BGC0002293: ohmyungsamycin A biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 56,950 nt. (total: 56,950 nt).
This entry is originally from NCBI GenBank MN480430.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002293
Short description ohmyungsamycin A biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MN480430.1
1 - 56950
via Knock-out studies
Compounds
  • ohmyungsamycin A
  • ohmyungsamycin B
Species Streptomyces sp. [taxonomy]
References
Chemical products information
ohmyungsamycin A Evidence: NMR [1]
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C75H119N13O16
Chemical database entries
NPAtlas
ohmyungsamycin B Evidence: NMR [1]
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C76H121N13O16
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QGA70146.1
 1 - 603 (+) hypothetical protein
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    • QGA70147.1
    		 694 - 1569 (-) transposase
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      • QGA70148.1
      • ohmA
      		 1933 - 43410 (+) nonribosomal peptide synthetase
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        • QGA70149.1
        • ohmB
        		 43413 - 43634 (+) MbtH-like protein
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          • QGA70150.1
          • ohmC
          		 43794 - 44030 (+) hypothetical protein
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            • QGA70151.1
            • ohmD
            		 44161 - 45249 (+) putative ATPase AAA
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              • QGA70152.1
              • ohmE
              		 45246 - 46556 (+) hypothetical protein
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                • QGA70153.1
                • ohmF
                		 46553 - 47383 (+) hypothetical protein
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                  • QGA70154.1
                  • ohmG
                  		 47446 - 48648 (-) transposase
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                    • QGA70155.1
                    • ohmH
                    		 48858 - 49820 (+) ABC transporter ATP-binding protein
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                      • QGA70156.1
                      • ohmI
                      		 49817 - 50650 (+) ABC-2 type transporter
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                        • QGA70157.1
                        • ohmJ
                        		 50774 - 51775 (+) flavin-dependent O-methyltransferase
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                          • QGA70158.1
                          • ohmK
                          		 51796 - 52875 (+) heme-dependent tryptophan 4-hydroxylase
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                            • QGA70159.1
                            • ohmL
                            		 52937 - 54133 (-) P450 L-phenylalanine beta-hydroxylase
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                              • QGA70160.1
                              		 54438 - 55868 (-) hypothetical protein
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                                • QGA70161.1
                                		 55967 - 56950 (+) acetyl xylan esterase
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                                  Biosynthesis information

                                  Biosynthetic paths

                                  4-methoxy-tryptophan
                                  Show structure
                                  Pathway: ohmK > ohmJ [1]
                                  Subcluster
                                  Precursor
                                  NRPS tethered beta-hydroxy-phenylalanine
                                  Pathway: ohmL+ohmA [1]

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  valine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  valine, isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  threonine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  threonine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk05
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  valine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk06
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  leucine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk07
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  valine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk08
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  valine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk09
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  4-methoxytryptophan (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk10
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  valine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk11
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  phenylalanine (evidence: Structure-based inference, Sequence-based prediction, Homology)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk12
                                  Type
                                  nrps-type1
                                  Genes
                                  ohmA
                                  Substrates
                                  valine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: next

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2024-08-18
                                  MIBiG v4 annotathon
                                  • (ID: LS4NEH7WEQDTT7KF4SQJKMYG)
                                  • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Entry added
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
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