BGC0002297: MC-LR biosynthetic gene cluster from Phormidium sp. LP904c
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Location: 1 - 54,162 nt. (total: 54,162 nt).
This entry is originally from NCBI GenBank MK870090.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002297
Short description MC-LR biosynthetic gene cluster from Phormidium sp. LP904c
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MK870090.1
1 - 54162
via
Compounds
  • MC-LR
  • MC-LHty
  • MC-HphHty
  • MC-LHph
  • MC-HphHph
Species Phormidium sp. LP904c [taxonomy]
References
Chemical products information
MC-LR Evidence:
(no structure information available)
MC-LHty Evidence:
(no structure information available)
MC-HphHty Evidence:
(no structure information available)
MC-LHph Evidence:
(no structure information available)
MC-HphHph Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QCQ67872.1
  • mcyI
 1 - 951 (-) phosphoglycerate dehydrogenase
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    • QCQ67873.1
    • mcyJ
    		 1021 - 2031 (-) O-methyltransferase
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      • QCQ67874.1
      • mcyD
      		 2278 - 14001 (+) type I polyketide synthase
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        • QCQ67875.1
        • mcyE
        		 14077 - 24546 (+) hybrid peptide synthetase/polyketide synthase
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          • QCQ67876.1
          • mcyF
          		 24560 - 25276 (+) amino acid racemase
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            • QCQ67877.1
            • mcyG
            		 25463 - 33397 (+) hybrid peptide synthetase/polyketide synthase
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              • QCQ67878.1
              • mcyH
              		 33626 - 35380 (+) ABC transporter
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                • QCQ67879.1
                • mcyA
                		 35453 - 43804 (+) non-ribosomal peptide synthetase
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                  • QCQ67880.1
                  • mcyB
                  		 43820 - 50212 (+) non-ribosomal peptide synthetase
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                    • QCQ67881.1
                    • mcyC
                    		 50272 - 54162 (+) non-ribosomal peptide synthetase
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      mcyG
                      Substrates
                      cinnamic acid, hydrocinnamic acid, D-phenylalanine (evidence: Structure-based inference, Homology)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      mcyE
                      Substrates
                      D-glutamic acid branched (evidence: Structure-based inference [1])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      mcyA
                      Substrates
                      serine (evidence: Structure-based inference [1])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      mcyA
                      Substrates
                      alanine (evidence: Structure-based inference [1])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      mcyB
                      Substrates
                      leucine, homophenylalanine, phenylalanine (evidence: Structure-based inference [1])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk06
                      Type
                      nrps-type1
                      Genes
                      mcyB
                      Substrates
                      3S-methyl-D-aspartic acid branched, D-aspartic acid branched (evidence: Structure-based inference [1])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk07
                      Type
                      nrps-type1
                      Genes
                      mcyC
                      Substrates
                      arginine, homotyrosine (evidence: Structure-based inference [1])
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: next

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2024-08-18
                      MIBiG v4 annotathon
                      • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Entry added
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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