKGLYGVGWGLIDGSFDNMTEDESNLLKQYFLRV
                     ITDNSNLQIRKRWGDDGVAIWDNRAVHHNPTYDVVDGERTTFRVAGVGEKPYFDPNSTS
                     RTEFLRKQRA"
     aSDomain        join(27057..27144,27207..27406,27463..27536,27607..27755,
                     27811..27922,27988..28109,28173..28251,28322..28348,
                     28406..28439)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PMG11_03963_TauD.1"
                     /evalue="1.50E-37"
                     /label="PMG11_03963_TauD.1"
                     /locus_tag="PMG11_03963"
                     /protein_end="324"
                     /protein_start="29"
                     /score="121.6"
                     /tool="antismash"
                     /translation="SPALGREYPGLQLSSIIDDEEIVRDLAITASERGVLFFDHQDIAP
                     SELKRLILKIGELMGNPKEAGLHRHAFSIKGNEELNIPEVDDPDILILSSAVQNTNFNV
                     ALPVGSRKFASWGWHSDESHEKYPPAYTGFKIAKSPPTGGDTLFVSSYGLYEYLSNPWQ
                     KFAESLTATHHAAEYLRHKDVGFKFHDNVKRGHPENVDLDFKASHPVVRTNPVTGWKGL
                     YGVGWGLIDGSFDNMTEDESNLLKQYFLRVITDNSNLQIRKRWGDDGVAIWDNRAVHHN
                     PTYDVVDGERTTFR"
ORIGIN
        1 atggcagcta cagtacagtc tctcttttcc ctgagtggcc gcaccgccgt cgtcaccggt
       61 ggcacgcgag gcattggcca ggccatggcc gtggctctgg ccgaggccgg cgccgatatc
      121 attctgatcc agcgcgacga gtccaacact gccaccaagg acgacatcat taatcgcctc
      181 ggtcgtaagg cgcatattca cgttgccgag ctatcaaacc gcaaggccgt caaggagatc
      241 attcctgccc ttgtgagcaa aggcttcaag cccgacatcc tgttgaactg cgctggcatt
      301 caacggcggc acccgagcga aaagttcccc gatgaggact gggacgaggt gagtgctgca
      361 ttcttttatt tcccccaaaa aatcaaatga cctttctata cttccaagct tctacaagct
      421 aggatccctt aattctatat gaaacacaag ctaatcatcc caatgaacag gtcctcgaag
      481 tcaacctctc tcaagtcttc atcctatgcc gcgagttcgg cgcctacctg ctagcccgtg
      541 acgcttccga gttcccatcc ggccgccggg gctccatcat caacgtggct tcgctcttga
      601 ccttccaggg tggtatcacc gtgcccgcct acgccgcatc caagggcggc gtgggccaac
      661 tcaccaaggc tctgtccaac gagtgggtag ccaagggaat caatgtcaat gctattgccc
      721 ctgggtacat tgccacggat atgaacaccg cattgatcaa tgacgagaac cggaatgccg
      781 gtattatggc gcggattcca gccggtcggt ggggtcaacc ggaggacttt aagggcgtgg
      841 tggtcttctt ggctagtggc gccagtagct atgtctctgg cgagattatt actgtggatg
      901 gcggatggat gggtcggtga agagggggtg gggtgatgtg aaataatttg acgggcctgg
      961 aagtaccgag ggagacagaa gcagagtggc ttgggattgt attgtacttt ggatattttc
     1021 tggcattttg ggcggttttg tatatagaga tggctgcatc ggaggttttt ggatatcatg
     1081 ctccgtatct gaattatcct tggcatttga attttgatct gggttggtaa gagattatgc
     1141 atgaacgcac gagtcgtaca tagttcattc gacatgtcat gtgtcgacga atatctccac
     1201 tttcgtcatg cgagctccct tgtagtagat gggagattgg tggaaaatcc aacaaggatg
     1261 aaaccgctgt gaacatctcg gttaggtatg ctactccgta ccatgaagag ctagtgtgtg
     1321 ctagtgatcc tcgctagtca gcagcatgga tgaagcaccc cgtgtgtatt ttgagctccg
     1381 gcaaggttgt gaaccgggcc ctgacagctg gtggggcact gtcattcagg caccgcggca
     1441 catagttgaa tgcccgctga accaggcaca actatcctgc ctgaggttgg agatccgaga
     1501 tcccgccttc tgttctgctc ggtcttactt tcaagtcact tccttcttga ccatccttct
     1561 tctttggcct tttttttgct cttttctcat tctgatcatg ccacagtttt acaaagaaaa
     1621 aaaaaaaaac cagaatcata ccattgcatc ggacatgcga tcctcttatc ggtccgggtg
     1681 cgccacaagg gggtcaatag tcagagcctt tcttgtccgt ggtttctaat taacagcagc
     1741 tttgaaaccg cccacaatgc cactgtttga ggcactgttg gcccgagctc caccataggc
     1801 agcgcgagaa gaactaatag aactccagtc ctgattcatc gattctcatc cagacaaaga
     1861 gctcacgctg gagaaatggt atgcagcaag ttgggcgcca cctttgcgaa tgacggtgcg
     1921 agcttgcaag ggtcagggcg ttacgccggt cgcaagatct gcaaggacca aagctggtcc
     1981 agcggagttc acctactccc tgaagcgcag cgaatcatca tgccgggttc tgtggtgcct
     2041 gcatctctta gaaacactgg ctggcccctg gtcatcagag gagtcctccc gataggccga
     2101 gatggtttag acccgcctgc caaccagcat gcagagatgt cctgacaaga cacgactgct
     2161 aggtcggacg tcgactgcga tgcaccactc gatggcctat taattacttt taataataaa
     2221 cgcttcccct ttcccctgcc atgacaggag ttcttgttct tggggaacat ccgttcgtct
     2281 gggttttttt cctttccgtt catttcttgg tcgatcggcg ggctttctcg aatcaccttg
     2341 cgtttgcctc atagaataga ccgtttcggc tctgcgttga ccgtagacct acttactttc
     2401 gctttgacat tttcttctct ccatcttgtc tctttgccct ttcacttacc ttgtttgcct
     2461 cttgtttgga cttgcctcac ccactgacgt ggaaaacgtg ctgaccagtc ggccggatcg
     2521 acctcccttg cctacattcc cgaagtcctg gacgatgcca ttgctcctca gcaagcaacg
     2581 gaaaatctaa gccttgccga tctgcttatt gaattcagat tccaccgatc atccgttgac
     2641 tgcccttccc gtctctcact cttgactggt tcactgccta cacgcctgcc tagcagcgtc
     2701 attgtcattc acatccaacc ttcctattga catcggcaca agagcagcaa caaggcttcc
     2761 tttgacggtg tgaatgccat tgcgcccgat tctacccccg atcatctcgc agatccctgt
     2821 gccattctac accccgttgg atcgtccttt gacttcctgg ctctgatttc atttcatcct
     2881 tcaacgtcac cacactcgat catcgcattc tctgtcgact ccccgcaacc accctcgacg
     2941 cttgatcgac cttcccagat cttgaaattt ggctcaagat ctccccggta gaacgtcgtt
     3001 catcttgcga gaatttcggt ccgtggcctg cacgtcactc caccacggct cgccaccata
     3061 agatcctccg tcacctcgat caaatcccct gccaaccaca tctgcaacaa ggataagcca
     3121 tacagccctg aacaggtgtc cccggggaca gttcaatggc gacgcctggc ccgcaacttg
     3181 cggcacgaga ctacggatct aacgagacat acgtctacga gtactcgaga ggactgggtg
     3241 gtgtcgacgt cccgcgcgat gttatcatca cccgcatcat ctactcttcg gtgatcattc
     3301 ttgccttcgg tgtgttctgt ggccgtatcg cactgatcag tcatgcatat ctccgccaaa
     3361 tcacctcatc tacggcaaac gggcggcagc agacctactg gcgccgggag acatcatcgt
     3421 ggtggtccag cctgaagaag catatattgt attctccact ggggaagaag aggcataatc
     3481 gagaaattca gctctcctcg gctgttggta tcggcacgtt gccctctcgt ttccagacca
     3541 tcttgatcac attctacttt gcaagtcaag tggtgtactg tctttatcta gactatgctg
     3601 tcaacaataa agctgcgctg attgcagaac tgcgcgggcg ctcagggacg ctggccgtct
     3661 tgaatatggt gccactgttt ctgctggcag cgcgcaataa ccctctgatc tcgatcctgc
     3721 atatcagttt tgatacttac aaccttctcc accggtggct gggccgcatg atcgtgctag
     3781 agtctgtcgt tcatactgtc gcctgggccg tcaatgcagt tgatgagcaa ggcatgggag
     3841 acatgctgtc gcggttgcga gacacgccct tcttcacctg ggggttggtc ggtacggtgg
     3901 ccatggtttt cctcggtctg cactcgccct cgccaatccg gcatgcattc tacgagacat
     3961 tccttcatct gcatcaactc gccgcgcttc tcgccttcct tggcgtatgg ttccaccttc
     4021 agctggacag cctcccacag cgcagctggg ccagcggtat tgccgtgatt tggattgtcg
     4081 agcgtagcac acgcctcatc cgcctcgcat atctcaacct ctccaccaag cacggctcca
     4141 cccatatgac cgtccaagcc ctgccaggag aagcatgccg ggtaaccttc cacttgccca
     4201 aaagtgtacg catcgatccc ggctgccacg tctttgccta catcccctgc gtctcatggt
     4261 ggatgtccca cccattctcc atcgcttggg ccgaagccag cagtccaaac ccgcagtcac
     4321 cgcgctatca tgactccaaa tcccccgact cactccccag tccatctgct ctagagaagc
     4381 aatcccaaga gctggatagc tacttcgagc ccacccaccg ccccacgcag gtttccctca
     4441 tcgttagcgc tcgccagggc atgacccgcc gtctgtacaa cctcgcccgc agcaaaccag
     4501 atcagatcct ccgcgcaccg ggcttcatcg aaggtcccta tggctcccac cctgccaatg
     4561 cctccagcta tggcactgcg gtactgttct ccgccggcgc gggtataacc caccacctca
     4621 tgtacactcg ggacctcgtc gaacgagccg cgacagcccg cgccgcaacc cgtcgcgtct
     4681 acctcatctg gtccgtccgt tcaacagatc acctcacctg ggtgagctca tggatggacc
     4741 aaatccttcg actcccgggt cgccgcgata ttctcatcgt caaggtgttc gtttctaagc
     4801 cccggcgcgc ggcggatatc gtatccccat ccgcgacggt ccagatgcac tctggtcggt
     4861 gtaggccaga tgttatcctt aatgagctta tgccgaaaag tgtgggtgcg accttcgttt
     4921 ctgtctgtgg gcctggtgcg tttgcggatg aagtgagagc tgcggcgagg ggaagaattg
     4981 ggaaaggcgc tgtggtggat tttgtggagg aggcttttac ttggtagata gaaatctttc
     5041 tgcctctgat tttatcttct tttgtgggag ttcttgctcg tttactagca tgtctttccg
     5101 gcgctgtgat tgcttttaat gtctatacta tcatctcgtc gactacagga atacttactt
     5161 actgcatcct tcttggatca cgtgcttcat agtaaaagta gatctgacaa gataacaaac
     5221 gatatacttc taaatcaggt tgatcaaatc tagacacaga gaaacatccg aaaaataaag
     5281 gaaatgaata tccatcacaa ccatacatcc catcctgata ctccacatga gtcataccta
     5341 gacattgtat ccctcacaag ccatcactat ggacagaccg aaagtgcggc accatgttgt
     5401 ccttccgact agaaaccctc tcgcaccctt cgtccagaca tggaatcgag tggggatcca
     5461 cgtgctgggt caccaggcga cgtttcagag ttgctttgag ggcgaatggg ccgggtttgt
     5521 tacatcgtga ccatttgcag attaaagtcg aaggacttga atcgggactg gatcttgaag
     5581 gaagagtcat gttattagaa tgattggagc tgggagagtc tggattacac cacaattcta
     5641 ggtgatggtg aaaagagcac gtgaccgcga ggagtcgata tacttacggg agtagcatat
     5701 actccaagaa gggccatcta ctccaggaag ggcttggtat ataaggacac tcatttcgca
     5761 ttctgtattt agttctttgc aatcaatctt taatgttact aggcacaatc agtgtacaca
     5821 tagtttacat ggttactacc tttagcactt tgcacttctg gcacgtcatg caagatactc
     5881 aactggacct gaacccacag taaggctttg catagcaacg gtacggttac gagatactct
     5941 tgcaatccgt ggtgggactt ggcaagtata accctgggaa gttctaactc tcagtgacca
     6001 gtcggctccg cgtaacaaag ggttgaacca actgcaggaa aaaggatcat ggttgaaaag
     6061 tccagaaaat tgaatatctg aggtcatatt gaaagggttg ttatatttaa aaacattatt
     6121 caattctaga tgatatggaa aagactccga attgggtaaa aggtcaagcg aaatatttgt
     6181 gtctatatga tgactccccc ttcctcagat attaatcaga tagcgtacgt actttttcat
     6241 cagttctgag tcaaaaagag gacatatcaa tccaccagga tacgttgcaa gcgcccgtct
     6301 tgtattcgtg tcatcataag tgggcatatt ctcgtacagc tcccaccgac tgagtccatt
     6361 gtgaaccttt tccgccagca tggggagcag aggctggaga ctggcatgcg agctgactga
     6421 aagacgctcg atccattcct cgtagctgac acattcaatc acaacgccgc tggcccgcgc
     6481 caccagctcc atgcactcgg tcatgtcaac agatactgcg cgtttgggta acaggtggaa
     6541 ggaatgacct aacgaaaaca cggaggagga gatatgcaac atcgcatcca ccacgtagtc
     6601 gacggggaca aattctttgc gctgattggg caggtcggga tagcaccgca ggtccacgct
     6661 ggcgcgaatt aatcgactga aaaagtcatc cgggttgcaa gctcccgttt tgcggtctcc
     6721 ggttatgaat ccaggccggt aaacagcgat ggggaaccct cgtttgacaa gccgctgtag
     6781 cagctcgtca gcggcccact ggctctgtgc ataaccgtga tcatatggaa gtgcgtccaa
     6841 gtgcgctgaa agcggggcgt cttcatagac agtttgggca ccggtcatga atcccgtggg
     6901 cccgaagcaa gagatgctag agcagtaatg aagtcccttg acacgacccg taacagcgaa
     6961 ccgagcgatg ttcatcgtgc cgatgacgtt agccggccgg tgcattgaat agggctgggt
     7021 gtaattgact ctggccccaa gatggaatac cacgcttgcc cagtgcgcaa tttcatgaaa
     7081 tcgctcccca tccattccga gccaggaatc ttctaacgag cctggaaacg ggagaagttt
     7141 tggaaggaag gtatcctgcc aaagattgta tttggccaat gtcccacgaa gtcgctccag
     7201 tcctgtagct gcggaggttg ctcggacaag acagccaacc tggcgtacgt ctggcaaagc
     7261 gagaagtgct gccaagagga acgcaccaac aaaaccggta gcccctgtta ggaacactct
     7321 accttctgta tcacggcgcc agtcgactac cggcccccac ggaagttcaa gatcatcccc
     7381 tagttttgtg tcggctaccc ataggtcaca ctcccgtcga acggtctgcg tggaagtacc
     7441 ccgattttgg tcaataatag aagcaagtcg actgagcgtg gaatgatcgt acagtgttaa
     7501 caaggagatc tcggtacaca actgctgtcg aatgcgagtg atgagcaacg aggcctgcag
     7561 ggatgttcca ccgagggcaa aaaagtcgtc atcatcggag tagtcggggg ccggagtggc
     7621 tagaatagta gcccagagcc gagcaaggtg ctcttgcgtg ctgacggagt caggtttcac
     7681 gctcaggtct ccgtagagag gacagaggtg tttctctcgg cgctgatggt acatctcctc
     7741 aagtcttctg cggtcgacct tggcgtgtgc attgaggggg atttctggta tcacttcgat
     7801 gtggggcacc atgtactctg ggagagaagc ccgcattgcc tccatggctt catcaacagc
     7861 gttgacctta gccttatcct gaagcaccac gaaagcgact agggctgcac cggctccttc
     7921 ttcctttgaa tctatgcgca tggcaaggcc ctcggaaaag tgacccgtct tcatcagcgc
     7981 cgagtcaaca gccggcagct cgactcggta cccacgtacc ttgacctggt gatcacgacg
     8041 cccgagaaag tcatgctttc cgtcaggact cagccgtact atatctccag tccggtacat
     8101 ccgaaagggc tcaccagtat gaggatcaac cattccagca acatatataa atgtcttttc
     8161 gtttttctcg gcctggttga cgtatcccgg tgagacacca ggaccgccaa cgagcagttc
     8221 gccctcctct cccacggcaa ccggacaacc ctcctcatca cagacgcagc acgcattgcg
     8281 cccgacgggg ctaccaatac ttacatgccc agctttgaca tcatccatgg tgatctcatg
     8341 tgtaagacag tagacgcaac actccgtggg tccataggca ttaatgagat gttttggtgg
     8401 gccagcagtt agaatcgcct tcatcgcgca gagattgacc gcttcaccac ccataagaac
     8461 gcatcggagc ggctggaatg tatcagggtg cgttgttgca gccaggttca ctagtggtgc
     8521 ggtgatagcc atgattgtga ttcccagacg gcggatggcg gctcccaagg ccggtatatc
     8581 gagcaatgtc gccttgttga ggacgccgat tgtggccccc cttgagagtg ctccccaaat
     8641 gtcgaacaag gctacgtcga aactggtgct gttgccatga cctaccacat cggatttgtg
     8701 gacggcttca tagggcgcat gatgcgctac atggactata gaacgcgcga caatctgtac
     8761 ggctttgggc tcgctggttg tgccagaggt gtggataagg tgcgtacagt gggtgagagt
     8821 tgtcgagact gggagcttgg aagattctgc tccggttgta cgagaccgtt ggcaaaatag
     8881 atctcccacg gtgagtagct taaaagggag actgcgtttg ctattggctt cgtcgaccag
     8941 gacgcgctga gcaccgagtc gtttcaagcg gtcgataatt tgctggtctg gcaagagagg
     9001 atccagaggg acgcaggtgc ctcccgcgta gatgatggcg acttgcgtga cagcgtctaa
     9061 gagcccgtgc tggacaatga tgccaacacg ttcttgagag tcgaaagttc cctgagtaag
     9121 agtccgagct aactcaatcg ccttgaaatg cagctcctca taagtgaggc tctgactctg
     9181 ctcatccaca atggccacag cagaggggtt ctcacgcatc cgctgataga agatctgtcc
     9241 caacccttga tcgtgagaaa cggcctcgtc gtaatcggag aaggatggtg taattgaccc
     9301 cattattctg tgatgttgag atagtttcgg tacttctctt cagagccctc cgacacggtc
     9361 aaccctcagt gagggctttg ttgtcaaata atttgatatc caaaagcttt attccatcca
     9421 aattcaacca actcatattt atatccgaca tctatttctc gatatcgagc tggcatgcaa
     9481 tattgaagct gtacaacacc tacaatgcta aatccttaca tgagactctt ggcaaaaact
     9541 tgactcgtac agctgtctaa gaaatgttgc tatgagggat aagcaatgaa ggtgtgggaa
     9601 tctcgatatt cttgatctag gcccacagag acaccttgcg gtgtaaaaga atcttcacga
     9661 atgcattccc aaatagccgc tctcctccag gtaaacatcg atcatgttcc aagccttcgg
     9721 gtactcaaat aatctatgta atatgtcgat caggaacgtc atcttaattc ctagtgtaac
     9781 aattttgggc taacctgatt accaatctga aattcattaa ctagttaaaa tacggtaagt
     9841 gtcaagagca gcattgtcct atacacttgg taagacagaa aatgcaatta tctatgaata
     9901 tgcaggtgaa aaaagaaagg aaaatagaat aatcaaatac cagaactaga agctattaac
     9961 tgcggtgtaa cgttgaacga atcgagtaaa gatggcaatt atgcaagatg ccaacttcat
    10021 aagatagccc gcatgacccc attactgcgc ctgcagtacc taaccatctt ggtggtacag
    10081 atctgaatta ggtacagcac tagtgagaca gtcgctgcaa gtctcatcaa gcaaatttct
    10141 caccgctact aagccgtcag tatgtgtccc ttggactaga gagatatcta gccatgaaat
    10201 gaaccattcg gattgtacac gatcgcatca atctcaagct ttcgaagtcc cgtttcgaat
    10261 tgaatcttag tcatgactgt ctcaattcct cttattactg tcttcggcgc taccggtaac
    10321 caaggtggtg ctgtcgccaa atctcttctt caaaaccctt ccttcaaggt gcgagcccta
    10381 actcgcaacc caaattcagc ggcgagccag tctctccttg cccaaggtgc agaaatccat
    10441 caagccaatg gattcagcag cgaatcgatg ctggaagcct tctctggcac gtggggtgtg
    10501 ttcgtgaata tcaattccga cgacaaggta tgtcttcgca ttgtactgca tttaagaagg
    10561 attgaggacc gacgagtaca aaggaattca agccggacgg gcccacagag tttgatatgg
    10621 gcaagactat cgtggacgca gcagtccaag ccggagtccg ccatttcatt ttcagctctg
    10681 gtcccgactg ccataccctt acaaagggca aggttaagat gaatgccgca gacagtacgt
    10741 gactctgttg cttttcacct tccccagata agtccaaagc taaaattaca cagtgaagtt
    10801 caaaatcgaa caatacgccc gcaatattgg caagttcgaa accgttagct tcatatgtgc
    10861 tgcatggttc tttgaaaact tcttgtcgaa agatatagca ccgatcttcg gcggtttccc
    10921 ctatatacca gacgccgaag gttatctcac cttcattgcc cccaaatggg gcgggaagga
    10981 agaagtccca ttcatcagca tgactgatga ttttggcgac attgtccaag gcatgtttat
    11041 cgaccctgtt cggtggcgtg accaaatagt ccacggctgc agtgatatct gcagttttga
    11101 agacctcgta tccagtttcg agaagctcag cggccgaaaa tctcgcttcc aaccgttacc
    11161 gtcctgggaa gatttcaaca cctatgggat acctgagttg gatgacacaa aggctatgtt
    11221 cggattcact caaaacaacc agggacggta ctttggacca gaaccatcgg agaaagagac
    11281 agctggtacg ctgaagcaga tcacagcagc ggccttgggt cggcccaagg aggagcaaaa
    11341 cctgacgtct gttgaggact ggttccggaa gcattttcac ttccagtaaa cttgttagca
    11401 caacttagcc gcagaacgat ttttaatcct ccaaaaccca atgaaacact gccttctaca
    11461 tccttagaca ggaaaattaa accagtgcta acttgagact tggacggtgg atagagaaac
    11521 ttctttccaa acaccgtgga caaatatagc catttaacag cggtgcaagt tacggactgc
    11581 tatcttccgg gtcactcgag acttataaat catgcatgca aagatattat tagctgcatc
    11641 aaatggtact tgaccgccat ttagaattag tacgcaccgc gcatacaact cacggacacc
    11701 tcggccagag agaataagag atagaaagac tccccctctt ctaatcggcc tctccaagtc
    11761 gttcgcctgc ttcgccgagg gacaatgatc gcttcaacta gtactacgga cgtgcttata
    11821 attggtgccg tatgtgtttc atgcttcgct tttcattact cagacggact aatacgtaga
    11881 ttatacaggg cccgtctggg tgagaattcc ccatctcagc caattatggt tatcatgcca
    11941 aaatgcgctc ggcgctgact ttcatgctca ggctggctgc cgcattgtat ctggcccagt
    12001 taggaatccc cttccgaatt atcgacaaac gatccgacga gcccagaata ggccaagctg
    12061 atgggtgaga gccaatgtta ttagcttata aggaagaaga tatgactgat ccggtacccc
    12121 ctcatagcct caatccgaag accatggaga tattcgaaag ctggggtatt cacaatcaaa
    12181 taacacagct ctgggagcca gcaacacacg aaaccatttg gtaccgagga ttggatgggg
    12241 agctcgtcag gacagatcgg tatctgaatc agccgcctat gggagttcgg tgcgttctca
    12301 cctgcacacg agagataggg taaggaagag cgtttctaag aatattctag gtggacgcat
    12361 gggactttac agcagggaac ggtggaagag atcatgaaga agaagatata cgaaattgcc
    12421 gacatgaccg ttgggtacca tacaaccctt tgtgagttga atatcgacat cactcaactt
    12481 actgctccag gagcctttcc ctgtacgacc caagtccaac aaatgaaaaa ggggagcatc
    12541 gtaaccgaga tcataacggc taagtacgtg atcggtgcgg atggtggaaa atctctgacg
    12601 cgaacattac tcgatattgg catgaatggg gagaaaggcg cctcagtatg gggagtaatg
    12661 gactttgcgg ggagctcgga ttttccagag tatatgccac tgtttattgc cccgcgaaag
    12721 acaaatgaca tactaactac tatctcatat tagtttcgga gcgacatcaa ttatacggag
    12781 cgccactgat ggatcattgg attttgtgcg gcgcgaggaa gggctcatac ggatgtacgt
    12841 tgagctcaac aaagggcctg aagggaagca catttgcaga gagaatatca ctccagaggc
    12901 tattgtccag aaatgccagt atatgattcg accctacagg gtaggtctct tcataaccgt
    12961 ccacctattt ggtagtgcta atacgagtca ttggcttata aagctggatg tccgccgctg
    13021 ggtctggtaa gattgttgtc tgtacgagat gaattatcgc aaaggcttac taggatcagg
    13081 tggtccgcat ttacagccac tcaaaagctg agcactgcat tgagcaaatt caaccgtgtc
    13141 tttctggtgg gtgatgctgt ccatacacac tcgcccgtca ctgggatggg aatgaacaca
    13201 agtattcagt atgtgtaata tcactcagct ttagacaaca tacgctaaga aaaaaaattc
    13261 agggactcgt acaatcttgc ctggaagctc gctggtgtca tcaaagggca gttaaatcca
    13321 aagattcttg caacctatga cactgaacga gggattgttg ccaagcagct cctccaggcg
    13381 gaccgaacca ccctggagct cttcgatacc aagtttggcc atgagacacc ctccttgctt
    13441 gaaagagcag agactttgcg agttttcctc gcgggccgtg ctatccgcta cgcagatgca
    13501 ttattgacgt cgccttcagc gcaagggatt ggctcctttc agcctggcga atgcctgcca
    13561 gatttctcca ttaccaacca tgccacaggc agatccgttc atatccacaa cgctctgaag
    13621 tcgaatgaaa cctggaacat gatcgttttt gctggtgacg tctcgtcagt gacccagatg
    13681 gtgcgtatcc atgaattagc caaaagattg gcagagctac gaaatgcgac ttccggagta
    13741 ctagacactc ttatagttca ttgtgcaaag tgggaaagtg tcgagctcac ggcatttcct
    13801 actcttttct taccttgcga ctcgattacc gggaggaatt atactaagat ttacatcgac
    13861 gaatggtctg tttatgatgc ggtcgggtta ggcccagaca acggtgggct tgtcctagtg
    13921 cgcccagacc ggtacatcgc gtggacaggg tttttggaaa acatcggcga tgttaggtca
    13981 tatctatcgg cggttttctc tttatgtctc taaggctcaa gtctgcagca ttttatcttc
    14041 ccgggctttg caagctgtgc tctttcatgg ctgatctaca aaaatacaac acataaaagc
    14101 gaaaccgaat tcgtaacatt acacgaatga aaaaaccaaa cgagcagttt tcaaatacgt
    14161 caattgtaag taagggacac agtaatgaaa aaaaagaaat cagcgagtac tacgcggtct
    14221 cattccttga gtaggaaaga gttccaacta tattatggag ctcatccccc gggcagtcga
    14281 caagtcttta cgaaacggaa gatatctgta tatcgactcg ccatgctaca agtttggctt
    14341 ctcttactcg ccgttgtgtc ggcccagaga tgcgacccta acaatcgggc tatccgtcgg
    14401 gaatggtcag ttcaatcatc aggaagaaca tcaacaagtt cgctaatatt tttgacaggg
    14461 ggtcattctc gcgacaggag cgtctcgact atatcgatgc cgtccattgt ctgcgagaga
    14521 aaccgcctat tctcccgaca gaacagtacc cgggtgttcg ccatcgaatg gatgatttcg
    14581 cagcgtatgg actctgtgaa ccgaaccatt caccccaaga gtaaagctta taagaacaga
    14641 acccacatca actacacact caatatccac ttgagcggta ttttctttgg ttggcatcgg
    14701 cgctttgtct ggttatggga gaaagcccta cgcgaggaat gtggttaccc cggctatcaa
    14761 ccgtaagtat agcacttctc ccttggggga gaagttgtgt ctaacgaagc cgcgcacagg
    14821 tattggaatt gggcaatatc cgccaacaac ttatccgcaa gtccactgtt cgacggtagc
    14881 gatacttcct tgtctgggaa tggcgatcca gctgaggacc aaaacgacac gatgacactc
    14941 gcgccaacaa atgttacaat acctacgggc tctggaggag gatgcgtcac aaatggaccg
    15001 ttcgcaaaca ttaccctcaa ccttcccgat ctagattcag ccccaggcga tgtctttcca
    15061 gaaaatgcct ttgcctacac gccacgttgc ctaacccgaa atctgaataa cttcatagcc
    15121 cagtctttca caagccaggc tgatgtcgac cgtcttctgt ctactccgga catcgtggat
    15181 ctacaacaca acatggacgt gagcgtatgg ccggagctga gcgaggcagg gattatgggc
    15241 ccacatgcgg cagcgcatat gcagcttggg cgggcaatgg atgacttctg gacggcgccc
    15301 caggaacctg ccttcatgct tcatcacgca atggtcgata gagtgtggac tttatggcag
    15361 gcacatgatc cggcgaatcg ccagtacgcg ctgaatggga ccagcgtgat gggaaatccg
    15421 gctagtgcgc cagaagttga tttggatacg caggtcacat ggggtccgct gggacagaac
    15481 aagaccttgc gcgatgtgat gagtactgag gcgtatgaat tttgctacga gtatggagat
    15541 tagactgcac acgagtcgtg cagaatccaa ttataaaaca ccacgtgctt gaccgctatt
    15601 tcagcttagt attaaagtat gtgcttaata caatcgttat catgtggact ttaacaatag
    15661 ctaatacgat caacgtaaaa cagacacatc ttgtattaat gaagctaaat ttgaattctg
    15721 aacctatttg caaggtttat aaccacaatt tgtcacagaa aagtcgaaat cgccactggc
    15781 gttttggaat tatgttcgaa aagcaatatg tcatgacacc tcgcatatgc gatagaaaag
    15841 caaagacaaa accggtggat tacttgaata atccaaatta tgactcagtc atgattcaga
    15901 gactattatt ttattgcagc aagataaaca attacgacgc atatatgaga aattgtatta
    15961 aataatataa attgcagacg agtatcaagg catgacagct gtgactttga aacttgggag
    16021 gcagttccaa aaatgaggga ttaattcctg atgtatcagt ttgaggcttt ggattattac
    16081 ctgctgtgtt cttgagctct ttccctcggg cttttcttct cttcctcctc cggctttgat
    16141 atgtttttcc atgtaatgaa ccaatatcat ttcgattgac ctatatcatc aagcataaga
    16201 tttgaagcta taagtagaca aatcagacgc ctttttgttt aagatttcaa ctttgggcag
    16261 aatgtaaagg aagcttgaga aattattttc atgtgtgaat gatttattca gacctgattc
    16321 ccaggggtga ctgtgaagcc gatttaaaag agtactatta caaactcagt ttcaattttt
    16381 aggcctttaa ggctgcagtc atatagtggt agtatcaaat aagaaaatgg tattattcag
    16441 atcaatttgc cccgatgatc ggtcaattaa gatgacgagc ttgtctggcc tattttcaca
    16501 aaatgaaatt tgaagaataa tcttctctga aaacataaat tgaacacgct ttcttctccg
    16561 ctagattatc gctcctagtc catctaaccc tttgcccagg aaatatggca gtccaccatg
    16621 atttcgacag cttcgagctt actccagcgg attatggatt tccaatgttt tacgcaggat
    16681 gcacgatttc ctttcgattg aataaccctg aggaaggagt cgacatcgta cgtgacgcta
    16741 ttgaaaggct ggtatgccat cttccgtttc tggcggggct cgttgtgccc tcggctcgca
    16801 aagtcggttt gatggaagtg cgtcctcccc gtcaaggcga agctatatca gatttctgca
    16861 ttattcagca tctaccgcat cttcgattac cttcgaggat ggattcttct agatcaaaga
    16921 atgttggaga gtacgaccgc aacgcaactc tcatcatggc tcctgtgcat attgccgcat
    16981 cccctacaga ccatccagtg atgcgctccc aaatcaacgt tctggatgat ggaatcattg
    17041 ttgcgctatt cttcaatcat atggtgattg acgggactgg gatcggcgcg ctgctcgagt
    17101 cactagcggc ttgctgcaat ggtgctactt tcatcccctg caacattgaa tgcgagcaga
    17161 atacccggga aaatttgctt gtcacacttg agcgaaacaa aatgcctggc catcctgaga
    17221 tccgttcgcc gccaatcttg gaggtcccca caggtaccgg tcacgaagaa gtgcatgact
    17281 cattattgct tgattataaa tttttcatat cgggcactaa gatcaagcta ttgcgtgaac
    17341 atattcagaa cctaggatct ggatttgtct ctgaagatga catccttaca gccattcttt
    17401 ggacatgtct cggtagatct cggccccacc ggctgtctca aaggggtctt cctgcgtctg
    17461 tatgcaagct ccaacgggtc gtcaatgttc gtcacaagct ccgtcctcat gtttcaccat
    17521 attacgttgg aaattgtttt attatgctca atgaagcctt gactaccgtg gagttagggc
    17581 aagaggcctc cgatagcgaa accggtgaac aagcgttcgc acggcagatc gcccctgtcg
    17641 cccgcttact gcggagccgg cttgataaag ttgatgatct cttcattcgt gattacttct
    17701 cgcattatga aacggccagc gactgggcca atacatctgt gcacgagcca gatgttgcgg
    17761 tgacgagcat tcgtcgcctg aatatctatg gagaatattt tggccctatc ctcggtaaag
    17821 tcgaggactt tgagatgctg ccttacatga atcccgaagg ggtttgtaca attatgccac
    17881 atcgtagggc tggtgacgat gcttgggaag ttggtgtaac gctgggacgg gaggatatgg
    17941 agcggctgag gaagaatgtc aagtggcgtt ggcttgtgga cagggagtcc ccactgcaag
    18001 tatttgaggg ccatcatgta gtataacgat gctattctct tatttgcccc actataacgc
    18061 aaggcttctg tgtatttcgg cagattaagg agttataccc atgagatgtg cctgctgagg
    18121 tatatccctt accgtagctc gatctatgag tgatgaattg ctggccgaga cactagaatc
    18181 ctttccacac cacggagtaa agagtagatt tggaaaggag ggatttgtgt tgaatgttgt
    18241 gtaggaggct tgcaaccatc tgtccaatat tgttgcagat cgcttctctg acccaccaga
    18301 gcacaacggt ccatttgtgc cgcaaggaaa gggggatact gttaaccgat gatcagtcat
    18361 atagtagtcc tcgtagacat ataggcctag ttctcaatcc cgagtgcggt gttgtaacaa
    18421 caaggcttaa cagggatata gccatcgcga tgaaacaata ttcatggatt gggctcactg
    18481 tagctgctag tctgtgtatg gtgtccatca atgattaatt gcctacattt cactaaccaa
    18541 ccgttcagtt ataggtattg agggccagcc ggcgagattt catccttcgg ggcgaaatga
    18601 catctccttc accatagcca catcggaaac ctcaaacgat cccccacgag gcgacttgct
    18661 cctccaaatc caggccccgg attccattca atggattggt attggaagtg gcaatcagat
    18721 ggccggagcc aatatcttcg ttgtctacgc atcatccgca acgaacgtgg ttgtctcccc
    18781 tcgtgaggga acaggccatg tgcccccact gcacaacgcg gagaatcaca tcaccgtact
    18841 tccaggtaca ggtattgcga acggcactat aacggccaga ttcaaatgga aaaacttcct
    18901 tgatgctcat tgggttgcat ctaatgccac cgactcggcc agcagctgga tctgggctta
    18961 caaaaacggg cctcccctgc tctccgagaa agtttcggca cccatcgaat atcacgacgc
    19021 ctttggaagg gagcttgttg acctgagacg cgcacagtca acatcaaatt tcaatattga
    19081 agatggcgtc ttcacagatt catcaagccc agaaatccaa aatctgccgt acatggcgac
    19141 cgcacatgga tacatgatgg cacttgcatt tgtgttgcta tttcccactt ttgctcttct
    19201 cgttcctctc tcaagcttta ttacaattcc tgtgatatcc gtccatgccc ctttacaggg
    19261 cctcgctctg gctacggcaa tagcgggggc tggactgggt ctgaagatgt ggataggggg
    19321 aaacagtcaa ccggccgcgc atcccatcat cggtatcatt gttgtagcaa cgctaacctt
    19381 catccaaccg gctcttggtt gggctcatca ccttcgattt aagcggaacg gggaaaagag
    19441 ctacttttct ttcggacacc ggtggctagg tcgttccatg ctggctcttg gtgtaatcaa
    19501 cggcggactt ggattttggt gggaggggcc agttactgga tccctaaaaa cgggaatggt
    19561 tatctatgcg gctattgctg gtgtggtgtg tgtggtatat ctcattttgc atctgtttat
    19621 cagagcgaag tttgcgtcgc ggcgagagca tgtacagtgt attcggttag aagatgctag
    19681 tgctccctcc tccaaaaggg cggacagctg gcaggtcgtg cacggacagt gattggctta
    19741 tgacttcgag cagtacttcc aatagctaag gccaggaata agtagtatgg tacacttact
    19801 tctacgtatg gatttgaatt tgtcttatca ggaagcaccg agatatcgta ggtgttaaaa
    19861 atcgagcatc cagtcggaaa gccagtagct gcagcaagca tctcatcact ctttccgaag
    19921 ggctcagacc atcagaacca ttttaaaggc caggaaaatc gtagtctctt actacgccgt
    19981 agcatcatgc tatagaatac tgtgagacag ctgaaaatcc ttgtttcaaa ctgcagggcg
    20041 tagttgagca gattttatct ccatgaaaca cattgattaa tgaagatcta taaccacaca
    20101 caagtgaaaa ctaaatccct atttccacat gatctgagtg actccattga aaagaggaat
    20161 cattgtggtc gtgacccgcg gatccttcgc agcatagcgg ttgaacgcat tcatcttatc
    20221 cgcaatagcg aggtatggct cttgaatctc ctctgggaag tttctagcga tagatgagtc
    20281 tacgaccagg ccttcgagga gaactacgcg cggtcaaagg tttagcaatg tcatcaggga
    20341 gtagaggaga ggtgtcaatg cttaccatcg tcgaccaaga tgactccgtt aggcgagagg
    20401 agtttgtggt ccaagatgta gcgggtatac gactcgtact cttcctccgc cgcgtcgata
    20461 tatacgaggt caaattggcc ggtcaatgtc ggtagcctgg tcatagccat gtgtaagtga
    20521 acttcccgga tttccatcac gtattaggaa aatggttaaa cttacatgtc caagcaaggt
    20581 ccctggacag tcttgattcg ttcgtccgct ccgtaccgac ggaatgcatc ttgagcgaat
    20641 tcgaggtact tttccgacat atccatgcta acgatttccg cagtaccctc ctttgtcgcc
    20701 tcgtaaaaaa caagggcact cacaccggta aacgtgccca gctcaaggac tatttatttt
    20761 tcagccgctt gacctcaatg aatttgatct tgaagcccca ggttaacaat aacgtacttc
    20821 gtttgggccg tagagcccgg gtaaagctca gcaaccagga acactgcgac tctgagggcg
    20881 ccataacaac ctcgtccttg tgtagttgat ctgtgaactt gatctgttca agaatggaga
    20941 ccggaagcgt agaacttttt tttctgcagt attcaccagt catagtgatc tgctctttcg
    21001 tgaagggtag catacaagtg tctctcattc tggcggtagt atctctgaac acaattactt
    21061 ccaacacaaa ccagggacca gaacaagaca ggctttatta acttggaaaa ttcaactatc
    21121 cgatattcta ggcgaaacga aagggcaaaa ggcgttgctg agtcccagcg gcaacccttg
    21181 cagctgcagg aggtaaccgc gccggtcggt gtggcccgaa ccgagcgcca atatctatgc
    21241 aaggcccact ttggaaatgc ggccaagtca tacagcatgt ttcatgcagt tttgcagcat
    21301 cgtacttcgc attccttcac cgcaagtcag ggtatccatg catcaagggg ctggagcatg
    21361 catatcttta gctagctttc accaactaac cgaattggat gaaatgggca agattatcag
    21421 cgtatgtttc ggtttcccga tgcatcaata catcctgtcg gctcagatca cgccttcaaa
    21481 gctcagaaaa tagagtagca gagctcaagt tgtttccttt caagtcactt aaccagttat
    21541 gtctgaagta gcaatttcag aggcaacttc ttggctaggt agatgctggt cgtccttcgg
    21601 tataggacgg ctactcctct ggtcattgag catcctcatt gcccatcgtt tgattcatcg
    21661 cttatttttc catccacttc gacacattcc aggaccatgg agtgccacgc tatccggatg
    21721 gtatgagttc tatacaaatg tctggcaaga cggtcagtgg tgcaagacat atccggattt
    21781 gcatagaaag tacagtatgt cgtgttgata ctatttctca gccgacttga aagatattga
    21841 tccagctaca tagaatcgcc cgtcgtcaga attggtccgg atcatgttca tatcaaggat
    21901 attgaggcat acgagaagta agaattcaac aatgttgtag ctgtctagat tttgctctca
    21961 caaacaagaa acaggatctt ccgcaacggc acaaattacc acaaagacca taccttttat
    22021 acctgcgccg ataacgatgg ctctatcttc tcgttgagtg attgccatga gcaccgagtt
    22081 cgtcgtaaag ctctcagtcc acgcttttcg aaacaggcgg cggaagccga tgctcctgga
    22141 attttacggc agcttcggcg tatggaaaac ttcatggtta aacaatcggc gctagacaag
    22201 acctacaaca tcaacgatct cttccgggcg cttgaagtga gttcgtctac acaaagaagc
    22261 tgctctgtat actgaactgc gggaagatca atgtcgtagg caaaacgctg ctaggagact
    22321 gtggtgattt agttgaatac caagagacca agcccgagct tctggagact gtcgacggat
    22381 tatccgcaat gataccccta tgtcagtcaa tcagtgatga accttcagac aatatcataa
    22441 agcagagcta aaattgttta cagtacgatt cttcccatat atggcagccg tcaaccaaat
    22501 catcccatcc gtgctagcag ataagttaat gcctgctggc gtgctcaatt tcaaaaaggt
    22561 tcatctatgt ctctacccaa aagaaccttg gaagactaat ccgtcataga cctgcgaaga
    22621 ctacacaaag ccacgaatga tcaagtctat ccgcactgac cttgatcgaa ctagggcatc
    22681 cgtaatcgag ctcttagtag cacatagcta cgatgttact gggaacccgc ctaatatcga
    22741 ctacttggca gcagaggcct ttacattcat tgatgccggg gtagacaccg ccggtagaac
    22801 actggcagca gcggtgtact acgttcttcg caatcaagaa attgaaaaga aactcgtgga
    22861 cgagctgaac gacgcgaagc tttggtgcaa tggcactaat gaagctgatg tccgcacact
    22921 agggagactt ccttacctgg tcagtccagt atttgtttac cagcgtcagt aggcttccct
    22981 gaccaccgtt attgcagaat gctatcatca aagaagcaca ccggatatgg ccagcacttc
    23041 cggggccatt gcctcgtgtg gtaccttcgg aagggctgcg aattgggcgt tacttcatcc
    23101 cagctggtgt aggttttttt tttcttttca gttcaaatct ttcctttgat caatgcagct
    23161 aatttctgct gtagaccatc gtatctgcta cccaccactc actgcacttc gatgagacaa
    23221 tcttccctga gcccaacaat ttcaaacctg aacggtggct acgagaagat agaacagatc
    23281 ttgaccgata ccttaacccg tacagtcgtg gaagtcgtgc ttgtatcggg atcaagtaag
    23341 atcatcaaca tgaatactac tgaagtagac tactaaccga aaacctagtt tggctcaaat
    23401 taagctacag ctaggattag ctgacctctt ctaccgtctt gatatggaat tatgtgagcc
    23461 aatcccgacg gctctaggct ggaaggacca ctttgtggca gagccgacga gcgctattta
    23521 ccttcgggcc cggtttagga aaggaatttc atgtagcgag tagatttctg ctatcctgtc
    23581 gaagcctagc gtaatgtctt ctcggtaatg aggttggaat atgtctctta ttgcttgata
    23641 taagctcaat ttcccgttct ggtaattgct tgtagacgtt tccaaggtca gtggcaggat
    23701 tcagggatat agtacaattt tccgtatttt tgtcgacctc tttcgcgttg tcgttaccaa
    23761 attggtctaa aagcaattgc tcctcgactg cagcaaacta cttgcatcta aatccgctta
    23821 tctgtctcac ataattggct agtatctgcc ccctagccgc atcccatttt ttcctaggtt
    23881 gctgcaaatc agcattgaaa tagaaggctc ggaaaggaac aaacgaactt tcaaagccct
    23941 ctccgcacta aaatcatcct ttcagatttt ctgaatctat gattacatct taatgagccc
    24001 catgagcttt tcaatttctt ctgggccctt tttgggacag ttttcagctt tgcataattg
    24061 gagcttttag gacaacaatt ctaatcggta acacatgttc gaaagccttt cctctcctct
    24121 caccaataaa ttgattatct gtacctccta ggcgaatgtt ttcgctttcc ataccaacaa
    24181 tgatgaagtg cccttccgta ttgcctacca cggcagagtg tactaaaccc ggcgatcagg
    24241 caatcctaca atggcgcaga cgatttgact ctggcgacac ggtagcggac gttttttcaa
    24301 ccataactat atattcatgc tggtcggtag ctgcatagcg agcttttata gtttgaatcg
    24361 ccgttaatcc aggtgcagtg taggctgtcg catccttccg gttgacatcc gcacctctcc
    24421 tcaaacccca ttttgatatc ctcagtcctg tagactcatt tcgccagacc ctatactttg
    24481 gtggaggtca aatatcgctt gaaaatacct ccgcgatttc atctgcctgg atttggaatg
    24541 tttcacctac atgggctaga tcttttacat gtggatctga attatacttt aaagagcttg
    24601 aacttcacat tactgttatg gcaccgtgaa gaaaggtgca tttggataaa tactttgcat
    24661 agttataacg tttcaggtgc cccgacgagg caatttagta cgaagggcgc attgataatt
    24721 atattgtcgt tcttgctatg ggacaaggtg aatggatcaa agtgattcaa ataaggtgat
    24781 cggcgtcgtg gtttgcgaca tccactgaaa ccaggaatct tgacgtaaga gctccatatc
    24841 ctttgggttc aaagttacca taatttccca atcgtcttgg tcgggccgct taggcatgat
    24901 ggtacaaaca ccatctgggc gcatgtatgg tagcaagtgg aatccatttg cttgtccgag
    24961 tactggcccg aaatcatgct tgtaggagct caaatgacgg agactgctca cgaagacatt
    25021 gggaccggga tcagcatcgg ggaggtgtgg cgatgagaag atttcacgga tgtactgatc
    25081 gtcaaggctt tggagacgtg aacgtagaac gtctgctgcc cggtggagaa caggcgcaag
    25141 agtactgcat gacttttggt catcatcgcc aggaagagta tttctccatt gcggcacttc
    25201 aagtggaagg ctctccttca agagcacaac acagttgccg aagtaggtgc taggaattgg
    25261 gttgctgaat cggttgcgga tatctacagc cctggtgagg gtggacttca ttgtaccatg
    25321 attaatactc atcccatctt gtcggagaga agtcaaagct atccagataa atacggtgac
    25381 aatatcatcg catgagatcc gcgggatcgg ttgatcgctg tctttgttct caggccagag
    25441 actccggaca caattcctta gcctttgaac cttggaggcc gcaaagcaga aattgtagtc
    25501 aacaagagaa gatacattgt tctctccttc tcccagagta ggagggccat ctgtctccgt
    25561 tcctgagttt gtgatggtat tcgtctggct cctagcgaaa ttcgccagaa ctgcccttgt
    25621 gtctgcctct acagaaggat cagtcggcag ttgacgagcc tttaggggat tattatctgc
    25681 ctggcagcag atggacaagg ctctggtcat attgtcgacg ccaataccat cgattgccat
    25741 atggttgacc caggggacca aaatgatacc gtccgcgaga acattgattt ggaatcttgc
    25801 caccggagtg ccggcgagag aacatagttc atagggcgca agaatgagtg attcatcacg
    25861 tatataatcc ctgcagagtt gactgcggga gccgggcttg caaagaaggc gtagcttggg
    25921 aaaatgccgt acgacagcaa ttggcggcga gctgccagag gtggtggtag gaataggatg
    25981 gacccccgct attttcccac tctggctgac ctttccagct agaaagggca aatgagaaac
    26041 aaggcgttcc aaacctccac acaatattgg gactgcttcc tcgggacaag agatatggaa
    26101 tgatagagca catccaccgt agaagagaga gaagagatga tcgaagcagg tgagctggta
    26161 tgcctcaaag gtaaccattt tgtgagcaaa aaaggccagt tagagttggt ctgggtagag
    26221 tgaataagag tgtagcaagt tggaggatat ctgggaacgt agtatattac gcagcgatga
    26281 gcgaaataaa aggagttacc ttgcttatgc gggcagacat gtcttattgt gatgtagaat
    26341 ttgatccaac ttgatagttt ctgatttact tcattaaaaa cactcaaggg gctgttcttt
    26401 tatgcatatg caagtgaatt tgtcagtcac tttgataggt gcttcagatg atgcaggcga
    26461 ggtactcttt acatgtatat gagtcagacc ttggccaagt aatgctgtgt atacctcatg
    26521 catataggag taggagttcc cactcacggt acatcgagaa gatgacgcat cttaaaggcc
    26581 acttgggaat ttcggcagca atggataatg actaccctgc atggcgtagt agcctgatta
    26641 atgcatgtcg cacgaactca ttgagcggcc ccactgggag attctccacc gtcgggttcc
    26701 cctgcttgag cataaaggga ctatgccact ttcagtaggt tgatctatag tacctaaagg
    26761 aagaacaatt ctcaaaatgg gtctggtatg cacatctgcc ttcaactcgc acaccgccat
    26821 tctatttccc acggtctata agtatgcgaa gttcaagggt agagagcact ttcctgtagc
    26881 cacattgatg cacatcaata gttaccaagt gcaaaacctt tctgctgccg aggcttgaat
    26941 tcagtttgac atcataccaa gccgacttca tgatgactgc cggcgaacca gctccctgtc
    27001 acccactccc tcatagaaaa tccggagctc tggacaattt caagtacatt gagaccagtc
    27061 ctgctcttgg aagggaatat ccagggctcc agctatcttc tataatcgat gatgaggaaa
    27121 tagtccgtga ccttgcgatc actggtatga tggccgtctt ttcctttgac tcagtagcaa
    27181 cacattggac taatgtctcc ataaagcatc cgaaagagga gttctcttct ttgatcatca
    27241 ggatatagcc ccatcagagc taaagcgact tatcctgaag attggtgaat taatggggaa
    27301 tcccaaggaa gctggtttac atcgtcacgc cttctctatc aagggcaacg aggagttgaa
    27361 cattcctgag gttgatgatc ctgatattct cattctttca tctgctgtgg gtggatgtct
    27421 agcaagaatc gatgccttct ttgttctaat cattctggtt aggttcaaaa tacgaacttc
    27481 aatgtcgcct tgccagtagg gtctcgtaag ttcgcaagtt gggggtggca tagtgagtga
    27541 gttaacacat ctaccacggc agccttatca cctagagact aatctaacca tcgaatatca
    27601 tcctagcgag tctcatgaga agtatcctcc tgcatacact ggcttcaaga ttgccaaaag
    27661 cccgcccact ggcggtgaca ctctctttgt ttcctcttat ggtctctacg aatatctctc
    27721 taatccgtgg cagaaatttg cggagagctt gaccggtgac tattttcgat gtctcaactt
    27781 aatgagctag gaattgctaa tttatattag ctactcacca tgcagctgag tatctccgac
    27841 acaaggatgt tggcttcaag tttcatgata atgttaagcg aggccacccg gagaatgttg
    27901 acctcgattt taaagcatca cagtttgttt tctcacattc ccccccggtc cttgactgtg
    27961 atcatgtgaa agctgacggt ctcgcagccc tgttgttcga accaatcccg ttactggctg
    28021 gaaaggcctc tatggtgtcg ggtgggggtt gattgatggt agctttgata atatgacgga
    28081 ggacgaaagc aacctgctga agcaatattg tgagtcaaca gtctggataa tttttaacta
    28141 ataacgtttg tacttataca gacctgttgc agttctccgc gtcattaccg acaactctaa
    28201 tctccaaatt cgcaagcgtt ggggcgatga tggggttgca atctgggata agtaagttaa
    28261 catccacatt tttcttatca tatacacaat aaatgctgat ttggagccaa aacaatcata
    28321 gccgcgccgt gcatcacaat ccaacatagt aagtccccgc attatccgtt aatataatag
    28381 ataatctgac tcaaataccg tccagcgacg ttgtcgatgg agaaagaacc accttccgtg
    28441 ttgctggtgt cggagagaag ccctattttg acccaaattc gacatcaaga actgagtttc
    28501 tacggaagca gcgagcatga
//
