BGC0002315 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002315 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	32,778	High	accramycin A	PKS

BGC0002315 - Region 1 - T2PKS

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Location: 1 - 32,778 nt. (total: 32,778 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,779
Label		BGC0002315

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

accO: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

accY: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: halogenase methyltransferase

accT: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

accV: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

accW: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Lyases: cyclase

accD: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

accL: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

QKO28672.1: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

accA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

accB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: permease

QKO28703.1: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002315.2	1.00	PKS	accramycin A	Streptomyces sp.
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.75	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000272.3	0.69	PKS	spore pigment	Streptomyces collinus
BGC0000215.5	0.64	PKS	curamycin	Streptomyces cyaneus
BGC0000271.5	0.63	PKS	spore pigment	Streptomyces avermitilis
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000275.4	0.61	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000234.5	0.57	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002315.2	1.00	PKS	accramycin A	Streptomyces sp.
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.75	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000272.3	0.69	PKS	spore pigment	Streptomyces collinus
BGC0000215.5	0.64	PKS	curamycin	Streptomyces cyaneus
BGC0000271.5	0.63	PKS	spore pigment	Streptomyces avermitilis
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000275.4	0.61	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000234.5	0.57	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 32778
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Product class(es):: pentangular polyphenol
tetracenomycin

accA: KS (Score: 701.8; E-value: 6.2e-214)
accB: CLF (Score: 513.5; E-value: 8.4e-157)
accC: ACP (Score: 52.0; E-value: 1.2e-16)
accD: CYC C9-C14 (Score: 239.5; E-value: 2.7e-74)
accL: CYC C4-C21/C2-C23|C2-C19 (Score: 125.7; E-value: 1.6e-39)
accR: CYC C5-C18 (Score: 191.4; E-value: 1.2e-59)
accT: MET C6|C8 (Score: 478.2; E-value: 2.6e-146)
accV: HAL (Score: 394.3; E-value: 1.6e-120)
accW: MET (Score: 227.8; E-value: 4.6e-70)