BGC0002294: streptozotocin biosynthetic gene cluster from Streptomyces achromogenes subsp. streptozoticus
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Location: 1 - 30,920 nt. (total: 30,920 nt).
This entry is originally from NCBI GenBank MK440296.1.

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core biosynthetic genes
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transport-related genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002294
Short description streptozotocin biosynthetic gene cluster from Streptomyces achromogenes subsp. streptozoticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
MK440296.1
1 - 30920
via Enzymatic assays
Compounds
  • streptozotocin
Species Streptomyces achromogenes subsp. streptozoticus [taxonomy]
References
Chemical products information
streptozotocin [synonyms: streptozocin] Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QBF29316.1
 413 - 1573 (+) RNA polymerase sigma factor SigA
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    • QBF29317.1
    		 1604 - 3532 (-) ABC transporter ATP-binding protein
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      • QBF29318.1
      		 3532 - 5319 (-) ABC transporter ATP-binding protein
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        • QBF29319.1
        		 5446 - 6867 (-) xylulose kinase
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          • QBF29320.1
          		 6998 - 7291 (-) phosphoglyceromutase
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            • QBF29321.1
            		 8185 - 8586 (+) ATP synthase subunit b
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              • QBF29322.1
              		 8583 - 10277 (+) pentatricopeptide repeat-containing protein
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                • QBF29323.1
                		 10341 - 10547 (-) ribonuclease
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                  • QBF29324.1
                  		 10749 - 11285 (+) tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase
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                    • QBF29325.1
                    • stzA
                    		 11278 - 11871 (+) RNA polymerase sigma-H factor
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                      • QBF29326.1
                      • stzB
                      		 11868 - 12668 (+) methylated-DNA--protein-cysteine methyltransferase
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                        • QBF29327.1
                        • stzC
                        		 12727 - 13272 (+) methylated-DNA--protein-cysteine methyltransferase
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                          • QBF29328.1
                          • stzD
                          		 13355 - 14122 (+) proline hydroxylase
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                            • QBF29329.1
                            • stzE
                            		 14472 - 15491 (+) protein arginine N-methyltransferase
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                              • QBF29330.1
                              • stzF
                              		 15562 - 16977 (+) cupin domain-containing diiron protein
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                                • QBF29331.1
                                • stzG
                                		 16977 - 17342 (+) Rieske domain-containing protein
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                                  • QBF29332.1
                                  • stzH
                                  		 17488 - 18738 (+) argininosuccinate lyase
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                                    • QBF29333.1
                                    • stzI
                                    		 18735 - 20030 (+) MFS-type transporter
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                                      • QBF29334.1
                                      • stzJ
                                      		 20074 - 21030 (+) putative alpha/beta hydrolase
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                                        • QBF29335.1
                                        • stzK
                                        		 21017 - 22291 (+) ATP-dependent N-fumaramoyl-DAP-amino acid ligase
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                                          • QBF29336.1
                                          • stzL
                                          		 22288 - 22920 (+) putative membrane protein
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                                            • QBF29337.1
                                            • stzM
                                            		 22958 - 24994 (-) regulatory protein AfsR
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                                              • QBF29338.1
                                              		 25489 - 26751 (+) putative hydrolase
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                                                • QBF29339.1
                                                		 26825 - 28252 (+) multidrug resistance protein
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                                                  • QBF29340.1
                                                  		 28300 - 29607 (+) serine/threonine-protein kinase
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                                                    • QBF29341.1
                                                    		 29757 - 30500 (-) nitrate regulatory protein
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                                                      Biosynthesis information
                                                      Annotation changelog

                                                      Entry version: next

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2024-08-18
                                                      MIBiG v4 annotathon
                                                      • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-10-07
                                                      Added chemical structures for compounds: streptozotocin.
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-10-07
                                                      Added NPAtlas links to compounds: streptozotocin.
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-10-07
                                                      Renamed compounds: streptozocin to streptozotocin.
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-10-07
                                                      Synonyms added: streptozocin for streptozotocin.
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Entry added
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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