BGC0002327: bolagladin A biosynthetic gene cluster from Burkholderia gladioli
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Location: 1 - 43,824 nt. (total: 43,824 nt).
This entry is originally from NCBI GenBank MT844061.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002327
Short description bolagladin A biosynthetic gene cluster from Burkholderia gladioli
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT844061.1
1 - 43824
via Knock-out studies
Compounds
  • bolagladin A
  • bolagladin B
Species Burkholderia gladioli [taxonomy]
References
Chemical products information
bolagladin A Evidence:
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Chemical database entries
NPAtlas
bolagladin B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QNH85853.1
  • bolU
 1 - 2415 (+) BolU
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    • QNH85854.1
    • bolV
    		 2557 - 3558 (+) BolV
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      • QNH85855.1
      • bolw
      		 3618 - 4991 (+) BolW
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        • QNH85856.1
        • bolX
        		 4994 - 6076 (+) BolX
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          • QNH85857.1
          • boly
          		 6096 - 6986 (-) BolY
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            • QNH85858.1
            • bolz
            		 7016 - 7696 (+) BolZ
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              • QNH85833.1
              • bola
              		 8767 - 9786 (-) BolA
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                • QNH85834.1
                • bolB
                		 10358 - 12109 (+) BolB
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                  • QNH85835.1
                  • bolC
                  		 12235 - 12483 (+) BolC
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                    • QNH85836.1
                    • bolD
                    		 12511 - 13569 (+) BolD
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                      • QNH85837.1
                      • bolE
                      		 13650 - 15092 (+) BolE
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                        • QNH85838.1
                        • bolf
                        		 15168 - 16199 (+) BolF
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                          • QNH85839.1
                          • bolG
                          		 16235 - 17560 (+) BolG
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                            • QNH85840.1
                            • bolH
                            		 17650 - 31290 (+) BolH
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                              • QNH85841.1
                              • bolI
                              		 31305 - 31499 (+) BolI
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                                • QNH85842.1
                                • bolJ
                                		 31626 - 32048 (+) BolJ
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                                  • QNH85843.1
                                  • bolK
                                  		 32138 - 32623 (+) BolK
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                                    • QNH85844.1
                                    • bolL
                                    		 32708 - 33553 (-) BolL
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                                      • QNH85845.1
                                      • bolM
                                      		 33981 - 35075 (+) BolM
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                                        • QNH85846.1
                                        • bolN
                                        		 35065 - 36261 (+) BolN
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                                          • QNH85847.1
                                          • bolO
                                          		 36272 - 37855 (+) BolO
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                                            • QNH85848.1
                                            • bolP
                                            		 37949 - 38731 (+) BolP
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                                              • QNH85849.1
                                              • bolQ
                                              		 38728 - 40575 (+) BolQ
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                                                • QNH85850.1
                                                • bolR
                                                		 40559 - 41938 (+) BolR
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                                                  • QNH85852.1
                                                  • bolS
                                                  		 41982 - 42644 (+) BolS
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                                                    • QNH85851.1
                                                    • bolt
                                                    		 42648 - 43721 (+) BolT
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                                                      Biosynthesis information

                                                      Biosynthetic modules

                                                      Name
                                                      Unk01
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      bolH
                                                      Substrates
                                                      serine (evidence: Structure-based inference [2])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk02
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      bolH
                                                      Substrates
                                                      isoleucine, valine (evidence: Structure-based inference [2])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk03
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      bolH
                                                      Substrates
                                                      homoserine (evidence: Structure-based inference [2])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk04
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      bolH
                                                      Substrates
                                                      serine (evidence: Structure-based inference [2])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk05
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      bolO
                                                      Substrates
                                                      aspartic acid branched (evidence: Structure-based inference [2])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Annotation changelog

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-10-07
                                                      Added chemical structures for compounds: bolagladin B, bolagladin A.
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-10-07
                                                      Added NPAtlas links to compounds: bolagladin B, bolagladin A.
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Entry added
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Added NRP substrate specificities
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                      Detailed domain annotation
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