BGC0002326: endopyrrole B biosynthetic gene cluster from Mycetohabitans rhizoxinica
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Location: 1 - 40,068 nt. (total: 40,068 nt).
This entry is originally from NCBI GenBank MN081797.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002326
Short description endopyrrole B biosynthetic gene cluster from Mycetohabitans rhizoxinica
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MN081797.1
1 - 40068
via Knock-out studies
Compounds
  • endopyrrole B
  • endopyrrole C
  • endopyrrole A
Species Mycetohabitans rhizoxinica [taxonomy]
References
Chemical products information
endopyrrole B Evidence:
(no structure information available)
endopyrrole C Evidence:
(no structure information available)
endopyrrole A Evidence:
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBRH_RS08130
  • QIH29223.1
 43 - 1185 (+) hypothetical protein
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    • RBRH_RS08125
    • QIH29224.1
    		 1223 - 1999 (+) putative metallo-hydrolase
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      • RBRH_RS08120
      • QIH29225.1
      • epyA
      		 2151 - 3296 (-) flavoprotein desaturase PigA
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        • RBRH_RS08115
        • QIH29226.1
        • epyB
        		 3280 - 4884 (-) adenylation domain protein
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          • RBRH_RS08110
          • QIH29227.1
          		 4881 - 5237 (-) hypothetical protein
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            • RBRH_RS08105
            • QIH29228.1
            • epyD
            		 6321 - 21920 (+) endopyrrole NRPS A
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              • RBRH_RS16740
              • QIH29229.1
              • epyE
              		 21878 - 32494 (+) endopyrrole NRPS B
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                • RBRH_RS08095
                • QIH29230.1
                		 32713 - 32949 (-) hypothetical protein
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                  • RBRH_RS17285
                  • QIH29231.1
                  		 34772 - 35107 (-) hypothetical protein
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                    • RBRH_RS08080
                    • QIH29232.1
                    		 35104 - 35556 (-) hypothetical protein
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                      • RBRH_RS17275
                      • QIH29233.1
                      		 36196 - 36456 (-) hypothetical protein
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                        • RBRH_RS08065
                        • QIH29234.1
                        		 36688 - 37950 (-) 50S ribosomal protein L16 3-hydroxylase
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                          • RBRH_RS08060
                          • QIH29235.1
                          		 37983 - 38546 (+) FKBP-type peptidyl-prolyl cis-trans isomerase
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                            • RBRH_RS08055
                            • QIH29236.1
                            		 38602 - 40068 (-) hypothetical protein
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              epyB
                              Substrates
                              proline (evidence: Structure-based inference, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              epyD
                              Substrates
                              valine (evidence: Structure-based inference [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              epyD
                              Substrates
                              proline (evidence: Structure-based inference [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              epyD
                              Substrates
                              valine (evidence: Structure-based inference [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              epyD
                              Substrates
                              valine (evidence: Structure-based inference [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk06
                              Type
                              nrps-type1
                              Genes
                              epyD
                              Substrates
                              threonine (evidence: Structure-based inference [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk07
                              Type
                              nrps-type1
                              Genes
                              epyE
                              Substrates
                              serine (evidence: Structure-based inference [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk08
                              Type
                              nrps-type1
                              Genes
                              epyE
                              Substrates
                              tyrosine (evidence: Structure-based inference [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk09
                              Type
                              nrps-type1
                              Genes
                              epyE
                              Substrates
                              tyrosine (evidence: Structure-based inference [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Entry added
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                              Detailed domain annotation
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