BGC0002287 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002287 (Streptococcus mutans)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	62,987	mutanocyclin/leuvalin/tyrvalin	NRPS:Type I	100%

BGC0002287 - Region 1 - NRPS

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Location: 1 - 62,987 nt. (total: 62,987 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 62,988
Label		BGC0002287

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002287	1.00	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0002058	1.00	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0001219	0.27	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002437	0.23	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000404	0.22	NRP	penicillin	Penicillium chrysogenum
BGC0001844	0.22	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758	0.21	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002158	0.21	NRP, Polyketide	tenuazonic acid	Pyricularia oryzae 70-15
BGC0001824	0.21	NRP	xefoampeptides A-G	Xenorhabdus beddingii
BGC0001641	0.21	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002287	1.00	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0002058	1.00	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0001219	0.60	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002437	0.57	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000404	0.54	NRP	penicillin	Penicillium chrysogenum
BGC0001844	0.54	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758	0.54	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002158	0.54	NRP, Polyketide	tenuazonic acid	Pyricularia oryzae 70-15
BGC0001824	0.54	NRP	xefoampeptides A-G	Xenorhabdus beddingii
BGC0001641	0.54	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 8876 - 51951:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

QCY50741.1

Search NORINE for peptide: strict or relaxed

AMP-binding (444..834): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DYFTFGLIIK
Nearest Stachelhaus code(s):: Leu DYFTFGLIIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)