BGC0002307: humidimycin biosynthetic gene cluster from Streptomyces humidus
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Location: 1 - 14,987 nt. (total: 14,987 nt).
This entry is originally from NCBI GenBank MN956991.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002307
Short description humidimycin biosynthetic gene cluster from Streptomyces humidus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
MN956991.1
1 - 14987
via Heterologous expression
Compounds
  • humidimycin
Species Streptomyces humidus [taxonomy]
References
Chemical products information
humidimycin Evidence:
Copy SMILES
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QHZ32188.1
  • humR1
 83 - 775 (-) response regulator
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    • QHZ32189.1
    • humG
    		 1426 - 2529 (+) sensor histidine kinase
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      • QHZ32190.1
      • humD1
      		 2631 - 3533 (+) ABC transporter ATP-binding protein
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        • QHZ32191.1
        • humD2
        		 3526 - 4278 (+) ABC transporter permease unit
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          • QHZ32192.1
          • humA
          		 4396 - 4524 (+) humidimycin precursor peptide
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            • QHZ32193.1
            • humC
            		 4581 - 6404 (+) lasso peptide isopeptide bond-forming cyclase
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              • QHZ32194.1
              • humB1
              		 6401 - 6664 (+) lasso peptide biosynthesis PqqD family chaperone
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                • QHZ32195.1
                • humB2
                		 6661 - 7092 (+) lasso peptide biosynthesis B2 protein
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                  • QHZ32196.1
                  • humD3
                  		 7089 - 8054 (+) ATP-binding cassette domain-containing protein
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                    • QHZ32197.1
                    • humD4
                    		 8051 - 8926 (+) ABC transporter permease
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                      • QHZ32198.1
                      • humE
                      		 8947 - 9522 (+) DoxX family membrane protein
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                        • QHZ32199.1
                        • humF
                        		 9528 - 10250 (+) thioredoxin domain-containing protein
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                          • QHZ32200.1
                          • humH
                          		 10247 - 11584 (+) CapA family protein
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                            • QHZ32201.1
                            • humR2
                            		 11706 - 12380 (+) response regulator transcription factor
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                              Biosynthesis information
                              Annotation changelog

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Entry added
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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