LOCUS       BGC0002316              9987 bp    DNA     linear   BCT 13-MAR-2019
DEFINITION  Saccharopolyspora cebuensis strain DSM 45019 cebulantin biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0002316
VERSION     BGC0002316
KEYWORDS    .
SOURCE      Saccharopolyspora cebuensis
  ORGANISM  Saccharopolyspora cebuensis
            Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
            Saccharopolyspora.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 08:12:58
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9987
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..9987
                     /db_xref="taxon:418759"
                     /isolation_source="marine"
                     /mol_type="genomic DNA"
                     /organism="Saccharopolyspora cebuensis"
                     /strain="DSM 45019"
                     /type_material="type strain of Saccharopolyspora cebuensis"
     misc_feature    1..9987
                     /note="cebulantin biosynthetic gene cluster"
     subregion       1..9987
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9987
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             317..1108
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 182.3; E-value:
                     1.2e-55)"
                     /gene_kind="regulatory"
                     /note="Lux R family DNA-binding response regulator"
                     /product="CebA"
                     /protein_id="QBK47604.1"
                     /transl_table=11
                     /translation="MFRSCRSASPSGGGTAPARVLRRSGRSAAVGGTRVAIRVLIVDDQ
                     VVVRRGLRAVLDAAPDVVVVGEAGDGAAAVREAQRLRPDVMLMDVRMPGLGGIEAVRRL
                     VELFGDAVRILVVTTFDLDEYVFESLRAGARGFVLKDIEPEALVTAVRALHAGKTVLDP
                     SITGRVTEEFVRLAAGQGVPVPTARPDPPVDELSARQREVVALVARGRSNAEIAAQLHL
                     SETTVKTHVSTVLAKWGLRDRVQLVVRAFETGVVLLDRGEV"
     CDS             1189..3240
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 130.8; E-value: 1.1e-39)"
                     /gene_kind="regulatory"
                     /note="sensor histidine kinase"
                     /product="CebB"
                     /protein_id="QBK47605.1"
                     /transl_table=11
                     /translation="MTSGAAAPRERSTTAGVRRWRPGALRFAPRHWLVVGLLAHAGLVG
                     VLLVPRGMWGAAAVLALAEALPVLWARRYPVLALSAHLAVKPLTYLWRMPVGELAWLVL
                     VHSVGRYRRPRVALPVLAGTALLVPVLLAACFPAHAITTGVLVGLVQLVAAWALGFGTR
                     LADEREQRARRDGERERLHRSLAAERATIGAELHEIVEKQVRRILAGTTELRRGRPPGA
                     EPLRGLHQECGAALSSLRCMLGLLRTDVPDAPAPRPERRRVERPPGSPHDDVLVVLGAV
                     VTAVVLHLSAPPGLAADALVISTLFALPSTPHLPDTAIGLALVLLQILPLGWRNRFPVT
                     ALLVTTAGVALGPAAAANSVVGHLCWFALAYSVGARGLPRSVPAVGAAVLAWMAGSAFL
                     AGAGDQAVAGSQLYGALLVGGLAVAGNVHRRIRAARQSAERAEQDHRIHEELRRERSRL
                     ACEVHDQVSHHVSGMVVQAGAARALAGSRPEGVDEALREIEDSAELALRALPRLLDVLG
                     PEPTGPTRLDGVELEHLVRPLRDLGARVRAELAGDPRRTAGDRAELGCRVVQEAVRNVI
                     RHAGPTATRVRVEHHPAHLLVEVADAGAVAGHHRADPGCGQGLAGLGERVELVGGRLRA
                     GPRGSGWRVTALLPLRSGSSAGRKPEPITAAAEPEMVLGDEVSGRRRA"
     CDS             3311..3478
                     /codon_start=1
                     /note="precursor peptide 1"
                     /product="LanA1"
                     /protein_id="QBK47606.1"
                     /transl_table=11
                     /translation="MSAPVQDFDLDVDTTSFAAPGGGALSEDGIEARGPITFGTTCWGT
                     PCPSANTVSC"
     CDS             3604..3771
                     /codon_start=1
                     /note="precursor peptide 2"
                     /product="LanA2"
                     /protein_id="QBK47607.1"
                     /transl_table=11
                     /translation="MSAPVQDFDLDVDTTSFAAPGGGALSADGIEAKGVLTFGTTCWGT
                     TCPSNNTISC"
     CDS             3805..4788
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251:luciferase family
                     protein (Score: 65; E-value: 1.1e-19)"
                     /gene_kind="other"
                     /note="luciferase like monooxygenase"
                     /product="CebC"
                     /protein_id="QBK47608.1"
                     /transl_table=11
                     /translation="MRWLGRPPHDRRPRRCAVVFGGRTAVSADPTGWWAAAPPLGVLEY
                     LDLDDDRPVRLKRRAAFASTLLAEDLGYRRLWIPEHHGTGVPSTNPALLAAVLASHTTR
                     IRVGTAVNLARVRDPHLVAEDLVTAGSFAGDRLDVGFGRGDVSGPAATALAGLRKDDVA
                     TEAAIGTAVAALRGGCDWIDPLEVPCQMWMHGAGTRSAELAARWEFHYCHAMFFNPDLD
                     ACASTLARYRAGFPGGRTAVAVAVVANDDARTARTDGLRAGISVGCAGTARQCAATIEA
                     LLDGSGADEVVLTELSRDAGDHHRALRDIHAHVAGARRSACGGGPR"
     CDS             4767..7748
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     345.5; E-value: 9.3e-105)"
                     /gene_kind="biosynthetic"
                     /note="lantibiotic dehydratase"
                     /product="LanB"
                     /protein_id="QBK47609.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.4e-75, bitscore:
                     241.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-28, bitscore:
                     89.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGRSAMSPHTGLLRIAALSVEDAARLIAEDRIDAPEVADAIALA
                     AGPQLLGDAAHRPRARTSALRYIARMGGRATPFGLFAGTAPVRIGQRRHLVLGDRHRVR
                     VRIDVAALEALVGRALAEADPARTPLRVNPSARIAGPSLRFARPGDATAEVVEMRATPL
                     LLEVVELLDCGAAPGEELVARLRGRHPGLPTAKLSGFLDAVVAGGLLVPAADLIEPGVE
                     PARRALDLLERIGDAPRAALLRSLLAETGERPAAPGLVARLGAAWRTATATEPALAGIA
                     ANARFDVQLRTCAPAAELDDATAEDLRGAALRLEAVCAEPGARPPVPGALDPAAFRAAF
                     RARYEDAEVPLLEAVDLESGVLRTWQRGTSELAGEAGVVAEAAPEAPDLPATPLRVLER
                     WMREGGDVDIADLPPVERPRSRAVLALLLDDARGPFHSVLVGAVGRSPHALSARFAMDR
                     PELADALRREIQGSGIPGSEVPGAASEPIRAELVHHGGGRIGNVLIRPRLLTDAIALGG
                     AAGGTLRPDRLLLRLRGDEFLLRDSVTGRPVVVELNSAHNVDLHGLDPLYAVLGHLASD
                     GGAGWSWGPLARLPHLPRVVCGRVIVAPEQWRLRGEEVREVLTAGDPAGRLRKLLRGAE
                     DRRWVGTGSQDHVLPIDLDSSRSVLAALSRDGAADHLRLVELPQVEAPAVTGPTGGHVA
                     EAVVPLGPVHRTARSEVDIAAPAAARAANWVYFQYFAGQAASDEVVDRAAALAEELRGQ
                     GLVGDWFFLRYQDDGYHVRVRMRATSPAARPSVLTAMDAFGRRLRATGLATRAVLRDYV
                     PEIARYGGEAGLPLAESLFTASSERAVALLARGRDEEGRLFRTVADVLHWTGALFPDPD
                     RRLEFLRRCQGGLGVAFTPTGNRHGKFARAHGARLEELLAGTCPDERVDAALSRLADSV
                     RERLPERRAWSVFGSALHLHCNRMFAFDAVRLEYLAHELAIRAVRRRKALDGNGTSGER
                     GAAV"
     CDS             7745..8905
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     126.5; E-value: 2.1e-38)"
                     /gene_kind="biosynthetic"
                     /note="lanthionine synthetase"
                     /product="LanC"
                     /protein_id="QBK47610.1"
                     /sec_met_domain="LANC_like (E-value: 1.5e-19, bitscore:
                     59.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVVVAEQVRLARRLHADAAAQVAERPTFPLLLDQALTAMEFAA
                     ALGEDVDARTPFREAMAALRAGTEVGPWLYRGAAQAGWVAIQLARFRGATATGLGPIDD
                     AVLGWLEAFPAEHDLDLPMGALGLGVYGLVHPDPAVRDRITAGVLDVVEDRTERDDAGR
                     YFRLSDSPARRADGSAGSRILGAAHGAAGLVSYLASAALAGGAPGPRARWLLDEARRWL
                     VGHRADVGGTVFPHRVETRYVPSRATWCTGDPGIGLALSVAAEATGDAGTAALAEEVGR
                     RTLARAPQDCGVLDGCLCHGAAALCWYGRRLRDDHGADSEGFTARWAGWLAEARAEGPL
                     TYFSPDGMVRNASFLEGDAGVALALLHAATGGSPSWQQLLLAAPVR"
     CDS             8966..9733
                     /codon_start=1
                     /note="ABC transporter ATP-binding protein"
                     /product="CebD"
                     /protein_id="QBK47611.1"
                     /transl_table=11
                     /translation="MLGRCRGCAHRFFDHRVFDHRARPGTRRPLRTCARVPAFARVGIT
                     GSGGPNRSRGSTTRPPGRSRWKRRRARAPGAAAGDRAGAAGAHRHGRGRTSAADARRPT
                     ARRCRRRCARSARYRPSPHRPAVRLRGGGAGRRLAAGQRQLVAPARAELVDPGVLLDEP
                     TAAPDHLSEAAVLATAERVSRSRTTFVVAHRPGAAERIAVLDGGRPVALRELDAAGGHE
                     ARPWRHARGNPVTTRPAGGARRRSTCRAASAAR"
ORIGIN
        1 gcctcctcgg cgtaggcggt gccgctggtg gttcgcggca cctgccctgg tcgtcggcac
       61 gatgcccccg gtgccttgac ggtcccgggg gcggcctcac ccgtgttccg cggctgatca
      121 cccggccggc ccccgctgcg ccggttcgca acccgacggg gtgggcggac cgtgcccgga
      181 aacgggaccg cgcgtctggc gagcgtcact ccacagggcg aaaatcgcgc gcgcacgtcg
      241 cggaacagca ggtccgcggg ccgttcgccc gtccggaacc ttgtcgtcgc gctccgcgga
      301 tcgctagcct cctcggttgt tccgatcttg tcgatcggct tcgccgagcg gtgggggaac
      361 ggctccggcg cgggtcctgc ggcgatcggg ccggagcgcg gcggtggggg gaaccagagt
      421 ggccatccgg gtgttgatcg tcgacgacca ggtcgtggtg cgccgcggcc tgcgcgcggt
      481 gctcgacgcc gcaccggacg tcgtcgtggt cggggaggcc ggcgacggcg ccgcagcggt
      541 gcgggaggcg cagcggttgc gccccgacgt gatgctgatg gacgtgcgga tgcccggcct
      601 cggcggcatc gaggcggtcc gccggctggt ggagctgttc ggcgatgcgg tgcggatcct
      661 ggtggtcacc accttcgacc tcgacgagta cgtcttcgag agcctccgcg ccggggcccg
      721 cggcttcgtg ctcaaggaca tcgaacccga ggcgctggtc acggcggtgc gggcgctgca
      781 cgcggggaag acggtgctgg accccagcat caccggccgg gtgaccgagg agttcgttcg
      841 gctggcggcc ggccagggcg tcccggtgcc gaccgcccgt cccgatccgc ccgtcgacga
      901 gctctccgcc cggcagcgcg aggtggtcgc gctggtggcc cgcgggcgca gcaacgccga
      961 gatcgccgcg cagctgcacc tgtcggagac cacggtcaag acccacgtct ccacggtgct
     1021 ggccaagtgg ggcctgcggg accgggtgca gctcgtggtc cgggccttcg agacgggcgt
     1081 ggtgctgctc gaccgcggcg aggtctgagt gcgtcccggc ggtgcgggga ccgcggtgca
     1141 cggcgtgcgg gccgcccccg gaccggggcg caccggcggt gatgccggtt gacgagcggg
     1201 gccgccgcgc cgcgggagcg gagcaccacg gccggggtgc ggcggtggcg cccgggagcg
     1261 ctccggttcg ccccgaggca ctggctggtg gtcgggctgc tcgcccacgc cgggctggtc
     1321 ggcgtgctgc tggtcccgcg cgggatgtgg ggtgccgcgg ccgtgctcgc gctggccgag
     1381 gcgctgccgg tgctgtgggc gcggcggtac ccggtgctcg cgctgagcgc ccacctcgcc
     1441 gtcaaaccgc tcacctacct gtggcggatg ccggtgggcg agctcgcctg gctggtcctg
     1501 gtccactcgg tcggccgcta ccgcaggccg cgcgtcgcgc tgccggtgct ggcgggcacc
     1561 gcgctgctgg tgccggtgct gctcgcggcg tgcttcccgg cgcacgccat caccaccggg
     1621 gtgctcgtcg ggctggtcca gctggtggcg gcgtgggcgc tgggcttcgg cacccggctc
     1681 gccgacgagc gggagcagcg cgcgcggcgc gacggcgagc gggaacggct gcaccggtcg
     1741 ctggccgccg aacgcgccac catcggcgcc gaactgcacg agatcgtcga gaagcaggtc
     1801 cgccggatcc tcgccgggac gacggagctg cgccggggcc gcccgcccgg cgccgagccg
     1861 ctgcgcgggt tgcaccagga gtgcggcgcg gcgctgagct cgctgcggtg catgctcggc
     1921 ctgctgcgca ccgacgtccc ggacgcaccg gctcctcgac cggagcgccg ccgcgtcgag
     1981 cggccgccgg gctcgccgca cgacgacgtg ctggtggtgc tcggcgcggt ggtcaccgcg
     2041 gtcgtgctgc acctgtcggc cccgccgggc ctggccgccg acgcgctggt gatcagcacc
     2101 ctgttcgcgc tgccgtccac cccgcacctg ccggacacgg cgatcggtct cgcgctggtg
     2161 ctgctgcaga tcctcccgct gggctggcgc aaccggttcc ccgtgacggc gctgctggtc
     2221 accacagccg gggtggcgct gggcccggcc gcggcggcga actccgtggt ggggcacctc
     2281 tgctggttcg cgctggccta ttcggtgggc gcgcgggggc tcccgaggtc ggtgcccgcc
     2341 gtcggtgcgg cggtgctggc ctggatggcg ggcagcgctt tcctggcggg tgccggggac
     2401 caggcggtcg cgggcagcca gctctacggc gcgctgctgg tcggcgggct cgccgtcgcc
     2461 gggaacgtgc accggcggat ccgcgcggcg cggcagagcg ccgaacgcgc cgagcaggac
     2521 caccggatcc acgaggagct gcggcgggag cgcagccggc tggcctgcga ggtgcacgac
     2581 caggtctcgc accacgtgtc cggcatggtg gtgcaggccg gggcggcgcg ggcgctggcc
     2641 gggtcccggc cggaaggcgt cgacgaggcg ctgcgcgaga tcgaggacag cgcggagctg
     2701 gcgctgcggg cgctgccgcg cctgctcgac gtcctggggc cggagccgac cggaccgacg
     2761 cgcctcgacg gggtcgagct cgaacacctg gtgcgtccgc tgcgcgacct cggggcgcgg
     2821 gtccgcgcgg aactggccgg ggacccgcgc cggaccgcgg gcgaccgcgc cgaactgggc
     2881 tgccgggtgg tccaggaggc ggtgcgcaac gtgatccggc acgccggtcc gaccgccacc
     2941 cgggtccgcg tcgagcacca cccggcgcac ctgctggtgg aggtcgccga cgcgggggcg
     3001 gtcgccgggc accaccgggc cgatccgggc tgcgggcagg gcctggccgg gctgggggag
     3061 cgggtcgagc tggtcggcgg gcggttgcgg gccgggccgc gcggctcggg gtggcgggtg
     3121 accgcgctgc tgcccctccg ttccggctcc tccgcaggga ggaagccgga accgatcacc
     3181 gccgccgcgg agccggaaat ggtcctcggg gacgaggttt ccggccgccg tcgtgcctaa
     3241 cctgggaatt gcttgacgca caaggccttt cgctgagagg ccgggttcat ccgaccgtgg
     3301 aggtaccgcc atgtccgctc cggttcagga cttcgatctc gacgtcgaca ccacctcgtt
     3361 cgccgcgccc ggcggcggtg cgctgtccga ggacggcatc gaggccaggg gcccgatcac
     3421 cttcggcacc acctgctggg gcaccccctg cccgagcgcc aacaccgtct cctgctgagc
     3481 cgggcccgtg cgcggcggcc cggtgatcgc cgcgcgcggg ctcacccgcc ccgccgccgg
     3541 tggggcgctc gtcgcaccgg ccctccgagc cgagggccgc tcctcgatcg tggaggtacc
     3601 gccatgtccg ctccggttca ggacttcgat ctcgacgtcg acaccacctc gttcgccgcg
     3661 cccggcggcg gcgcgctgtc ggccgacggc atcgaggcca agggggtgct gacgttcggc
     3721 accacctgct gggggacgac ctgtccgagc aacaacacca tttcctgctg atcagcccgt
     3781 ccggcgccgc gagcgcgaac cggcgtgcgg tggctcggga ggccgccgca cgaccgccgt
     3841 cccaggaggt gtgccgtggt gttcggaggc aggaccgcgg tgtcggcgga tcccaccggg
     3901 tggtgggcgg cggccccgcc gctgggggtg ctggagtacc tcgacctcga cgacgaccgg
     3961 ccggtgcggc tcaaacgccg cgccgccttc gccagcacgc tgctggccga ggacctcggc
     4021 taccgcaggc tctggatccc ggagcaccac gggaccgggg tgccgagcac caatcccgca
     4081 ctgctggccg ccgtgctggc cagccacacc acgcggatca gggtcggcac ggcggtgaac
     4141 ctggcgcggg tccgcgaccc gcacctggtc gccgaggacc tggtcaccgc cgggtccttc
     4201 gccggggacc ggctcgacgt cggcttcggc cgaggtgacg tgtccggtcc ggccgccacc
     4261 gcgctggccg ggctgcgcaa ggacgacgtc gcgacggagg cggcgatcgg caccgcggtg
     4321 gccgcgctgc gcggcggttg cgactggatc gacccgctgg aggtgccctg ccagatgtgg
     4381 atgcacggcg ccgggacccg ctccgcggaa ctggccgcgc ggtgggagtt ccactactgc
     4441 cacgcgatgt tcttcaaccc cgacctggac gcgtgcgcca gcaccctcgc gcggtaccgc
     4501 gccggattcc ccggcggccg caccgcggtc gcggtcgcgg tggtcgccaa cgacgacgcc
     4561 cgcaccgccc gcaccgacgg cctgcgcgcc gggatctcgg tcggctgcgc cggaaccgcg
     4621 cggcagtgcg ccgcgacgat cgaggcgctg ctcgacggca gcggcgccga cgaagtggtg
     4681 ctcaccgagc tctcccgcga cgccggggac caccaccgcg cgctgcggga catccacgcc
     4741 cacgtcgccg gagcacggcg gtccgcgtgc gggggaggtc cgcgatgagc ccgcacaccg
     4801 gcctgctgcg gatcgccgcc ctcagcgtcg aggacgcggc ccggttgatc gccgaggacc
     4861 gcatcgacgc cccggaggtg gccgacgcga tcgcgctggc cgccggaccg cagttgctcg
     4921 gcgacgccgc gcaccgaccg cgcgcccgca ccagcgcgct gcgctacatc gccaggatgg
     4981 gcggccgggc gaccccgttc gggctgttcg ccgggaccgc accggtgcgc atcgggcagc
     5041 gcaggcacct ggtgctcggc gaccggcacc gggtgcgcgt gcggatcgac gtcgcggcgc
     5101 tggaggcgct ggtcggtcgc gcgctggcgg aggccgaccc ggcgcggacg ccgttgcggg
     5161 tcaaccccag cgcgcggatc gccgggccat ccctgcgctt cgcccgcccc ggcgacgcca
     5221 ccgccgaggt ggtggagatg cgggccaccc cgctgctgct ggaggtcgtg gagctgctgg
     5281 actgcggtgc cgcgccgggg gaggaactcg tcgcccggct gcggggccgc cacccgggcc
     5341 tgcccaccgc gaagctgagc gggttcctcg acgcggtcgt ggcgggcggg ctgctggtcc
     5401 cggcggccga cctgatcgaa cccggcgtcg aaccggcgcg gcgggcgctc gacctgctgg
     5461 agcggatcgg ggacgcgccg cgggcggcgc tgctgcgctc gctgctcgcc gagaccggtg
     5521 agcgtcccgc ggcgccgggg ctggtcgcgc gcctcggcgc ggcgtggcgc accgcgaccg
     5581 cgaccgaacc cgcgctcgcc ggcatcgccg ccaacgcccg gttcgacgtg cagttgcgga
     5641 cctgcgcccc ggcggccgag ctggacgacg ccaccgccga ggacctgcgc ggcgccgcac
     5701 tgcggctgga ggcggtgtgc gccgaacccg gggcccggcc tccggttccc ggcgcgctgg
     5761 accccgccgc cttccgcgcc gcgttccggg cccgctacga ggacgccgag gtgccgctgc
     5821 tggaggccgt cgacctcgaa tccggggtgc tgcggacctg gcagcgcggg acctcggagc
     5881 tggccggcga ggcgggggtg gtggccgaag cggcaccgga ggcgccggac ctgcccgcga
     5941 ccccgttgcg ggtgctggag cgctggatgc gcgagggtgg ggacgtcgac atcgccgatc
     6001 tcccgccggt cgagcgcccc cggtcccgcg cggtgctcgc gctgctgctc gacgacgccc
     6061 gcggcccgtt ccacagcgtg ctggtgggcg cggtcggccg gtccccgcac gcgctgtcgg
     6121 cccgcttcgc gatggaccgc cccgagctcg ccgacgccct gcgacgcgaa atccagggca
     6181 gcggaatccc gggcagcgaa gtcccgggcg ccgcgagcga accgatccgc gccgaactgg
     6241 tgcaccacgg cggtggccgg atcggcaacg tgctgatccg gcccaggctg ctgaccgacg
     6301 cgatcgcgct gggcggggcc gcgggcggca ccctccgacc ggaccggctg ctgctgcggc
     6361 tgcgcgggga cgagttcctg ctgcgcgact cggtcaccgg gcggccggtc gtggtggagc
     6421 tcaacagcgc gcacaacgtg gacctccacg ggctcgaccc gctctacgcc gtgctcggcc
     6481 acctggcctc ggacggcggg gcggggtggt cgtggggacc gctggcgcgg ctgccgcacc
     6541 tgccgcgggt ggtgtgcgga cgggtgatcg tcgcccccga gcagtggcgg ctgcgcggcg
     6601 aggaggtccg ggaggtgctc accgcgggcg atccggccgg gcggctgcgc aagctgctgc
     6661 gcggggcgga ggaccggcgc tgggtcggta ccggcagcca ggaccacgtg ctgccgatcg
     6721 acctggactc gtcccgctcg gtgctcgccg cgctgagccg ggacggtgcc gccgaccacc
     6781 tccggctcgt cgaactgccg caggtcgagg cgcccgccgt caccggcccg accggcgggc
     6841 acgtcgcgga ggcggtggtg ccgctggggc ccgtccaccg caccgcccgg tccgaagtgg
     6901 acatcgccgc gcccgcggcc gcgcgcgcgg cgaactgggt gtacttccag tacttcgcgg
     6961 ggcaggccgc ctcggacgag gtcgtcgacc gcgccgccgc gctcgccgag gagctgcgcg
     7021 ggcagggcct ggtcggggac tggttcttcc tgcggtacca ggacgacggt taccacgtcc
     7081 gggtccggat gcgggccacc tcgccggccg cccggccgag cgtgctcacc gcgatggacg
     7141 cgttcgggcg gcggctgcgc gccaccggac tcgccacccg ggccgtgctg cgcgactacg
     7201 tcccggagat cgcccgctac ggcggggagg ccgggctccc gctcgccgaa tcgctgttca
     7261 ccgcctccag cgaacgggcg gtggcgctgc tggcccgggg ccgcgacgag gagggccggt
     7321 tgttccgcac cgtcgccgac gtcctgcact ggaccggcgc gttgttcccc gacccggacc
     7381 gccggctgga gttcctgcgc cgctgccagg gcgggctcgg ggtggcgttc acccccaccg
     7441 gcaaccggca cggcaagttc gcccgggcgc acggcgcccg gctcgaggag ctgctcgccg
     7501 gcacctgccc cgacgaacgg gtcgacgcgg cgttgtcccg gctggccgac tcggtgcgcg
     7561 agcggttgcc cgaacggcgc gcgtggtcgg tgttcggctc ggcgctgcac ctgcactgca
     7621 accggatgtt cgccttcgac gcggtccggc tcgaatacct ggcccacgag ctggcgatcc
     7681 gcgcggtgcg ccggcgcaag gccttggacg gcaacggcac atccggagag cggggcgcgg
     7741 cggtatgacg gcggtcgtgg tggcggagca ggtgcggttg gcgcggcggt tgcacgccga
     7801 cgccgcggcg caggtggcgg agcggcccac gttcccgctg ctgctcgacc aggcgctgac
     7861 ggcgatggag ttcgccgcgg cgctgggcga ggacgtcgac gcgcgcaccc cgttccggga
     7921 agcgatggcc gcgctgcgcg ccgggaccga ggtggggccg tggctctacc ggggtgccgc
     7981 gcaggccggc tgggtcgcga tccagctcgc ccggttccga ggtgctaccg ccaccgggct
     8041 cgggccgatc gacgacgcgg tgctgggctg gctggaggcg ttccccgccg agcacgatct
     8101 cgacctgccg atgggcgccc tcgggctcgg cgtctacggg ctcgtgcacc ccgacccggc
     8161 ggtccgcgac cggatcaccg ccggggtgct ggacgtggtc gaggaccgca ccgaacggga
     8221 cgacgccggg cggtacttcc ggctgtccga ctccccggcg cgccgcgccg acggttccgc
     8281 cggatcgcgc atcctcggcg cggcgcacgg ggcggccgga ctggtgtcct acctcgcttc
     8341 ggccgcgctg gccggaggcg ctcccggccc ccgggcccgg tggctgctcg acgaggcgcg
     8401 gaggtggctg gtgggccacc gcgccgatgt cggcggcacg gtcttcccgc accgcgtcga
     8461 gacccgctac gtcccgtccc gggcgacctg gtgcaccggc gacccgggca tcgggctggc
     8521 gctgtcggtg gccgccgagg cgaccgggga tgccgggacc gcggcgctgg ccgaggaagt
     8581 cggccgccgg acgctggccc gcgccccgca ggactgcggg gtgctcgacg gctgcctgtg
     8641 ccacggtgcc gccgcgctgt gctggtacgg gcggcggctc cgcgacgacc acggcgccga
     8701 ctcggagggg ttcaccgccc gctgggccgg ttggctcgcc gaggcgcgcg ccgaggggcc
     8761 gctgacctac ttcagcccgg acggcatggt gcgcaacgcc tcgttcctgg agggcgacgc
     8821 gggcgtggcg ctggccctgc tgcacgccgc caccggtggt tccccgagct ggcagcaact
     8881 gctgctggcc gcgccggtcc ggtagccggg tgcgcacgat cccggctggc cgcgcgcgct
     8941 ccggcgacgg cggtgctccc accgcatgct gggccggtgc cgcggctgcg cgcaccggtt
     9001 tttcgatcac cgggttttcg atcaccgggc gcgaccgggg acgcgtcgtc cgctgcggac
     9061 ctgcgcccgc gtcccggcct tcgcgcgggt ggggatcacc ggctcgggag ggcccaaccg
     9121 atcgcgaggt tccacgacgc gaccaccggg caggtcgcgt tggaagcgtc gacgtgcgcg
     9181 agcaccgggt gctgcggcgg gggatcgggc cggtgccgca ggtgcgcacc ggcacggacg
     9241 cggacgaacg tccgctgcgg acgcccggag gccgaccgcg cggcggtgca ggcggcggtg
     9301 cgcgcgatcg gcgcgctacc ggccctcgcc gcaccgcccg gcggttcggc tacgaggtgg
     9361 gggagcgggg cgacggctgg ccgcggggca acggcagctc gtcgcaccgg cgcgggccga
     9421 gctcgtcgat ccgggcgtgc tgctcgacga gccgacggcc gcgccggacc atctgagcga
     9481 ggcggcggtg ctggccaccg ccgagcgggt gtcccgctcc cgcaccacct tcgtcgtcgc
     9541 gcaccggccg ggcgcggcgg agcgcatcgc ggtgctcgac ggcggccgac ccgtcgcgct
     9601 ccgggagctc gacgcggccg gtgggcacga ggcgcggccg tggcgccacg cccggggcaa
     9661 cccggtcacc acgcgaccgg caggcggtgc acgccgtaga tcgacatgcc gtgccgcatc
     9721 ggcagcgcgg tgaccggttc ggccaggcgc agctccggga accggtgcag cagcgcggtg
     9781 tagccgatcc gcagctccag gcgggccagc tggtgtccga ggcagtggtg cgccccgtgg
     9841 ccgaaggcga ggtgcccgcc ggacggcgtc cgcaggtcga gcacctcggg gttccggaac
     9901 cgggccgggt cgcggttggc ggcgggcagc gacagcacca ccgcctcgcc cgcggcgatc
     9961 cgcgcgccgc cgaagtcgaa gtcctcc
//
