BGC0002291: efomycin K biosynthetic gene cluster from Streptomyces sp. M56
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 2,039,904 - 2,119,811 nt. (total: 79,908 nt).
This entry is originally from NCBI GenBank CP025018.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0002291
Short description | efomycin K biosynthetic gene cluster from Streptomyces sp. M56
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Unknown)

Loci
CP025018.1
2046004 - 2109226
via
Compounds

- efomycin K
- efomycin L

Species Streptomyces sp. M56 [taxonomy]
References

- [1] Efomycins K and L From a Termite-Associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin. Klassen, J et al., Frontiers in Microbiology (2019) DOI:10.3389/fmicb.2019.01739
- [2] Efomycins K and L From a Termite-Associated . Klassen JL et al., Front Microbiol (2019) PMID:31447803

Chemical products information
efomycin K Evidence:
Copy SMILES
Chemical database entries
NPAtlas
efomycin L Evidence:
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
CFP59_01540 AUA09450.1 fpg2 | 2046004 - 2046870 (-) | putative formamidopyrimidine-DNA glycosylase-like protein |  |  | copy AA seq copy Nt seq
CFP59_01541 AUA09451.1 | 2047097 - 2048431 (+) | Catalase |  |  | copy AA seq copy Nt seq
CFP59_01542 AUA09452.1 ccr_1 | 2048458 - 2049798 (-) | Crotonyl-CoA reductase |  |  | copy AA seq copy Nt seq
CFP59_01543 AUA09453.1 | 2049911 - 2051335 (-) | NDP-hexose 2,3-dehydratase |  |  | copy AA seq copy Nt seq
CFP59_01544 AUA09454.1 gpr_6 | 2051329 - 2052315 (-) | L-glyceraldehyde 3-phosphate reductase |  |  | copy AA seq copy Nt seq
CFP59_01545 AUA09455.1 tal_1 | 2052315 - 2053280 (-) | dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(P)(+)) |  |  | copy AA seq copy Nt seq
CFP59_01546 AUA09456.1 liaR_3 | 2053373 - 2054104 (-) | Transcriptional regulatory protein LiaR |  |  | copy AA seq copy Nt seq
CFP59_01547 AUA09457.1 liaS_1 | 2054101 - 2055363 (-) | Sensor histidine kinase LiaS |  |  | copy AA seq copy Nt seq
CFP59_01548 AUA09458.1 yhhJ | 2055365 - 2056102 (-) | Inner membrane transport permease YhhJ |  |  | copy AA seq copy Nt seq
CFP59_01549 AUA09459.1 drrA_5 | 2056125 - 2057039 (-) | Daunorubicin/doxorubicin resistance ATP-binding protein DrrA |  |  | copy AA seq copy Nt seq
CFP59_01550 AUA09460.1 novW | 2057201 - 2057797 (-) | dTDP-4-dehydrorhamnose 3-epimerase |  |  | copy AA seq copy Nt seq
CFP59_01551 AUA09461.1 eryCIII | 2057794 - 2059047 (-) | Desosaminyl transferase EryCIII precursor |  |  | copy AA seq copy Nt seq
CFP59_01552 AUA09462.1 lgrE_2 | 2059062 - 2059847 (-) | Linear gramicidin dehydrogenase LgrE |  |  | copy AA seq copy Nt seq
CFP59_01553 AUA09463.1 | 2059904 - 2066155 (-) | Phenolphthiocerol synthesis polyketide synthase type I Pks15/1 |  |  | copy AA seq copy Nt seq
CFP59_01554 AUA09464.1 eryA_20 | 2066194 - 2076384 (-) | Erythronolide synthase, modules 3 and 4 |  |  | copy AA seq copy Nt seq
CFP59_01555 AUA09465.1 eryA_21 | 2076409 - 2081358 (-) | Erythronolide synthase, modules 5 and 6 |  |  | copy AA seq copy Nt seq
CFP59_01556 AUA09466.1 eryA_22 | 2081420 - 2086456 (-) | Erythronolide synthase, modules 1 and 2 |  |  | copy AA seq copy Nt seq
CFP59_01557 AUA09467.1 eryA_23 | 2086456 - 2099811 (-) | Erythronolide synthase, modules 1 and 2 |  |  | copy AA seq copy Nt seq
CFP59_01558 AUA09468.1 strE_1 | 2099948 - 2100922 (-) | dTDP-glucose 4,6-dehydratase |  |  | copy AA seq copy Nt seq
CFP59_01559 AUA09469.1 rmlA2 | 2100936 - 2101808 (-) | Glucose-1-phosphate thymidylyltransferase 2 |  |  | copy AA seq copy Nt seq
CFP59_01560 AUA09470.1 nreC_4 | 2101945 - 2104821 (-) | Oxygen regulatory protein NreC |  |  | copy AA seq copy Nt seq
CFP59_01561 AUA09471.1 fadB2_1 | 2105382 - 2107100 (-) | 3-hydroxybutyryl-CoA dehydrogenase |  |  | copy AA seq copy Nt seq
CFP59_01562 AUA09472.1 | 2107403 - 2108887 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
CFP59_01563 AUA09473.1 | 2108906 - 2109226 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2022-10-07
Changed chemical structures for compounds: efomycin L, efomycin K.

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-10-07
Added NPAtlas links to compounds: efomycin L, efomycin K.

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Entry added

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains