BGC0002315: accramycin A biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 32,778 nt. (total: 32,778 nt).
This entry is originally from NCBI GenBank MN477201.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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General
Compounds
Genes
Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0002315
Short description accramycin A biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MN477201.1
1 - 32778
via
Compounds
  • accramycin A
Species Streptomyces sp. [taxonomy]
References
Chemical products information
accramycin A Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QKO28672.1
 752 - 1432 (+) polyprenol-monophosphomannose synthase
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    • QKO28673.1
    		 1429 - 2061 (+) glycosyl transferase
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      • QKO28707.1
      • accM
      		 2058 - 2720 (+) methyl transferase
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        • QKO28674.1
        		 2758 - 2940 (-) hypothetical protein
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          • QKO28675.1
          		 3146 - 3262 (-) hypothetical protein
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            • QKO28676.1
            • accN
            		 3280 - 3618 (-) transcriptional regulator
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              • QKO28677.1
              • accO
              		 3687 - 4604 (+) 3-hydroxyisobutyrate dehydrogenase
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                • QKO28678.1
                • accP
                		 4730 - 5557 (+) transcriptional regulator, MerR family
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                  • QKO28679.1
                  		 5589 - 6170 (-) nucleotide phosphorylase
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                    • QKO28680.1
                    		 6384 - 6824 (+) VOC family protein
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                      • QPA18727.1
                      		 6866 - 7474 (-) maleyl pyruvate isomerase family myco-thiol dependent enzyme
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                        • QKO28681.1
                        • accI
                        		 7606 - 8517 (+) LysR family transcriptional regulator
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                          • QKO28682.1
                          		 8720 - 9046 (+) hypothetical protein
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                            • QKO28683.1
                            		 9121 - 9543 (-) hypothetical protein
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                              • QKO28684.1
                              		 9543 - 10703 (-) molybdopterin-binding protein
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                                • QKO28685.1
                                		 10795 - 12237 (+) hypothetical protein
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                                  • QKO28686.1
                                  • accH
                                  		 12234 - 13709 (+) ABC transporter ATP-binding protein
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                                    • QKO28687.1
                                    • accI_rename1
                                    		 13706 - 14665 (+) ABC transporter ATP-binding protein
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                                      • QKO28688.1
                                      • accL
                                      		 14769 - 15128 (+) Type II PKS cyclase
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                                        • QKO28689.1
                                        • accK
                                        		 15125 - 16654 (+) sodium/hydrogen exchanger
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                                          • QKO28690.1
                                          • accJ
                                          		 16727 - 17164 (+) MarR family transcriptional regulator
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                                            • QKO28691.1
                                            • accG
                                            		 17491 - 18570 (+) sensor histidine kinase
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                                              • QKO28692.1
                                              • accF
                                              		 18567 - 19250 (+) LuxR family DNA-binding response regulator
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                                                • QKO28693.1
                                                • accD
                                                		 19207 - 19665 (-) cyclase/dehydrase
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                                                  • QKO28694.1
                                                  • accC
                                                  		 19662 - 19955 (-) acyl carrier protein
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                                                    • QKO28695.1
                                                    • accB
                                                    		 20001 - 21248 (-) beta-ketoacyl synthase
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                                                      • QKO28696.1
                                                      • accA
                                                      		 21245 - 22525 (-) beta-ketoacyl synthase
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                                                        • QKO28697.1
                                                        • accR
                                                        		 22522 - 22917 (-) AraC family transcriptional regulator
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                                                          • QKO28698.1
                                                          • accS
                                                          		 22940 - 23281 (-) antibiotic biosynthesis monooxygenase
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                                                            • QKO28699.1
                                                            • accT
                                                            		 23278 - 24330 (-) O-methyl transferase
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                                                              • QKO28700.1
                                                              • accU
                                                              		 24446 - 24787 (+) antibiotic biosynthesis monooxygenase
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                                                                • QKO28701.1
                                                                • accV
                                                                		 24780 - 26072 (+) halogenase
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                                                                  • QKO28702.1
                                                                  • accW
                                                                  		 26069 - 27115 (+) O-methyl transferase
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                                                                    • QKO28703.1
                                                                    		 27175 - 28617 (-) phenylalanine-specific permease
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                                                                      • QKO28704.1
                                                                      • accX
                                                                      		 28714 - 31047 (-) glycoside hydrolase family 92 protein
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                                                                        • QKO28705.1
                                                                        		 31066 - 31197 (+) hypothetical protein
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                                                                          • QKO28706.1
                                                                          • accY
                                                                          		 31202 - 32755 (+) pyruvate oxidase/decarboxylase
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                                                                            Biosynthesis information
                                                                            Annotation changelog

                                                                            Entry version: 1

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-09-15
                                                                            Entry added
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                            Modifications to original record
                                                                            • renamed CDS with name accI at [13705:14665](+) to accI_rename1 to avoid duplicates