BGC0002287: mutanocyclin biosynthetic gene cluster from Streptococcus mutans
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Location: 1 - 62,987 nt. (total: 62,987 nt).
This entry is originally from NCBI GenBank MK144293.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002287
Short description mutanocyclin biosynthetic gene cluster from Streptococcus mutans
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MK144293.1
1 - 62987
via Heterologous expression, Knock-out studies
Compounds
  • mutanocyclin
  • leuvalin
  • tyrvalin
Species Streptococcus mutans [taxonomy]
References
Chemical products information
mutanocyclin Evidence:
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Chemical database entries
NPAtlas
PubCHEM
leuvalin Evidence:
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Chemical database entries
PubCHEM
tyrvalin Evidence:
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QCY50736.1
 24541 - 25587 (+) translation elongation factor ts
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    • QCY50738.1
    		 26118 - 27197 (+) hypothetical protein
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      • QCY50739.1
      		 27212 - 28423 (+) thiolase family protein
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        • QCY50740.1
        		 28424 - 28870 (+) hypothetical protein
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          • QCY50741.1
          		 28877 - 31951 (+) non-ribosomal peptide synthetase
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            • QCY50742.1
            		 31955 - 34696 (+) PKs and AMP-binding domain-containing protein
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              • QCY50743.1
              		 34885 - 35388 (-) HXXEE domain-containing protein
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                • QCY50744.1
                		 35518 - 36060 (+) TetR/AcrR family transcriptional regulator
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                  • QCY50745.1
                  		 36202 - 36744 (-) TetR family transcriptional regulator
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                    • QCY50746.1
                    		 36923 - 38719 (+) DHA2 family efflux MFS transporter permease subunit
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                      • QCY50747.1
                      		 38925 - 39263 (-) putative small multi-drug export protein
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                        • QCY50748.1
                        		 39294 - 39389 (-) hypothetical protein
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                          • QCY50737.1
                          		 39561 - 40025 (+) CtsR family transcriptional regulator
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            Unk01
                            Type
                            nrps-type1
                            Genes
                            QCY50741.1
                            Substrates
                            leucine (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Annotation changelog

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Entry added
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Added NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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