BGC0002304: varicidin A biosynthetic gene cluster from Talaromyces variabilis
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Location: 1 - 25,713 nt. (total: 25,713 nt).
This entry is originally from NCBI GenBank MK376933.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002304
Short description varicidin A biosynthetic gene cluster from Talaromyces variabilis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • NRPS (Type I)
Loci
MK376933.1
1 - 25713
via Heterologous expression, Enzymatic assays
Compounds
  • varicidin A
Species Talaromyces variabilis [taxonomy]
References
Chemical products information
varicidin A Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AZZ09610.1
  • pvhE
 82 - 1764 (-) PvhE
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    • AZZ09611.1
    • pvhD
    		 2304 - 3444 (-) PvhD
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      • AZZ09612.1
      • pvhC
      		 3887 - 4963 (-) PvhC
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        • AZZ09615.1
        • pvhB
        		 5393 - 6508 (-) PvhB
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          • AZZ09613.1
          • pvhA
          		 7641 - 19956 (+) PvhA
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            • AZZ09609.1
            • mfs
            		 20563 - 22506 (-) major facilitator superfamily ORF1
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              • AZZ09614.1
              • TF
              		 24097 - 25638 (+) transcription factor ORF2
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                Biosynthesis information

                Biosynthetic modules

                Name
                Unk01
                Type
                nrps-type1
                Genes
                pvhA
                Substrates
                isoleucine (evidence: Structure-based inference [2])
                Integrated Monomers
                Domains
                adenylation
                Annotation changelog

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-10-07
                Changed chemical structures for compounds: varicidin A.
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-10-07
                Added NPAtlas links to compounds: varicidin A.
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Entry added
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Added NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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