LOCUS       BGC0002319              6178 bp    DNA     linear   BCT 10-FEB-2019
DEFINITION  Streptomyces sp. strain GSL-6C salinipeptin gene cluster, complete
            sequence.
ACCESSION   BGC0002319
VERSION     BGC0002319
KEYWORDS    .
SOURCE      Streptomyces sp
  ORGANISM  Streptomyces sp.
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:19:06
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6178
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..288
                     /gene="sinA"
     CDS             1..288
                     /codon_start=1
                     /gene="sinA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypemycin"
                     /gene_kind="biosynthetic"
                     /note="salinipeptin structural protein"
                     /product="SinA"
                     /protein_id="QBA31011.1"
                     /sec_met_domain="cypemycin (E-value: 5.8e-28, bitscore:
                     86.1, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAGDVLATFGTPRPFARIDHRRKVSEVRSELTSTRPDSSATHPE
                     SLAAQEFANTALGAATPGFHADCETPAMATPATPTAAQFVIQGSTICLVC"
     source          1..6178
                     /db_xref="taxon:1931"
                     /isolation_source="Great Salt Lake"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp."
                     /strain="GSL-6C"
     misc_feature    1..6178
                     /note="salinipeptin gene cluster"
     subregion       1..6178
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6178
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            432..2153
                     /gene="sinH"
     CDS             432..2153
                     /codon_start=1
                     /gene="sinH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /note="contains N-terminal HTTM domain and C-terminal
                     alpha/beta hydrolase fold"
                     /product="SinH"
                     /protein_id="QBA31012.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.1e-12, bitscore:
                     37.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METAAQKAIDRALLPVAIGQFLAAVETLSLRVEFDDDGYLRGTSA
                     RQFPPGSLRHRIGRALDHPRTPRVLAGVTLAASAGLVLARGHRKAQITAAGIIGVCNRL
                     SEIRTPYGRDGADQMTAIITQYRALTALIPDREVSDDLFLRGVNFQAGLSYAVSGVAKA
                     FGSSWVQGDALLEVLQTESYGRGPAAALLRRHPRLCRALTIGTLAWEASFPLIYLLPRR
                     RASHALWAVKAFHIGVATTMELPRFVWGFLGSHGAVGYVLDTRGAQRTFEKAVVGIASG
                     VVLASALIAREKRKIAEQRRLGPKGAARLRHGDGVVEYRVDRPADEAASSTVIVLECGL
                     GQSLESWEWVAESLARDHTVVRYHRPGYGLTTSRASSGALLAAVLDEVGAEGEVVVVTH
                     SIGSLSAASYVRSSPFADRVNKLVVVDGTDPALLEEDRTDRRRLGKFVQAQVYTLLAAV
                     AGIYEWAPNAVERQAGYTPDTQYSHVQFVFSPRNIVNSVREYRGIQTDGAVDRLSAVKS
                     VLVIASDEFAEQQAVLAEKIAAKIEVVHGSAHRSIIGYRRHAEKVEGAIRRFMDAR"
     gene            2143..2703
                     /gene="sinL"
     CDS             2143..2703
                     /codon_start=1
                     /gene="sinL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /product="SinL"
                     /protein_id="QBA31008.1"
                     /sec_met_domain="cypI (E-value: 2.6e-32, bitscore: 101.0,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLADRIKSAVASCAVGALAAHLVATVLQNTPDSYNQDLRKFTGGW
                     PIPGWRFFAPNPGVQNVHLLVRETAGDGPTPWRDVTPVVPHGWTQVLYNPRSRGPKALF
                     DAMQQLSVMSANQADFAWVTQSLPYELVLAASRAAAAEGAQALQFLLMNVFPSAPAEHR
                     MKPILTSEWIPLGASARMTGASG"
     gene            2700..3272
                     /gene="sinD"
     CDS             2700..3272
                     /EC_number="1.3.99.36"
                     /codon_start=1
                     /gene="sinD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /note="cypemycin decarboxylase; HFCD family decarboxylase"
                     /product="SinD"
                     /protein_id="QBA31013.1"
                     /sec_met_domain="Flavoprotein (E-value: 2.5e-14, bitscore:
                     42.3, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVDKFEGAELHLHITGSISAALVPWWVHWLRELHPNLVVNVSVT
                     PAASRFLAVRSLQHLANGTVWTDSWDEPDTPREVNSGRSGCSECFLIFPATLDTVMRLA
                     QGRADSPALLMLQVTDAPIVIADTFPGTNEIVESHVQALKLRRNVEFAPRVSGVRASNR
                     STAEVGFNLPGAITVANKMLKEGRPHE"
     gene            3265..4002
                     /gene="sinM"
     CDS             3265..4002
                     /EC_number="2.1.1.301"
                     /codon_start=1
                     /gene="sinM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 77; E-value: 2.5e-23)"
                     /gene_kind="biosynthetic-additional"
                     /note="cypemycin N-terminal methyltransferase;
                     SAM-dependent methyltransferase"
                     /product="SinM"
                     /protein_id="QBA31010.1"
                     /transl_table=11
                     /translation="MSEPSVYDEAAIEAYDLVSSMLSPGAGLAAWVSSHRPLAGVTALD
                     LGCGTGVSSFALAEAGARVVAVDASRPSLKVLDGKRADRNVEAVEGDFRNLRLDSTFDV
                     ITLSRNTFFLAREQEEKLDLLRVIARHLKPEGAAFIDCTDPSEYQRAGGDARSVTYPLG
                     REQMVTVTQTADRAAQEILSIFLVQSASTLTAFHEQATWATLAEIRLMARISDLKVADV
                     NGSYAGEPYSARSREMLVVLERQ"
     gene            3999..4631
                     /gene="sinT"
     CDS             3999..4631
                     /codon_start=1
                     /gene="sinT"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 117.2; E-value:
                     1.6e-35)"
                     /gene_kind="transport"
                     /note="ABC transporter ATP-binding protein"
                     /product="SinT"
                     /protein_id="QBA31009.1"
                     /transl_table=11
                     /translation="MNEVPAIAAEDATVVLDETTLLAPTTFAVMPGQFWSLTGSNGSGK
                     TTLLRAFLGSRKLTGGAVRVQGEAVDLSRPRHRRLLASLVEPVPVARDMTLREQVTLVA
                     ASWYGNTTKTAERAEEVIDRLGLSALGGRFPSQLSSGQLQLFSLALTLVRPADVVLLDE
                     PERHLDTGRVDLVVTLLAERAERGTALLVATHESAVVDACDGVMELG"
     gene            4628..6178
                     /gene="sinP"
     CDS             4628..6178
                     /codon_start=1
                     /gene="sinP"
                     /note="putative transmembrane protein"
                     /product="SinP"
                     /protein_id="QBA31007.1"
                     /transl_table=11
                     /translation="MTTDSITAVESGPEARVHAVRHRYARRSDRATAADWAYTTYLTVI
                     LALVYLVPVLYLVRTSPTLLPLESATAATPVACLVAAGTVWGAQLAGRFWGPLVLKPFL
                     LHVFTSTDLPPLSYLGPIARRRLAYAGLGTLLTVSTATLLMTDLFDHSETALVAQGAAV
                     AVGIGAIAAVTWLWGQVRTVRENITLAAAVAVVAVAVALLGQSALADGGGLWLTAGVLA
                     VSAAVLGRSAFRSIHTVDLARLARESARAAEAQTFAWTGTLHHALDLYRPEPRGLTSAL
                     VHSDGRLRGHLAQGAVRALRTRGRAAAAAAFLLTGGALLTLGVAEPDASSATLFWVTGA
                     TAVYWGSGWVSETWRGLRDELALAPLFGEWWGGMLARTLAWPVVAVVTTVGLAGGIAAV
                     IRFPLRGACPADAVLLTTASVALVLSARFLREMKTNLPIELLLPIITPLGDLSGVRVFV
                     WQFDGLVVVLVGILVMAKMPSALGAALVSLGLTGWCVWTGLRRTGWARRALFTRLGRV"
ORIGIN
        1 gtgggtgcgg gcgatgtgtt ggcaacgttc ggtacgccga gaccattcgc tcgcattgac
       61 caccgacgaa aggttagtga agtgcgatct gaactgactt cgacccgacc ggattcttcc
      121 gctacccacc ctgagtcgct ggcggcgcag gaattcgcga acaccgccct tggcgctgcg
      181 acgccgggct tccacgcgga ctgcgagacg cccgccatgg ccacgccggc cacgccgacc
      241 gcagctcagt tcgtcatcca gggcagcacg atttgcctcg tctgctgacc tggggctgat
      301 tcaggagccg gggaggtcgc atcgctcgga cttctccggc tcctgaattc atgtgttcgc
      361 gtcggaatga tgtttgtgac gggggagcga aaaaatcagt gaaacggaag cgctgggggc
      421 aacgtgtctc tgtggaaact gcagctcaga aggcgattga tcgagcactt ttgccagtag
      481 cgatcgggca gtttctggcg gcggtggaga ccctttccct tcgggtagag ttcgatgacg
      541 acggctatct ccgaggcacg tcggcccgac agttcccgcc gggcagtctg aggcaccgta
      601 tcggccgcgc ccttgaccat ccgcgcaccc cgagagtgct cgcgggagtc accttggcgg
      661 cgtcggctgg tcttgtgctc gcacgcggcc accggaaagc acagatcacc gcagcaggga
      721 tcatcggggt gtgcaaccgg ctgagcgaga tccgcacacc gtacggacgc gacggcgcgg
      781 accagatgac ggccatcatc acccagtacc gtgcgcttac ggcgctgata cccgaccgag
      841 aggtatccga cgacctcttc cttcgaggag tcaatttcca ggcggggctg agctatgcgg
      901 tctcgggcgt cgccaaggcc ttcggcagca gttgggtgca gggcgatgcc ctgctcgaag
      961 tcctacagac cgagtcctac ggccggggac cggctgcggc cctccttcgc cggcatccga
     1021 gactctgccg tgccctgacg attggcacac tggcctggga ggcgtctttc ccccttatct
     1081 acctgttgcc gcgtaggcgg gcctcccacg ccctctgggc agtcaaggcc tttcacatcg
     1141 gtgtggcgac gaccatggag ctgccacgct tcgtgtgggg gttcctcgga tcccacggag
     1201 cggtcggcta cgtgctggac acacgcggcg cacaacgcac gttcgagaag gccgtggtcg
     1261 gcatcgcctc cggcgtcgtc ctcgcaagcg ccctcatcgc ccgggagaag cgcaagattg
     1321 ccgagcagcg gcggctcggc cccaagggcg cggcacggct ccgccacggg gacggcgtag
     1381 ttgagtaccg ggtagaccgc cccgcagacg aggctgcctc cagcacggtg atcgtccttg
     1441 aatgcggctt gggacagtcc ctcgaatcgt gggagtgggt cgcggaaagc ctggcgcggg
     1501 accacacggt cgtccgctac caccggcccg gatacggcct gacgacgtcg cgtgcgtcaa
     1561 gcggggccct ccttgccgcg gtgctcgacg aggtcggggc cgagggtgag gtcgtggtgg
     1621 tcacccactc gatcggttcg ctgagtgcgg cctcctacgt gcggagcagc cccttcgccg
     1681 accgtgtcaa caagctcgtc gtcgtcgacg gcaccgaccc ggcgcttctg gaggaggacc
     1741 gcacggaccg caggcggctg ggcaagttcg tccaggcgca ggtctacacc ctgttggcgg
     1801 ccgtggcggg aatttacgag tgggcgccca acgcggtgga gcgtcaggcg ggatacacac
     1861 ctgacactca gtacagccat gtgcagttcg tgttctcgcc gaggaacatc gtcaactcgg
     1921 tccgtgagta ccggggcatt cagaccgacg gcgccgttga ccgcctcagc gcggtgaagt
     1981 cagtcctggt tatcgcctcg gacgagttcg ccgagcaaca ggcggtactg gccgagaaaa
     2041 tcgcggcgaa aatcgaagtg gtgcacggct ctgcgcaccg gtcgatcatc ggataccgac
     2101 gccacgctga aaaggtcgaa ggtgctatca gaaggttcat ggatgctcgc tgaccggatc
     2161 aagagtgcag tggcttcctg tgccgtagga gcgctcgcgg cgcacctggt cgcgaccgtt
     2221 ctgcagaaca cacccgactc ctacaaccag gacctgcgta aattcacggg cggctggccc
     2281 atacccggat ggcggttctt cgcaccgaat ccgggtgtgc agaacgtgca cttgctggtg
     2341 cgtgaaacgg ccggcgacgg tccgacaccg tggcgcgacg tgacgcctgt cgtaccgcac
     2401 gggtggacac aggtgctgta caacccgcgg agccgcggcc ccaaggcact gttcgacgcc
     2461 atgcagcagc tttctgtcat gagcgcgaac caggccgact tcgcctgggt cacccagagc
     2521 ctgccgtacg agctagtgct tgccgcgagc cgggccgcgg cggccgaggg cgcgcaggcc
     2581 ctccagttcc tgctgatgaa cgtgttcccc agcgcgccgg cggagcaccg aatgaagccg
     2641 atcctcacat ccgagtggat ccccctaggc gctagcgctc gcatgacggg agccagcgga
     2701 tgaacgtcga caagttcgag ggagccgagc tgcacctcca catcacaggc tccatcagcg
     2761 cggcgctcgt gccatggtgg gtccactggc tgcgggagct ccacccgaac ctggtcgtaa
     2821 acgtgtcggt gacccccgcc gcctcacggt tcctcgcggt ccggtccctt cagcacctgg
     2881 ccaatggcac agtatggacc gactcctggg acgagccgga cacgccgcgc gaagtcaact
     2941 ccggaaggag cggctgctcc gagtgcttcc tgatcttccc ggccacgctg gacaccgtca
     3001 tgcgcctggc gcaggggcgc gccgactcgc ccgccctact gatgctccag gtgactgatg
     3061 cccccatcgt gatcgccgac acgttcccag ggaccaatga gatcgtcgag agccacgtgc
     3121 aggccctcaa acttcggcgc aacgttgagt tcgctccgcg agtcagcggt gtacgggcaa
     3181 gtaaccggtc aacggccgag gtggggttca acctgccagg cgcaattacc gtcgccaaca
     3241 aaatgttgaa ggaaggccgt cctcatgagt gagccgagtg tgtacgacga ggcggcgatc
     3301 gaggcgtacg atttggtgtc ctcgatgctc tccccaggcg ccgggctcgc cgcttgggtg
     3361 tcgtcgcacc ggccacttgc cggggtcacc gccctggacc tggggtgcgg cacgggcgtg
     3421 tcctcgttcg cactcgccga ggcaggtgcg cgagtcgtgg ccgtcgacgc ctcacggccg
     3481 tcgctgaagg tacttgacgg caaacgcgcc gaccgcaacg ttgaagcggt ggagggcgac
     3541 ttccggaacc tccggctcga ctccacattc gacgtcatca ccctgtcgag gaacacattc
     3601 ttcctcgccc gggaacagga ggagaagctt gacctcctgc gcgtcatcgc acggcaccta
     3661 aaaccggaag gtgcggcttt catcgactgc accgatccct ccgagtacca gcgagcgggg
     3721 ggcgacgcgc gctcggtcac ctacccgctg ggccgcgaac agatggtgac cgtgacacag
     3781 acggcggacc gagccgccca ggagatcttg agcatcttcc tcgtccagag cgcgtcgaca
     3841 ctcaccgcat tccacgagca ggccacctgg gctacgctcg cggagatccg gctgatggcc
     3901 cgcatctcag atctgaaagt ggcggacgtc aacggatcgt acgcgggaga gccctacagc
     3961 gcgcgctcgc gggagatgct ggtagttctg gagcggcagt gaacgaagtg cccgcgatcg
     4021 cggcggagga cgccacggtc gtcctggacg agaccaccct gctggctccg acgacgttcg
     4081 cggtgatgcc cggccagttc tggtctctga ccggcagcaa cggctccggg aaaacgactc
     4141 tcctgcgggc atttctaggg agtcggaagc taacgggcgg cgccgtccgc gtgcagggcg
     4201 aggccgtcga tctgtccagg ccccggcacc gtcggctcct ggcctcgctc gtcgaacccg
     4261 tgcccgtcgc ccgcgacatg acgctgcgcg agcaggtgac cctcgtcgcc gcctcctggt
     4321 atggcaacac cacgaagacc gccgagcgcg ccgaagaggt catcgaccgg ctgggccttt
     4381 ccgcgctggg cgggcggttt ccctcccagc tctcctccgg ccagctacag ctcttcagcc
     4441 tcgcgctgac cctggtccgc cctgccgatg tcgtcctgct cgacgagccc gagcggcacc
     4501 tcgacaccgg tcgcgtcgac ctcgtcgtca cactgctcgc cgagcgggcc gagcggggga
     4561 ccgcgctcct ggtcgccacc cacgagagcg ctgtggtgga cgcctgcgac ggcgtcatgg
     4621 agcttggatg acgacggaca gcatcaccgc ggtcgagtcc ggccctgagg ctcgcgtcca
     4681 cgccgtacgg caccgatacg cacgccgcag cgaccgcgcc acggcggcgg actgggcata
     4741 cacgacctac ctcaccgtca tcctcgccct cgtctacctg gtgccggtcc tctacctggt
     4801 gaggacctcc ccgacactcc tcccgctgga gtccgccacc gcggcaacac ccgtggcgtg
     4861 cctggtcgcg gcggggacgg tctggggcgc tcagctcgcc ggccggttct ggggaccgct
     4921 ggtgctcaag ccgttcctac tgcacgtgtt cacttccacg gacctgcccc ccttgtctta
     4981 cctcggtccg atcgcccgcc gtcgactggc gtacgcgggg ctcggcacgc tgctgacggt
     5041 atccacggcc acgctcctca tgaccgacct gttcgaccac tcggaaaccg cgctcgtagc
     5101 gcaaggcgca gccgtcgcgg tcggcatcgg agccatcgcc gccgtaactt ggctgtgggg
     5161 ccaggtccgg acggtgcgcg agaacatcac gctcgccgcc gccgtggcag tcgtcgccgt
     5221 cgccgtagcg ctgctcgggc agtccgccct cgcggacgga ggcggcctgt ggctcaccgc
     5281 cggtgtactc gcggtctcgg cggcggtact cggtcggtcc gccttccgct ccattcatac
     5341 cgtcgacctc gcccgactcg cacgcgaatc agctcgcgcc gccgaggccc aaaccttcgc
     5401 ctggaccggc accctccacc atgcgctgga cctgtaccgc ccggagccgc gcgggctcac
     5461 ctccgctctg gtgcattctg acggacgcct acgcggccac ctcgcacagg gagcggtccg
     5521 cgcgctgcgc acgcggggcc gcgctgccgc cgccgcggcg ttcctgctga ccggcggcgc
     5581 cttgctgacg ctcggcgtcg cggaaccgga cgccagctct gcgacgctgt tctgggtgac
     5641 cggcgcaacc gctgtgtatt gggggtccgg atgggtcagc gagacctggc gcggtctgcg
     5701 cgacgaactg gccttggccc cgctgttcgg tgagtggtgg ggtggaatgc tggctcgcac
     5761 cctggcctgg cccgtcgtcg cggtggtgac caccgtgggg ctggcgggcg gtatcgcggc
     5821 cgtgatccgg tttccgcttc ggggtgcctg tcccgctgac gctgtgctgc tcaccacggc
     5881 ttcggtggcg ctcgtgctca gcgccaggtt cctgcgcgag atgaagacga acctaccgat
     5941 cgaactgctg ctccccatta tcacgccctt gggcgacctc tccggggttc gcgtcttcgt
     6001 gtggcaattc gacggactcg ttgtcgtgct agtcggcatc ctcgtgatgg caaagatgcc
     6061 gtccgcgctc ggtgctgccc tggtctcgct gggtctgacc ggctggtgcg tctggacggg
     6121 cctgcgccgg acagggtggg cccgccgcgc cctgttcacc cgactcggcc gggtatag
//
