BGC0002314: corbomycin biosynthetic gene cluster from Streptomyces sp. WAC 01529
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Location: 7,746,101 - 7,835,715 nt. (total: 89,615 nt).
This entry is originally from NCBI GenBank CP029617.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002314
Short description corbomycin biosynthetic gene cluster from Streptomyces sp. WAC 01529
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP029617.1
7756521 - 7823825
via
Compounds
  • corbomycin
Species Streptomyces sp. WAC 01529 [taxonomy]
References
Chemical products information
corbomycin Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • DMA15_34265
  • AZM57013.1
 7756521 - 7757402 (-) LysR family transcriptional regulator
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    • DMA15_34270
    • AZM57014.1
    		 7757486 - 7759837 (-) ABC transporter
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      • DMA15_34275
      • AZM58098.1
      		 7760029 - 7761111 (-) alpha-hydroxy-acid oxidizing enzyme
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        • DMA15_34280
        • AZM57015.1
        • hppD
        		 7761188 - 7762306 (-) 4-hydroxyphenylpyruvate dioxygenase
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          • DMA15_34285
          • AZM57016.1
          		 7762477 - 7763622 (+) prephenate dehydrogenase
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            • DMA15_34290
            • AZM57017.1
            		 7763748 - 7766024 (+) aminotransferase
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              • DMA15_34295
              • AZM58099.1
              		 7766101 - 7767219 (+) type III polyketide synthase
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                • DMA15_34300
                • AZM57018.1
                		 7767267 - 7767932 (+) enoyl-CoA hydratase
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                  • DMA15_34305
                  • AZM58100.1
                  		 7767998 - 7769314 (+) enoyl-CoA hydratase
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                    • DMA15_34310
                    • AZM57019.1
                    		 7769325 - 7770149 (+) alpha/beta hydrolase
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                      • DMA15_34315
                      • AZM57020.1
                      		 7770250 - 7770474 (+) MbtH family protein
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                        • DMA15_34320
                        • AZM57021.1
                        		 7770522 - 7772687 (+) ABC transporter
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                          • DMA15_34325
                          • AZM58101.1
                          		 7772865 - 7774172 (+) two-component sensor histidine kinase
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                            • DMA15_34330
                            • AZM57022.1
                            		 7774341 - 7785590 (+) non-ribosomal peptide synthetase
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                              • DMA15_34335
                              • AZM57023.1
                              		 7785587 - 7790203 (+) non-ribosomal peptide synthetase
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                                • DMA15_34340
                                • AZM57024.1
                                		 7790272 - 7804356 (+) non-ribosomal peptide synthetase
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                                  • DMA15_34345
                                  		 7804439 - 7808323 (+) non-ribosomal peptide synthetase
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                                    • DMA15_34350
                                    		 7808492 - 7809049 (+) non-ribosomal peptide synthetase
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                                      • DMA15_34355
                                      • AZM58102.1
                                      		 7809080 - 7815715 (+) non-ribosomal peptide synthetase
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                                        • DMA15_34360
                                        • AZM57025.1
                                        		 7815764 - 7816969 (+) cytochrome P450
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                                          • DMA15_34365
                                          • AZM57026.1
                                          		 7817012 - 7818124 (+) cytochrome P450
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                                            • DMA15_34370
                                            • AZM57027.1
                                            		 7818137 - 7819342 (+) cytochrome P450
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                                              • DMA15_34375
                                              • AZM57028.1
                                              		 7819416 - 7819628 (+) ferredoxin
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                                                • DMA15_34380
                                                • AZM57029.1
                                                		 7819833 - 7820432 (+) hypothetical protein
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                                                  • DMA15_34385
                                                  • AZM58103.1
                                                  		 7820453 - 7821838 (+) hypothetical protein
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                                                    • DMA15_34390
                                                    • AZM58104.1
                                                    		 7821874 - 7822578 (+) ABC transporter ATP-binding protein
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                                                      • DMA15_34395
                                                      • AZM57030.1
                                                      		 7822575 - 7823825 (+) ABC transporter permease
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                                                        Biosynthesis information

                                                        Biosynthetic modules

                                                        Name
                                                        Unk01
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34330
                                                        Substrates
                                                        4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk02
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34330
                                                        Substrates
                                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk03
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34330
                                                        Substrates
                                                        tryptophan (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk04
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34335
                                                        Substrates
                                                        4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk05
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34340
                                                        Substrates
                                                        4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk06
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34340
                                                        Substrates
                                                        tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk07
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34340
                                                        Substrates
                                                        tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk08
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34345
                                                        Substrates
                                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk09
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34355
                                                        Substrates
                                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk10
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        DMA15_34355
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Annotation changelog

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Added chemical structures for compounds: corbomycin.
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-10-07
                                                        Added NPAtlas links to compounds: corbomycin.
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Entry added
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Added NRP substrate specificities
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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