LOCUS       BGC0002304             25713 bp    DNA     linear   PLN 15-JAN-2019
DEFINITION  Talaromyces variabilis strain HXQ-H-1 varicidin A and B biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0002304
VERSION     BGC0002304
KEYWORDS    .
SOURCE      Talaromyces variabilis (anamorph: Penicillium variabile)
  ORGANISM  Talaromyces variabilis
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae;
            Talaromyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:17:42
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 25713
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..25713
                     /country="China: coast of Fujian Province"
                     /db_xref="taxon:28576"
                     /isolation_source="mangrove rhizosphere soil"
                     /mol_type="genomic DNA"
                     /note="anamorph: Penicillium variabile"
                     /organism="Talaromyces variabilis"
                     /strain="HXQ-H-1"
     misc_feature    1..25713
                     /note="varicidin A and B biosynthetic gene cluster"
     protocluster    1..25713
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[7640:19956]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7641..19956
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     protocluster    1..25713
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[7640:19956]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      7641..19956
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     cand_cluster    1..25713
                     /SMILES="C([*])C(-O)(C)NC(C(C)CC)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="chemical_hybrid"
                     /product="NRPS"
                     /product="T1PKS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..25713
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002304"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..25713
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(82..1764)
                     /gene="pvhE"
     CDS             complement(join(82..1021,1085..1764))
                     /codon_start=1
                     /gene="pvhE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 296.2; E-value: 7.6e-90)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="PvhE"
                     /protein_id="AZZ09610.1"
                     /sec_met_domain="p450 (E-value: 1.7e-66, bitscore: 213.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVLNIAVSRCSPTVAFCSLVILCILFKVLTRVREDRKIRSLGKY
                     GHQIQSKLPLGIGFLYSMVKAVRAQKNFEFWRDNIFGASGRWTVETRIMNERTIFTADP
                     GNIKAMLATQFSDYGKGAAFHAMWKDFLGNSIFATDGERWSASRKLIRPQFTRDRLSDL
                     QCFEAHMQTLFRVLDAGGSPLDSKHAEETPMSQGKAIDIRDLLYRFTFDVSTDFLLGQD
                     VQSLTTPRQEFAHAFDEVQRMQTIFVRSRHFSKFMSKKSFRDSLKVMNGFIHKHVRRAL
                     SLSPQETQQKSQSGSKYTFLEAIAGFTRDPTMLRDQIVGVLLAGRDTTAATLSWALYEL
                     SRHPEAVDALRREILQTVGSDAPTYDQLKNMPYLKAVLNETLRIYPAVPYNVRIALEDT
                     TLPHGGGPDGSEPIAVLKNTKIAYSTLILHRRRDLYPATSEKFADPAIFSPDRWLHWHP
                     SAHDYIPFSAGPRLCTGQQFALMEMSYVLCRLFQRFERVESHMQHIDGGNPTLKADIIL
                     SPGDGVWVSFHEPKQIDSNQLL"
     gene            complement(2304..3444)
                     /gene="pvhD"
     CDS             complement(join(2304..2608,2667..3444))
                     /codon_start=1
                     /gene="pvhD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 162.3; E-value:
                     3e-49)"
                     /gene_kind="biosynthetic-additional"
                     /note="N-methyltransferase"
                     /product="PvhD"
                     /protein_id="AZZ09611.1"
                     /transl_table=11
                     /translation="MPPSLPCRCQEAPTPVFGYLYQIVELGVMRLFVEKRVFNEIPDEG
                     ILIADLATKTGIEFNLLERLVNFLISSRIFTSSSPGYVHHTPTSKYFTERRAQLWYPHI
                     FDTFLTSAVKWPEYFDINGMQEPQCSSKSPFGFGSGYSDKSVYEIFDLMPKRSSDFNAT
                     MALSMGEMPILGMYDFSWIGEYGKRPEVKDRTLFVDVSGGKGQALQAILEAFPSIIPEQ
                     CVLEDQEKVIEEAKLATGPLETVKKVPIDLFGEQPVKGALVYYIRRVLNDWSDAEVVQI
                     LRSIRDACAPDSKVLISENLLPDEPPLKLAAIDVWMLNFGGKRRNKGNFGALARRAGFE
                     LSSIAEDDKTKSAVLELVVA"
     gene            complement(3887..4963)
                     /gene="pvhC"
     CDS             complement(3887..4963)
                     /NRPS_PKS="Domain: PKS_ER (29-232). E-value: 9.7e-19.
                     Score: 59.4. Matches aSDomain:
                     nrpspksdomains_pvhC_PKS_ER.1"
                     /codon_start=1
                     /gene="pvhC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 166; E-value: 2e-50)"
                     /gene_kind="biosynthetic-additional"
                     /note="a trans-acting enoylreductase; trans-ER"
                     /product="PvhC"
                     /protein_id="AZZ09612.1"
                     /sec_met_domain="ADH_N (E-value: 4.1e-09, bitscore: 25.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-11, bitscore:
                     33.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSRTQNIQSAWIGTTDGGSRLAHDAPIPAIARERVLIKTKAVSV
                     SPVDSKLVGPYVTPNAVAGFDFSGIVEELGPEATKCGLKVGDRVCSAVVGMNPADPTIG
                     AFAEYTAAVEWILLKLPPSITFEQGATLGISFLTSGLALFRSLGIPGRPLEPAPKPLCI
                     LVYGGSSSCGTASLQLLREAGHIPITTCSPHNFELVKSYGAVDAFDYNDPDTMDKIKKY
                     TKNGLRYALDCISTTSSMQFCYKVIGRAGGKYTSLEPFSAAVAQTRKVVSPDWVMGPSL
                     LGQEVAWPEPHYRKQDDDLAQFGAEWTATLNQLLKKELIKPHPMQIRDGGLENIQQGLE
                     DLRAKKVSGAKIVYPLGS"
     aSDomain        complement(4268..4876)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhC_PKS_ER.1"
                     /evalue="9.70E-19"
                     /label="pvhC_PKS_ER.1"
                     /locus_tag="pvhC"
                     /protein_end="232"
                     /protein_start="29"
                     /score="59.4"
                     /tool="antismash"
                     /translation="AIARERVLIKTKAVSVSPVDSKLVGPYVTPNAVAGFDFSGIVEEL
                     GPEATKCGLKVGDRVCSAVVGMNPADPTIGAFAEYTAAVEWILLKLPPSITFEQGATLG
                     ISFLTSGLALFRSLGIPGRPLEPAPKPLCILVYGGSSSCGTASLQLLREAGHIPITTCS
                     PHNFELVKSYGAVDAFDYNDPDTMDKIKKYTKNGLRYALD"
     gene            complement(5393..6508)
                     /gene="pvhB"
     CDS             complement(5393..6508)
                     /codon_start=1
                     /gene="pvhB"
                     /note="cis-decalin forming Diels-Alderase"
                     /product="PvhB"
                     /protein_id="AZZ09615.1"
                     /transl_table=11
                     /translation="MGNKMTKRISHFNIENAIIPGEVSASAHVPGENNIFPKYSSNIND
                     RTWEIWCCEGINHEGAGVMFGFQRAAFNKKMGGGWRVQIIAVWPDGKNWYKALALPESI
                     FEESMASGDITSVWKTADNSTNVSFTYHKVDNKIDVVVCIPGVATGKASFQGQPGDSGL
                     STSPSLGPYVSYMRPVGRADMTSDMIFHFPDDGTTRQISFSDGHGGFDRYWGEKLWLSI
                     QSESYFMRAFLGPYVIQIIRLVSTEELGKQQWPIARLFHQGKLVCAPQRCGSPDEQGIS
                     QDTLVMSKVHDSDTGALSAEFHDKSTGYDLTFVEAGNARRRWTFTVRHQTKIWSLPIGP
                     KGGNSGFVEHVCGGLAGETCEGLGVSGQIVY"
     gene            7641..19956
                     /gene="pvhA"
     CDS             join(7641..8280,8340..11781,11844..14983,15044..15618,
                     15682..19956)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (9-441). E-value:
                     3.3e-170. Score: 558.4. Matches aSDomain:
                     nrpspksdomains_pvhA_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (549-869). E-value: 2.4e-86.
                     Score: 281.6. Matches aSDomain:
                     nrpspksdomains_pvhA_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (944-1121). E-value: 3.1e-21.
                     Score: 68.3. Matches aSDomain:
                     nrpspksdomains_pvhA_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1414-1585). E-value: 2.8e-46.
                     Score: 149.2. Matches aSDomain: nrpspksdomains_pvhA_cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (2119-2292). E-value: 1.4e-52.
                     Score: 170.1. Matches aSDomain:
                     nrpspksdomains_pvhA_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2405-2471). E-value: 1.2e-10.
                     Score: 33.5. Matches aSDomain:
                     nrpspksdomains_pvhA_PKS_PP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (2602-2896). E-value:
                     1.3e-63. Score: 206.6. Matches aSDomain:
                     nrpspksdomains_pvhA_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (3077-3476). E-value:
                     7.4e-83. Score: 270.2. Matches aSDomain:
                     nrpspksdomains_pvhA_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (3598-3668). E-value: 1e-10. Score:
                     33.5. Matches aSDomain: nrpspksdomains_pvhA_PCP.1"
                     /NRPS_PKS="Domain: TD (3715-3933). E-value: 7.7e-46. Score:
                     148.1. Matches aSDomain: nrpspksdomains_pvhA_TD.1"
                     /codon_start=1
                     /gene="pvhA"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 65.8; E-value:
                     4.9e-20)"
                     /gene_kind="biosynthetic"
                     /note="polyketide synthase-nonribosomal peptide synthetase;
                     PKS-NRPS; KS_AT_DH_MT_KR_ACP_C_A_T_R"
                     /product="PvhA"
                     /protein_id="AZZ09613.1"
                     /sec_met_domain="itr_KS (E-value: 7.4e-178, bitscore:
                     580.5, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3e-87, bitscore: 281.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.1e-45, bitscore:
                     144.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.3e-51, bitscore:
                     164.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-93, bitscore:
                     302.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.7e-10, bitscore:
                     30.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 5.7e-39, bitscore:
                     122.6, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHSDQDERIAVIGTGCRFPGGCDSPSKLWDLLKAPRDVLREIPR
                     ERFDANAWYHPDNKHHGTSNVRSAYLLDQDPAAFDNEFFNIQSSEAEAVDPQQRILLET
                     VYDSLCEAGCTIEGLRGSNTAVYVGLMCDDWSAIVTKDTEVFPQYAATGTSRSVMSNRV
                     SYFFDWHGPSMTIDTACSSSLVAVHQAIHTLRSGESNVAIAAGANLILSPDMFIAESNL
                     SMLSAGGRSRMWDRDVDGYARGEGIAAVVLKRLSDAVRDNDQIECVIRATSVNQDGKTA
                     GLTMPSGTAQAALIRSTYARAGLDISNPRDRPQFFHAHGTGTAAGDPQEARAIHEAFYS
                     GTARNTDKLYVGSVKTVIGHTEGTAGLASLISTSLAMRHKIIPPNMHFNNLNPRLKPYY
                     RNLEVPTKAYPWPEPAPGHPRRASVNSFGFGGTNAHAIIEEYLPSQTRDLAEHTTAVSL
                     LTPLVFSASSEISLRSLLASYSAYLKENLTISLQSLAYTLQARRSTMPHRVAITCNTTS
                     ELISAIDGIISGQENSTIAVRHLSKPTPKVLAVFTGQGAQWARMGAKLVETSPFVSKRL
                     KELDEALATSAAGNSPQWTLSEMILAGPALSRVAEAAISQPLCTAVQIVLVDLLRQAGV
                     RIDAVVGHSSGEIGAAYASGLYTARDAIRAAYYRGLYSSLAKSPNGGKGSMMAVSTTHQ
                     DAIEFCELETFEGRLQVAAVNSFDSITLSGDADAVAEACEVYQDEGAFARQLKVDTAYH
                     SSHVLPCSKPYLEAMTSAGREALPKAPSDALPWPTWYSSVRDGQEMTREDVQPQYWVDN
                     MANPVLFSTAVEAACSDKGLFDLIIEVGPHPALQKPCLDTVEETAGARPPYVGLLGRGK
                     DDVSAFSKALGFIWTQLGPQSVAFDNVERAASEPPVVPRELLKDLPQYPFDHSSKFLSL
                     SRVSGFYNRSQMATHPLLGKRCYDRETNLCIQWRNILSLKEVPWLTGHQIQGLTVFPAA
                     GFVSMAIEAIVALAKDSTIGLLSLENVNIGRAMAFQDDSSRVEVLFDMRIIAQTPHEIA
                     AEWASYSGDPHDIKTVLTLNASGVVRATLAENNASAEPDVLPALDVIDNNDLSPVDTER
                     FYKFLRKLGYNYSWPFYGTKSIQRKAGFSTGMLEDQSGDEWQDQLLVHPGMIDTALQTA
                     FAAFCCPGDERLWSLHVPTRFKSLVINPFFTARGIGKQRMLKFVSTAAAVKQGKIAAEL
                     YLQSEHEGQTHTFLQAEGLEIVPLAAAVPDNDTVLFSRFDYKLACADGETAAILDTPLS
                     QDAIDDVINAERVAFYHLYNVVKSITPGEEASALPHYQQFLSWARNVVENVLRGDNKYV
                     PASAAQDSASDIASLLTGLPFRFDKNGEVSLAEAIGKNLISAIRTSSTVFQAEDRNLPA
                     ELYEKAIGFDTGNQCLANMIASISHRYPRMNILEVGSQVGSSTEAILSQLDTAFDTYTY
                     TNISDDSFGLAEEHFTAYGDRINFKTLDITQSPTSQGFALGEYDLVVASNVISSGSDMT
                     ESLTNLRALLKPGGFAVILEPVDNDCLRLGLALGCMPDRSPPLGLPQWNSLLSETGFSG
                     TDTISPRSHGAVPGVVFCTQAIDDRIKMLRSPLSNISCLPGLEAPELAIVGRGQSSELQ
                     NLCGELSDLLSSAFPKVTFVDSVEQVTAETIPTTSAVIMLAELGESPWASLNPVKLEGI
                     KNIYRQARNLLWVTSGADSKDPYSNISLGIGRAMQFEYPHLSIQALDVDTISENTAKII
                     AEHLLRLGTLSTWKEDPEQPTMLWSMEPEVWIKNDMPIIPRLCPYTPGNDRYNTTRRTV
                     RNQVIPRDTHLALTNDNGAWEVQVTSPLHQAPKIPYATDTKQVRVTDVLLSTLGIIPGT
                     MLMLCTGQDTSTGEALLALSPIAETLVQVPRSWTTGIDNAEPRDALGAVAANIVAKLMA
                     KSAFRGDVLIVHDPHPAVAHELAIIANKGAFTIHFTTASAQVSIEQGWHHIGSRFSASK
                     VKSLLPINANKLLDLSKSSADGISAHILSSLPRGCRVVDMSHIMGNTTELQSWVSEDEV
                     ATVLQESVTEVLRSDRYTNLVNNVPLVSLESISEPTHHASFAIADCSVPAVTARVRAVD
                     DGIIFRGDNTYLLVGLTGEIGRSLCKWMAERGARHIVLTSRTPKEDVVFSSAMKALGAV
                     VKYLPMDVRSRDSIHACYAMIQNTMPPVAGVANGAMIIHDMVFDNMSFEVMDKVLAPKV
                     VGSQLLDELFYDTPLDFFIFFSSMTAVMGNSGQANYLAGNMYMNALAAQRKERGVAGSS
                     INISSVIGVGYVERSDQLDEEYFLNMGYRPMSEQDLQVSFAEAIVLGKPGSSEIAELST
                     GINSTLNGQSIGKWLQDIKFSHMMMHESNDNAGMGPGASAAPLKVQLSEAKSKEDIISI
                     IKEVFLARLRRILSIPADKNINEDVTLVEQGVDSLMAVEVRSFFNKELDVDIPVLKILG
                     DISINGIIKQVVELLPAAVYDLPEETPQTLSKNPAPTPVKAPVSAPSTPAAASQPVLTD
                     STASSSRDSDDDQASSNSTSYETSKDASREDSEVDETPLESPVNTPNVMSKPSASSQLL
                     EKKQLLEVDALIASSRPETLAPMSHGQEGFWFLQDYLPDKTVFNTSVMLKLEGEISVET
                     LSQALQMVARRHEILRTRFFSADDDGEQKVMQAIAANSSLELETKQITSGNEAQVEFTR
                     FNKHVFDLANGEAARVLLLSLSKTEHFLMAGMHHIYLDGYSFSIFFNDLNTAYTSKRLP
                     PLPSNSQYRSFVEQERERYESGEFDETIAHYRETLPKDLAPIELLPFARGTTRREVNNY
                     DQTESKMRIDRPLADKIRQLARNNRSTSFHVFLAAFQALLFQLLPESDDLIIGMGDANR
                     DDKKYLNSIGYFFNLLPLHFSRFKSGTKIADLVQDSRSAVREALERPHVPLSILLDELD
                     VPRSNKHTPLFQVCIDHRQVLQEQSNWGGCRVSDEQWHDAGTGFDISLQITEFNTDASL
                     SLRLQKPMYTEEHTNMLLRSFVAVLEHMADVPTDNMVEDIPSWSELDIQKALTVGKGRE
                     FHSRWDSNPPTVMHRIHEMITVHGSTTALKDGHGSTLSYEQMGRRIAAISAALIEKGIA
                     RGDVIGVFQEPSVDWICSMMAIFNIGATYMALDQRLTLPRLATIVQTAKPAAILTDSFT
                     SSQVTDIGASAITTVLVSHLASSVNTKPINAARAEDVAVVLFTSGSTGVPKGMRMTHAN
                     LVFSTDSISGAFNVTQESMVLQQSPFSFDPSLCQTLVALTNGAALYVVPSRSRGDPMAV
                     TKIMAEEKVTFTVGTPSEYAMLLEYGADNIRQCHAWKCAAWGGEQMPHGLAKQLAAANL
                     PGLKAHNVYGPSETTMLSHFHLVNPAEIEGNGYIPVGAGFDGYKYCIVDHQMRVQPIGV
                     PGEIIIGGPAVVAGYLNNQQLTDTKFLADSFFGTNGKVYRSGDLGRMLEDGTLVVEGRL
                     DGDDLIKLRGFRIELEEIEKAIVKQADGTLGDAIVSLRGEGDAQFLAAHVTLSADLSPP
                     AKQKLISALQRLPLSSYMIPSVFGVIKAIPKTAHDKVDRKAAKELPLPSADDENSLAVH
                     GIDGGDDSVLSGTERQLGTLWRQVIPVYVGSLASTSDFFLAGGNSLLLVKLQALLRTEF
                     GATPKLMDLMGASNLAAMADAVQKEVDSSLTRDGIDWDLETRPPVALQHKLSGFISSAR
                     TNTTRPDASRFNVLLTGATGQLGRHVLSQLVTNGKTSRVICLTRQPDKIEANDKVTTLR
                     GDVSEPNFGLSEQEYQQLATETDVIMHCVANRSFWDRYEVLQPVNVSAVKSLVGLIADS
                     GRIIPLHFMSSGAVSHYYNLGTSPPRDGSDGYVASKWAAEGFLRRIAAETSIPIYIHRP
                     SSVDGDALGSPQEREAVTDQLMGIVNSMEIQPEFGGVDGTLDIAPVDDMAQSLAELVLK
                     SITEAAETDGSEKNLIQEFKHKAALQVYARDFAARLESEGQHAQFPKMPILEWFGQAKA
                     AGFSYIIAAQELVMTSGLDAITTRR"
     aSDomain        join(7668..8280,8340..9022)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.30E-170"
                     /label="pvhA_PKS_KS.1"
                     /locus_tag="pvhA"
                     /protein_end="441"
                     /protein_start="9"
                     /score="558.4"
                     /tool="antismash"
                     /translation="IAVIGTGCRFPGGCDSPSKLWDLLKAPRDVLREIPRERFDANAWY
                     HPDNKHHGTSNVRSAYLLDQDPAAFDNEFFNIQSSEAEAVDPQQRILLETVYDSLCEAG
                     CTIEGLRGSNTAVYVGLMCDDWSAIVTKDTEVFPQYAATGTSRSVMSNRVSYFFDWHGP
                     SMTIDTACSSSLVAVHQAIHTLRSGESNVAIAAGANLILSPDMFIAESNLSMLSAGGRS
                     RMWDRDVDGYARGEGIAAVVLKRLSDAVRDNDQIECVIRATSVNQDGKTAGLTMPSGTA
                     QAALIRSTYARAGLDISNPRDRPQFFHAHGTGTAAGDPQEARAIHEAFYSGTARNTDKL
                     YVGSVKTVIGHTEGTAGLASLISTSLAMRHKIIPPNMHFNNLNPRLKPYYRNLEVPTKA
                     YPWPEPAPGHPRRASVNSFGFGGTNAHAIIEEY"
     aSModule        7668..15234
                     /complete
                     /domains="nrpspksdomains_pvhA_PKS_KS.1"
                     /domains="nrpspksdomains_pvhA_PKS_AT.1"
                     /domains="nrpspksdomains_pvhA_PKS_DH.1"
                     /domains="nrpspksdomains_pvhA_cMT.1"
                     /domains="nrpspksdomains_pvhA_PKS_KR.1"
                     /domains="nrpspksdomains_pvhA_PKS_PP.1"
                     /iterative
                     /locus_tags="pvhA"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       8151..8198
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0001"
                     /evalue="5.20E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="pvhA"
                     /protein_end="186"
                     /protein_start="170"
                     /score="21.4"
                     /tool="antismash"
                     /translation="GPSMTIDTACSSSLVA"
     CDS_motif       8417..8479
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0002"
                     /evalue="3.20E+01"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="pvhA"
                     /protein_end="260"
                     /protein_start="239"
                     /score="-2.1"
                     /tool="antismash"
                     /translation="GYARGEGIAAVVLKRLSDAVR"
     CDS_motif       9347..9394
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0003"
                     /evalue="1.10E-04"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="pvhA"
                     /protein_end="565"
                     /protein_start="549"
                     /score="14.8"
                     /tool="antismash"
                     /translation="VFTGQGAQWARMGAKL"
     aSDomain        9347..10306
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_PKS_AT.1"
                     /evalue="2.40E-86"
                     /label="pvhA_PKS_AT.1"
                     /locus_tag="pvhA"
                     /protein_end="869"
                     /protein_start="549"
                     /score="281.6"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFTGQGAQWARMGAKLVETSPFVSKRLKELDEALATSAAGNSPQW
                     TLSEMILAGPALSRVAEAAISQPLCTAVQIVLVDLLRQAGVRIDAVVGHSSGEIGAAYA
                     SGLYTARDAIRAAYYRGLYSSLAKSPNGGKGSMMAVSTTHQDAIEFCELETFEGRLQVA
                     AVNSFDSITLSGDADAVAEACEVYQDEGAFARQLKVDTAYHSSHVLPCSKPYLEAMTSA
                     GREALPKAPSDALPWPTWYSSVRDGQEMTREDVQPQYWVDNMANPVLFSTAVEAACSDK
                     GLFDLIIEVGPHPALQKPCLDTVEETAGARPPYVGLLGR"
     CDS_motif       9599..9694
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0004"
                     /evalue="4.20E-08"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="pvhA"
                     /protein_end="665"
                     /protein_start="633"
                     /score="25.8"
                     /tool="antismash"
                     /translation="GVRIDAVVGHSSGEIGAAYASGLYTARDAIRA"
     aSDomain        10532..11062
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_PKS_DH.1"
                     /evalue="3.10E-21"
                     /label="pvhA_PKS_DH.1"
                     /locus_tag="pvhA"
                     /protein_end="1121"
                     /protein_start="944"
                     /score="68.3"
                     /tool="antismash"
                     /translation="HPLLGKRCYDRETNLCIQWRNILSLKEVPWLTGHQIQGLTVFPAA
                     GFVSMAIEAIVALAKDSTIGLLSLENVNIGRAMAFQDDSSRVEVLFDMRIIAQTPHEIA
                     AEWASYSGDPHDIKTVLTLNASGVVRATLAENNASAEPDVLPALDVIDNNDLSPVDTER
                     FYKFLRKLGYNYSW"
     CDS_motif       10619..10696
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0005"
                     /evalue="6.00E-11"
                     /label="PKSI-DH_m2"
                     /locus_tag="pvhA"
                     /protein_end="999"
                     /protein_start="973"
                     /score="34.8"
                     /tool="antismash"
                     /translation="WLTGHQIQGLTVFPAAGFVSMAIEAI"
     aSDomain        12004..12516
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="2.80E-46"
                     /label="pvhA_cMT.1"
                     /locus_tag="pvhA"
                     /protein_end="1585"
                     /protein_start="1414"
                     /score="149.2"
                     /tool="antismash"
                     /translation="NQCLANMIASISHRYPRMNILEVGSQVGSSTEAILSQLDTAFDTY
                     TYTNISDDSFGLAEEHFTAYGDRINFKTLDITQSPTSQGFALGEYDLVVASNVISSGSD
                     MTESLTNLRALLKPGGFAVILEPVDNDCLRLGLALGCMPDRSPPLGLPQWNSLLSETGF
                     SGTDTISP"
     CDS_motif       14119..14217
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0006"
                     /evalue="4.10E-18"
                     /label="PKSI-KR_m1"
                     /locus_tag="pvhA"
                     /protein_end="2152"
                     /protein_start="2119"
                     /score="57.9"
                     /tool="antismash"
                     /translation="TYLLVGLTGEIGRSLCKWMAERGARHIVLTSRT"
     aSDomain        14119..14637
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_PKS_KR.1"
                     /evalue="1.40E-52"
                     /label="pvhA_PKS_KR.1"
                     /locus_tag="pvhA"
                     /protein_end="2292"
                     /protein_start="2119"
                     /score="170.1"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="TYLLVGLTGEIGRSLCKWMAERGARHIVLTSRTPKEDVVFSSAMK
                     ALGAVVKYLPMDVRSRDSIHACYAMIQNTMPPVAGVANGAMIIHDMVFDNMSFEVMDKV
                     LAPKVVGSQLLDELFYDTPLDFFIFFSSMTAVMGNSGQANYLAGNMYMNALAAQRKERG
                     VAGSSINISS"
     CDS_motif       14374..14418
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0007"
                     /evalue="2.80E+00"
                     /label="NRPS-E2"
                     /locus_tag="pvhA"
                     /protein_end="2219"
                     /protein_start="2204"
                     /score="1.1"
                     /tool="antismash"
                     /translation="MIIHDMVFDNMSFEV"
     CDS_motif       14488..14595
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0008"
                     /evalue="8.90E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="pvhA"
                     /protein_end="2278"
                     /protein_start="2242"
                     /score="60.1"
                     /tool="antismash"
                     /translation="LDFFIFFSSMTAVMGNSGQANYLAGNMYMNALAAQR"
     aSDomain        join(14977..14983,15044..15234)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_PKS_PP.1"
                     /evalue="1.20E-10"
                     /label="pvhA_PKS_PP.1"
                     /locus_tag="pvhA"
                     /protein_end="2471"
                     /protein_start="2405"
                     /score="33.5"
                     /tool="antismash"
                     /translation="IKEVFLARLRRILSIPADKNINEDVTLVEQGVDSLMAVEVRSFFN
                     KELDVDIPVLKILGDISINGI"
     aSDomain        15691..16572
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.30E-63"
                     /label="pvhA_Condensation_LCL.1"
                     /locus_tag="pvhA"
                     /protein_end="2896"
                     /protein_start="2602"
                     /score="206.6"
                     /tool="antismash"
                     /translation="APMSHGQEGFWFLQDYLPDKTVFNTSVMLKLEGEISVETLSQALQ
                     MVARRHEILRTRFFSADDDGEQKVMQAIAANSSLELETKQITSGNEAQVEFTRFNKHVF
                     DLANGEAARVLLLSLSKTEHFLMAGMHHIYLDGYSFSIFFNDLNTAYTSKRLPPLPSNS
                     QYRSFVEQERERYESGEFDETIAHYRETLPKDLAPIELLPFARGTTRREVNNYDQTESK
                     MRIDRPLADKIRQLARNNRSTSFHVFLAAFQALLFQLLPESDDLIIGMGDANRDDKKYL
                     NSIGYFFNLLPLH"
     aSModule        15691..19683
                     /complete
                     /domains="nrpspksdomains_pvhA_Condensation_LCL.1"
                     /domains="nrpspksdomains_pvhA_AMP-binding.1"
                     /domains="nrpspksdomains_pvhA_PCP.1"
                     /domains="nrpspksdomains_pvhA_TD.1"
                     /final_module
                     /locus_tags="pvhA"
                     /monomer_pairings="Ile -> Ile"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       15754..15864
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0009"
                     /evalue="2.80E-13"
                     /label="C2_LCL_024-062"
                     /locus_tag="pvhA"
                     /protein_end="2660"
                     /protein_start="2623"
                     /score="42.3"
                     /tool="antismash"
                     /translation="VFNTSVMLKLEGEISVETLSQALQMVARRHEILRTRF"
     CDS_motif       16078..16143
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0010"
                     /evalue="3.00E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="pvhA"
                     /protein_end="2753"
                     /protein_start="2731"
                     /score="23.0"
                     /tool="antismash"
                     /translation="MHHIYLDGYSFSIFFNDLNTAY"
     CDS_motif       16483..16569
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0011"
                     /evalue="8.60E-04"
                     /label="C5_LCL_267-296"
                     /locus_tag="pvhA"
                     /protein_end="2895"
                     /protein_start="2866"
                     /score="11.9"
                     /tool="antismash"
                     /translation="DLIIGMGDANRDDKKYLNSIGYFFNLLPL"
     CDS_motif       16624..16734
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0012"
                     /evalue="3.30E-08"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="pvhA"
                     /protein_end="2950"
                     /protein_start="2913"
                     /score="25.8"
                     /tool="antismash"
                     /translation="RSAVREALERPHVPLSILLDELDVPRSNKHTPLFQVC"
     aSDomain        17116..18312
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_AMP-binding.1"
                     /evalue="7.40E-83"
                     /label="pvhA_AMP-binding.1"
                     /locus_tag="pvhA"
                     /protein_end="3476"
                     /protein_start="3077"
                     /score="270.2"
                     /specificity="substrate consensus: Ile"
                     /tool="antismash"
                     /translation="GSTTALKDGHGSTLSYEQMGRRIAAISAALIEKGIARGDVIGVFQ
                     EPSVDWICSMMAIFNIGATYMALDQRLTLPRLATIVQTAKPAAILTDSFTSSQVTDIGA
                     SAITTVLVSHLASSVNTKPINAARAEDVAVVLFTSGSTGVPKGMRMTHANLVFSTDSIS
                     GAFNVTQESMVLQQSPFSFDPSLCQTLVALTNGAALYVVPSRSRGDPMAVTKIMAEEKV
                     TFTVGTPSEYAMLLEYGADNIRQCHAWKCAAWGGEQMPHGLAKQLAAANLPGLKAHNVY
                     GPSETTMLSHFHLVNPAEIEGNGYIPVGAGFDGYKYCIVDHQMRVQPIGVPGEIIIGGP
                     AVVAGYLNNQQLTDTKFLADSFFGTNGKVYRSGDLGRMLEDGTLVVEGRLDGDDLIKLR
                     "
     CDS_motif       17158..17193
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0013"
                     /evalue="2.30E+01"
                     /label="C3_starter_134-155"
                     /locus_tag="pvhA"
                     /protein_end="3103"
                     /protein_start="3091"
                     /score="-1.6"
                     /tool="antismash"
                     /translation="SYEQMGRRIAAI"
     CDS_motif       17512..17571
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0014"
                     /evalue="9.90E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="pvhA"
                     /protein_end="3229"
                     /protein_start="3209"
                     /score="21.3"
                     /tool="antismash"
                     /translation="AVVLFTSGSTGVPKGMRMTH"
     CDS_motif       18097..18186
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0015"
                     /evalue="2.30E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="pvhA"
                     /protein_end="3434"
                     /protein_start="3404"
                     /score="35.9"
                     /tool="antismash"
                     /translation="PIGVPGEIIIGGPAVVAGYLNNQQLTDTKF"
     CDS_motif       18292..18342
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0016"
                     /evalue="5.70E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="pvhA"
                     /protein_end="3486"
                     /protein_start="3469"
                     /score="18.9"
                     /tool="antismash"
                     /translation="DDLIKLRGFRIELEEIE"
     aSDomain        18679..18888
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_PCP.1"
                     /evalue="1.00E-10"
                     /label="pvhA_PCP.1"
                     /locus_tag="pvhA"
                     /protein_end="3668"
                     /protein_start="3598"
                     /score="33.5"
                     /tool="antismash"
                     /translation="ERQLGTLWRQVIPVYVGSLASTSDFFLAGGNSLLLVKLQALLRTE
                     FGATPKLMDLMGASNLAAMADAVQK"
     aSDomain        19030..19683
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pvhA_TD.1"
                     /evalue="7.70E-46"
                     /label="pvhA_TD.1"
                     /locus_tag="pvhA"
                     /protein_end="3933"
                     /protein_start="3715"
                     /score="148.1"
                     /tool="antismash"
                     /translation="VLLTGATGQLGRHVLSQLVTNGKTSRVICLTRQPDKIEANDKVTT
                     LRGDVSEPNFGLSEQEYQQLATETDVIMHCVANRSFWDRYEVLQPVNVSAVKSLVGLIA
                     DSGRIIPLHFMSSGAVSHYYNLGTSPPRDGSDGYVASKWAAEGFLRRIAAETSIPIYIH
                     RPSSVDGDALGSPQEREAVTDQLMGIVNSMEIQPEFGGVDGTLDIAPVDDMAQSL"
     CDS_motif       19033..19095
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pvhA_0017"
                     /evalue="2.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="pvhA"
                     /protein_end="3737"
                     /protein_start="3716"
                     /score="10.5"
                     /tool="antismash"
                     /translation="LLTGATGQLGRHVLSQLVTNG"
     gene            complement(20563..22506)
                     /gene="mfs"
     CDS             complement(join(20563..21037,21089..21157,21206..21788,
                     21921..21973,22043..22506))
                     /codon_start=1
                     /gene="mfs"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 175.6; E-value:
                     1.9e-53)"
                     /gene_kind="transport"
                     /product="major facilitator superfamily ORF1"
                     /protein_id="AZZ09609.1"
                     /transl_table=11
                     /translation="MTTSTSKNAISKSSQEDLCSDTKDKGSSGGGNEANAEASKAIQGF
                     RLVLLFVGLALSVFCLSLVCISEFISTFLFTRTYPDVFGFGRIVQSWLRPFRELRPSLI
                     PLTTWRGSAPLTCYPRVVFSFLLESCTRSSRYGACSLRRWVFSSWDHSSAHLAPSLLLP
                     GLCPCIVAQSVFTDRATWRWCFWINLPLGGVTAVAVFLFVRLPSPQGGATTFLGLLQKL
                     DALGTCILMPLIICLLLALQWGGTTYAWNSWRVVLCLVLFTVLLVAWLYVQYRQGDGGA
                     LPLRIVRQRSIRSAILFTFGINGSMFIIVYYVPIWFQAVKDVTAQQSGINFLACSGSMS
                     VAAIIAGTLVSTGEEKQHQGQWRIFNYTTLVSIATGLIWRYNPATSTAYCRAGTLVMFG
                     FGAGSGMQMPFIAAQTVLSASDISLGSSLIILIQTMGGAVFLAVSQNLFQSKLIGLLES
                     HPYGVEPEFILDTGASGLRSAVQHKYGTKAVETVLQAYNTALRQCFLVCIVLACLTIIA
                     DAGMEWKNVRAGKKPAKAPDAHHESKTDIK"
     gene            24097..25638
                     /gene="TF"
     CDS             24097..25638
                     /codon_start=1
                     /gene="TF"
                     /product="transcription factor ORF2"
                     /protein_id="AZZ09614.1"
                     /transl_table=11
                     /translation="MPSSPGNRQHSLRSACERCRLHKLKCTILPQKRFEGPQEAPEQCT
                     RCARAKAKCVFGRRAPPKHRASSSNDRSSVSKGINSTTPATRTMQPNATGFVSSHRIEL
                     PPSPASNQSSLKHSSVWDNLLDKTTPQEPRADFSSFSYPPVPFDLQSMCLDEVDMAASA
                     LPTTEPNFSSAQREHEFSAMSMSPGLGYDNLDELLALNEQPNISDASSPLLSETDPSHG
                     MIRLSSLLKEIHETQHNLQERSFSCTTSRGLAGYPIGRVLHAAQTFSSMVTNLMRPRVV
                     QTSHTDVQGFNPSLYSSSPESTELPSLHQEFVSSLEQMKTNALEQSRRLGEDDLDKYAS
                     PCSSTTSLQDTMLDMPIVMLVFCCFASLSKLYCSVFRFFEKSLHSQSCRAKDSTYVPPL
                     QDTRTLQLGELSIENDTEFKVLKALRMLLDAFQAAEASLGLPSSLTVLNSNKSTISASA
                     EPAVSDTGSLQHHLRHSLIKQCVTFDDRHLERTLTSLVTHVENLKQLLRVQNGLH"
ORIGIN
        1 tcttacaaaa gatgacgata atagtaatgg caataagagt ctagaaatta tcaactacat
       61 acggtcctcc gtccattcga gtcagagaag ttgattcgag tcaatttgtt tgggctcatg
      121 gaaagacacc caaaccccat ctcctggtga tagaataata tctgctttta gagtggggtt
      181 accaccatct atgtgctgca tatgactctc aaccctctca aagcgctgga acaacctaca
      241 cagcacatat gacatttcca tcagagcgaa ttgctgaccg gtacaaagcc gtggccctgc
      301 actgaacggg atatagtcat gagcgctggg atgccagtgc agccaacgat cgggactaaa
      361 aatggcaggg tctgcaaatt tctccgaagt agccggatat agatctcgac gacgatgtaa
      421 aatcagagtc gagtaagcga tctttgtatt tttcaacacg gcaataggtt cacttccatc
      481 aggcccgccg ccgtgtggta gagtggtatc ctctagcgca attcgcacat tgtatggaac
      541 tgcgggatag atacgcaaag tttcgttcaa cactgccttg agatatggca tgttcttgag
      601 ttggtcgtat gtcggcgcat cagatccgac tgtctgtaga atctcacggc gcaatgcatc
      661 aacagcttca gggtggcgac ttagttcata tagagcccaa gagagcgtag ctgctgttgt
      721 gtctctgcca gcaagtagaa caccaacaat ctgatcgcgg agcattgtag ggtcgcgcgt
      781 gaacccagca attgcctcaa gaaaggtgta cttgctgcca gattgggact tttgctgtgt
      841 ttcctgcggg gataggctca gtgcacgacg cacgtgtttg tggatgaatc cgttcatgac
      901 cttgagacta tctcgaaagg acttctttga cataaatttg ctaaaatggc ggcttctgac
      961 aaaaatggtt tgcatacgct ggacttcgtc gaatgcatgg gcaaattctt gtcttggagt
     1021 gctggatcat atggatgtca gtgatcaagt ttccatatcg agaaagtagc gaacaaacac
     1081 ttacgtgagc gattggacgt cttgtccaag tagaaagtcg gttgaaacat cgaatgtgaa
     1141 ccgatagagc agatcacgta tatctatagc ctttccttgt gacatgggcg tctcctccgc
     1201 gtgcttggaa tccagtggtg agcctccagc gtcaagcact cggaacaaag tctgcatatg
     1261 ggcttcaaag cattgcaagt cactaagacg gtctcgagtg aactgcggcc gaatcaattt
     1321 ccgactcgcg gaccatctct ctccatcagt cgcaaagatg ctattgccga gaaagtcttt
     1381 ccacatagca tgaaaggcgg cgcccttgcc atagtcgctg aattgagtgg caagcattgc
     1441 cttgatattt cctggatccg ctgtgaagat ggttcgctcg ttcatgatgc gagtctcaac
     1501 tgtccaccgg ccgctggccc cgaatatatt atccctccaa aattcgaagt ttttctgcgc
     1561 cctgactgcc ttgaccatgc tgtacaagaa accgatcccc aaaggtaact tggattggat
     1621 ttggtggcca tatttgccaa ggctcctgat ctttctgtcc tctctaacac gagtaagtac
     1681 tttgaaaagt atgcacaaaa tcactaggga acaaaaagca accgtgggcg agcacctcga
     1741 cacagctatg ttaaggacac tcatggcgtg aagtaaaata ttgccgtacg gaaagtgttt
     1801 ttactaactt gatgcatacg gttaaaagtc ttaaatcact gtatgttttc cagtgataat
     1861 ctttaaggct attttctcca attaattttg tagaatctgg aaccggaaga attggtggcc
     1921 tgatcggtga tcatcggata agccatacga ggacttctcc ggcacaagtc accgatgttt
     1981 tccgacctta ccactgatga taacacgagc aaattccgat cgtagaatta cattgtcacg
     2041 ttcttcttta accatccagc cattctaggt attcgggcta ttgaaatgct catgtggcgt
     2101 aaaacctatc ctactaatag cccacaaaac gcctctcttg accactattt gattatgatt
     2161 tttatttgtt aaagagtaaa ccatcgaata ataacttgta tggccgtatt agaaacatct
     2221 attatagaga gcaatacatc gagcgtttat tggcgaagga agtgcagtat acgaaagaca
     2281 caaatttatt tccacgagtc tccttaagca accactaatt caagtactgc cgatttggtc
     2341 ttgtcatctt cagcgatgct tgacagctca aaccctgcgc gccgggctag tgctccaaag
     2401 tttcctttat tacgtcgttt accaccaaaa tttaacatcc agacgtcaat agcggccaat
     2461 ttcaatggtg gttcgtcagg aagaaggttt tctgagatga gaaccttgga gtcgggagcg
     2521 caagcgtcac gaatgctgcg aagaatctgg acaacttctg catctgacca atcattcagc
     2581 actcggcgaa tgtagtaaac cagagcacct agaatatgtc agtaactgat agaagagacg
     2641 attgaaaagc aaagttggca gcgaaccttt tacgggttgc tccccaaaca gatcgatcgg
     2701 gacctttttc acagtctcta gagggccggt tgctagtttc gcttcttcga tgactttctc
     2761 ttgatcctcg agaacacatt gttctggtat aatactaggg aatgcttcga gaatagcttg
     2821 gagagcttgc cctttgcctc cactgacatc cacaaacaag gttctatctt tgacctcggg
     2881 gcgttttcca tactccccaa tccatgagaa gtcatacatg cccaggattg gcatctcgcc
     2941 catgctcaat gccatggtgg cattaaaatc agaggatctt ttcggcatga gatcaaagat
     3001 ttcgtaaact gatttgtctg aatacccgga accaaagcca aatggcgact tgcttgagca
     3061 ttgaggctct tgcatgccgt taatgtcaaa atactcgggc catttgactg cagaggtcaa
     3121 gaaagtgtcg aaaatgtgcg gataccatag ctgagctctt ctctcggtga aatactttga
     3181 agtgggtgta tggtgtacgt atcccggaga cgaagatgtg aaaatacggc tggatatgag
     3241 aaaattgaca agcctctcta gcaggttgaa ttcaatgcca gttttggttg ctagatcagc
     3301 tattaaaatt ccttcgtcag gaatttcgtt aaagacgcgc ttttcgacga ataatctcat
     3361 gacacccagt tcgacgattt gataaagata gccaaacacg ggtgttggtg cctcttggca
     3421 acgacagggt aaactgggtg gcatcgtcat ggattgcgtg gttgtaggtg cggacatgaa
     3481 gtttcccatt atagcgaaaa agaagatggc gctgaaataa ctgaaataga tcaataaaat
     3541 tgatagctaa gtcacgattt ccatgaggaa tcagacatat atcttggatt atactttgcc
     3601 atcgatatac atcattccgt gaccccggat tgaccccgga cccacatcgg catcggagtg
     3661 cgtattcgta tttggagatc ccaaatccga gatctccgag gcaccgaata gggcaaatta
     3721 acctaaccct aactgccatg cgtgagtgca acacatggct gttagcattc agaagccact
     3781 gacagtgctt tgtcttcgaa attagcctct ttaaccttgt tagagcacta tagtaataat
     3841 cgttgaggat tcaatgttgg ttgaattgtg aggtctgtct acttgactag ctacctagag
     3901 gatatacaat cttggcgccc gatactttct ttgccctcaa atcctccagc ccctgttgta
     3961 tattttccaa tcccccatcc cgaatttgca ttggatgtgg cttgatgagc tccttcttca
     4021 aaagttgatt caaagtggct gtccattcag caccgaactg agccaagtca tcatcctgct
     4081 tgcgataatg gggttcgggc caggcgactt cttggcctaa taatgaggga cccatgaccc
     4141 aatctggaga aacaaccttt cgagtctggg cgacggcagc ggaaaatggc tccagagacg
     4201 tgtatttacc accggctcga ccaataacct tgtagcagaa ctgcatgctg cttgttgtgg
     4261 atatgcagtc aagagcgtaa cgcagtccat tcttggtgta ctttttgatt ttatccatgg
     4321 tgtcaggatc gttgtaatca aaagcgtcca cggccccgta gctcttgacc aactcaaagt
     4381 tatgcggaga gcaagtagta atggggatgt gaccggcctc tcgaagaagc tgcagactgg
     4441 cagttccaca tgacgatgaa ccaccgtaca cgagaatgca aagtggcttt ggcgctggtt
     4501 caagcggcct tcctggaata cccaggcttc gaaagagagc aagtcccgac gtcaaaaagc
     4561 tgataccgag cgtcgctcct tgctcaaaag taatgctggg tggcagctta agcagaatcc
     4621 attcgacagc tgctgtgtac tctgcaaatg ctccgattgt aggatctgcg ggattcatcc
     4681 ccacgacagc gctgcacacg cgatctccta ctttgaggcc acatttggta gcttccggcc
     4741 ccagctcttc cacaatgcct gagaagtcga agcccgccac agcattgggg gtgacgtagg
     4801 gaccgaccag tttggagtca actgggctaa ctgaaaccgc tttggttttg atcagtactc
     4861 tttcgcgggc tatggcgggg attggcgcgt cgtgcgcgag tctgcttcct ccgtctgttg
     4921 tccctatcca tgcggactgg atattttgag tccttgacgg cattttgagg aataagtgaa
     4981 aagatgaagg taataataag gatgagttta tgagaaacag tcgtagtgga aagtgatatc
     5041 gttaagtcgg cgtttttctg tcacttcccc atgctatggg aagcggtatt cgtttttatc
     5101 tgattaaagt aatcgtagta cagggattaa cataaatccc gaatgtaatg tggggtcaca
     5161 ttctccgaat attcctgtgg caaattccga taatacgata gcatcgcaat tgctgaaaaa
     5221 taggtcacga agaatggggt cgtcatcaat tgattactct agaccgctat acatgtaaga
     5281 catcaatggc tacgtattga aattcataaa ttttgcatgg aaatggcacc gtgttttcgt
     5341 tgtaattcat gtagacaagt gatatttcca ataaatatat aacggagacg atttagtaaa
     5401 ctatttgacc actgacccca agcccttcac aagtttcccc tgcaagtcca ccgcaaacat
     5461 gctctacgaa gccagaattg ccgcccttag gcccaatagg tagggaccag atcttggtct
     5521 gatgtcggac cgtaaaggtc catctgcgtc gcgcattacc ggcctcgaca aaagtcaaat
     5581 cataaccggt gcttttatca tggaactcgg ctgaaagagc accggtgtcg ctgtcgtgaa
     5641 ccttagacat gacgagggtg tcctgagata tgccttgctc gtctgggctg ccacaacgct
     5701 gaggagcgca cactaatttg ccttgatgaa aaagtcttgc gattggccat tgctgctttc
     5761 ccagttcttc tgttgacaca agtcgaataa tctgtataac atagggtcca aggaaagcgc
     5821 gcataaagta tgactcggat tgaatggaca gccatagctt ctcaccccag tatctgtcaa
     5881 agcctccatg accgtcggaa aaggaaatct gtctcgtagt gccgtcgtct gggaagtgga
     5941 aaatcatgtc cgaagtcata tcagcccttc caactggtcg catgtagctt acgtacggac
     6001 cgagactggg cgaagtgctc agccccgaat ctccgggctg gccttgaaag ctggcttttc
     6061 ctgtggcaac tcctgggatg caaacaacaa cgtcaatttt gttatcaact ttgtggtagg
     6121 tgaatgaaac attggtactg ttgtcggctg tcttccagac actggtaatg tcgcctgatg
     6181 ccatggattc ttcaaagatg gactccggta aagccaatgc tttgtaccaa ttcttgccat
     6241 cgggccatac tgcaatgatt tgtactctcc agccgccgcc catttttttg ttgaaggcgg
     6301 cgcgctggaa tccaaacatg acgccagctc cttcgtggtt gatgccctcg cagcaccaaa
     6361 tctcccatgt gcggtcgttg atattcgacg aatacttggg gaaaatgttg ttttcgccag
     6421 gcacatgggc actggcactc acttcacctg gtatgatggc attttcaatg ttaaaatggg
     6481 aaatgcgttt tgtcattttg ttccccattg gactgtcaac agaaacgtca gagttgaggc
     6541 cggctgtgta gaatgtaaca agctttttag cggtcgtctt ggctaaggaa caatgccatt
     6601 gcactttatg ggtcttgtca ctgttttgtt ggtacccatc gtcaacacca ccccgggtta
     6661 tgagagcgtt gcccccgaaa gatgccgaat cttgggcaac ctcgtcggtc tcggagaccc
     6721 actttatctg ccgaacccta acgactccac atgttggtca tctacaccag cccctgtttt
     6781 ccattttccg tggtcggaga aagggagaac aagccgcaac aaggagaccg atgttgtata
     6841 ggctcgagca ctattttcct tggagctgta ttagacataa gctgtgcatt ccagccccaa
     6901 tgtacagtgg ggggccgaag gtttgaatcc aatgcgaaaa gaagtcctca attcttgcta
     6961 ctttactatt tatctatcat ttttttaata aaaaaaagtt attgctatgg aattttaaca
     7021 ccaatataaa aagaaaatta aattaatatt aaataaagca tatatgtcag ttagtaagat
     7081 gagatatatc ttttaggaag taatataccg tgctagtatt agcgttggat tcaaataatt
     7141 gacacctggg tgtcgctctt gatcgctcaa tgccagtttc ggaccgatat acgtactgcg
     7201 ttccaacatt gatgacgctt ctagccttgt gcgctacacg aatgaaacct ttttggcgca
     7261 agcgctccga accattcaac aatccatccg tataaatctc cgtattgtta atctctctgt
     7321 ctatagatgc ctcgtattat tagctagctt tcattatact cgtatccagt cttctcgtac
     7381 tcgaaaattc agctccgaag ttgttagact ggctctattt agcctactgg ccagccatgc
     7441 ttgccatgtg ttttgttaaa accttttgaa ttcaactcgt cacaattcgg ggcttcaact
     7501 tctttgatcg tcgcagtcta cactacatat ttcactgttt tatatatact tatacttgta
     7561 cttttatgtg agcgaagcta catgtacttt gctttgctcg attaggccat agtcaatacc
     7621 gctcccaatc accacccacc atgtcacatt ccgatcaaga cgagcgcatc gcagtcattg
     7681 gcactggctg ccggtttccg ggaggttgtg attctccttc aaaactttgg gacctactga
     7741 aggccccgcg tgatgtgctc cgcgaaatcc cccgcgagcg cttcgacgcg aacgcttggt
     7801 atcacccgga taacaagcat catggaacaa gcaacgtgcg aagcgcgtat ctcttggacc
     7861 aggaccctgc tgcatttgat aatgaattct tcaatattca gtccagtgag gcagaagccg
     7921 tggacccgca gcaaaggatc ctattggaaa cagtatatga ttctctctgc gaagccggct
     7981 gtaccattga agggctgcga gggtccaaca cagccgttta tgtcggactt atgtgcgatg
     8041 actggtcggc cattgttacc aaagatacag aggtgttccc ccaatatgca gccactggaa
     8101 caagtcgcag cgtcatgtcg aaccgcgttt cctacttttt cgactggcat ggcccgtcca
     8161 tgaccattga cactgcctgc tcgtctagct tagttgctgt acaccaagca atacacacct
     8221 taaggagtgg cgaatcaaat gttgccattg ctgctggagc caatttgatt ctatccccag
     8281 gtatacccac atttcaccca tcatgtagat gaattcggct aattgggaat ctcctgcaga
     8341 tatgttcatt gcagaaagca atctttccat gttgtctgca ggtggacgct cacgcatgtg
     8401 ggacagagac gttgatggct atgctcgtgg tgaaggcatc gcagcagtcg tcttgaagcg
     8461 tctcagtgat gctgttcgag ataacgatca gattgaatgc gtcattcgcg ccaccagcgt
     8521 caaccaggat ggaaagacgg ccggcttgac catgcccagc ggtacagccc aagctgcctt
     8581 aatacgtagc acatatgctc gagctggtct tgacatttcc aacccacggg atcgcccaca
     8641 gttcttccat gcccacggaa caggcacagc cgccggtgac cctcaggaag ctagggccat
     8701 acacgaagcc ttctattcag gtacagcacg caacacggat aagctgtacg ttggatcggt
     8761 aaagacggtc attggccaca cagaaggcac cgctggcctt gccagcttga ttagcacatc
     8821 gctggcaatg cgccacaaaa tcatcccacc caacatgcac ttcaataact tgaacccccg
     8881 cctcaagccc tactaccgta acctcgaagt gcctaccaag gcctatcctt ggccagagcc
     8941 cgctccaggc cacccgcgaa gggccagtgt gaatagcttt ggctttggtg gcaccaacgc
     9001 gcacgcaatc attgaggagt acctaccatc tcagacacga gatctagccg agcataccac
     9061 agctgtatcg ctgctgaccc ctctggtgtt ctcagcatct tctgaaattt cattgaggtc
     9121 tctgctagcg tcatactcgg cctatctcaa agaaaatctg acaatatcct tgcaaagtct
     9181 tgcgtacact ttacaagccc gacgttcaac tatgccgcac cgggtagcaa tcacttgcaa
     9241 caccacatca gaattaattt cagctataga tggcattata tctgggcagg aaaacagtac
     9301 tattgctgtg cgccaccttt ccaagccaac gccaaaggtt ttggccgtct tcactggaca
     9361 gggagctcaa tgggctcgca tgggagccaa actcgttgaa acgtcaccgt ttgtatccaa
     9421 aagattgaaa gaactagatg aagcgttggc cacttctgct gctggcaatt cgccacaatg
     9481 gactttgtcc gagatgattc tagccggtcc cgcattgtct cgcgtggctg aggctgccat
     9541 ctcacaaccc ctatgtactg cagtacaaat tgtattggta gacttgttgc gccaggctgg
     9601 tgtgaggatc gatgctgttg ttggtcactc ttctggagaa attggtgctg cgtacgcgtc
     9661 cggactgtat acagctagag atgcgatccg agctgcttac tacagaggcc tctattcctc
     9721 gttagccaag tcccccaacg gtggtaaagg ctccatgatg gctgtaagca ccactcatca
     9781 ggatgcaatt gagttctgcg agctggaaac atttgaagga cgacttcaag tggccgcggt
     9841 taactcattc gacagcatta ctctttctgg cgatgcggac gctgtcgccg aagcctgtga
     9901 agtttaccaa gacgaaggcg cattcgcgcg acagctcaag gtcgacacgg cataccactc
     9961 gtcacacgtt ttgccttgct caaagcccta tctcgaagcc atgacaagtg cagggcgtga
    10021 ggctcttccc aaagcacctt cagatgctct accttggcca acttggtact caagtgtacg
    10081 agatgggcag gaaatgacca gggaagacgt tcaaccgcaa tactgggtag ataacatggc
    10141 aaatcccgta ctgtttagta cagcagtgga ggcagcatgc tctgataagg ggcttttcga
    10201 cttgataatt gaggttgggc cccatccagc tcttcagaag ccttgcctcg atacagttga
    10261 ggagaccgcg ggagcgcgcc caccctacgt cggacttctt ggccgaggca aagatgatgt
    10321 ctctgcattt tccaaggctc tcggattcat ttggactcag cttggtccgc agtcggttgc
    10381 ctttgacaat gttgagcgag ccgcgtctga accaccagtt gtaccacggg agctgttgaa
    10441 ggatctgccc caatacccat tcgaccattc ttccaaattc ctttctctgt cccgcgtgtc
    10501 aggattctat aacaggtcac agatggcaac acaccctctg ctaggaaagc gatgttatga
    10561 tcgtgaaacc aatctctgca tccaatggcg caacatactc agcctcaagg aagtgccttg
    10621 gctaacaggc caccagattc aggggctgac tgtcttcccg gcggcaggat ttgtctctat
    10681 ggcaattgag gccatagttg cgttggccaa ggatagcacc attggtctct tgtctctcga
    10741 aaatgtcaac atcggccgcg ctatggcttt ccaagacgac tcgtcccgag ttgaggtact
    10801 tttcgacatg aggatcatcg ctcagacccc tcatgagatt gctgcagagt gggcatccta
    10861 ttctggtgac ccgcatgaca tcaaaacggt gctcacactc aacgcttcag gagtagttcg
    10921 agcaaccttg gcggagaaca atgccagtgc agaaccagat gtactgccag ctcttgatgt
    10981 gattgataac aacgatcttt ctcctgtcga cactgagcgc ttctataaat ttctgaggaa
    11041 gcttgggtac aactactctt ggcccttcta cggaacaaag agtatccaac gtaaggcagg
    11101 ctttagcaca ggcatgcttg aagaccaatc tggcgatgaa tggcaggacc aactcttggt
    11161 ccacccgggt atgattgata cagccctgca gactgcattt gccgctttct gctgccctgg
    11221 agacgagaga ctgtggtcac tgcatgtgcc aactcgcttc aagtctcttg taatcaaccc
    11281 attctttact gccaggggca ttgggaaaca gcggatgttg aaattcgttt ctacggctgc
    11341 agctgtgaag cagggtaaga ttgctgccga gctttacttg caatccgagc acgaaggaca
    11401 aacacacaca tttctacaag ctgagggatt ggagattgtt cctcttgccg cagctgttcc
    11461 tgacaacgat accgtcttat tctcaagatt tgactataaa ttggcttgtg cagacggtga
    11521 aacggccgct atcttggata ctccgcttag tcaagatgca atcgacgatg tcattaatgc
    11581 agaaagggtt gccttttatc atctttacaa cgttgttaaa tccatcactc caggggagga
    11641 agcaagtgcc ctgccacact accaacaatt cctttcatgg gcgcgaaacg ttgtggagaa
    11701 cgtactgaga ggtgacaaca agtatgtccc ggccagtgca gctcaagact ctgcgagtga
    11761 cattgcatcc ctcctcactg ggtaagttta cctttccccc ccctgaaaaa actacctgaa
    11821 tgtagcatat tattaacatg aagattgcct tttagatttg acaagaatgg ggaggttagc
    11881 ctggcagaag ctattgggaa gaacctcatc agtgctattc gtacctcttc aactgttttc
    11941 caagccgaag atcgcaacct gccagccgag ctctacgaaa aggcaattgg tttcgatacc
    12001 ggcaatcaat gcttggccaa tatgattgct tccatctctc accgttatcc tcgcatgaac
    12061 attctcgaag ttggatcaca agttggtagc tcaacagaag cgattctttc acagctcgac
    12121 acggccttcg acacatacac ttatacaaac atttctgatg attcatttgg tctcgcggaa
    12181 gaacatttta cagcgtacgg tgatcgtatc aacttcaaga ctctcgacat aacccagagc
    12241 cctacctctc agggattcgc tctaggagag tacgacctcg ttgttgcgtc caatgttatt
    12301 tcctcaggct ctgatatgac cgagtccttg actaatctcc gtgctcttct caaacctggc
    12361 ggatttgccg tcattctgga gcctgttgac aatgactgcc ttcgacttgg actggcctta
    12421 ggttgtatgc ccgatcgaag tccaccgctt ggcttaccgc aatggaacag tttacttagt
    12481 gagactggtt tctctggcac ggacacgata tctcctcgat ctcatggtgc tgttcccggt
    12541 gtagtattct gcacacaggc aatcgatgat cggatcaaga tgttgcgctc tcctcttagc
    12601 aacattagtt gcctaccagg ccttgaagca ccagaattag ctattgttgg ccgaggtcag
    12661 agctctgagc tgcagaatct gtgtggtgaa ttatcagatt tactttcctc tgctttcccc
    12721 aaagtaacct ttgtcgattc cgtggaacag gtgactgccg aaactatccc tactaccagt
    12781 gcagtcatca tgcttgcgga acttggcgaa tctccctggg caagcttaaa ccccgtgaag
    12841 cttgagggta tcaagaacat ttatcgacaa gccagaaact tgctgtgggt aactagtgga
    12901 gctgactcca aggatccata ttcgaatatc agtttgggta tcggacgtgc catgcaattt
    12961 gagtatcctc atctcagcat tcaagcacta gacgtggata ctatcagcga aaatactgcg
    13021 aagatcatcg ctgaacattt attgcggctg gggaccctta gcacatggaa agaagatcct
    13081 gagcaaccga cgatgctgtg gtctatggaa cccgaggtct ggattaagaa cgacatgcca
    13141 atcattccta gattgtgtcc gtacacaccg ggcaatgatc gatataacac aactcgtcgt
    13201 actgtccgta atcaggtcat tccaagagac acacatcttg ctttgacaaa tgacaatggc
    13261 gcctgggaag ttcaagtgac atcacctctc catcaagcac ctaagattcc ctatgccacg
    13321 gatacaaagc aagtgcgcgt aacagatgtg ctgctgtcga ccttgggcat tattcctgga
    13381 actatgttga tgctttgtac gggccaagat acctccactg gcgaagctct tcttgctctt
    13441 agcccaattg cggagacatt ggtccaagtt cctcgttcgt ggacaactgg tatcgataat
    13501 gctgagccac gcgatgcgct cggcgctgtg gctgctaaca tcgtggccaa gcttatggct
    13561 aaatctgctt ttagaggtga tgtgctcatc gttcacgatc ctcatccagc agttgcccat
    13621 gagttggcga taattgctaa taaaggagca ttcacgattc atttcacaac cgcctcagct
    13681 caagtcagta tcgagcaagg ttggcaccac attggatcaa gattctcggc cagcaaggtc
    13741 aaaagtcttc taccaatcaa tgcgaacaaa cttctggatc tttccaagtc ttcggcagat
    13801 ggcattagtg cacatatttt gtcgtctttg cctcgtggct gccgggtagt agatatgtcg
    13861 catatcatgg gcaatacaac tgagctccag tcatgggtgt cagaagacga ggtagcaact
    13921 gtgttgcaag aatctgtgac cgaggttctg cggtcagata ggtacacaaa tctcgtcaat
    13981 aatgtgcccc ttgtctccct ggaaagcata tctgagccga ctcatcatgc aagcttcgcc
    14041 atcgccgatt gttctgtccc tgctgttaca gccagggttc gtgcagttga cgatggtatt
    14101 atcttccgcg gtgacaacac ataccttcta gtgggcctga ccggtgaaat cggaagatct
    14161 ctttgcaaat ggatggctga gcgtggagca cgccacattg tgcttacaag tcggacgcct
    14221 aaagaggatg ttgtcttctc cagtgctatg aaggccttgg gcgcagtcgt taagtacttg
    14281 ccaatggatg tgaggagccg cgactcgatc cacgcatgct atgcgatgat tcaaaataca
    14341 atgcccccgg ttgcaggagt agccaacgga gctatgatta ttcatgacat ggtttttgat
    14401 aatatgtcgt ttgaagtcat ggacaaggtt ctggctccca aggttgtagg atctcaactc
    14461 cttgacgagc tgttttacga caccccgtta gacttcttca tcttcttttc ctctatgact
    14521 gccgtgatgg gcaacagtgg tcaggccaat tatcttgccg gaaacatgta catgaatgcc
    14581 ttggcagctc aacgcaagga gcgtggtgtt gcaggctcat ctataaacat cagttccgtc
    14641 ataggcgttg gttatgtgga aagatccgat cagcttgatg aagaatactt tttgaatatg
    14701 ggctatcgac caatgtccga acaagactta caggtctcgt ttgcggaagc cattgtccta
    14761 ggaaaaccag gctcatctga aattgcggaa ctgtccacgg gcatcaactc aactctcaat
    14821 gggcaaagta tagggaaatg gttgcaagac atcaaatttt cccacatgat gatgcatgag
    14881 agcaacgaca acgctggaat gggaccgggt gcatctgcgg caccactaaa ggtgcaattg
    14941 tcggaggcca agagtaagga agatatcatc tctattatta aaggcaagca aattccatgt
    15001 tcaatcccat ttagatgtat caattcttat taacaaactg cagaggtctt tcttgctcgc
    15061 ctcagacgaa ttctttccat cccggctgac aagaacatca acgaagatgt tacactcgtc
    15121 gaacaggggg tcgattcgct catggctgtg gaagtacgat ccttcttcaa caaagagctc
    15181 gatgtcgata ttccagttct caagattctt ggtgatatct caatcaacgg cataatcaag
    15241 caggttgttg aactcttgcc tgctgcagtg tacgacctcc ccgaagagac gccacagaca
    15301 ctctcaaaga accctgcacc aacacctgtc aaggccccag tatcagcacc ctcaactccc
    15361 gcggctgcaa gtcaaccagt attgacagac agcaccgcta gcagcagcag ggattccgat
    15421 gatgaccaag catcgtcaaa ctccacatct tatgagactt caaaagacgc atcgcgtgaa
    15481 gacagtgagg ttgatgagac gccccttgag tcaccggtca acacacccaa tgttatgtct
    15541 aaaccatcgg cctcgtctca gctgcttgaa aagaagcagc ttctagaagt tgatgctcta
    15601 atcgcctcgt ctcgccctgt ctttgcaccc gatgcttcca agctgcctag tgccgtcgct
    15661 tcatcacagt ctggacgcaa ggaaacactc gcaccaatgt ctcatggtca agaaggtttt
    15721 tggtttctgc aggactattt gcctgacaaa acggtcttca atacaagtgt catgcttaag
    15781 cttgaaggag aaatctctgt agagactctc agccaggctc ttcagatggt tgcgagacgc
    15841 cacgaaatcc tgcgcacacg tttcttctca gccgatgatg atggtgagca gaaggttatg
    15901 caggctattg cagctaattc gtctcttgaa ctcgagacga agcaaatcac gtctgggaac
    15961 gaggcgcaag tggaatttac caggttcaat aagcacgtat ttgatctcgc caatggagaa
    16021 gctgcacggg tgttgctcct atcactctcg aagacggagc atttcctaat ggccggaatg
    16081 caccatatct acctggacgg ctacagcttt agcatcttct tcaatgatct caacactgcc
    16141 tacacttcca aaaggctccc gcctctgcca tcaaactcac aatatcgctc tttcgtagag
    16201 caggagagag aacgctacga gtccggcgaa tttgatgaaa ctattgcaca ctaccgagaa
    16261 actctcccca aagatttggc gcccattgaa ttactgccat ttgcaagagg caccacgcga
    16321 cgagaggtca acaactacga ccaaactgag tcaaagatga gaattgaccg tccacttgcg
    16381 gataaaattc gtcagctggc tcgcaataac cgcagcacgt cgttccatgt ctttttggca
    16441 gcattccagg ctctgctctt ccaacttcta ccggagtccg atgatctgat tatcggcatg
    16501 ggagacgcta atcgcgatga caaaaagtat ctcaatagca ttggatactt tttcaatttg
    16561 ctgccattgc atttcagccg attcaagtct ggcaccaaga ttgctgattt agtacaagac
    16621 tctcggagcg ctgtacgtga agcactggag cggccacacg ttcctttgag cattctacta
    16681 gacgagctag acgttccccg gtcgaacaag catactccac ttttccaagt ctgtatcgat
    16741 catagacaag tgctacaaga acaatcaaat tggggcggct gtcgagttag tgatgagcaa
    16801 tggcacgacg ctggcactgg gttcgatatc tctctgcaaa tcactgaatt caacacagac
    16861 gcgtcgctta gcctgagatt acaaaagcca atgtacacag aagagcatac aaatatgctt
    16921 cttcgatctt ttgttgccgt cctagaacac atggccgatg tgccgacgga taacatggtt
    16981 gaagacatcc ccagctggtc cgagctagac atccaaaagg ctcttaccgt gggcaaaggc
    17041 cgagaattcc attcacgctg ggattccaat ccacccactg taatgcaccg tattcatgag
    17101 atgatcacgg tgcatggttc cacaacagca ctcaaagatg gacatggatc cacgcttagc
    17161 tatgaacaga tgggtcgccg cattgccgcc atctccgcag cacttatcga gaagggcata
    17221 gcaagaggag atgttatcgg tgtattccaa gagccatctg tcgactggat ctgttccatg
    17281 atggcaattt tcaacattgg cgcaacttat atggccctcg accaacgcct gaccttgccg
    17341 cgtctggcca caattgtaca aaccgccaaa cctgctgcca ttctgacaga tagcttcaca
    17401 tccagccagg tcaccgatat tggagccagc gccatcacca cggtcttggt ttcccatctc
    17461 gcgagttcag tcaacacaaa acccatcaac gctgcacgag cagaagatgt ggctgtcgtt
    17521 ctcttcacaa gcggctctac cggtgttccc aagggaatga ggatgacgca cgccaatctg
    17581 gtattcagca ctgactccat ctcaggcgca tttaatgtga cgcaagagtc tatggttctc
    17641 caacaaagcc ctttcagttt tgacccttca ctgtgccaga ctctcgtagc attgaccaac
    17701 ggtgctgctc tttacgtcgt gccaagtaga agccgaggtg atccaatggc agtgaccaag
    17761 atcatggctg aagaaaaggt tacattcacg gttggaacac ccagcgaata cgccatgttg
    17821 cttgagtatg gcgcagataa tattcgccaa tgccatgcat ggaaatgtgc tgcctggggc
    17881 ggagagcaga tgcctcatgg tcttgccaaa cagcttgcag cagctaacct cccaggctta
    17941 aaggcgcaca atgtctacgg gccgtcggaa acaacaatgc tttcgcattt ccatcttgtc
    18001 aatcccgcag agattgaggg caatggctac attcctgtcg gggctggttt tgatggatac
    18061 aagtattgta tcgttgacca tcaaatgaga gtgcaaccta taggtgttcc gggagaaatc
    18121 ataatcggcg gcccagctgt tgttgccggc tacttgaaca atcagcaact cactgatacc
    18181 aaattccttg ctgactcttt ctttggaact aatggcaagg tataccgctc aggagatctc
    18241 ggccgtatgc tggaagacgg aacactggtg gttgagggcc gtttagatgg cgacgacttg
    18301 atcaagctac gcggttttcg aattgagctc gaagaaattg agaaggcaat tgttaagcaa
    18361 gccgacggta cacttggtga tgcaattgtg tcattgagag gcgaaggcga cgctcaattt
    18421 ctagcagccc atgttactct ctcggctgac ttgtcgccac cagcgaagca aaaattaata
    18481 tcagccctac aaagactccc tctgtcttcc tacatgatac catctgtctt tggggtaata
    18541 aaggcgatac ccaaaactgc gcacgacaaa gtggacagga aagctgcaaa ggaactgcca
    18601 ctgccatcag cagatgatga aaactcactt gccgttcacg ggatcgacgg tggtgacgac
    18661 tcggttctga gtggaacaga gcgtcaactg ggcaccttgt ggcgtcaggt gataccagtt
    18721 tatgtgggat cacttgcatc tacctctgac ttcttcctgg caggcggaaa ctcgcttctc
    18781 ctcgttaaac tccaagcgtt gcttcgaact gaatttggcg ctacaccaaa gctcatggat
    18841 ttgatgggtg ctagcaactt ggcagcaatg gctgatgccg ttcaaaaaga ggttgacagt
    18901 agccttacgc gggatggtat cgactgggat ttggaaacga ggccgccagt tgcattgcaa
    18961 cacaagttga gtggttttat cagttctgcc agaacaaaca ccacgcgccc agacgcatcg
    19021 agattcaatg tcctgctaac cggcgccact ggtcagcttg gccgtcatgt gctgtctcag
    19081 cttgttacta atggcaaaac ctcacgggtg atttgtctca ctcgacagcc agacaagatc
    19141 gaagcaaacg acaaagtaac aacgctgaga ggcgacgtat cagaaccaaa ctttggattg
    19201 tcagagcaag agtatcaaca gcttgccacg gaaaccgacg taattatgca ttgcgttgcc
    19261 aaccgctcat tttgggatag gtatgaggtc ttgcaaccag tcaatgtctc tgcagtcaaa
    19321 agccttgtcg gcctcattgc cgattcaggc cggataattc ccctacattt catgtcatca
    19381 ggcgctgtgt cccactatta caatcttgga acgagtccgc ctcgcgatgg tagtgatggt
    19441 tatgtcgcta gtaaatgggc tgcggaaggg tttttgagac gcattgcagc cgaaacgagt
    19501 atcccgatct acattcaccg gccatctagt gttgacggag atgcgctcgg atctcctcaa
    19561 gaacgagagg cagtgacaga ccagctgatg ggcattgtta actctatgga gatacagcca
    19621 gagttcggag gtgttgatgg tactctggac attgctccag tagatgacat ggcccaatcg
    19681 ctcgctgaat tagtcctcaa aagtataact gaggcggccg aaacagatgg atcggaaaag
    19741 aacttgattc aagaattcaa gcacaaggca gccctacaag tctacgctag ggattttgcg
    19801 gcaaggctag aaagcgaagg ccaacatgcc caatttccaa agatgccaat cttggaatgg
    19861 tttggtcaag caaaggcggc tgggttctcg tacatcattg ctgcccagga gcttgtcatg
    19921 acatccggtc ttgacgcaat cacgacacgc cgctgatgga tttcattttt tcttttttgt
    19981 tttctttttt gttctctctt tttttttttt tttttttttt ttttttttat ttttaaaatg
    20041 cgtgtatctg ttcaccccgc aaatcactta attagtccta acgatgccct gacagcttca
    20101 taaacaagta aattatccta ttgaatatca gtgtacatta acacgtagta gtttatctta
    20161 ctttctccta gatatcaaga taggaaacag aggcgattcg gtgtggaggg taaccgaaaa
    20221 caacgtttga agaacacttg tttccctacc acattgaatg cagaataact tttcttgttg
    20281 agaaagtctc gcatctttca ggtcatatta taatctttat tttgagctat tccatggtac
    20341 atacgtcctt aatattttat tttcgtcgta ctagcaaata catatggaca gcaaaatgaa
    20401 ttatatatat ttggtcaaca gacatgcaca tgactcgtgc acttgaccat caatgcaatg
    20461 attaaaccaa ttaatctatt cttttaaaat caaatccata catatgtaaa cgtcaactag
    20521 ttcatttcat acgcccaaaa ttggttacga aattcctttt tatcatttta tatccgtctt
    20581 cgactcgtga tgagcatctg gcgctttcgc cggttttttt ccagctcgca cattcttcca
    20641 ttccatgcca gcatctgcaa tgattgtcag acatgctaac actatgcata ccaaaaaaca
    20701 ctgtctcaat gcagtattat aagcttgtag gaccgtctca actgctttgg taccatactt
    20761 gtgttgaaca gcagagcgaa gaccagaggc cccggtgtcc agaatgaact cgggttcaac
    20821 gccgtatggg tgagattcca gaagcccgat caatttgctt tgaaacaaat tttgactgac
    20881 tgcaagaaac acagcgcctc ccatggtctg aattagtata atcagcgagc tgccgagaga
    20941 gatgtcgcta gcactaagca cggtttgtgc ggctatgaat ggcatttgca tgcctgaacc
    21001 agcgccgaac ccaaacatta ccagtgtacc tgccctgctt aaataatcag tgtcttcgat
    21061 tcaagtcgaa atctcggcat taactcacca atatgctgtt gacgtggcag gattatagcg
    21121 ccatatcaga cccgttgcga tggaaacaag tgttgtgctt gtaatcatcg atggcacgta
    21181 gtatccgatt tttgaagtct atgactagtt aaaaatcctc cattgtcctt ggtgttgctt
    21241 ttcctctcca gtacttacca gggtaccagc gataatagcc gcgactgaca tggacccaga
    21301 gcatgcgagg aaattaatcc cggactgctg ggcagtgaca tccttgacag cttgaaacca
    21361 gatgggaaca tagtacacaa tgatgaacat ggatccgttg ataccaaatg tgaatagaat
    21421 cgcacttctg atcgatctct gacgaactat gcggagtggc aaagctcctc catctccctg
    21481 tctatactgg acatatagcc atgccacgag taggacagtg aatagaacaa ggcataatac
    21541 gacgcgccag ctgttccatg cataagtcgt tcctccccat tgaagggcca aaagcagaca
    21601 tatgattaac ggcatcagga tgcaagttcc gagggcatcc aacttttgca aaaggccgag
    21661 aaatgttgtg gcaccccctt gcggactggg gagtcgaaca aataagaaca cagcaacggc
    21721 tgtaactcca ccgagtggaa gattaatcca gaagcaccag cgccatgttg ctcgatctgt
    21781 aaagacacct gtttttcgtt agctgtcaat ttcttcgtat ttctcacact tgtgttaaaa
    21841 ggcaagatgt atgctgacct ccgagagtcg gggcaatgac ttgacctatc ccggaaatgc
    21901 caccaataat gcccgtatac tttgggcgac tatgcaaggg caaagcccgg gcaataataa
    21961 tgatggcgcc agactggacg cctgcacagc caacaccagc caaggctcgt ccaataataa
    22021 gcacaacaga actaggtgct actgcgcaga tgagtgatcc cagctcgaaa acacccagcg
    22081 ccgtaaggaa cacgcgccgt accgagaact ccttgtacag ctttccaaaa ggaagctgaa
    22141 aacaacacga ggataacagg taagaggagc cgaaccacgc cacgtcgtca agggaattaa
    22201 actcggtcgt aattcgcgga acggccgtag ccaggattga acgatcctac caaagccaaa
    22261 gacatcaggg tatgtgcgag taaagaggaa tgtagatatg aactctgaga tacacaccag
    22321 gcttaggcag aacacggaga gtgctaaccc aacgaagagc agaacgaggc gaaacccttg
    22381 aatggctttt gaggcttctg cattagcttc atttccgcct ccacttgagc ctttatcttt
    22441 tgtgtcagaa caaagatctt cttgggaaga cttagaaata gcattcttgc tcgtggaggt
    22501 ggtcatgatt ttacaaggag ctgggagaac ctcgcccagc ttcaacacca gtaagccgca
    22561 aatgacaaaa taaaaattga acggcaaata tctagacatt ccacattgtt gcatgacaga
    22621 ccgtgtctac ttagcgtcaa aggaaatctg ggagatcgac aatcagatcg gggtgggtgg
    22681 tcagcaaatg cctctagtcg gggtttcggg gggagatcaa cggggagata aaataccgaa
    22741 tagttgcgaa cacgagcacc acattccgac catgtgtttt aaatggacgg gcggtggtat
    22801 tgtttttcgt gttttaattg tcaccttgtt gttggtttgt tccttcacgc accaattctg
    22861 ggcgagatct ttaaggtttg tatacgcgaa gtagatcagt caatacatgc catgcccgtt
    22921 gtcccgctaa tctgctcgcc atttcgctct ttcagctact gtaaagcacc agtataagtg
    22981 cacagtccag gcaggctgac tacgtgcata tattgaggta aggcttatcc attgatgtag
    23041 atttgtgtgt aaaccagtca ttttctacta tgaagtgcgc taaagcttaa accaaaccac
    23101 ataacgtcga ttgatatatg ccaaaatttg agtattttag ctgatcttac catcgatcat
    23161 atagtgtaaa gcttaatata gactaaccat atatagcaat gccttacttc aacgtaagac
    23221 atttttgttg aggaagcggg gaaaaacaaa gcacaatacg aagatcgggt tcatgacatt
    23281 aagcactttt gggtgtaaac tcaattttaa cacggttata cgatgcttat atgggagtaa
    23341 tttttaaatc tgatgtgctt ataatggtga tctacgaaaa gttcttctag ttcttctcga
    23401 actgtggtac ggagtcgcca ctaaccctcc aactgcaccc ccggagatgc aacatcgtgt
    23461 ccattgcccc tgaaaagttc tcgaacggcg gatagtttgg tcaggcaagt ccattcgcag
    23521 aaaatacatg tactattatg gagtatgtag tacgcggaag ggagagcagc cataattgga
    23581 ctgccatcaa ctgacctctc caaccgagaa tgacctcgac aatcataaaa ctagagcatt
    23641 gtttcactct attcagccgc tttagacctc attaacagga atacactccc agctatccac
    23701 tggtaactga aatttgcgac ttgtcgcaca aaccaagtgt gcttacgtta gttacgaggt
    23761 atgcgacacg ggatacgagg catgcatgcg acatgcgata cgaggcatgc gtcattggat
    23821 acgatgtata gttattaccc aattcagatt tgccatcttg aacagagctg gccattcgtt
    23881 cgctgaggga agttcgccca gttatttttt ctttaattgt tatgttttat ttctcagcat
    23941 agctgctacg agtcataaaa cacagcgcca cacgcaaaac gctacatatg tacacgtagt
    24001 gtcggtgcaa actgaaacta cttcattata tacttatata tatttttcat caaaatttaa
    24061 tgtcagaaac tttgagccat tttgaaagct tgaaatatgc cctcatctcc agggaatcgg
    24121 cagcattccc tccgatccgc ttgtgagcgc tgcagattgc acaaactgaa atgcaccata
    24181 ctccctcaaa aacgatttga aggtccccaa gaggcgcctg agcagtgtac tcgatgcgca
    24241 cgcgcaaagg caaagtgtgt ttttggtcgt agagcgccgc caaagcaccg agcgtcgtct
    24301 tccaatgacc gatcttcagt gtccaagggc atcaactcta cgacgccagc aacaagaaca
    24361 atgcaaccga acgctacggg cttcgtgagc tcccatcgta tagagttacc tccatctccc
    24421 gcttcgaacc aatcctcact caaacactca agcgtctggg ataacttgtt ggacaagacg
    24481 acgccacagg agccaagggc tgatttcagc agcttttcct atcctcctgt gccgtttgac
    24541 ctacaaagta tgtgcctcga tgaggttgac atggctgcct ctgcactacc gaccacagag
    24601 ccgaatttct catcggcgca gagggaacat gaattttctg ccatgtcaat gtcacctggc
    24661 ctgggctacg acaatctaga tgaactcctc gctctcaatg aacagccaaa tattagcgat
    24721 gcaagttcac ccctgctgtc ggagacagat ccgtcacacg gcatgatacg tctgtcttcc
    24781 ctgcttaaag agatacacga aacccagcac aacttgcagg agcgatcctt ttcctgcacg
    24841 acttcaaggg ggctggccgg ataccccatt ggccgcgtgc tacatgcagc acagacgttc
    24901 agtagtatgg tgacgaatct gatgcggccg agggtcgttc agacaagtca tactgacgtg
    24961 caaggcttta atcccagtct atacagcagc tcgcccgagt ctacagagtt gccaagtctc
    25021 caccaagaat ttgtcagtag cttagagcaa atgaagacga atgcgcttga acaaagcagg
    25081 cgtttaggcg aagatgacct tgacaagtat gcctcaccct gtagcagcac aacatcactg
    25141 caagacacaa tgctggatat gccgattgtc atgcttgtct tctgctgctt cgcctcgtta
    25201 tcaaagctct actgcagcgt atttcggttc tttgaaaaga gtctccactc tcaatcttgt
    25261 cgtgccaagg acagcacgta cgtcccgcca ctgcaagata ctcggacttt gcaacttggc
    25321 gaattatcta ttgagaatga caccgaattc aaagtcctca aagctcttcg gatgttatta
    25381 gatgcgttcc aggctgctga agcttcactc ggcctgccta gttcgctgac agtgctcaac
    25441 tccaataaat cgaccatatc ggccagtgct gagcccgcag tatctgatac cggttcactg
    25501 caacaccatt tgcggcattc tctgataaaa cagtgtgtta cttttgacga tcgtcatcta
    25561 gaaaggactt taaccagctt agtgacacat gtggaaaact tgaaacagct tcttagagtg
    25621 cagaacggcc ttcactaatt acgtggttac ttcaatgtta tattgatagc tagaattgat
    25681 gacaatgata attataaagg agaggatata ttg
//
