LOCUS       BGC0002311              5945 bp    DNA     linear   BCT 04-FEB-2019
DEFINITION  Cutibacterium acnes KPA171202 chromosome, complete genome.
ACCESSION   BGC0002311
VERSION     BGC0002311
KEYWORDS    .
SOURCE      Cutibacterium acnes KPA171202
  ORGANISM  Cutibacterium acnes KPA171202
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Propionibacteriaceae; Cutibacterium.
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:18:15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 936308
            Orig. end    :: 942253
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..2613
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     52.5; E-value: 3e-16)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011183760.1"
                     /locus_tag="cbac_04685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine biosynthesis protein"
                     /protein_id="QAZ50816.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.8e-30, bitscore:
                     91.7, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLSPYVVFRRTRLAYSQLQSSSFDALWQQVQEMVDKHAQLEVQT
                     SRLTAHLESVISVTAPRDRSRLITLKRDVHNMRVEKVKQRLLHCQGCTASNIMEPVSSW
                     IDTCRSYEILERRLSQVYADSRDEVSRHYRSLYQADAIEPSIQLSGGQLHSDLTRLISH
                     GSRIKPTKERTLETTLVNYLYRAATKPSPFGRFVEVGAFDPSQPNSEPRRCSESSVTTN
                     RILTSWLTAVTARSFAAPEMLAILNSTLRVKRDIIQFIGIPPGEWRGAPSIPEERLLTI
                     RKREDMMSVLKLLMGGPRSVGDLIIALNDQGIDESHATNLLSSLSTAGIIFFRLPVDDH
                     DVHYVQTACTALRLTKDESLRAAFQSLANAEKEFPTASVATRHDLLLSIKDSVNTVASA
                     HDVPAPPDSVLKSPLYEDLPATAAPQTWDSNTVERSARALRSIWLLGDLMDSSQRRQLG
                     LSQFIADMNNGAPVTFLDFFDSFSRLSIRERQGILRGENSPQIARFAQQYSEALLKIRD
                     AVNYTQDEAHLESQVILDAITNIDDFRPTKSVTIRGQFTTSLTSHISQLIINGVMTGYG
                     TYMSRFATFVNPSGTWSLVDGIRRHLSDHFPGQCDLNSVLGFNFNVHPQMTAHSIAYPG
                     VVPVLNGAKTHSIQDLILIPTAEAGPRRVAIFDRAENELIDLQPMNFMVPFGVPLLYRT
                     LEFLCPSTRYLWNPAQDLLDIPMIENSCPRIYFDDVVAQRRSWTCSAETLPCPPEKLFR
                     GDLAALQAFDSWRLSARVPRHVFALVQTATERQIFSGAADAPTLLSEYKHLRRASVHKP
                     IYLDLRNPLLVRSLAKVIMSRPELYVTFSEFLPSEADYTQNGSCPSYAEEYFIELCAE"
     subregion       1..5945
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..5945
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..2613
                     /locus_tag="cbac_04685"
     gene            2624..3547
                     /locus_tag="cbac_04690"
     CDS             2624..3547
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002531456.1"
                     /locus_tag="cbac_04690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine biosynthesis protein"
                     /protein_id="QAZ52267.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-71, bitscore:
                     229.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDPGGWRALHIHLPPSVQSEYLADVILPSMSALMPEHDYFFLRY
                     WQGGSHLRLRLRSTPERPLDDEAINEVACHLRSLLPALSDQKRAEYRYSQSLQDQLAEM
                     ERADCLPLEAVGTVVERRYQPEYRKYGGSVGVSIAEDVFCSTSRSVLRILSERPTSHRQ
                     PLGYACQVFIQMLGCLGLATSQVDQFLTRYAQWWTPYSMAARPEILAARLYANLSSVVA
                     DLWAASEPNGMFSVPALNAYTQWSRRRSSARNTSVKIDPMFLSCLANYIHTTNNRLGLP
                     PALESTAAYLVQLGFRSVAVRGEKVR"
     gene            3544..4626
                     /locus_tag="cbac_04695"
     CDS             3544..4626
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002518053.1"
                     /locus_tag="cbac_04695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="QAZ50817.1"
                     /transl_table=11
                     /translation="MNPKNSKVTELWFPDNSDSPCTLLLDLSRASAEGTEPSPQYYCRT
                     WDPTTKDPGVRVGILDPNRLTHQTAFLGGSGITHHFLVMEKPPSWPLLWNAGFAGLKLS
                     TISKQLFTASYPWMVKWALQASAWTDDERLLALTKLLVAHADASLPPVDKTEMLGRLPL
                     KLSLRLITYRSHYESIRARTIDPKAMDTAVNRAFMKYQDELLRWSQSLTCSSSYREKEW
                     SNPNLSEWSAIIYCHLPQIRQLLSGGGLTVAGPTREDIEASLGHSIPDTRFHERLDPAM
                     QYYLNHDQDFTAYRFCTGFLYSNLYSLGIPLRLRYLVCGLAARFNEELSDTTWRDLRDL
                     FHEAATVAYYTRDTDGSGIR"
     gene            4626..5945
                     /locus_tag="cbac_04700"
     CDS             4626..5945
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002518052.1"
                     /locus_tag="cbac_04700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="QAZ50818.1"
                     /sec_met_domain="YcaO (E-value: 1.6e-77, bitscore: 249.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 7.1e-116, bitscore:
                     375.1, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVERQPLRERARSLVSPYGLVSQVHPLHANEADPPFHVHLGRTG
                     HSIHEGQITFEGDIGNTDGAGSGSDSTTAEFIAVMESLERYSSAMWDARSFLLESENNL
                     QERLVSPNQFPRCSTAELDSGHVLRRYDPGVPIRWVRGWSLTSGHQVWVPAIAVYLHLP
                     YLNDSERFIRSVSTGCAVHESMRKAVLNGLLEVVERDAIALTWLHELPLPRIAASEAGE
                     FPPEALASWKSYRDYGIETHLFDATTDFGIPVIFALQISDQDDDIAQLVGAASALEPAE
                     ALTKVFREMASIRIALRAFLAQSTSIKIYPDVANVTGGAALMGQRAYRDAFSFLLNSER
                     ETSPSRMPNLLELNDDPLREMIIRIRLAGAEVIAVDITTDKARSVGARVVKVLVPEAVP
                     LSFVHRERYLDTPRLISAPNSMGYLVDTAPTFNRNIQPFA"
ORIGIN
        1 gtgcatctca gtccatatgt agtctttcgc aggacacgac tcgcctactc tcaacttcag
       61 agcagctcct tcgacgcact ctggcagcaa gtgcaagaaa tggtcgataa gcatgcgcaa
      121 ttagaggttc agaccagcag gcttacggca cacctggagt ctgttatttc agtaactgcg
      181 cctcgtgaca gatctcgact aatcacatta aaacgtgacg tgcataacat gcgcgtggaa
      241 aaagtgaagc aaagactact gcactgtcag ggctgcacgg ctagcaacat tatggagcct
      301 gtatctagtt ggatcgatac atgtcgatca tacgaaatac ttgagcgtcg gttgagtcaa
      361 gtatatgcgg acagccgaga cgaagtgtct cgtcactaca ggtccctcta ccaggctgac
      421 gcaatagagc caagcattca actctcaggt ggccagctcc acagtgacct gacgcgtctg
      481 attagccacg gttctaggat aaaacccact aaagagcgga ctctggaaac gactcttgta
      541 aactatctct acagggcagc aacaaagcca tcacctttcg gtcgtttcgt ggaagtaggg
      601 gccttcgacc cgtctcaacc aaattccgaa cctcgacgct gcagtgaatc cagcgtgacg
      661 acaaaccgga ttcttaccag ctggctcact gcagtaacag cgcgttcttt cgccgcacca
      721 gaaatgcttg ctatcctcaa cagcaccctg cgcgttaaac gcgatataat ccagttcatt
      781 ggaattccac ctggggagtg gcgaggtgca ccgagcattc ccgaggagcg cctgctaact
      841 atccgcaagc gcgaagatat gatgtctgtt cttaagctcc taatgggcgg cccaagatca
      901 gtcggtgacc tcattattgc ccttaatgac caaggcatag atgaatcaca cgcaactaat
      961 cttctcagca gtttgagtac agcagggata atcttctttc ggctcccagt agatgaccat
     1021 gacgtacact atgtacagac tgcgtgtaca gcgctaaggt taaccaaaga tgagtcactt
     1081 cgtgccgctt tccaaagtct ggcgaacgct gaaaaggagt tccccacagc gtcagtcgcc
     1141 acgcgtcacg accttctcct cagcatcaag gattccgtga atactgtcgc gtcggcacat
     1201 gatgtgccgg ccccaccgga cagcgtactc aagagccctt tgtatgagga cctccccgcc
     1261 accgcggcac cccagacatg ggattcgaac acggttgaga gatcagcccg cgcactcagg
     1321 agcatctggc tactgggcga tttaatggat agctctcaac gccgacagtt gggcctctcc
     1381 cagttcatag cagacatgaa taatggcgcg ccagttactt ttctggattt cttcgactcg
     1441 ttttcgcgcc ttagcattcg tgagcgccaa ggaatcctgc gcggagaaaa ctcaccgcaa
     1501 atcgcccgtt tcgctcagca atatagtgaa gcattgctta aaattcgcga tgccgttaac
     1561 tacacgcagg acgaagccca ccttgaatct caggtaattc tcgatgcgat caccaatatt
     1621 gatgatttcc gaccgactaa gtcggtcaca attcgaggac aattcacaac atcgctcacc
     1681 tcccatataa gccaactgat aatcaacggt gttatgacgg gatacggtac atacatgtcc
     1741 cgattcgcaa catttgtaaa cccatcaggt acttggagtc tagtcgacgg gattcggaga
     1801 catctatccg atcattttcc aggtcaatgt gatttgaatt ccgtactggg attcaacttc
     1861 aatgttcatc cgcaaatgac agcacatagt atcgcctatc ctggagtagt tcctgtgctt
     1921 aatggtgcca agacacattc gattcaggat ttaatactga ttccaactgc tgaagcaggt
     1981 ccgcgccgcg tcgctatctt tgatagagca gagaacgaac ttatcgacct ccagcccatg
     2041 aatttcatgg ttccttttgg ggtgcctttg ctgtatcgga ctctagagtt cctgtgccca
     2101 tcgaccagat acctatggaa cccagctcaa gaccttctgg atatcccaat gatagagaac
     2161 agttgccctc ggatttactt tgacgacgta gtggctcaac gccgttcctg gacgtgcagc
     2221 gccgagacgc tcccgtgtcc cccagagaaa ctctttaggg gtgatcttgc tgctttgcaa
     2281 gccttcgact cgtggagact atcagcgagg gtacccagac atgtctttgc cctagtacaa
     2341 acggctacgg aaagacaaat tttttccgga gcggccgacg cgccaacctt gctctccgaa
     2401 tacaagcatc ttcggagagc aagtgtgcat aagccaatct acctggatct acgaaaccca
     2461 cttctagtcc gttctctcgc gaaggtgatc atgtccaggc ccgaactata tgtcacgttt
     2521 tccgagttcc tcccatcgga ggccgattac acgcagaacg gaagctgccc cagttacgca
     2581 gaggagtact tcattgaact gtgtgccgag tgacagcgca agcatgtctg atcctggcgg
     2641 ctggcgggcg ctccatattc acttgcctcc ctcggtgcag tccgagtacc tagctgacgt
     2701 gattcttccc tcgatgtcag ccttgatgcc agaacatgac tacttcttcc tccgatattg
     2761 gcagggggga tcacatctcc ggcttcggct ccgtagcact cccgagcgcc ccctagatga
     2821 tgaggctatc aacgaggttg catgccatct ccgtagcctt ctcccggcgt tgtcagacca
     2881 aaagcgcgcg gagtaccgct attcgcaatc gcttcaggat cagttagccg aaatggaaag
     2941 ggctgattgc cttcccctag aggcggttgg gaccgtggta gagcgccggt accagcctga
     3001 atatagaaag tatggcggat cggtcggagt atccattgca gaggatgttt tctgtagtac
     3061 tagccgatct gtccttcgca ttctaagtga gcgaccaact agccaccgac agcccttggg
     3121 gtatgcttgc caagttttca tccagatgct gggctgctta gggctcgcaa cttcgcaggt
     3181 tgaccagttc ctcaccagat atgcgcagtg gtggacccct tactcaatgg ccgctcgccc
     3241 tgagatctta gcggcgcgtc tctacgccaa cttgtcaagc gtggtggcgg acctatgggc
     3301 cgcaagtgag cccaacggaa tgttctcggt tccggctctc aatgcttata cccaatggtc
     3361 acggcgacgg tcgtccgcga gaaataccag cgtaaagata gacccaatgt ttctatcttg
     3421 cttagcgaac tacattcaca caaccaataa ccgacttggg ctcccacccg ccctagaatc
     3481 gacagcggca tatcttgtcc aacttggatt ccgatcggtg gctgtcaggg gggagaaagt
     3541 gcgatgaatc caaaaaactc caaagtgacg gaactttggt ttccagataa ttcagactcg
     3601 ccatgtactc ttcttctcga cttatctcgg gcctccgctg agggcactga gcctagtcct
     3661 caatactact gtcgaacttg ggacccaaca acaaaagatc ccggagtaag ggttggcata
     3721 cttgatccca accgcttaac tcatcaaacg gctttccttg gcggttccgg tattacgcat
     3781 cacttcttgg taatggaaaa accacccagc tggcctcttc tatggaacgc gggtttcgcg
     3841 ggcttgaagc tttccacgat aagcaaacaa ttgttcaccg cgtcatatcc atggatggta
     3901 aagtgggcgc tacaggcatc ggcttggacg gacgacgaac gccttctggc tcttacgaaa
     3961 cttctagttg cccacgctga tgcaagcctt ccaccggtcg ataagactga aatgctcggc
     4021 cgcctccctt tgaagttgag cttgcgactg atcacatatc gttcccacta cgaaagcatc
     4081 cgcgctcgca cgattgaccc gaaagcgatg gatactgcgg ttaatcgggc cttcatgaag
     4141 tatcaagacg agctcctgcg atggtcccag tcgttgacat gctcgtcgag ctatcgtgag
     4201 aaagaatgga gtaatcccaa cctttcagaa tggagcgcca tcatttattg ccatctccca
     4261 caaattaggc aactcctcag cgggggagga ttaactgtcg cgggcccgac acgcgaggat
     4321 atagaagcct ccttaggtca cagtattcct gatacacgat ttcacgagcg tcttgacccc
     4381 gccatgcagt attatctcaa tcatgaccaa gacttcacgg catacagatt ctgcacgggt
     4441 tttttgtaca gcaacctgta ctcgctagga ataccgttga ggctgcgcta ccttgtctgt
     4501 gggttggcag cacgtttcaa cgaggagctg tcggacacga cttggcgcga tttacgggat
     4561 ctcttccacg aggctgctac tgttgcatat tacacacgcg acacagacgg gagcgggatt
     4621 agataatgac agttgagcgt cagcctctgc gggagcgtgc aaggagcctc gtttcaccat
     4681 acggactagt ttcccaagta caccctctgc acgccaatga agcagatcca ccgtttcatg
     4741 tgcatttggg tcgaacaggc cactcaatac acgaggggca aattactttt gagggagata
     4801 tcggaaacac cgacggggca gggtcgggat ccgacagtac cacggcagaa tttattgcag
     4861 taatggagtc cttagagcgc tactccagcg caatgtggga cgctcgttcc tttttgctgg
     4921 aatcggaaaa taatctgcag gagcgacttg tatctcccaa ccaattccca cgctgttcta
     4981 cagccgagct agattctgga catgtactca ggcggtacga cccgggcgtc ccaatacgat
     5041 gggtcagagg atggtcactg acttcaggtc atcaggtgtg ggttccggcg atcgcggttt
     5101 atctgcatct gccgtactta aacgactctg aacgattcat acgttcagtc tcgaccggat
     5161 gtgcggttca tgaatccatg cggaaggctg ttcttaacgg tcttttagaa gtcgtcgagc
     5221 gagatgctat tgctttgact tggttgcatg agttgccctt gcccagaatc gcggctagcg
     5281 aggccggtga gttcccgccg gaagcgctag ccagttggaa gtcatatagg gattacggaa
     5341 tcgagaccca tctctttgac gcaacgacgg attttgggat tccggtgatc tttgcgctcc
     5401 agatatcgga tcaggatgac gacatcgctc agctcgtagg cgctgcatcc gctttggaac
     5461 ccgctgaggc gctgactaaa gtattcaggg aaatggcatc gatccgaata gcactacgcg
     5521 cctttctcgc ccagtccaca tcgattaaga tttaccccga tgtggctaac gtgacagggg
     5581 gtgccgccct catgggccag cgcgcgtacc gagatgcatt ttccttcctc cttaacagcg
     5641 agcgcgaaac gtcaccgtcg cggatgccta acctcctaga gctgaatgat gatccactgc
     5701 gcgagatgat tattcgaata cgcctggctg gcgctgaagt tatcgccgtc gatatcacga
     5761 cggacaaagc gaggtcagtt ggtgcaagag tagtgaaggt tttggtccca gaggcggttc
     5821 cactctcctt tgttcaccga gagaggtatt tagatactcc tcggctcata tccgcgccta
     5881 atagcatggg atatttggtt gacacagcgc ctacgttcaa ccggaacatt caaccttttg
     5941 cgtga
//
