LOCUS       BGC0002323              9758 bp    DNA     linear   BCT 06-APR-2020
DEFINITION  Staphylococcus capitis strain APC2923 plasmid pJOS_01, complete
            sequence.
ACCESSION   BGC0002323
VERSION     BGC0002323
KEYWORDS    .
SOURCE      Staphylococcus capitis
  ORGANISM  Staphylococcus capitis
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:19:43
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..708
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.6; E-value:
                     3.1e-51)"
                     /gene_kind="transport"
                     /product="nsjF lantibiotic protection ABC transporter
                     ATP-binding"
                     /protein_id="QGN18861.1"
                     /transl_table=11
                     /translation="MNNALEIKNLNKKYENNSILTDLSITVKKNRIFGLLGPNGAGKTT
                     LLKIVSGIISQTSGDIEMFGEPWNRKNLDYIGALIEKPAIYENLTAYENLEIICQLLDL
                     SKNKIPETLSIVGLNNIDHRKLTKNFSLGMKQRLGIAMAIINDPKLLILDEPTNGLDPI
                     GIQELRDLIKNFPNKGMTVIISSHILSEIEIIADDICIISNGLLGFQGTIDNHKNDLED
                     LFIQTVKKNKEGK"
     protocluster    1..9758
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2214:8075]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2215..8075
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..9758
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..9758
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002323"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9758
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             710..1456
                     /codon_start=1
                     /product="nsjE ABC2 membrane superfamily"
                     /protein_id="QGN18862.1"
                     /transl_table=11
                     /translation="MKFFETELKKNRRTANKKLIWITPCIFTLFSFLASLLMVPSSKGN
                     VFIAGAYNWFPLIILPSIISLLVANSINLERKNKNIEYLKSKNVNLSKLYFYKSVIVSL
                     FLFSIIIIAFFIISIVTMILTPSTVNLLPLFLANIMLFICCLPLIPVSYIIIELTNTLV
                     LLTVNFIGGLLASIISTTSFWIIYPWSYSFRAIAPLLKINPNGTFIEGENNLSNINNVF
                     LAFVLAIIFYLVGILVMNLISKRVFK"
     CDS             1453..2190
                     /codon_start=1
                     /product="nsjG lantibiotic protection, ABC transporter"
                     /protein_id="QGN18863.1"
                     /transl_table=11
                     /translation="MIKLCEMQWKKTKRNFIRILMLVLPIIYSLVMYLYFNISSLDNNN
                     KKTIFFLLLFISVQFFLAIYTNQFIQIDRDANNFIHELSSKVPRRKIFLSKVILLIMIS
                     ISVYILSVSVFLLLNLIHKVVLIHTYELCLYFLLSIIFQTPTLLLNIFVSYKYSLYGIV
                     IIATINFLTTILIGTTQLGALIWYFVPSSWGSKYIVDFIPSNIYTLENLFVILLLIAVD
                     IILIFTQILWFSQWEGESKYSEN"
     gene            2215..5130
                     /locus_tag="J26"
     CDS             2215..5130
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     519.9; E-value: 1.9e-157)"
                     /gene_kind="biosynthetic"
                     /locus_tag="J26"
                     /product="nsjB lantibiotic dehydratase"
                     /protein_id="QGN18864.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.5e-71, bitscore:
                     230.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.9e-09,
                     bitscore: 25.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.2e-19, bitscore:
                     59.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHYIRNKQINFRKKLPKKRIDKNIADIKTEDLIDYFSKNDTFQEQ
                     ILVASPTLFFKVNHYIETYNISNKDYRNIGSSLFNYYLRSITRHTPFGLFSGVGVINKQ
                     SIPISYQKSIRVSYKWLLSIIKNIEKEHPNNLKFYVNNLITYKDYYLSIENHFSDENDL
                     YTDYNQPFEYIRSYNNKFTFNEIFKYLQKYFVEVDEEIIHKYLEELIEKELIISELRPS
                     LSITNKLSNVATKLSSIENYSDLAKQLKYLNKLFFEYQKTDIGNGISIYLQILSEMKKI
                     FKTGSQDIIVNLIYSDNLYQHLKIKEESIDELVNLLAYISNKYNVQDYYVEKFIEKFGV
                     DSEVPISVVVDGNLGIGLPKEGDVKAEIINDGIQQEINYKFWKSLYKNKTFSLDKLNIT
                     LPIDIENPYITESFELCIEHYHQKNKVKRYISPIKGSNNTDNMIGRFTLDNKKLLTDLN
                     PTRKYENALLCNINVIPKKISLTNVIESMFLGNSTLSINTSSGEKSTEIKLDNILVGYE
                     NNNLYFKDKNTQKNIIFRDKNMLNEQLKNPLIDLLLRYSHPRFSTIHNYPWSYMDNQMV
                     FYPEIKYKDIVVEPQRIRIYKDLLNLTSFKSFKKNINTLLEDVECNETLYFIMADNKIP
                     YINSDLSLNSLYKAIKKSKLEYAEFIDLPDHQECDESYELIYNFSFDKDDRKIINNNNK
                     KLWTHNNNRLMDPSQGWLYFKILFAKNEIDYFIKHYYHLIEKEILKTTKKFKIFYIKYT
                     ENDSYSLRFRIKLSSPNAYSNVITDITKFFKQLKSEGKIKAFSLQDYEREIERYGGVEG
                     VTYCEEVFYEDTKLTNYIIINTSEKYRLAYCCLSIYNYLNFYFESHVEIMKYLMKNFNV
                     KKKDFPKYNTYFRENKMVLDKLFINKDIEEDIDILLKNRIQKLLKLKDKEILNCEMLDS
                     LIHMSCNRILGIDRDKENGCIYLVYKLLDSLEKRRRKNNIT"
     gene            5303..6853
                     /locus_tag="J27"
     CDS             5303..6853
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 156.2; E-value:
                     1.9e-47)"
                     /gene_kind="transport"
                     /locus_tag="J27"
                     /product="nsjT ABC transporter ATP-binding protein"
                     /protein_id="QGN18865.1"
                     /transl_table=11
                     /translation="MVIELFSLICGPMIEYISLKIKKLSTLKIEKLILEKTSLVKYEML
                     ENSEFYSDLERFTQEGASKSYDLYETFISIITSLLLLTNATIYIFVINKYYAIVIIILT
                     LFSIYFLNKVSDEQFKIKWGRAEEERKSWYIKYISTHDFGFKELFSYRLFPYFRKIYTF
                     IEKKFIKQDLYLLKKISILNFIYEAIVLLVNFFLILFVVKGILKGTSSVGILTSISSLQ
                     QNMQDSIKKLVHDLYSLRYDKKMVAKLNSFLSNTEINRRTETGLELKDINIIDFKNVSY
                     SYDEIYVLKNINFTLKKGQNTAIVGKNGAGKSTVIKLLAQLYESYEGQININKIEFEKY
                     DLTSFLKKVSVLYQDFLKYEFTVKDNIGLGHIEKIDDISKIDAIKQLYCGSIRHISLKT
                     QLGNWFDSGQQLSGGQWQRIAIARTLMNENSSMILLDEPSSALDLESENYLFNNLMDNV
                     KRKNKIGVFISHRIASIKKADQIIVLEDGVIAGIGTHQYLLENCKEYQLLIEEENINE"
     gene            6846..8075
                     /locus_tag="J28"
     CDS             6846..8075
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     228.4; E-value: 2.3e-69)"
                     /gene_kind="biosynthetic"
                     /locus_tag="J28"
                     /product="nsjC Lanthionine synthetase C-like protein"
                     /protein_id="QGN18866.1"
                     /sec_met_domain="LANC_like (E-value: 4.6e-53, bitscore:
                     169.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENEIKKLFDLVYPYENLKRNKKEDKLWEDTALCSGYPGVILFI
                     SDYLKKKNLEGSIDQYVQKMIDAYNNMRTIDLSLFSGLSGVSFALSIIDYNKYESLINQ
                     STNYIIDNLMIFTNAIDEDDLKFEDYDLMSGLCGILLYLIYYYHKKPSKRLLNKIELSI
                     NKLLLIYDKNKFFVKSQYFFTEVEQKNYPNGGFNIGLSHGITGFLAVLIKYSDITNINH
                     RTKINNYKNKIYNDLISDGYNSHERYVWPQIKTNSFCKNEYAFFDSWCYGPPSIIYHLY
                     KVAKENHRINDKTMFEEMMKNIAKDIQGITSPSFCHGYAGLLTIFIEFNKLAGKEIIEE
                     NILNSISEKIMEFYNHNDFPFYENHYDIDSGRKYRFKDLGLLTGISGIGLSLLHLQNQN
                     SLQWFQVFTL"
     gene            8116..8298
                     /locus_tag="J29"
     CDS             8116..8298
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="J29"
                     /product="Nisin J"
                     /protein_id="QGN18867.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.9e-15, bitscore:
                     45.8, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 2.1e-08, bitscore:
                     22.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNQFNLKSKSANVSGSKGNNLETRITSKSLCTPGCKTGALQTCF
                     AKTATCHCSGHVHTK"
     CDS_motif       8116..8220
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MNNQFNLKSKSANVSGSKGNNLETRITSKSLCTPG"
                     /locus_tag="J29_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8221..8298
                     /prepeptide="core"
                     /locus_tag="J29_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-7.80"
                     /molecular_weight="2525.9"
                     /monoisotopic_mass="2524.2"
                     /core_sequence="CKTGALQTCFAKTATCHCSGHVHTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNQFNLKSKSANVSGSKGNNLETRITSKSLCTPG"
                     /leader_location="[8115:8220](+)"
                     /alternative_weights="2543.9"
                     /alternative_weights="2562.0"
     gene            8418..9758
                     /locus_tag="J30"
     CDS             8418..9758
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 177.4; E-value: 1e-53)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="J30"
                     /product="nsjP S8 family serine protease"
                     /protein_id="QGN18868.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.7e-34, bitscore:
                     107.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAKLLVSVLLVFLLFSTCQLNHSLYAETNSIYILTNAKNNFQQE
                     YRDKLKDLKNENVTITDTVPEIGLIEIKNNKNNRNKLRDRSFKETIYQKESKNSHIVNY
                     SKSQSWDMQLMAKSKDAKKRIKSGGRKIKVGVLDSGVSQKYKKTHPNILPSSKNFVGNI
                     SENEKGRSDDISDRVGHGTQVLSQLAGSDQNQGIIPNAKFNVYRIYSSNTVKSTWALKG
                     IIQSAKNNDDILNISSGKYLLISGKYKNGGNDKLEFEAWQRAINYATTKGTLVVSSIGE
                     ENINENNNDQLKKVLNKRQKIYNNKGIVKDVPSQLNNVVSIGSLNPENKISSFSNRSTK
                     TYYTPGGGLELYKKYGLKNYTKSMIEKELIPVYGLDGPTYSYGTSLSSPKAAGVIGHLI
                     EKESLYDNPKLTQEYLNLYKKQNGNKLSLDKLMKNNYHIDYPIKKAN"
ORIGIN
        1 atgaataatg cacttgaaat aaagaattta aataaaaaat atgaaaataa tagtatttta
       61 accgatttat ctattacagt aaaaaaaaat agaatatttg gattgttagg acctaatgga
      121 gcaggtaaaa ctacgctatt aaaaatagtc agtggaatca tttcacaaac aagcggtgac
      181 attgaaatgt ttggagaacc gtggaataga aaaaatttag actatatagg tgcattaatt
      241 gaaaagccag ctatatatga aaatttaact gcatatgaaa atttagagat tatttgtcaa
      301 ttattagacc tttcaaaaaa taaaattcct gaaactcttt caatagttgg tttaaataat
      361 attgatcata gaaaattaac gaaaaatttt tcattgggaa tgaaacaaag attaggaatt
      421 gctatggcaa tcataaatga tcctaaatta cttatattag atgaacctac taatggatta
      481 gacccaatag gtattcaaga gttaagagat ttaatcaaaa attttcccaa taaagggatg
      541 actgttatta tttcaagtca tattctatct gaaatagaaa ttattgctga tgatatatgt
      601 ataatatcta atggattatt aggctttcaa ggaactatag ataaccacaa aaatgacttg
      661 gaagatttat ttattcaaac tgttaagaaa aataaggaag gaaaataaaa tgaaattttt
      721 tgaaacagaa ttaaaaaaaa atagaagaac agccaacaaa aagttgatat ggataactcc
      781 ttgtatattt actttgttta gttttttagc ttctttatta atggtgccta gttctaaagg
      841 taacgtattt atagctggtg cctataactg gtttccacta ataatattac cttctattat
      901 tagtttatta gtggctaact ctataaattt agaaagaaaa aataaaaaca tagagtattt
      961 gaaatctaaa aacgttaatt taagtaaact atatttttat aaaagtgtaa ttgtatcttt
     1021 atttttattt agtataatca ttattgcatt ttttattatt tcaatagtta caatgatttt
     1081 aacacctagt actgtaaatt tattaccttt atttctagct aatataatgt tatttatttg
     1141 ctgcttaccg ttaataccag taagttatat aatcatagag ttaactaaca cattagtttt
     1201 actaacagta aattttatcg gtggtttgtt ggcatctata atttcaacaa caagtttttg
     1261 gattatatat ccgtggagtt attcatttag agctatagct cctttattga aaataaatcc
     1321 taacggaaca tttattgaag gagaaaataa tttatctaac attaataacg tgtttttagc
     1381 ttttgtttta gctattatat tctatttagt aggaatttta gttatgaact taattagtaa
     1441 gagggtattt aagtgattaa attatgtgaa atgcaatgga aaaaaacaaa aagaaacttt
     1501 ataaggatat tgatgttagt acttcctata atatattctt tagtaatgta tttatatttt
     1561 aatataagct cattagataa caataacaaa aaaactatat ttttcctttt gttattcata
     1621 tcagtacaat tttttttagc tatatacaca aatcaattca tacaaattga tagagatgct
     1681 aataatttta tacatgagtt gtcatcaaaa gtacctagaa gaaagatatt tttatcaaaa
     1741 gtaatattat taataatgat atcaatttct gtttatatat tatcggttag cgttttttta
     1801 ttattgaatt taatacataa agtagtttta attcatacgt atgaattatg cttgtatttt
     1861 ttattatcaa taatttttca aactccgacg ttacttttga acatctttgt ttcatataaa
     1921 tattcattat atggcatcgt tattatagca actattaatt ttttgacgac gatattaatt
     1981 gggactacac agcttggtgc tttgatttgg tattttgtac caagttcttg gggaagtaaa
     2041 tatatagtag atttcatccc tagtaacata tacactttag aaaacttatt tgtaatttta
     2101 ttgttgatag cagtagatat tattttaata tttactcaaa tattatggtt ctctcaatgg
     2161 gagggagagt cgaagtacag tgaaaattaa tattacttag ttaggggaat taagttgcat
     2221 tacattagaa ataaacaaat taatttcaga aaaaagcttc caaaaaaaag gatagataaa
     2281 aatatagcag atattaaaac tgaagattta attgactact tttcaaaaaa tgatacattt
     2341 caagaacaaa ttttagtagc aagtcctact ctttttttta aagtaaatca ttacatagaa
     2401 acgtacaaca ttagtaataa agattataga aatattggta gctctttatt taattattat
     2461 ttacgctcta taactcgtca tactcctttt ggtttattta gtggtgtggg agtaattaat
     2521 aaacagagta ttcctattag ttatcaaaaa agtattaggg tgagttataa atggttatta
     2581 tcaatcataa aaaatataga aaaagaacat cccaataatt tgaaatttta tgttaataat
     2641 ctaattacat acaaagatta ttacctaagt attgaaaatc atttctcaga tgaaaatgat
     2701 ttgtatactg attataatca gccttttgaa tatattagaa gttataataa caaatttacc
     2761 tttaatgaaa tatttaaata tttacagaaa tattttgttg aagtagatga agagattatt
     2821 cataaatatt tagaagaact tatagaaaaa gaactaatta tttcagaatt aagaccttct
     2881 ctatcaataa caaacaaatt atcaaatgtt gctactaaat tgtctagcat agaaaattat
     2941 tcagatttag caaagcaatt aaagtattta aataaattgt tttttgaata tcaaaaaact
     3001 gatattggta atggtatttc catctattta caaatattaa gtgaaatgaa aaaaatattt
     3061 aaaactggtt cacaggacat tattgtgaat ttgatttatt ccgataacct ataccaacat
     3121 ttgaaaataa aagaagaaag catagatgaa ttagttaatt tattagcgta tatttccaat
     3181 aaatataacg ttcaagacta ttatgtagaa aaattcatag aaaaatttgg tgttgatagt
     3241 gaagttccaa taagcgtagt tgttgatggg aatttaggaa tcgggttacc taaggaaggt
     3301 gatgtgaaag ctgaaataat taatgatggt atacaacaag aaattaatta taagttttgg
     3361 aaaagtcttt ataaaaacaa aacattttct ttagataagc ttaatataac attacccata
     3421 gatatagaaa acccatatat tactgaatcg tttgaattat gtatagagca ttatcatcaa
     3481 aaaaacaaag ttaaaagata tatttcacct ataaaaggtt cgaacaatac ggataatatg
     3541 ataggacgtt ttactttaga taacaaaaaa ttattaactg atttaaatcc tacaagaaaa
     3601 tatgaaaacg cgctgctatg taatataaat gttataccaa aaaaaatatc tttaaccaat
     3661 gttattgaga gtatgttttt aggtaattca acattgagta ttaatacaag ttcaggggaa
     3721 aaaagtacag agataaaatt ggataatatt ttagtaggat atgaaaacaa caatttatat
     3781 tttaaggata aaaacaccca aaaaaatatt atatttagag acaagaatat gttgaatgaa
     3841 caattaaaaa atccgttgat tgatttatta ttgagatatt cccatccaag attttcaact
     3901 attcataatt atccatggag ttatatggat aatcaaatgg ttttttatcc tgaaattaaa
     3961 tataaagata tcgttgtaga gcctcaacgt attagaattt ataaagattt attaaatctt
     4021 acttctttta aaagttttaa aaaaaatata aatactttat tagaagatgt tgagtgtaat
     4081 gaaacattat attttataat ggcagataat aaaatacctt atattaatag tgatttatct
     4141 ttaaatagtt tatataaagc aatcaaaaaa agtaaactag aatatgctga gtttatagat
     4201 ttacctgatc atcaagaatg tgatgaatct tatgaattaa tttataattt ttcttttgat
     4261 aaagatgaca gaaaaataat taataataat aacaaaaagt tatggacaca taataataat
     4321 aggttaatgg atccttctca aggatggtta tatttcaaaa tattattcgc taaaaatgaa
     4381 atagattatt ttataaaaca ttattatcat ttaatagaaa aagaaatatt aaaaacaacc
     4441 aaaaaattca aaatttttta tattaaatac actgaaaacg attcatattc tttaaggttt
     4501 agaattaaat tgtcatctcc taatgcttac tcaaatgtca taacagacat tactaaattt
     4561 tttaaacaac ttaaaagtga gggaaaaata aaagcatttt ctttacaaga ttatgagaga
     4621 gaaatagaga gatatggtgg agttgaaggt gtaacttatt gcgaagaagt tttttacgaa
     4681 gatacaaaac taactaacta cattattatt aatacatctg aaaaatatcg attagcttat
     4741 tgttgcttat cgatatataa ttatttgaat ttctattttg aaagtcatgt tgaaataatg
     4801 aaatatttaa tgaaaaactt taacgttaaa aagaaggatt tcccgaaata taatacatat
     4861 tttagagaaa ataaaatggt tttggataaa ctttttatta acaaagatat tgaagaagat
     4921 atcgatatat tgttgaaaaa tagaattcaa aaattactta aactaaaaga taaagaaatt
     4981 ctgaattgtg agatgttgga tagtctaata catatgtcgt gcaatagaat tttaggtatt
     5041 gatagagata aagaaaatgg gtgtatatat ttagtgtata aattgttaga tagtttagaa
     5101 aagaggagaa gaaaaaataa cattacttaa aaattttaat tttatattca aaatcaatag
     5161 aatattagtt tctatccatg ttgtttcttc aatttttatt acttttattc caatagcagc
     5221 tatatataca tttcaattgt ttataaataa cctggtatat acccaaaata tcagcatgac
     5281 tttcactatt ttaggaatat ttatggtcat agaattattt tctttaatat gtggaccaat
     5341 gattgaatat atcagtttaa aaatcaaaaa attatctaca ttaaaaatag aaaaattaat
     5401 attagaaaaa acgtctttag ttaaatatga aatgttggaa aatagtgaat tttattctga
     5461 tttagaaaga tttactcaag aaggggcttc taaatcttac gacttgtatg aaacttttat
     5521 ttcaatcata acttcattgt tattacttac taatgctact atatatatat ttgtgattaa
     5581 taaatattat gcaatagtta taataatttt aactttgttt tccatttatt ttttaaataa
     5641 agttagtgat gaacaattta aaataaaatg gggaagagca gaagaagaac gaaagtcgtg
     5701 gtatataaaa tatataagta cacatgattt tggatttaaa gaattatttt cttatagatt
     5761 gttcccttat tttagaaaaa tatacacttt tatagaaaag aaattcataa aacaagattt
     5821 atatttatta aaaaaaataa gtattttaaa ttttatatac gaagctattg ttttattagt
     5881 taactttttt ttaatattgt ttgtggttaa aggtatatta aaagggactt caagtgtagg
     5941 gatattgact agtatttcga gtcttcaaca aaacatgcaa gatagtataa aaaaacttgt
     6001 tcatgattta tattcattaa gatatgacaa aaaaatggta gctaaattga atagtttttt
     6061 atctaataca gaaataaata gaagaactga aacaggatta gaattaaaag atataaatat
     6121 aattgatttt aaaaatgtta gttatagtta tgatgaaatt tatgttttga aaaatataaa
     6181 tttcactctt aaaaagggtc aaaatactgc tatagtaggt aagaatggtg ccggtaagtc
     6241 aactgtaatt aaattattag ctcaacttta tgagtcatat gaagggcaaa taaatattaa
     6301 taaaatagaa tttgaaaaat atgatttaac atctttttta aaaaaagtat ctgtattata
     6361 tcaagatttt ttaaaatacg aattcacagt taaggataat ataggtttag ggcacattga
     6421 aaaaattgat gatatatcta aaattgatgc tataaagcaa ttatattgtg gatctatccg
     6481 tcatattagc ttaaaaactc aattaggaaa ttggttcgat agtggacaac aactttctgg
     6541 tggacaatgg caacgaattg ctatagctag aactttaatg aatgagaata gtagtatgat
     6601 acttttagac gagcctagtt cggctcttga tttagaatca gaaaattatt tatttaataa
     6661 cttaatggat aatgttaaaa gaaagaataa aataggtgtt ttcatttcac atagaatagc
     6721 ctctataaag aaagctgatc aaataattgt attagaagat ggagttattg ctggaattgg
     6781 gacacaccaa tatttattag aaaattgtaa agaatatcaa ttgttgattg aggaggaaaa
     6841 tattaatgaa tgagaatgag ataaaaaaat tatttgattt agtctatcct tatgagaatt
     6901 taaaaagaaa taaaaaagaa gataaactat gggaagatac ggctttgtgt tctggatatc
     6961 caggtgtaat tctgtttata agcgattatt taaaaaagaa gaatttagaa ggatctattg
     7021 atcagtatgt acaaaaaatg atagatgcat ataataatat gagaactatc gatttatcat
     7081 tattttctgg attatctggt gtgtcttttg ctttatcaat tattgactat aataaatatg
     7141 aatcattaat caaccaatca acaaactata taatagataa tttaatgatt tttacaaatg
     7201 ctatcgatga agatgattta aaatttgaag actatgattt aatgagtggt ttatgtggca
     7261 tcttacttta tcttatatac tattatcata aaaaaccatc taaacgtctg cttaacaaaa
     7321 tagaattatc tattaataaa ttactattga tatatgataa aaataaattt tttgttaaat
     7381 cacaatattt ttttactgaa gtagaacaaa agaattatcc taatggggga tttaatatag
     7441 gcttatctca tggtattaca ggatttttag ctgttttgat aaaatattct gatataacca
     7501 atattaatca tagaacaaaa ataaataatt ataaaaataa aatttacaat gacttaatta
     7561 gtgatggtta taatagtcat gaacgatatg tatggccaca aataaaaaca aatagttttt
     7621 gtaaaaatga atatgctttt ttcgacagtt ggtgttatgg gccaccctca ataatctatc
     7681 atttatataa agtcgctaaa gaaaaccata gaattaatga taagactatg tttgaagaaa
     7741 tgatgaaaaa catagccaag gatattcaag gaataacatc tccaagtttt tgtcatggct
     7801 acgcgggact gttaactata tttatagaat ttaataaatt agctggtaaa gaaattatag
     7861 aagaaaatat attaaattct attagtgaaa aaatcatgga attttataat cataatgatt
     7921 ttccatttta cgaaaatcat tatgatattg actctggtag aaaatatcga tttaaagact
     7981 tgggattatt aactggaatt tcaggtattg gcttatctct tttacattta caaaatcaga
     8041 attcactaca atggtttcaa gttttcactt tataactaag attagcagta ctgaacaaaa
     8101 aaaggagaga actttatgaa taaccaattt aatctaaaat caaaaagcgc taatgtaagc
     8161 ggctctaaag ggaataattt agaaactaga attactagta aatcactttg tacaccagga
     8221 tgtaaaactg gagcactaca aacatgcttt gctaaaactg caacttgcca ctgttctgga
     8281 cacgtgcata ctaaataata aagcgaacta tatataacat aaaaagtaca attattaatt
     8341 taatattttt actttgaaat tataaaaaat atgttcaggc tgctaatctt aattataaaa
     8401 tgaaaaggag attttttatg aaagcaaaac ttttagtatc agttttgtta gtatttttat
     8461 tattttcaac ttgtcaatta aatcattcat tatatgctga aactaatagt atttatatat
     8521 taaccaatgc taaaaataat ttccaacaag agtaccgtga taaattaaaa gatttaaaaa
     8581 acgaaaatgt tactatcact gatacagtac ctgaaattgg tttaattgaa ataaaaaata
     8641 acaaaaataa cagaaataaa ttaagagata gatcatttaa agaaacaatt tatcaaaaag
     8701 aaagcaaaaa cagtcatata gtaaactact ctaaatcaca atcttgggat atgcaattaa
     8761 tggctaaaag taaagatgct aaaaaaagaa ttaaaagtgg ggggaggaaa ataaaagttg
     8821 gtgttttaga ctctggtgta tctcaaaaat ataaaaaaac tcatcccaat atactaccta
     8881 gttctaaaaa ttttgtaggt aacatatctg aaaacgagaa gggacgttca gatgatataa
     8941 gtgatagagt gggtcatggt actcaagttt taagtcaatt agcaggtagt gaccaaaatc
     9001 aaggtattat acctaatgcc aaatttaatg tatatagaat atattctagt aatacagtaa
     9061 aatctacatg ggctctaaaa ggaattattc aatctgctaa aaataatgac gatattttaa
     9121 atattagttc aggcaaatat ttgttaattt caggtaaata caaaaatgga ggtaatgata
     9181 aattagaatt tgaagcatgg caacgtgcta tcaattatgc caccactaaa ggtacgttag
     9241 tggtatcgtc tataggtgaa gaaaatataa atgaaaataa caatgatcaa ttaaaaaaag
     9301 ttttaaataa acgacaaaaa atatacaata ataaaggaat tgtcaaagat gtaccgagcc
     9361 aattaaataa tgtcgtatct ataggatcct taaatccaga aaataaaata tcttcttttt
     9421 ccaatcgtag tacaaaaaca tattatactc ctggcggggg actagaatta tataaaaaat
     9481 atggattaaa aaattacaca aaaagtatga ttgaaaaaga attaataccc gtttatggtt
     9541 tagatggccc tacatactca tatggaactt ctttatcatc accaaaagct gctggagtta
     9601 ttggtcattt gatagaaaaa gagagtttat atgataatcc aaaattaaca caagaatatt
     9661 taaatttata caaaaagcaa aatggtaata agttatcttt agataaatta atgaaaaata
     9721 attaccacat agattatcca attaaaaaag ctaattaa
//
