BGC0002278: brasiliamide I biosynthetic gene cluster from Penicillium brasilianum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 3,030,630 - 3,059,149 nt. (total: 28,520 nt).
This entry is originally from NCBI GenBank CDHK01000003.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002278
Short description brasiliamide I biosynthetic gene cluster from Penicillium brasilianum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
  • NRPS (Type I)
Loci
CDHK01000003.1
3030630 - 3059149
via Knock-out studies, Enzymatic assays, Gene expression correlated with compound production
Compounds
  • brasiliamide I
  • brasiliamide A
  • brasiliamide B
  • 2,2-dibenzylpiperazine
  • brasiliamide D
Species Penicillium brasilianum [taxonomy]
References
Chemical products information
brasiliamide I Evidence:
Copy SMILES
Chemical database entries
NPAtlas
brasiliamide A Evidence:
Copy SMILES
Chemical database entries
NPAtlas
brasiliamide B Evidence:
Copy SMILES
Chemical database entries
NPAtlas
2,2-dibenzylpiperazine Evidence:
(no structure information available)
brasiliamide D Evidence:
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PMG11_03952
  • CEO59270.1
 3030630 - 3031549 (+) Putative 2-deoxy-D-gluconate 3-dehydrogenase
    copy AA seq
    copy Nt seq
    • PMG11_03953
    • CEO59271.1
    		 3033785 - 3035656 (+) hypothetical protein
      copy AA seq
      copy Nt seq
      • PMG11_03954
      • CEO59272.1
      		 3036834 - 3039932 (-) hypothetical protein
        copy AA seq
        copy Nt seq
        • PMG11_03955
        • CEO59273.1
        		 3040902 - 3042018 (+) hypothetical protein
          copy AA seq
          copy Nt seq
          • PMG11_03956
          • CEO59274.1
          		 3042572 - 3044385 (+) Putative FAD binding domain protein
            copy AA seq
            copy Nt seq
            • PMG11_03957
            • CEO59275.1
            		 3044952 - 3046172 (+) Putative Tyrosinase central domain protein
              copy AA seq
              copy Nt seq
              • PMG11_03958
              • CEO59276.1
              		 3047585 - 3048655 (+) hypothetical protein
                copy AA seq
                copy Nt seq
                • PMG11_03959
                • CEO59277.1
                		 3049079 - 3050361 (+) hypothetical protein
                  copy AA seq
                  copy Nt seq
                  • PMG11_03960
                  • CEO59278.1
                  		 3050748 - 3051642 (-) hypothetical protein
                    copy AA seq
                    copy Nt seq
                    • PMG11_03961
                    • CEO59279.1
                    		 3052168 - 3054192 (+) Putative Benzoate 4-monooxygenase cytochrome P450
                      copy AA seq
                      copy Nt seq
                      • PMG11_03962
                      • CEO59280.1
                      		 3055386 - 3056807 (-) hypothetical protein
                        copy AA seq
                        copy Nt seq
                        • PMG11_03963
                        • CEO59281.1
                        		 3057599 - 3059149 (+) Putative Taurine catabolism dioxygenase TauD, TfdA family protein
                          copy AA seq
                          copy Nt seq
                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          Unk01
                          Type
                          nrps-type1
                          Genes
                          PMG11_03954
                          Substrates
                          phenylalanine (evidence: Structure-based inference, HPLC)
                          Integrated Monomers
                          Domains
                          adenylation
                          Annotation changelog

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Added chemical structures for compounds: brasiliamide A, brasiliamide I, brasiliamide B.
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-10-07
                          Added NPAtlas links to compounds: brasiliamide A, brasiliamide I, brasiliamide B.
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Entry added
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Added NRP substrate specificities
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                          A domain glossary is available here, and an explanation of the visualisation is available here.
                          Selected features only
                          Show module domains
                          Similar known gene clusters from MIBiG 4.0
                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                          Click on reference genes to show details of similarities to genes within the current region.
                          Click on an accession to open that entry in the MiBIG database.