LOCUS       BGC0002301             22627 bp    DNA     linear   PLN 17-JUL-2019
DEFINITION  Aschersonia paraphysata strain BCC11964 Ash gene cluster, complete
            sequence.
ACCESSION   BGC0002301
VERSION     BGC0002301
KEYWORDS    .
SOURCE      Aschersonia paraphysata
  ORGANISM  Aschersonia paraphysata
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
            Aschersonia.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:17:11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22627
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..22627
                     /db_xref="taxon:370937"
                     /mol_type="genomic DNA"
                     /organism="Aschersonia paraphysata"
                     /strain="BCC11964"
     misc_feature    1..22627
                     /note="Ash gene cluster"
     subregion       1..22627
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22627
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(<2655..>4915)
                     /gene="ashL"
     mRNA            complement(join(<2655..3897,3970..4098,4159..4329,
                     4388..4558,4632..4672,4724..>4915))
                     /gene="ashL"
                     /product="AshL"
     CDS             complement(join(2655..3897,3970..4098,4159..4329,
                     4388..4558,4632..4672,4724..4915))
                     /codon_start=1
                     /gene="ashL"
                     /product="AshL"
                     /protein_id="QDK64758.1"
                     /transl_table=11
                     /translation="MARITCFAVLLCLFTEQSFAAMVQRTLRVTWRLGSPNGQSREMIL
                     TNGQFPGPELTFDEDDDVEITVHNDMKFNTTIQQEGTPWSDGVLGLSQKPILPGESFVY
                     KFKASPPGTHWYHSHERMTLVDGLHGAIFIRPKANMTDLWSRISDDPKDIEEMNHAVLD
                     PKLLVLSDWSQFTSEAYWKGIEESKLLVFCVDSILLNGHGEVYCPPQEFLNAETPWGPQ
                     HFGFPDQNVTDKGCFPATAVGIEGPWVNVSHPEKIPNHMQSGCVPSSGSNYTLEVDAAN
                     GWVSLNFIAAAANKQVDFSIDEHPMWIYEIDGNYVEPRRYVAAAITGGERFSVMVKLDQ
                     EPGRYTMRLPDTGATQVISGYADMVYKGAGHVSPETRPYVTYGGLAGREETATESYVPY
                     ILESDHMPPWPANVPAAVADEEFLLVMGRAGAPFLYTMNTKYLYPMDFKQDNPFLFSPN
                     QTLGTDDENLVIRTKNGSWVDLILQVSTLPGDEAAFEHIMHKHGSKTWRIGNGAGLWKY
                     GSVAEAMQAEPESFNLKNPGYRDSWLTTFSPVPTGGYWSVFRYHATNPGPWLFHCHFEV
                     HAMGGMSIAILDGVDAWPDVPQEFAAQNARVSDGRHVLSPLTSSKPLYAKIWDFAQRVL
                     GLRPSEDLGELRR"
     gene            <7881..>9670
                     /gene="ashT"
     mRNA            join(<7881..8072,8216..>9670)
                     /gene="ashT"
                     /product="AshT"
     CDS             join(7881..8072,8216..9670)
                     /codon_start=1
                     /gene="ashT"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 325.8; E-value:
                     5.4e-99)"
                     /gene_kind="transport"
                     /product="AshT"
                     /protein_id="QDK64761.1"
                     /transl_table=11
                     /translation="MPQDSPQSDPAVPSDGKEGKDGVDGLNQAEAGASGGDSEASYPGR
                     GAMAVTMIAISMGVFLVSLDRTIVSTAAPTITDQFHSPTDIGWYASAYTLTGSALQLPL
                     GRFYKFYSPKRVYMTLVFIFMVGSAIGAGAMNSNTVIVGRAVQGIGLGGVLSGSMILVA
                     QNAPLARQPMFMGILMATMSISSIVGPLIGGALTTNTSWRWCFLINIPIGAVIIAVLFF
                     FAGAKESKEQVSQSWKAKVQRLDPLGAAFLLPAVVCIILALQWAGSEYSWSNWRIILLL
                     VLGGLLAIAFVASQILMPETATVPPHVARQRTVFASFLFSLMTGGSMLIVTYWLADWFQ
                     AIQNVSAVEAGIRTIALVLSQAVGAIGGGASSRLIGYPPAIMMLSATFISVGNGLLSTL
                     EVDTGSGKWIGYQVLLGLGFGLGTQQASLAVQTVLKPEDVPTAISIVFFGLQLGGSIFI
                     CVGQNVFNQLFQKLLRQAAIPGLDLDLVLKTGATEIRRLVPDGADLQKLLTAYNTSVTS
                     TFYVAAATGVAAFLSALFVQWKSVKNVDPVH"
     gene            complement(<10003..>10547)
                     /gene="ashZ"
     mRNA            complement(join(<10003..10278,10398..>10547))
                     /gene="ashZ"
                     /product="AshZ"
     CDS             complement(join(10003..10278,10398..10547))
                     /codon_start=1
                     /gene="ashZ"
                     /product="AshZ"
                     /protein_id="QDK64759.1"
                     /transl_table=11
                     /translation="MESQQPLCLNILSYKKDGITSEEYKHYMVNEHGPLVAGLMEKYGF
                     LQWTMSHVSDQSPQLMSQLYDAQFGNIAPYDCCVQIVFPNIEAFVKMKADPYFKQTVGP
                     DHEKFADTKKSQMMIGYFSPLVKDGKALDSNERNGKS"
     gene            <12959..>19498
                     /gene="ashP"
     mRNA            join(<12959..13248,13313..18504,18648..>19498)
                     /gene="ashP"
                     /product="AshP"
     CDS             join(12959..13248,13313..18504,18648..19498)
                     /NRPS_PKS="Domain: SAT (8-244). E-value: 1.2e-60. Score:
                     196.9. Matches aSDomain: nrpspksdomains_ashP_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (380-813). E-value:
                     2.9e-145. Score: 476.2. Matches aSDomain:
                     nrpspksdomains_ashP_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (919-1222). E-value: 2.6e-81.
                     Score: 265.1. Matches aSDomain:
                     nrpspksdomains_ashP_PKS_AT.1"
                     /NRPS_PKS="Domain: PT (1308-1642). E-value: 1e-106. Score:
                     348.7. Matches aSDomain: nrpspksdomains_ashP_PT.1"
                     /NRPS_PKS="Domain: ACP (1701-1764). E-value: 6.4e-12.
                     Score: 37.5. Matches aSDomain: nrpspksdomains_ashP_ACP.1"
                     /NRPS_PKS="Domain: Thioesterase (1863-2014). E-value:
                     4.2e-26. Score: 84.6. Matches aSDomain:
                     nrpspksdomains_ashP_Thioesterase.1"
                     /codon_start=1
                     /gene="ashP"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 169.4; E-value: 2.3e-51)"
                     /gene_kind="biosynthetic"
                     /product="AshP"
                     /protein_id="QDK64760.1"
                     /sec_met_domain="itr_KS (E-value: 1.3e-158, bitscore:
                     516.3, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.8e-82, bitscore: 265.1,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.5e-12, bitscore:
                     36.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNFQVVTFGDLSTPYFAELQKLVFHKTDFVLTSLFDDTYRALR
                     AELSRLPPSQKASLPQSSNLLELLAGSDASSTRNCALTGALACLYQIASLVSYIGKTKV
                     SYPQNSTCCISGGCFGLLASVAVSCSETVVDLVSITPDTVALAFRLGLLVQARTDSVVP
                     SSSDGSSSYSYVLPGADETLVARLVDEYCQLRDLSTLSRVYISALSVGSITVSGPPAEL
                     KEFMSLHPELKSAKLQINGLFHSSWLYTPQDVAELVATFDAGLKSRTSHLDIMPNSVEN
                     KEQYSRGVTCESLLRVAISDILLHRLRWDLVVKGTVTAVQRSASASAVDVLPFAAGSVE
                     GMASSIRASAGVDRVQIQDTLPAPPPEEDARKDKRATRSKIAIIGFSGRFPEADDNKEF
                     WELLAAGLDVHKEIPKDRFDPWLYYDAAGKKKNTSCVTKGCFVRNPDLFDSRFFSMSPR
                     EADQADPAQRLVLMTAYEAMEMAGFVPDSSPSTQRSRVGVFYGTASDDYREINAAQNVD
                     TYFVPGGSRAFLPGRVNYHFRFSGPSFDVDTACSSGLAAVHIACNSLWSQDCDVAVAGG
                     TNILTNPDNWCGLDRAHFLSRTGNCNTFDDAADGYCRSDSVATVLLKRLDDALLDGDPI
                     FGTILGAYTNHSAEAVSMTRPHSGAQRAIFSRILNAASVDGSDVSYVEMHGTGTQHGDA
                     CEMDSVLSVFAPQGSGARDKALFLGSAKANIGHAESASGVASLIKVLLMMQNHAIPPHV
                     GIKTKINRNFPTDLAQRNVHIAMKTTPWPRPDPRDRPHGRRAFVNNFGAAGGNSSVLIE
                     DGPVPILPETGDGDHVDGCWATHVVAVSAKTQASFKNNLAALVGHLDAHPDVSLDSLSY
                     TTTARRAHYAFRTAVAGTSVDEIKRALQSVADREKHLSVAGGGPPIGFCFTGQGSQYLG
                     MGKRLFSLPRFREFMVGLDETAGRQGFPSFLDVIQGRGETPVEQMAPVKVQLAITCLQM
                     ALGKLLIALGVTPRLVVGHSLGEYAAMNVAGVIGDADTIHLVGSRARLLEKHCAVGTHA
                     MLAIKASAVKVASLKAASHPDLDIACVNGPEETVVAGSNEQIESFKAALSSQSIKSTTV
                     KVQFAFHSAQVEPLLDEFRRICSSVTLRDPSFPILSPMMAKVINKAADMGSTSDYLARH
                     CRESVRFHDCLSWARQSSLLPDRTTWVEIGPHPLCSNMLRSVLGSSTKTLPCLRRGEDD
                     WAVFLPTLMSLYDSGLPVDWIEYHHGGGSKKRKQVIQLPAYQWDLKSHWIPYEHDWCLT
                     KGDAPTVPLQAPTPSPSRAEAKFSTTSVQDVVYERYAADESCITARSDVQHPDFREVLL
                     AHKVNGRPLCTSSVYADMAMTLFARLLDKSPIAFDKTDIGIEVANMAVDKSLILDESSN
                     TALTQLLEMKAHVKWSTRQATFSLSSIASDGKATEHHAKCTGSFTEKSRWRAEWKRHDF
                     LIKARVQHLRQSAHSDDDDGGETAAAHLIKTGLFYKLFSALVDYEAPFKGCRELVMRSA
                     DMESTAKVKFNTPPGTSDKWMNPPYWIDSLGQITGFTMNGNDQVDSKTQVYINHGWDNM
                     KLSERLSDQKTYTTYVKMQPRDKGSYSGDVYVFGPGMDEVVAVYEGVTFAAVPRKVLDR
                     VLPKKGQATGEATATRSTTSSREAKTAPESAPAGYNIPTSETQPLPQLVVPEKQGVAAE
                     KLKLIIAEEVGASLSDIEDDAELAALGVDSLLALTMSDRMLEELKLKVDSTCFITCTTV
                     AELLEAIVGPPSPSSGSGSVADTPLKTPDAEPEYGTFGALQSLDAAAMALDSNGLPSLG
                     GGIDDGQAEPMLLNPAAAAAMTKQPPQTVAVPPASSVLLQGDPTTCTRKMWLFPDGSGI
                     AASYMPLPDLDAKRVAVFGLNSPYVKRTDSIVPCQFHELTAVYLAEIRRRQPAGPYVFG
                     GWSAGGISAYEAAQELAAAGETIDGLILLDTPKPIDLKELPSRLYGQLDGLNVFGIGNS
                     RPPPWLLTHFALFSAILDTFKPRPWRAATPLRAWAIWAQHGVDEAGSIAISPDDPDNVA
                     WLLKRRVQESLVANGWDQLVGSDNVTPFIVEGAHHFNMLKQPAVKQVCDYMQRIMKSLD
                     "
     aSDomain        join(12983..13248,13313..13754)
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ashP_SAT.1"
                     /evalue="1.20E-60"
                     /label="ashP_SAT.1"
                     /locus_tag="ashP"
                     /protein_end="244"
                     /protein_start="8"
                     /score="196.9"
                     /tool="antismash"
                     /translation="TFGDLSTPYFAELQKLVFHKTDFVLTSLFDDTYRALRAELSRLPP
                     SQKASLPQSSNLLELLAGSDASSTRNCALTGALACLYQIASLVSYIGKTKVSYPQNSTC
                     CISGGCFGLLASVAVSCSETVVDLVSITPDTVALAFRLGLLVQARTDSVVPSSSDGSSS
                     YSYVLPGADETLVARLVDEYCQLRDLSTLSRVYISALSVGSITVSGPPAELKEFMSLHP
                     ELKSAKLQINGLFH"
     aSDomain        14163..15461
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ashP_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.90E-145"
                     /label="ashP_PKS_KS.1"
                     /locus_tag="ashP"
                     /protein_end="813"
                     /protein_start="380"
                     /score="476.2"
                     /tool="antismash"
                     /translation="IAIIGFSGRFPEADDNKEFWELLAAGLDVHKEIPKDRFDPWLYYD
                     AAGKKKNTSCVTKGCFVRNPDLFDSRFFSMSPREADQADPAQRLVLMTAYEAMEMAGFV
                     PDSSPSTQRSRVGVFYGTASDDYREINAAQNVDTYFVPGGSRAFLPGRVNYHFRFSGPS
                     FDVDTACSSGLAAVHIACNSLWSQDCDVAVAGGTNILTNPDNWCGLDRAHFLSRTGNCN
                     TFDDAADGYCRSDSVATVLLKRLDDALLDGDPIFGTILGAYTNHSAEAVSMTRPHSGAQ
                     RAIFSRILNAASVDGSDVSYVEMHGTGTQHGDACEMDSVLSVFAPQGSGARDKALFLGS
                     AKANIGHAESASGVASLIKVLLMMQNHAIPPHVGIKTKINRNFPTDLAQRNVHIAMKTT
                     PWPRPDPRDRPHGRRAFVNNFGAAGGNSSVLIED"
     aSModule        14163..19207
                     /complete
                     /domains="nrpspksdomains_ashP_PKS_KS.1"
                     /domains="nrpspksdomains_ashP_PKS_AT.1"
                     /domains="nrpspksdomains_ashP_PT.1"
                     /domains="nrpspksdomains_ashP_ACP.1"
                     /domains="nrpspksdomains_ashP_Thioesterase.1"
                     /final_module
                     /iterative
                     /locus_tags="ashP"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       14643..14690
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ashP_0001"
                     /evalue="1.90E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="ashP"
                     /protein_end="556"
                     /protein_start="540"
                     /score="16.8"
                     /tool="antismash"
                     /translation="GPSFDVDTACSSGLAA"
     CDS_motif       14832..14867
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ashP_0002"
                     /evalue="5.00E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="ashP"
                     /protein_end="615"
                     /protein_start="603"
                     /score="10.3"
                     /tool="antismash"
                     /translation="FDDAADGYCRSD"
     CDS_motif       15063..15110
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ashP_0003"
                     /evalue="2.00E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="ashP"
                     /protein_end="696"
                     /protein_start="680"
                     /score="10.7"
                     /tool="antismash"
                     /translation="YVEMHGTGTQHGDACE"
     CDS_motif       15177..15221
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ashP_0004"
                     /evalue="8.10E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="ashP"
                     /protein_end="733"
                     /protein_start="718"
                     /score="9.2"
                     /tool="antismash"
                     /translation="GSAKANIGHAESASG"
     aSDomain        15780..16688
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ashP_PKS_AT.1"
                     /evalue="2.60E-81"
                     /label="ashP_PKS_AT.1"
                     /locus_tag="ashP"
                     /protein_end="1222"
                     /protein_start="919"
                     /score="265.1"
                     /tool="antismash"
                     /translation="CFTGQGSQYLGMGKRLFSLPRFREFMVGLDETAGRQGFPSFLDVI
                     QGRGETPVEQMAPVKVQLAITCLQMALGKLLIALGVTPRLVVGHSLGEYAAMNVAGVIG
                     DADTIHLVGSRARLLEKHCAVGTHAMLAIKASAVKVASLKAASHPDLDIACVNGPEETV
                     VAGSNEQIESFKAALSSQSIKSTTVKVQFAFHSAQVEPLLDEFRRICSSVTLRDPSFPI
                     LSPMMAKVINKAADMGSTSDYLARHCRESVRFHDCLSWARQSSLLPDRTTWVEIGPHPL
                     CSNMLRSVLGSSTKTLPCLRRG"
     CDS_motif       15783..15830
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ashP_0005"
                     /evalue="1.90E-05"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="ashP"
                     /protein_end="936"
                     /protein_start="920"
                     /score="17.2"
                     /tool="antismash"
                     /translation="FTGQGSQYLGMGKRLF"
     CDS_motif       16017..16136
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ashP_0006"
                     /evalue="4.30E-14"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ashP"
                     /protein_end="1038"
                     /protein_start="998"
                     /score="44.5"
                     /tool="antismash"
                     /translation="GVTPRLVVGHSLGEYAAMNVAGVIGDADTIHLVGSRARLL"
     CDS_motif       16239..16277
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ashP_0007"
                     /evalue="5.10E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="ashP"
                     /protein_end="1085"
                     /protein_start="1072"
                     /score="10.2"
                     /tool="antismash"
                     /translation="ACVNGPEETVVAG"
     aSDomain        16947..17948
                     /aSDomain="PT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ashP_PT.1"
                     /evalue="1.00E-106"
                     /label="ashP_PT.1"
                     /locus_tag="ashP"
                     /protein_end="1642"
                     /protein_start="1308"
                     /score="348.7"
                     /tool="antismash"
                     /translation="TTSVQDVVYERYAADESCITARSDVQHPDFREVLLAHKVNGRPLC
                     TSSVYADMAMTLFARLLDKSPIAFDKTDIGIEVANMAVDKSLILDESSNTALTQLLEMK
                     AHVKWSTRQATFSLSSIASDGKATEHHAKCTGSFTEKSRWRAEWKRHDFLIKARVQHLR
                     QSAHSDDDDGGETAAAHLIKTGLFYKLFSALVDYEAPFKGCRELVMRSADMESTAKVKF
                     NTPPGTSDKWMNPPYWIDSLGQITGFTMNGNDQVDSKTQVYINHGWDNMKLSERLSDQK
                     TYTTYVKMQPRDKGSYSGDVYVFGPGMDEVVAVYEGVTFAAVPRKVLDRVLPK"
     aSDomain        18126..18314
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ashP_ACP.1"
                     /evalue="6.40E-12"
                     /label="ashP_ACP.1"
                     /locus_tag="ashP"
                     /protein_end="1764"
                     /protein_start="1701"
                     /score="37.5"
                     /tool="antismash"
                     /translation="IIAEEVGASLSDIEDDAELAALGVDSLLALTMSDRMLEELKLKVD
                     STCFITCTTVAELLEAIV"
     aSDomain        18755..19207
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ashP_Thioesterase.1"
                     /evalue="4.20E-26"
                     /label="ashP_Thioesterase.1"
                     /locus_tag="ashP"
                     /protein_end="2014"
                     /protein_start="1863"
                     /score="84.6"
                     /tool="antismash"
                     /translation="KMWLFPDGSGIAASYMPLPDLDAKRVAVFGLNSPYVKRTDSIVPC
                     QFHELTAVYLAEIRRRQPAGPYVFGGWSAGGISAYEAAQELAAAGETIDGLILLDTPKP
                     IDLKELPSRLYGQLDGLNVFGIGNSRPPPWLLTHFALFSAILDTFKP"
     CDS_motif       18938..19012
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ashP_0008"
                     /evalue="3.10E-11"
                     /label="NRPS-te1"
                     /locus_tag="ashP"
                     /protein_end="1949"
                     /protein_start="1924"
                     /score="35.6"
                     /tool="antismash"
                     /translation="QPAGPYVFGGWSAGGISAYEAAQEL"
ORIGIN
        1 tatcgaccgc tcccaatgac gctgctctgt atacgctgtt gtgattcacg cgctatcaaa
       61 accatgatgg tttcagatac ttcggattcg gattccgaac atacgagcga tcttatcaac
      121 gtcattagat attatcctca tcgtcgtgcc gttccacaca tatagacacc tgtgtgcaaa
      181 caaatattgt ggttcgcggt aggtccggct cacgacctcg gcaaccatgg agaacgcttc
      241 acctgcgcct gcccatgaga ttctccttcc ttggattgac tctgcgaaaa tcttttgcgc
      301 gacgtttaca ttcttgtcgg atcctagacc taattggcct tggacaccaa aacctgttgc
      361 aaaggcttgg ccatccgcat tgacaaagat tgtgtggttg gtgccacaag cgacactggt
      421 gacacgaccg atgttcggta ccagggtcgg gcgtgtacag acttgaggca tgtgacaagc
      481 gcctcggcga aaaagagatt cgtcttgcag ctgctcctta gtaaagtcga tgccgagctg
      541 accatcgtcc atcctgcccc aagcaaaaca gcgcccgtcc tcggtcacgg cgcatgaatg
      601 gctctggcca ccggataaga ctttgatctt cattcccgca agatgggtca atctcatcgg
      661 attcgaaaga caagacaggc ggtcggaatt atatccagtc tcgcagtttt cgttccgacc
      721 ccaggcccac acgtcgccgt ctttgtccac tgcgaatgag tggcaatgac ctgaggcgat
      781 atagacaatg ctgttgaggc acacgattag tcggcgcgga atcaagggat ccaggtcgcg
      841 accgaaaaat cgttggcaac cgagctgaaa ttcatcatta acaccccatc cccaaacact
      901 tccatcctta tctaaggcta gaacatggtt tgagccacag gctatttgga caatcttggg
      961 gagtccgaga aaatgaaccg gatcatgttg ccaggcaact cgcctaccgc ggacgccgta
     1021 tctgaagctc tcgacgccct gggcattctg cagaagctct cagtacagag tgtttcaaga
     1081 aacgagtgaa aggaaacgca acgcacacga aatgttcccc agccatagac ttcgcccagc
     1141 gtggtcaata caaacgagca attggcgccc gcggccacct gctcgaagcg aatattgcgc
     1201 ccgaaatatt gtggaggaac ttgcatcggg accgattcca gaggattgag ttcctacagg
     1261 ccatcgtgcg agccatctct tgagtcttca tccgtgacgg gcagttcacc atactggtcc
     1321 gtctcccgtc cgagagcacc aacgtgattt gctccccacg tcaagatttt gttgtccgtg
     1381 gtcaaagcaa tcgtatgcat ggagccgcat gcgacctgaa ggacatgaaa ctttgtggca
     1441 tcgctggggt cgaggtaggg gttcaaacgc ggcacctggc tttcagagtg atcttgaccc
     1501 aagcccaatt ccctattttc gccttcgccg aagaccaaga tgctgaaagc ttgtttgggc
     1561 tcggagtacc ctggcaacaa tgctgtcaca ttgaggattt tttcttgttg ttcctcgagc
     1621 ttcggatctc gctctgggac ctgacccgct gcagctgcgg tttcgccagg catcgtggcg
     1681 cgattccctc gtatggacgg gatcttgtct catctaagga tgagggtcgg aaacttgtcc
     1741 cgtctgaaga ttaggctcct atcgcggagc gctttcagga acagatccgt gcatggcaga
     1801 ataagaatat aagtgaacga tgaagatagg catagccggt tgctcctggg acaatgtttt
     1861 tggctggcca tcccagcact cctgcctgaa agaaccccgc cgtgcctacc ttctcgactt
     1921 ttcgacgtag agtagcctac cctacaatca aagacgctct accttgaaag tggtcgcgac
     1981 tcgctgcaca tattttgcct ttaaacgaaa ttgagccatc ccttgatcac atccaaatgt
     2041 ctggggcacg ggcccgtcct tgtcgtcgga cacgcctggt cgacaagctt cgattgagtc
     2101 accacaaaat gagattgggc atgggctatc atgatgattc attggtcact ggagagcctg
     2161 cagaaaggtg tcgtcatatc attcagccac accgcagcac gagccgtgga gatgacaggc
     2221 cgggtcatca gcttgcagac gaacgacatc tgagctgttc aatggcgtca attgccgacc
     2281 tctttctttg atgggttgga cgtcgagaag cgatgccacc ttctgccgac acttctgctg
     2341 ctcagtgtca tgttgcgacg aggttgatgc cacgtctact tgtcaatgta ggggcgttgc
     2401 actttcgtgc gataattcac ttgcaaaacc gcggtggcaa gggtcgcact tcctccgaaa
     2461 cacctcgagc gtatgcgagc ctgtcttttc gctcaacgct cttcatttcg cttattgtgc
     2521 attatgatct gaggtacaag atgaagatac atgcccatcg aacggtaagt gccatgccaa
     2581 aagccgctga acaacccccc cccttcttac ctcccaaatg cacattctgc tcttggctac
     2641 gtcctgtaga tcattcaacg ccgtagctcg ccgagatctt cgctcggccg cagtcccaac
     2701 acccgctgcg caaagtccca gatcttggca tacagtggct tggaactggt caaagggctc
     2761 agaacgtggc gtccgtcaga gacccgagcg ttctgagcag caaattcttg cggaacatcg
     2821 ggccaggcgt caaccccgtc taaaatagca atcgacatgc ctcccatggc atgcacctca
     2881 aagtggcagt ggaatagcca agggcccggg tttgtcgcgt ggtatcggaa gacactccag
     2941 tagccaccag tcgggacggg ggaaaacgtg gtcagccaag agtctctgta gccggggttc
     3001 ttgaggttga agctctcggg ctcggcctgc atggcttcag caacgctgcc gtacttccag
     3061 aggccggctc cgttgccgat tctccacgtc ttgctgccgt gtttgtgcat gatgtgctcg
     3121 aacgcggctt cgtcgccggg aagcgtggac acttgcagga tcagatccac ccaagagcca
     3181 ttcttggtgc ggatgacgag gttctcatcg tcagtaccaa gagtctgatt cgggctgaag
     3241 aggaatgggt tgtcttgctt gaaatccatg gggtagagat acttggtgtt catggtgtat
     3301 aggaatggtg caccagcccg gcccatgact aggagaaatt cctcatcggc aacggccgcg
     3361 ggaacattcg ccggccacgg cggcatgtga tccgattcaa gaatgtaggg aacgtagctc
     3421 tccgttgccg tctcttcgcg cccggccaag ccgccatacg tcacgtacgg cctcgtctct
     3481 ggggacacat ggcccgctcc cttgtagacc atgtcggcgt atcctgaaat gacttgcgtc
     3541 gctccagtat ctggcagtcg catggtatac cggccgggtt cttggtcgag tttcaccatg
     3601 acggagaagc gctcgccgcc tgtgatggcg gcagcaacat accttcgagg ctcgacgtag
     3661 ttgccgtcaa tctcgtagat ccacatggga tgctcgtcga tggagaaatc cacctgtttg
     3721 ttcgctgccg ccgcgatgaa gttcaagctc acccatccat tcgctgcatc aacttcaagc
     3781 gtataattcg atccgctgga ggggacgcag cccgattgca tgtggttggg gatcttctcc
     3841 ggatggctca cgttgaccca ggggccttca attcccacgg ctgtggccgg gaagcagctg
     3901 catccaagtc aaaaggtcag tatacgtctg gagatggttg cacggccatg agtaagaaga
     3961 agtgcgaacc ctttgtccgt cacgttctga tcagggaacc caaaatgctg cggtccccag
     4021 ggtgtttcag cgttgaggaa ctcttgtggt gggcagtaga cttccccgtg tccattcaac
     4081 aagatgctgt cgacgcaact gggatttctc tgtcagcaga ctttctcccc gtcgacgtag
     4141 atcgagctag agactcacaa caccaaaagc ttggactcct ctattccttt ccagtatgct
     4201 tcagaagtga attgtgacca atccgaaagc accaagagct tcggatctag gacagcatgg
     4261 ttcatttcct caatatcttt cggatcatca ctgattcgag accacagatc cgtcatgttt
     4321 gcttttggtc tagcttccat agttagcctc gtgttggctc ttgccaagtt gttaatagtg
     4381 cgcttgcctg atgaaaatgg cgccatggag tccgtccaca agagtcatcc gctcgtgcga
     4441 atgataccag tgcgtccctg gaggagaagc tttgaatttg tacacaaatg actccccagg
     4501 caaaattggt ttctgagaaa gacccaggac accatcagac cacggcgtgc cttcctgcct
     4561 atgatccagt gttagcattg ttggaacgac tgaagggcgg caaagggggg ccatacgaaa
     4621 taccgtgcca gtgaatggtt gtgttgaatt tcatgtcatt gtgaactgta atctagaaag
     4681 tactgtcaac cagatttcaa acttcgaatg atgcttcttt tacctcgaca tcatcgtctt
     4741 cgtcaaaggt gagttctggg cctggaaatt ggccgtttgt taaaatcatt tctcgagact
     4801 gtccgttggg agaacccagt ctccatgtga cgcggagagt cctctgtacc atggcagcaa
     4861 acgattgctc cgtgaaaaga caaagaagca cggcaaagca agtaattcga gccatggtga
     4921 atgctgtcag tcacgctgga cagaagcgca atttttgaga ctcgcgccga ggcaatttgc
     4981 tctggtcaga aggcgtgagg cccgccgcag gaaacgatgt tttgctacta agtgattaag
     5041 gtgtaagaaa agtgaggtca attttgtctc ctcgtgtttc tgaactcgca gtgtgtgagg
     5101 caagataata tgagcaaatg ggataacgcc aatgagcaac ggcttcttaa ggtacgcggg
     5161 cacaatctct cgggactatg gaaaacacgg agctgatctg gacggagaga aactgtaaga
     5221 acctgaactt tgccacacct acgttcctaa gccctgtttg catgacgaga tcatccggtg
     5281 atatcgacat cttgcatttc ccggcgctta caggttttcg tccccctgag gacgcttcat
     5341 ggccagtcga ggaagatatt gatggcttga gacaaatcgt tgctttggat cccgtgccgg
     5401 acgccacccc ttttggtact gaaggcttgt gctattggtt cctttgaggt cggaggctga
     5461 gatggcatga ttcagcgggg acttgatgaa tcatgaactt gggaatctca agatcaacat
     5521 tgctccttta tcagtgtcga ggtcaggttc tacagagttt ctgaactgtg ggtcgatgag
     5581 aaatccgtgt agcctatcag aatttagtcg ttgatcctgc gcgaatgttg agacatgttt
     5641 ctcggcttct atcgctggcc ttcacaaggt gttcgtggcg tcgaaggctc cctccgagaa
     5701 agatagcgcc accggacagg gggggagggt ctggcattgt ccattgcttt gttgctcagg
     5761 tacggtggcg taggtactgt aggtacagtg gtcatggccg tgtacaagat tgtggggatc
     5821 ggagttactc tggaatatgg ggatcttggt cgtggagact tttgttttcg agtccttttc
     5881 tcatgacatt ccaggaaaac cggagcatgc gggacagaat tgaaagaagc gccgctcgga
     5941 gtgtaagacc gttgctcggt gagggggggg gaaggggggt tggcgagggc ttttcctgag
     6001 ctatcgagca gtacgacaat cctcaggctg aagtgatgcc acgcagtacc aaatttgacc
     6061 tctctgctct tctttcacgg gcttgttcca atctgagcga cctgttcaac tatggatgag
     6121 gtatcttcta tcgagtgttt tttcggcgat ttagcttcag attttggaat tgcatatgat
     6181 gtgcgatagt cggttcatgt cagcatcatg gactttgtga ttgatatccg agacagtcca
     6241 gcctttggga ttggttgggt agtcgttggc ggaagtgtca gtcaagtcca acacttatcg
     6301 gacggacact gattgaaaga tgcaggactt gccacctcgg aactgatgca cactccacgg
     6361 cagcggttcg tcctgctgct tttttctgcg gatccttgat ccaccggcac gtcctctcga
     6421 aatccatgtc ctatgcccgt tgatgaaact ataatctgtc ctggtcgagt tcagtcattg
     6481 acgagtgttt gacatccttg aagatgagat ggcgggaccg ctacaaggtc tcctggccaa
     6541 aaaagagtgg ctgcactcct ttgcccattt gcgcaccctg ttcatgcgaa ttgttcagta
     6601 agatgactag tggcgacacc agcttccatc gccttctgca cctgggttgg taccctattg
     6661 acattgtgtg ggcgcggcgt tgtgaatgct cccatgtctt tcgcggcctc cagagagctg
     6721 tttgccttgg tgtagcacgg tttctttatt tttcagaaac ctgaccatat ggcaaatcag
     6781 gcagctatat cgagatgttc gagatcgaaa cgattggggt gtcacgagct gatgtgtgat
     6841 gtgttgtcaa agtcgagatt ctggtccgat caagtcatca ccactgtgtc tcttccttcg
     6901 tttcaaagac gcgctgggga cgacggacgg ggatggcaat ggggtcaagt cacgtgagac
     6961 cccctactca gacaacctcc actaaagggc ccctcccagg aagattttca tgttgcgcac
     7021 tcaattccga tcagctcaat caacgattcc ttgagcaaca tcatttcatc atccctggtg
     7081 ctcgttcact caattccccg tgggaactca cagataacaa tgatgaggcg aaacaaccaa
     7141 cttgggaatc aggtgtggtg gcttgtatga ctcatttggt ggtagagatt ggcaaagtct
     7201 ctgtgcgaac catgacgcat gactattgag gcatctgtct cttttttttt ctttttttct
     7261 tttttttttc cttcctcctt tccgtgacga acacgttttg cgtcactgca tggcacgcga
     7321 ggagtgctgg caggcacttt gaaatcgaag aatcgagtcc gaatcgtttc gatacaaagc
     7381 cgccgtttta tttccgcccc ccggatatgg cgtcgggacc gagataaatt gcgagaaccc
     7441 gtttgtcgtt ggttgggtcg aacccctgct ccgagacccc ttgttcccga tgtagcgatg
     7501 cagccaccac caaaccgggc ctatccagca gccagctgat ggcccagacg cgtgtcgaga
     7561 catgcggctc ctgtggccag agttcgcatt ctacgaatgg catttccaca ggatgttgtt
     7621 tgtgtgacga ctttccccct tccttgcctc gttttctccc gtccaagatg gcttactgcc
     7681 atcccctcca gctcgcgggc ggcaattaca aaaagctttc cttatcatct ctgcatctca
     7741 tggacagcaa agaaaagaga agcgaaagaa gcccggcgga ccaatttgac gtcgacgttg
     7801 atttgtccaa ttcgcccctc agctcagcac gcgcctcagc agctgattct ttccgtcaca
     7861 caacctcgtc gtgatcgatc atgcctcaag acagccctca gtcggatccc gccgtcccct
     7921 cggacggcaa agagggaaaa gatggcgttg atgggcttaa ccaggccgaa gccggcgcat
     7981 cgggcggcga cagtgaagca tcttatcctg gtcggggagc catggccgtc accatgatag
     8041 ccatctccat gggtgttttc cttgtctcat tagtgagtgc tgcgtgcaaa gagatgggaa
     8101 agagagggct ctgctctgct ctgctcttct cttctccgag ttgtcttgtt tcgtttttac
     8161 ccgcgcgtcg gcctggcatg tcactgacca acacgtcgcc gcatcatcct caaaggatcg
     8221 caccatcgtt tccacggcag ctcccaccat cacggatcag ttccactccc ccacagacat
     8281 tggatggtat gccagcgcct acaccttgac tggcagcgcg ctgcagctgc cgctgggccg
     8341 cttctacaag ttctactcgc ccaagcgcgt gtacatgacg ctcgtcttca tcttcatggt
     8401 tggctcggcc attggggccg gcgccatgaa ctccaacacc gtcatcgtcg gccgtgctgt
     8461 gcaaggcatc ggcctgggtg gcgtcctgtc cggctccatg attctcgtcg cccagaatgc
     8521 ccccctcgcc cggcagccca tgttcatggg catcctcatg gccaccatga gcatatcgtc
     8581 catcgtcggt cccttgattg gaggcgccct gacgaccaac actagctggc gctggtgttt
     8641 cctcatcaac atccccatcg gcgccgtcat catcgccgtc ctcttcttct tcgccggtgc
     8701 caaggaaagc aaggagcagg tctcgcagag ctggaaagcg aaagtgcaaa ggctggaccc
     8761 tctcggcgcg gctttccttc tgcccgccgt cgtctgcatt atacttgccc tccagtgggc
     8821 aggctccgaa tacagctgga gcaactggcg aatcatcctt ctccttgtgc ttggcggcct
     8881 tttggccatt gcctttgtcg cttcgcagat tctcatgcct gaaacagcca ccgtcccgcc
     8941 gcatgtcgcc cgacagcgta ccgtcttcgc ctccttcctc ttttccctca tgacgggggg
     9001 ctccatgcta attgtgacgt actggttggc ggattggttc caggccattc agaacgtcag
     9061 cgctgtcgaa gcgggcataa ggaccatcgc tctcgtctta tcccaggctg tgggtgccat
     9121 tggcggtggc gcctcctccc gcttgattgg ataccctccc gccatcatga tgttgagcgc
     9181 caccttcatc tccgtaggca acgggcttct ttctacgctg gaagtcgata cagggtctgg
     9241 caagtggatt ggctaccaag tcctactggg tttgggattc ggcttgggca cgcagcaggc
     9301 atcgctcgct gtgcagacag tcttgaagcc cgaagatgtt ccgactgcca tctccattgt
     9361 attcttcggc ctgcagctgg gcggatccat cttcatttgt gtgggccaaa acgtcttcaa
     9421 ccagcttttc caaaagcttt tgagacaggc cgctatacca gggctcgatc ttgacctggt
     9481 gctcaagacg ggcgcaacag aaatcaggcg cctagttcct gacggtgcgg atctgcagaa
     9541 gctcctgacg gcctacaata cctcggtgac gtccaccttc tatgtcgccg ccgccactgg
     9601 agtcgcagcc tttttgagtg ctttattcgt gcagtggaag agcgtgaaga atgtcgaccc
     9661 ggtccactga tgcatcaaga agattgatct acattgcgta gtgtcgagac ttggtggcgc
     9721 cttgtaaatc atgaacaagg gattcagttg aattaaagta acttcccttc cgcaggccca
     9781 gattcgggct caccttcata gagcaagtac atagatagtc atttccttaa cacgaacaca
     9841 tgccgctccg cacacgtctt tccaaacacg gtgctacatg tgtacatgac aaatgtcgtg
     9901 gtccacgtga acaaatgagg tcatgatgtt tgccaagccc aatatctgat atatcgatta
     9961 cgtgcatgag caaaagatat atgagtacat gcccattcga tcctacgatt tcccattcct
    10021 ctcattcgaa tcaagtgcct ttccatcctt gacaagcggg gagaagtagc caatcatcat
    10081 ctgcgatttc tttgtgtctg caaacttctc atgatcgggt cctaccgtct gcttgaagta
    10141 cgggtctgcc ttcatcttga caaaggcctc gatgttgggg aagacgatct gcacacagca
    10201 gtcgtagggc gcaatgtttc caaactgcgc atcatagagc tggctcatga gctgcggcga
    10261 ttggtcggaa acgtgggact gtagccaaag aagtttttcc tcgcgaatat taacatttta
    10321 attttttttt ccgccgacgc tgcttcctca ccccccaacc caaaaaaata aaagggggag
    10381 gggggaaagt cacccaccat ggtccactgc aggaatccgt acttttccat caagccggcc
    10441 accaggggac cgtgctcatt caccatgtag tgcttgtact cctcgctcgt gatgccatcc
    10501 ttcttgtagc tgagaatgtt gagacagaga ggttgttggg actccatgtt gttgattcct
    10561 ttctactgtc gttttccaaa attggcacgc ttttgtcgtt ggcaggaagc gggaagtagg
    10621 gagtcgaatg agccccgtga tagtgtcaaa gggtgctcga aaacccaaaa agtgaagagg
    10681 gagggggggt tggagtcgga gccggcgggc caaagcaaaa gcggcacgga aaaaaaagcg
    10741 acggcctgac ttagtcatgg gctgagggct tcgcggctga agtcaaggcc atcatagcag
    10801 tacaatgtaa ccatgggcaa gcgaggcagg gggttgtggg gggacgagat tctgcagccg
    10861 cagatcggga aggaaaatat ctgcatggct ggtcacaaaa gtggttcctc tcctatggct
    10921 gggaacaaaa cactcaacac gttctgcaag cagcatgatt gtttgaaatt gtttggagtc
    10981 gcgggagccg ggtatagtgt caagggcact gccttgtctc agtggtcaag tctggactgt
    11041 gatatcagtt tggtttttca atattcttcg agtcctcgtt gacgtctacg gtgggcatgc
    11101 gtgcatatgg gcatcatgga tcggcagtcg tgggctctgc gtccacatga tgattcatga
    11161 gtctcgtgat aagctgtaag ctgccaggac tcttttgata gactccaatc cgcctccttg
    11221 tctcggtgca tacaaagcac gctatcaaag catccaattc gaggcgtgat gtcttaagcc
    11281 ggcggcagta gcgtcgcaat aaagtgttgt gactgggttt gagtggaaaa ggaaaaggtg
    11341 gcggaaagct ttgaatcaga gcagaacagg attgcacctc ggataatgca gcttcgcatt
    11401 tgtctctgac cctgtgactg aaaataaaag tgaatctttt cgtcatgaaa tcacgaaaga
    11461 ctttacaaga acctatcgtg acgacttcgt aacatctcac agcaacgtcc ttgctgtcct
    11521 tccaaacatg atttgtcccg cacatttaca agctttctct gatcagatta ttctcgtcat
    11581 ggaattatgt cacagatcac atcgtagtaa ggcacgcgac atatcatgaa aatgcatgat
    11641 ttccttcagg aattggcacc aaggcagagg aaagaagcgg gccaaaggca gttttcggct
    11701 tcaaatgttg atcaagagga ctcaattcaa agctcattca aagctcagga gtttttacaa
    11761 gagtaactag ccagatcttg tcgattggcc ctgtatttaa tcgaaggtgc atcttgcgga
    11821 ttatggtccg tttggtatgt aacactggac gggaaatacc ttatccgccc cggtattttt
    11881 ttgctgcccc attgatgccg acgattctca gtcggcagca gcatcgtcct gtccacttca
    11941 aatagattgc tctgccgggt tgcttggtcc ttcacagttt gcatacaaga ctccctttgc
    12001 ttttcctgtg gctattcagg ctacgtatac gatgtcgagg cattaggtcc acccaaatgt
    12061 tccgtatccg cgatcagcat gtggctgatg caaacaggca atactctcct cttcattttt
    12121 ttgccgttcg tctccatgac gtctgcttgc gatggtcatt ttcagcccca cgttgcaggc
    12181 atcagcggac aagcgtttgt tgcgaagctc gcgtgcgcgt ggcaattggt cgcttcatgg
    12241 atgccagctc tggggctcga gaaattggca cggccgagat ggcaatcgcg actgccatat
    12301 cagctgcctt tgagacattt ggagagggac gaaacagaaa aggaaatagt cagtatctgc
    12361 atggatggaa atagtcagat ctgcatggat tgattcagga cgatagcgtc gacaaatctg
    12421 caagaaaagc aatatatccg ggcagctggc cagggggggg aacgaaacag ccacaacggc
    12481 ttatcagcta gactcaagtc atggcatggt atgtcctggc aaagagtcac cggatcgttc
    12541 ttcatatgac ggaagcacat tagttgcgca tgcaagatta cgggcgtcag ctccggacct
    12601 attggctcct ctcaacgact cgcgcgaggt ggtttgcggc caagacattc ttggtctcat
    12661 ttggaacgaa aatggtccgc cacaaaggag aaaaaaaaaa gccgttcttt agattcgatg
    12721 attcattgat cgccgtggcc atctctgccc ccaaggccca tttgacatgt acaggtcgat
    12781 caagtccccg agtccgcgga taaaggactt ttttatatgc gcgacggaca acgcttcgga
    12841 gatgaggaag tgcttctcgc gtccttgatc ccatttcttt gtgttggtct tctgctcctt
    12901 cactgacttg gcctgtcatc tcctctccac catgtcaaac gaggtcgagc cagcacccat
    12961 ggcagacaac ttccaggtcg tcacctttgg tgacctgagc actccttatt ttgccgaatt
    13021 acagaaactc gtctttcaca aaacagactt tgtcctgact agtctgtttg acgacacata
    13081 ccgtgctctc agggccgagc tgtctcgatt gccacctagc caaaaggcta gtctgcctca
    13141 gtcctccaat ctcctggagc ttttggccgg atccgatgct tcgagtacaa gaaattgcgc
    13201 cctgaccggt gcacttgcct gcttgtatca gatagcatcc ttggtttcgt gagttgcttt
    13261 ggttccgtgg cacttgacaa tgcgagcatg acaggctcac cgtccttaac agatacattg
    13321 gcaagaccaa agtctcgtat ccgcagaact cgacttgttg catctctggc ggctgctttg
    13381 gccttttggc gagcgttgct gtgagttgca gcgagacggt cgttgatctt gtctccatca
    13441 caccagatac cgtggcactg gcgttccggc tcggactcct cgtgcaagcc aggacagact
    13501 cggtggtgcc cagcagttcg gacgggagct cttcgtactc ttatgttctg cccggtgctg
    13561 acgagacact agtcgctcgt ctcgtggatg agtattgtca attgagggac ctgtccacct
    13621 tgagccgcgt gtacatcagt gctttgagcg tcggtagcat caccgtttca ggacctccgg
    13681 cggagttgaa ggagttcatg tccctgcacc ctgagttgaa atcggccaag ctccagatca
    13741 atggattgtt ccactcgtcc tggctgtaca caccgcaaga tgtggcagaa ttggtggcaa
    13801 cttttgacgc gggcttgaag agcaggacgt cgcacctgga catcatgccc aactcggttg
    13861 agaacaagga acagtactcg cgcggtgtga cctgcgagag cttgcttagg gtggcaatat
    13921 ctgacatttt actccatcgg ctacgatggg acctcgtggt aaagggtact gttaccgcgg
    13981 tccagaggtc cgcgtccgct tcggctgtgg acgtgcttcc cttcgctgcc ggcagtgtcg
    14041 aaggtatggc ttccagcatt cgggcctcgg cgggcgttga ccgcgtacag atacaagaca
    14101 cgttgcccgc tccgcctcct gaagaggatg cgcgcaagga caagcgagca acgaggtcca
    14161 agattgccat catcggcttc tcaggcagat ttcccgaagc cgatgacaat aaggaattct
    14221 gggaactgct tgccgcgggg ctcgacgtgc acaaagagat ccccaaggac cgcttcgacc
    14281 cctggcttta ctacgacgcc gcgggcaaga agaagaacac gagctgcgta accaaggggt
    14341 gttttgtgcg gaaccccgat ctcttcgact caaggttctt cagcatgtcc ccccgcgaag
    14401 ctgatcaggc cgatccggcg cagcggctgg tcctgatgac ggcctacgaa gccatggaga
    14461 tggctgggtt tgttcccgac tcgtcgccgt ccacgcagcg cagtcgggtc ggcgtctttt
    14521 acggcacggc cagtgacgac taccgagaga tcaacgcagc ccagaacgtg gacacgtatt
    14581 tcgtgcccgg gggcagtcgg gcattcctgc cggggcgagt caactaccac ttccgcttta
    14641 gcgggccgtc ctttgacgtg gacacggctt gctcatctgg cctcgcggct gttcacatag
    14701 cttgtaactc cctctggtcc caagactgcg acgtcgccgt tgcgggaggc accaacatac
    14761 tgacgaatcc tgataactgg tgcggtctgg accgcgcgca tttcctgtcg cgcaccggaa
    14821 actgcaacac gtttgatgac gcggccgacg ggtactgcag atctgacagc gtggcgacgg
    14881 tcctcctcaa gagattggac gacgcgctgc tcgacggcga ccccatcttt ggcaccatcc
    14941 tcggcgccta caccaatcat tctgccgaag ccgtgtccat gacgcggcct cactcgggtg
    15001 cccagcgggc tatcttctcg aggatcttga acgcagccag cgtggacggc tcggacgtga
    15061 gctacgtcga gatgcacggg acggggacac agcacggcga cgcctgcgag atggactcgg
    15121 tcctcagcgt ctttgcgccc cagggctccg gcgcgaggga caaggctctc tttctcggct
    15181 cggccaaagc taacatcggc cacgccgagt cggcgtcggg cgtggcctct ctgatcaagg
    15241 tgctgctcat gatgcagaac cacgccatac cgccgcacgt gggcatcaag accaagatca
    15301 accgaaactt ccccacggat ctcgcccaga gaaatgtcca cattgccatg aagacgacgc
    15361 catggccgag gcccgatccc agagacaggc cccacggccg gcgagccttt gtcaacaact
    15421 ttggtgccgc gggcggaaac tcgtctgtcc tcatcgaaga tggtccggtg cccatcctcc
    15481 cggaaacagg agacggcgac catgtcgacg gctgctgggc aacgcacgtc gtcgccgtct
    15541 cggcgaagac gcaggcttcc ttcaagaata acctcgctgc gctggtgggc catctcgacg
    15601 cccatcctga cgtgtccctc gattccttgt catacacgac cacggctcgt cgtgcgcatt
    15661 acgcttttcg caccgccgtg gccggcacgt ctgttgacga gatcaagagg gctcttcagt
    15721 ccgtcgcgga cagggaaaag cacctctccg tggctggcgg cggaccaccg attggcttct
    15781 gcttcaccgg ccagggctcg cagtaccttg gcatgggcaa gaggctcttc tcgctgcccc
    15841 ggttccgtga gttcatggtg ggccttgacg agactgctgg cagacagggg ttcccgtcat
    15901 tcctcgatgt catccagggg cgtggcgaga ctcctgtcga acaaatggcc ccggtcaagg
    15961 tccagctggc catcacctgc ttgcagatgg cgctgggtaa gctcctcatt gcccttggcg
    16021 tcactccgcg cctcgtcgtc ggccatagcc tcggcgagta cgccgcaatg aacgtggccg
    16081 gcgtcatcgg tgatgcggac acgatccatc tcgttggcag cagagcacgc ctcttggaaa
    16141 agcactgcgc cgtcgggacc catgccatgc tggccatcaa ggcatctgca gtcaaggtag
    16201 cgtctctcaa ggcagcgtcc caccccgact tggacatcgc gtgcgtcaat ggccctgagg
    16261 agacggtcgt tgccgggtcc aacgagcaaa tcgagtcgtt caaagccgcg ctcagctcgc
    16321 agtccatcaa gtcgacgacc gtcaaggtgc agtttgcttt tcactccgct caagtcgagc
    16381 ctttgctgga cgagttccgg cgcatctgca gctcagtcac cctgagggac cccagcttcc
    16441 cgatcctgtc tcccatgatg gccaaggtca tcaacaaggc tgccgacatg ggctcgacga
    16501 gcgactacct ggcccgccac tgccgcgaaa gcgtcaggtt tcacgactgc ctgtcgtggg
    16561 ctcggcagtc cagtctcctc ccggaccgca ccacttgggt cgagatcggc ccgcaccccc
    16621 tgtgcagcaa catgctcagg tccgtcctgg gctcgtctac caagacgctc ccctgtctgc
    16681 ggcgtgggga agacgactgg gccgtcttcc tgcccacctt gatgagccta tacgatagcg
    16741 gactgccggt ggattggatc gagtaccacc acggcggcgg ctccaagaag cggaagcagg
    16801 tcatccagct gccagcctat caatgggatc tgaagagcca ctggattccc tacgaacacg
    16861 actggtgctt gacaaaaggt gatgcgccta ctgtgcctct gcaggctccg acgccatcgc
    16921 cgtctcgagc cgaggccaag ttctccacga cgtccgtcca agacgtcgtg tatgaaagat
    16981 atgcggccga tgagagctgc atcacggcgc ggtccgacgt acagcaccct gatttccggg
    17041 aggtccttct ggcgcacaag gtcaacggca gaccgctctg cacctcgtcc gtgtacgcgg
    17101 acatggccat gacgctgttt gccaggctcc tggacaagtc ccctattgcc tttgacaaga
    17161 cagacatagg catcgaagtt gcaaacatgg ccgtagacaa gtctctcata ctcgacgaga
    17221 gttcaaacac cgccctcacg cagctccttg agatgaaggc ccacgtcaag tggtcaacgc
    17281 ggcaagcgac cttttccctg tccagcattg cgtccgacgg caaagccacc gagcaccacg
    17341 ccaaatgcac aggctcattc accgagaaga gccgatggag ggctgaatgg aaacgacacg
    17401 actttctcat caaggcccgg gttcaacacc ttcgccaatc cgctcacagt gatgatgacg
    17461 atggtggtga gactgctgct gcgcacctca tcaagacagg cctgttttac aagctgttca
    17521 gcgccctggt ggactatgaa gcccctttca aaggatgccg cgagctcgtg atgcgctcgg
    17581 cagacatgga gtcgacggcc aaggtcaagt tcaacacgcc gccgggaacg tcggacaagt
    17641 ggatgaaccc gccgtactgg atcgacagcc tcggccagat cacaggcttc accatgaacg
    17701 gcaacgacca ggtcgactcc aagacgcagg tctacatcaa ccatggctgg gacaacatga
    17761 agctgtcgga gcgcctctcg gaccagaaaa cgtacacgac gtacgtcaag atgcagccca
    17821 gggacaaggg ctcgtactcg ggagacgtct acgtctttgg gccgggcatg gatgaagtcg
    17881 tcgccgtgta cgagggcgtc actttcgcgg cggtcccgag gaaagtcctc gacagggttc
    17941 tgcccaagaa gggccaggct accggcgaag caacagcaac gagatcaacc acatcgagcc
    18001 gtgaagccaa gacagctccc gagtcagcgc cagcaggcta caacattccc acgtctgaga
    18061 cgcaaccgct gccgcagctc gtcgtgcccg aaaagcaggg cgtggcggca gagaagctca
    18121 agctgatcat cgccgaggag gtcggcgcct cgttatccga cattgaggac gacgccgagc
    18181 ttgccgccct cggagtcgac tcgctcctgg ccctgaccat gtcggaccgc atgctggagg
    18241 aactcaagct caaggtcgac tctacatgct tcatcacctg caccaccgtg gctgagcttt
    18301 tggaggccat cgtcggcccg ccctcgccat cctcgggctc cggctcggtg gcagacacgc
    18361 cgctgaagac gcccgacgcg gagccggaat acggcacctt cggtgcactt cagagcttgg
    18421 acgctgcggc catggcgctc gactcaaacg ggcttccaag ccttggcggc ggcatcgacg
    18481 atggacaggc agagcccatg ttgcgtaagt ctgccctccc atttctttcc actttccggg
    18541 gaaacgcccc aaacgataga tgggaagaag aagaagagaa gaagaagaag aaatgcaaca
    18601 aaggaagaaa tgaggcggca tactcacaac atcactaaca aatgcagtga acccagccgc
    18661 cgccgccgcc atgacaaaac agccgccgca gaccgtggcc gtgccaccag catcttccgt
    18721 cctcctacaa ggcgacccaa cgacctgcac gagaaagatg tggctgtttc ccgacggctc
    18781 cggcatcgcg gcgtcgtaca tgcctctgcc agacctcgac gccaagcgtg tcgccgtctt
    18841 cggcctcaac agcccctacg tcaagcgcac cgacagcatc gtgccctgcc agttccacga
    18901 gctcacggcc gtgtatctcg ccgagatacg ccgccggcag cctgcgggcc cgtacgtctt
    18961 cggcggctgg tccgcgggcg gcatctccgc ctacgaggcg gcgcaggagc tcgccgccgc
    19021 cggcgagacc attgacggcc tcatcctgct ggacacgccc aagcccatcg acctcaagga
    19081 gctgccgtcg cgtctctacg gccagctcga cgggctcaac gtctttggca tcggcaactc
    19141 gcggccgccc ccgtggctgc tcacgcactt tgccctgttc tccgccattc tcgacacctt
    19201 caagccgcgg ccctggcgcg ccgcgacgcc gctgcgcgcc tgggccatct gggcccaaca
    19261 cggcgtcgac gaggccggct ccattgccat atcgcccgac gatcctgaca atgtcgcctg
    19321 gctgctcaag aggcgtgtgc aggagagcct ggtggccaac ggatgggacc agctcgtcgg
    19381 gtccgacaac gtcacgccct tcattgtcga gggcgcgcac cacttcaaca tgctgaagca
    19441 gccggctgtg aagcaggtgt gtgactatat gcagcgcatt atgaagtctt tggattagcc
    19501 atgcagatga gatgatggct ttgagttttt tgtgcgtggg cgcgtctgtc tgttatggct
    19561 ttgtgtatcg tttcgcataa tcaaacagtt atttttaatt ccattgtaat cgtgaagatc
    19621 aagtttcctt attccagtaa aattttcctg aaaccgtatt ccgctcagaa gtagagatga
    19681 tttccgaaaa tgcattagca agactcacgc gtcccaccaa gcacaataaa aaaaccccca
    19741 acaagcacca cagtacggag aagagcaaaa aaagaaaaga aacaaagatc cacatgcaca
    19801 gtctccactc gaacatccac tctctctctc tctcttacaa aaaaattcaa ggcgaagaaa
    19861 ggatctaagt tcttcgcaga cccaaaaaac ttctccaggg cgtgattcga acacgcgacc
    19921 ttccggtttc tctgaaccct tacagccggc tgctcttcca actgagctac ccagagatgc
    19981 tgtgcttgtt gaaacactct ccattgtttc agattatata ctgcacttct tttagcacga
    20041 gccgactcag aaaactcatg atgcgcattc acggctcgcg caaacaagcc tccatctttg
    20101 tgcgcataag acgatacgcc tggcacatga gttccctttc gcgactgcct ccggagctcc
    20161 taaaagtacc gaggaattgc atgacggagc agcagagtcc agcaacgtgc tgtacagcgt
    20221 atgcgttgga cacagcgtct ctgtgagccg acgtgggtgg acttacccta tgccgagacg
    20281 gagacgagga aaacgtcagc ctgtctgcgc gacgaccttt ataaagtaaa acaagaatcg
    20341 tcggttcttc tcatctcttg tatatgctct acgtttcgtc ttggccacgg acgcatcaat
    20401 cgctgcggcg gaattcacgg cagaacttcc agcggccgac aaacagacgg gctccaaact
    20461 cgctgcggat gaggcaagtg acgtcctgga ggaacatgtc gcgctggcgt ccaattcaaa
    20521 attaccactg cttcctttca atacaaatca ctcaagagga cagcttgatg gagatgcaag
    20581 ctctgctttg aatgctccgg cgttcgctct gccttcctgc gcacctcgta catcaccaga
    20641 tgcatcttcg gtacacttcc cttcatcaaa ctcaagtccg actcccaatg gtgcgtgcaa
    20701 ctcccatcgc tacatagata cccaatcaaa tgaagaaact acacacagac gcacaagccg
    20761 aaagaaaaat cacgtgttat gattctcaca aaatgcccat cgtccagcat ccaatcgtgg
    20821 ccaagaacaa atcacggtca agaaaacaaa atgtcccaag aaaaaggaaa aaggagcaag
    20881 aaaacttttg aaatcatgtg ctacgctcct gcgacctggg tatctagatg tatgtatctc
    20941 aataactaaa atcaacattc gccatgggta tggccttgtt tccgtttgat gaacaaggcg
    21001 tgtggtgctc ttcgtcgtga tgaatcgtaa tagtcgacga gtctgagtcg ccgagagtcg
    21061 tgatggcgct tgtctgtgaa ggtgtcgtct gtagctcgtt ttctggtacg ccgctcggtg
    21121 accagccctc atcgagaatt tgctggaagc tccagcttgg ttggaagttc ttgctgttcc
    21181 aagcatgatg aacgcgctca tacatttcat cgatctgctc cagactgatt ttgcttgttt
    21241 cgtacaccaa gcaccacacg aaaaagaagg caaagacgca aaaggctccc caaatgaaga
    21301 atatcttggg cccaaagctg gcagagccgg ggcccgtttc gaccacgaat ggggtggcat
    21361 aggcaatgcc aaagttcaag atccaattcg atgcggtaga aagtgacatg gccttggcgc
    21421 gcactttgag gggataaatc tccgacgtca cgacccagac aaccgggccc caagatgcgg
    21481 caaagaagaa aatgttgaaa cagcaaaaga cgacgaggac ggtttccttg acgttttgca
    21541 aatcctcggc ggccgcagtg gtgaaggagg ccatgaaaag ctggcatgaa gccatgccga
    21601 gggccccaac catgaggagc cgcctacgtc cccaggactc aatgatgagg aggccgggaa
    21661 tggtggagac gacattgatg atgttgatga tggttgattt ggtgtacggg ctttccacgc
    21721 ccacaccgtt gaaaaacgtg gtgctgtagt acatgatgaa gttgatgccg ctcagttgct
    21781 gaagcatctg gaggccgcag cccgtaagcg tccttctgcc gagatggggc gagccaaaga
    21841 acgcttcccg gtacgttgac gtgcccaaag agagctcgta ttggtgattt gcaatgattt
    21901 cctgcaattc ctcaatgagg gccgggtggg tgatgtcgag gcgcctcagc cgactcagag
    21961 agagtccggc ggcctcggcc ttccctttct tgaccaagaa tcggggcgtt tcgggaagaa
    22021 ccagaagacc ggcagtgagg atcaaggcag gtattatttg gaggcccagg ggtatacgaa
    22081 acgaagacga gtcgttgagc tttgaggtga tgatgttgat gatggacgcg gagagcagcc
    22141 cgatggttat ggacagttga tacgcacata ccaaggatcc acgaacccat ttcggagcca
    22201 tctccgactg atacaagggg acgaggactg acacagcccc gacgccaatg ccggccaatg
    22261 ctctgtgacg agaagggtca gcatcgtgtg gttcattgaa gagcccaaat gagctacggt
    22321 ttcacacaag cacgtacctg ccaaccagga gggttgacgt gacggtggcg cagacttgac
    22381 agacggcacc gatacagaag atgcccgtgg atatgaggag cgtgattctt cgaccgagtg
    22441 agtctccggc aggggcggcg agcagagcgc cgacaaaggt gccggcgctg agaatggcga
    22501 cgatgagtga ggcgtccatg gggcagatgg atgccgatgc gtcagtgttg accgtcgtgc
    22561 ggcaattggc gccgaactgt tctttgaatt ccggcatggc gagaataccg ttgatggctc
    22621 tgtgaat
//
