LOCUS       BGC0002332             13618 bp    DNA     linear   BCT 15-SEP-2019
DEFINITION  UNVERIFIED: Candidatus Entotheonella sp. isolate TSWB2 cep gene
            cluster, partial sequence.
ACCESSION   BGC0002332
VERSION     BGC0002332
KEYWORDS    .
SOURCE      Candidatus Entotheonella sp
  ORGANISM  Candidatus Entotheonella sp.
            Bacteria; Nitrospinae/Tectomicrobia group; Candidatus Tectomicrobia;
            Candidatus Entotheonella.
COMMENT     GenBank staff is unable to verify sequence and/or annotation
            provided by the submitter.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:20:38
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13618
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..13618
                     /altitude="-20 m"
                     /collection_date="2014"
                     /country="Israel"
                     /db_xref="taxon:2066855"
                     /host="Theonella swinhoei W"
                     /isolate="TSWB2"
                     /mol_type="genomic DNA"
                     /organism="Candidatus Entotheonella sp."
     misc_feature    <1..>13618
                     /note="cep gene cluster"
     protocluster    1..13618
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[10338:11463]"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10339..11463
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     cand_cluster    1..13618
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..13618
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002332"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13618
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             138..1160
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QEO32858.1"
                     /transl_table=11
                     /translation="MAVGEQRLKRMVRRTGKGEEDGTELTAILRQGDRTYRLYLPLSSE
                     GVDEARLRSQEDYEQMHFVWEQLQKQVCVSYGASRNISEYNDTRYSELNEMVQRQMTLF
                     DPLTQISSINVLLKGGEQAAPVLQTLYQLLREVLDTDILRVEKPNPANRLYFRQGDASI
                     ETIDLPDGFRATVAWLADLCATWHKIALHAAQQTDPKHISGIVLLDEIDLHLHPSLQRV
                     LVPRLRKVLPNVQFIVTTHSPMVLASFDRAELVVLDQDHQGAPRPLDRQVFGMSIDDVI
                     EWLMDTPSESKVIEEIMAEGTDADRALYLYQSKEANEERARRLLEERRSLLEELRDESS
                     "
     CDS             867..1160
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QEO32859.1"
                     /transl_table=11
                     /translation="MVLASFDRAELVVLDQDHQGAPRPLDRQVFGMSIDDVIEWLMDTP
                     SESKVIEEIMAEGTDADRALYLYQSKEANEERARRLLEERRSLLEELRDESS"
     CDS             complement(2216..3238)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083:oxidoreductase (Score: 162.5; E-value: 2.5e-49)"
                     /gene_kind="biosynthetic-additional"
                     /product="hypothetical protein"
                     /protein_id="QEO32860.1"
                     /transl_table=11
                     /translation="MAMRFGIRVPTQGTPQDTGIYAAKVEAAGFDFLWMPDTPLLAGRW
                     RDVYVHLTCAALNTSRLRLGPGVTNPLTRHPVATASAILSLDEASQGRADLVVGTGYSS
                     AYIIGRKAATRASMRQATELWRSIFQGQTTELGGLEINLMPPRPQLPIYLAATGPKMLQ
                     LAGEMADGVLIQVGAAPGTVAWALEQVEIGMQRAGRKRHEVERLLVITARVDADKPRVI
                     DHMRPSAAGMYRHQHAKTLLGTAGLSVPASLPAYPRPYPDLSHAVDWDEAKRVTTFVPD
                     EAVEALLAVGSAEEIIERVRALAALDIDAIWWRDEGSYAHPVDLAEALSREVLPRVRGA
                     "
     CDS             complement(3352..5640)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /product="hypothetical protein"
                     /protein_id="QEO32861.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.2e-11, bitscore:
                     34.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 6.2e-09, bitscore: 25.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPPELDLPPINARNHNLTLFMLRRLESHLDVRIRLHDLTDQFDM
                     GGGLIVANHFTRLETFVVPFVVHRATNITLRILASHVLFGNKTFGDYLMSIGALPTNHP
                     NKYELIARDILQGGWWLIFPEGGLIKDRRVIEKGRLNVTTDAGQVRRRPRSGSAILAMT
                     VQRYKAALRQALENNWETQTICESLGLGDRRPSELEALAFRPTPIIPLNITYYPLNPQD
                     NALKSLATRLMPNLPHTSFGQELLEELTVEGSMLLKGVEIDMRFGSPLLVGDDDVQLVD
                     DWRIVPWSASPWRRYLTALRSWRPMRPYTYLVDRWAVSSSWRQRQRAWQITRTTMQALY
                     RLATIHIDHLLSAMLLQTLRTTKQRRFEILDLQKRLYLAAQRLKENGNLALHPNLTDPD
                     LQYLLVTDTPHPFLEDFARRASELELLTCKDQIWEPNTDLLLEPWSFNSVRLKNFIQVY
                     FNEVEPVTEVIQAVRYAMRADLKAHQTTFSDAMHNYEDELYEADHAEFVTPETIAKLTP
                     LPPETGRPALLRGHGSHSAVGILLIHGFSASPGEVMPLAKSLNGQGFTVYVVRLRGHGT
                     SPYDLQQRSWQDWYDSVQRGYAYLRTITDTQFVGGMSTGGGLALYLSMHEPTVQGVFAV
                     AAPIKLANRAIHLAPLLKTVRGFVDSNPGNPNTNYLAFPVQALQELLHFITVYSKTLQN
                     VAIPTLLIQARGDTTVRPDSAQYIYDELGTTKKELIWKDVDQHVIVSDAFPDVHDDILT
                     FVQQHQPSR"
     CDS             complement(5790..7610)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QEO32862.1"
                     /transl_table=11
                     /translation="MTEPILLGLASIVVLGIAAQWLAWFIRIPSIFLLLLIGLAAGPLT
                     GWLHPQQLFGELLFPAVSLSVAVILFEGGLTLRTVVLRDIGRVLRNLVTLGVLVTWLIT
                     SVAAYFLLGLDRSMAVLIGAMLVVSGPTVVGPLLRHVRPIDRLRSTLQWEGILIDPIGV
                     LLAVLVFEVILIGELRAATTLVITGMLKMVVVGSALGFVSAKMVVWLIQRGLIPDYLHN
                     AVTLMVVVVSFTLANVLHHEAGLFTVTVMGIVMANQKAIIVRHIIEFKETLTVLLISGL
                     FILLSARLNFSDLAQLGWVSLAFLAVLILIARPAAVALSTMGSDMPWQERAFLAWVAPR
                     GIVAAAMASIFTLRLEAEGYAQADQLVPITFLVIIGCVAVYGLTAAPVARWLGVAQDNP
                     QGVLFIGASPLSRALAEALQAEDIATCLADSNWSNITTARLSGFKTHYGNALTENALDN
                     IDLDGIGRILALTSNDEANALAALHFAELFGRTEAYQLVPSTADSETVSHLRGHFLFDE
                     NANYNALSIHLATGATIKTTGLSEQFDYDTFQAYYQHCALSLFVITNSGDLLVWTTERP
                     LSPTPGQRIVSLISAATLAAVAADTVPDNT"
     CDS             7784..8206
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QEO32863.1"
                     /transl_table=11
                     /translation="MNDACVFCRIVAGVVPSHQVFEDDDVLAFMDHRPLNPGHVLVIPK
                     WHEPDIHRLDDHTYLAVMKAGKRLTEVLAELFEPPKVGLFVIGFHVPHVHVHVVPLYTI
                     DDFSADAIKLAMRTRPDEGALLETCRRIREPLSRTD"
     CDS             8242..9663
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QEO32864.1"
                     /transl_table=11
                     /translation="MVRWMNPQAAAADARRDRADLKLEFEDVFRNEALAGLKLATWGRL
                     VSLAVIAVLVFFLMPIPILYYYYILIAVFVLLGIIPYVLSSKGAGPWVVDAFIALDFAV
                     LTFTVFSPNPFDTNALPLQLLFRYDPIVYYFLLLSIVALSFSPRRMWLAGISAGLSWTA
                     GVVWLVTLPGSLTRWDHAPNLTPEQHYMEHLHPLFVDTNLWLQDLIVLLLMSGILALVV
                     RRSRQLVIRQAEVTRQRASLSRYFSPNVLDEVMDSAGPLTTVRKYDVAILFADIVGFTH
                     LCETIPPENIMDLLRNYHSRLEAEVFRFGGTLDKFIGDAVMASFGAPRPGSQDATQSLQ
                     CAQAMLRTMADWNAERELAGEVPIRIGIGIHYGPAVMGDVGSERCAAFAVIGDTTNTTS
                     RLQSLTRSLEAEVVASQTLLDAVQRETPDDKALLDGFEDAGWQAIRGRQNAMHVWILRD
                     LSQGESGITGISGPS"
     misc_feature    complement(9638..10346)
                     /note="similar to CepB"
     CDS             complement(10339..11463)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_C"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:chalcone and stilbene synthase domain protein
                     (Score: 358.4; E-value: 5.1e-109)"
                     /gene_kind="biosynthetic"
                     /note="phenolic lipid synthase; type III polyketide
                     synthase"
                     /product="CepA"
                     /protein_id="QEO32865.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 4.4e-32,
                     bitscore: 100.9, seeds: 21, tool: rule-based-clusters)"
                     /sec_met_domain="Chal_sti_synt_C (E-value: 1.1e-27,
                     bitscore: 86.6, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHETESTALWSIGTAVPDFHLSQQKVLAFALSRVPAEMVRHLQF
                     LYRRSQIDSRYSCSQALYNAIQFGTEAVTGDEMSTAERMQAYEAQAAELAATAAKRALA
                     QQPHFTAADITHLVMVTCTGFVAPGPDVVLFEHLGLQPDVRRVQVGFMGCHGAMNGLHT
                     ATAICRSEPQAVVLLVSVELCTLHFQTTPTEENLVISSLFGDGAAATLLSGRGYTEGQP
                     RCYLDAFGSRVYPEARHAIAWRVGNQGFDMGLALSNAKDLRPFIADFVDRWLSSHEMQQ
                     DDIDLWAIHPGGRAVLDTCERTLGLAPGALASSRAILRHYGNMSSATLLFVMDHLLEKA
                     DPQEPTRVRHGLSLGFGPGVTLEGILWHRGGGHG"
     CDS             11659..12189
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QEO32866.1"
                     /transl_table=11
                     /translation="MAASDGVMTALERNWAMVDAALAGLDETTLAWRPTAQCNSIAWNL
                     WHMNRVLDSFVNTRLQGTPQLWVQDGWHQQFGMGADPDERGVGWSMEQVAAWTPPNTEV
                     QLGYYEAIKAATRAYVTSLSFADLEVERVIPPVAEPRTVGAALGQVTWDNVSHGGQISF
                     LRGLFLGSGWFSR"
     CDS             complement(12186..12815)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QEO32867.1"
                     /transl_table=11
                     /translation="MAKTASLNPEPPDQFALKSTYDPALVAMLKNMPTDQRAWHAGRRV
                     WLIHISRHGYVLAILQQLHYQVTDHVEAAMAKAAQQTPPGIWLLAGHPDVGQMQAQCPV
                     CWNREQVFYHATYADAGGTTHVQFYSSACGHMWELCLQSAFGRLTSWTEVVEAAHDDDH
                     DLDDPTMETTTPHQLLEAHRQRLQTFDFDTWLEQAMDDEDEGDEAG"
     CDS             13032..>13618
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QEO32868.1"
                     /transl_table=11
                     /translation="MHQPGLNVYQPEKACQGYTLFSPMTASTTYLIDMQGAIVHRWSLL
                     GPRVGSYGYLLDNGHLLVNLRTGEEPLSFGGRGSRIVELDWEGRVLWEYAEPTLHHDFC
                     RMPNGNTMVLAWERVPDEMASDIQGGLPGTEHDEGIWGDCFREITPNHQVVWEWHGHEH
                     LDVKTDHIGPLHRRAEWTHANTCEVLPDGNIL"
ORIGIN
        1 tacgactggc tctagcggag gcctgatgcc ctctaagcct gatatcatgc ggctcaagaa
       61 ggctttgaga ctttgttcga gcaacattta agattttaca ggcaatctgc ctcctcctct
      121 taggtgaacg acgcagtatg gcggtcggcg agcaacgctt aaaacggatg gtgcgccgaa
      181 cgggcaaagg cgaagaggat ggcactgaac tcactgcaat cctgcggcaa ggtgatcgga
      241 cctatcgtct ctatctgcct ctatcttcag aaggcgttga tgaagctcga ctaagaagcc
      301 aggaagatta cgaacaaatg cacttcgttt gggaacagtt gcaaaagcag gtgtgtgttt
      361 cctacggcgc gtcgcggaat atttcggagt acaatgacac tcggtacagc gaactcaatg
      421 agatggtcca gcgtcagatg acgctttttg atccgttgac acagatttcg agcatcaacg
      481 tcttgctcaa agggggtgag caagcagcgc cagtcctaca gaccctctac caattgctgc
      541 gtgaagtgct tgatacggac attttgcgcg tcgaaaagcc aaaccctgcc aatcggctct
      601 attttcgtca aggcgatgct tctattgaaa cgattgatct gcctgacggt tttcgcgcta
      661 ccgtcgcatg gttggccgat ctctgtgcca catggcataa aatcgcgcta catgcagctc
      721 agcagaccga tccgaaacat atctccggta ttgtgttgct cgatgagatc gacttgcatt
      781 tacatccgag cctgcagcga gtcctcgttc ctcggcttcg caaagtgctc ccaaacgtgc
      841 agtttattgt caccacccat tccccaatgg tgcttgccag tttcgatcga gccgagttgg
      901 tggtgctcga tcaagatcac cagggggcgc cgcgaccgtt ggatcggcag gttttcggta
      961 tgtccatcga tgacgtgatc gagtggctga tggacacgcc gtccgaaagc aaggtgatcg
     1021 aagagatcat ggcagagggg accgatgcgg atcgagcact ctatctctat caatccaaag
     1081 aggccaatga agaacgtgct cgcaggcttc ttgaggaacg ccggagcctt ctcgaagagc
     1141 tacgcgatga atcctcatga ggcaattgca acggcccaat gtctccttgc cgacgctgat
     1201 acgcattgcc aacacctaca aaaacaagct gaacaaacta ccgagtaagg gcggtccccc
     1261 ggaagaccgc tggcggcatc ccgatgtccg tggcgcgctg tatgccatgc agggcgatgt
     1321 gtgtgcctac tgtcagcgcg agctctccga tagtgacccc ggcgatgtcg aacatttccg
     1381 gcctaagtcc aagtaccgtt ggctcatgta tgctttcagc aatttgtttc tgagttgccg
     1441 aaaatgtaac cagcgcctca agggagccga attcccgctc atccccggcg cccggcgcac
     1501 cccctactgg aaacggcgat tccttgcaaa cgaaaagcgg ctgctcattg atcctgctct
     1561 cgatcccgtc gaggattgga tacaggttga tttccaagac gatctgtggt tgttcaaatg
     1621 caaggatgcc tttccacctg accatatcgc gacactgcgg gtagaagaga cgatgagatt
     1681 tttcatgctc aatcagaata cccgattggt gaggagaagg agtgagcgtg tggaccaagc
     1741 gctacgtatc ctgaaagata tcaaaggggg tgatcatagg agacgtgaag aactccaaga
     1801 aatggcgagc cgttatcgac cgcatggcat cgccgttcgc catattctgg ccgagcacat
     1861 gcctgcactg cttccccgac cgaaagatga actcctttgg cttgtcaccg actttttagt
     1921 gctactcaaa gataaccttc gcaaacgttc tgaaacagat atacagcgcc gcatactgga
     1981 aaaagagaag gcagagctat gctggtctct cgccgtactc tgaaaggcgc cgccctctct
     2041 atcgcccgga gatgtcaaac gatggattac caaggtgggc ttgatcgctg aggttcgacc
     2101 tttttatgat cagctataag tgtttgcgta tctactctct ttccagcatg gcgaaactga
     2161 cttcttggta gggttcacct ggctcatgag gactgatgcg gataactaag catttttagg
     2221 ccccgcgcac acgtggcaac acctcccgcg acaacgcctc cgccagatca accggatgcg
     2281 cgtaactccc ctcatcacgc caccaaatcg cgtcgatatc cagtgccgcc agcgcccgaa
     2341 cgcgctcgat gatttcctcg gctgatccta ccgccaacaa cgcctcaact gcctcgtccg
     2401 gcacgaacgt ggtgacacgc ttggcctcgt cccaatccac cgcgtgcgac aaatcgggat
     2461 acggacgcgg atacgccggt agcgacgccg gcacgcttaa ccccgccgtt cccagcaggg
     2521 tcttggcgtg ttggtggcgg tacatgccgg ccgcactggg tcgcatatgg tcgatgacgc
     2581 gcggtttgtc cgcatcgacc cttgccgtaa tgactagcaa acgctccacc tcgtgtcgtt
     2641 tgcgaccggc gcgttgcata ccgatttcaa cttgctccaa ggcccaggcg acggtgccgg
     2701 gtgcggcgcc gacctggatt aagacgccgt ctgccatctc gcccgccaat tgcagcatct
     2761 tgggaccggt ggcggctagg taaattggca actgtggccg tggtggcatg agattgattt
     2821 ccaggccgcc caactcggtc gtctggccct gaaaaatgct gcgccacagc tcggtggctt
     2881 gtcgcatcga ggcccgtgtc gcggccttgc ggccaatgat gtaggctgag ctgtagcccg
     2941 ttcccaccac caggtcggcc cggccctggg atgcctcatc cagggataaa atcgcactgg
     3001 cggtggccac cggatggcgc gtcaaggggt tggtcacgcc ggggcccagt cgtaaccgcg
     3061 atgtgttcaa ggcggcacag gtgaggtgca catagacgtc gcgccagcgg ccggctaaca
     3121 ggggggtatc gggcatccag agaaaatcga atccggccgc ttcgactttt gcggcataga
     3181 tacccgtgtc ctgtggggtg ccttgcgtgg gcactcgaat tccaaagcgc atggccatct
     3241 ggtggactcc tatgaaacaa ggatgaagga tgaaatgaaa acgggagcga tcataacatg
     3301 aaggcgagga aatcgcacag ggggataggt gtgggagatt ggccaagccg gttaccgcga
     3361 tggctgatgc tgttgcacaa acgttagaat gtcgtcgtgc acatccggaa acgcgtcgct
     3421 gacgatgacg tgctggtcaa cgtctttcca aatgagttct ttttttgtcg tgccgagttc
     3481 gtcgtaaatg tactgtgcgc tatcgggtcg cacggtcgtg tcccctcgtg cttgaatgag
     3541 tagggtgggg atcgcgacat tttgcagggt tttggaataa accgtaataa agtggagtaa
     3601 ttcttgcagt gcttgcactg ggaaggccag atagttggtg ttgggattgc ctggattcga
     3661 atcgacaaag ccccgtaccg ttttgaggag gggggccagg tggatggcgc gattggccag
     3721 tttgatcggg gcggctacag cgaacacccc ttgtaccgtc ggttcgtgca tcgataaata
     3781 gagggcgagt ccgccgccgg ttgacatgcc gccgacaaat tgcgtgtccg tgatggtgcg
     3841 aagataggca taaccgcgct gaaccgagtc gtaccagtct tgccaactgc gttgttgcag
     3901 gtcgtagggc gaggtgccgt gaccgcggag ccggacgaca tataccgtga atccctgtcc
     3961 gttcaggctt ttggccaagg gcatgacttc gcccggtgag gcactaaaac catggatgag
     4021 gagaatgccg acggcgctgt gactgccgtg accgcgcagc agggccgggc gcccggtctc
     4081 aggcggtagc ggggtgagtt tcgcgatggt ttccggggtg acgaactcgg catggtccgc
     4141 ctcgtaaagt tcgtcttcat agttgtgcat ggcgtcgctg aacgtggtct ggtgcgcctt
     4201 aaggtcggcg cgcatggcgt agcgcaccgc ctgtatcact tcggtgacgg gctcgacttc
     4261 attgaagtag acttggatga agtttttgag ccgcacactg ttaaacgacc agggttcgag
     4321 cagtaggtcc gtgttcggtt cccaaatctg atccttgcag gtgagcaatt ccagttcact
     4381 ggctcgacgt gcaaagtctt cgagaaacgg atgcggggta tccgtgacca agagatattg
     4441 cagatccgga tcggtgaggt tgggatgcag cgccaaattt ccgttttcct taagacgttg
     4501 ggcggcgaga tagagacgct tttgaagatc caggatctca aaacggcgct gtttggtggt
     4561 gcgcaaggtc tggagcagca tggccgagag caggtgatcg atgtgaatgg tggccaatcg
     4621 atacagggcc tgcatggtgg tgcgcgtgat ttgccaagcc cgctggcgct gccgccaact
     4681 gctcgatacc gcccagcgat ctaccaaata ggtgtagggt cgcatggggc gccacgagcg
     4741 caaggcggtg agatagcgcc gccagggcga cgccgaccag gggacaatgc gccaatcatc
     4801 gacaagctgt acgtcgtcat cgccaaccag cagagggctg ccaaagcgca tgtcgatttc
     4861 tacccctttg aggagcatcg agccctcgac ggtgagctcc tctaataatt cttgtccaaa
     4921 ggaggtgtgg ggcagattgg gcatgaggcg tgtggccagg gatttgagcg cgttgtcttg
     4981 cggattgagc ggataatacg taatgttgag gggtatgatc ggggtggggc gaaaggccag
     5041 ggcctcaagt tctgatgggc gccgatcgcc cagcccgagc gactcgcaga tggtctgcgt
     5101 ctcccagtta ttctctaggg cttggcgcag agctgctttg tagcgttgca cggtcatggc
     5161 gaggatggcg gagcccgagc gcggtcggcg tcgcacctgg ccggcgtcgg tggtgacgtt
     5221 gagccttcct ttctcgatga cccggcggtc tttgatcaaa ccgccttccg gaaagatcaa
     5281 ccaccaccca ccctgcagaa tatcgcgggc gatcagttcg tatttgttgg gatgattggt
     5341 gggcagggcg ccgatgctca tcagataatc gccgaaggtt ttgttgccaa acaggacgtg
     5401 ggaggcgagg atccggagcg ttatattggt ggcgcggtgt accacaaacg gcaccacaaa
     5461 cgtctccagg cgggtgaagt ggttggcgac aatgaggccg ccacccatat cgaattggtc
     5521 ggtaagatcg tggagccgta tgcggacgtc gaggtggctt tccaggcgtc tgagcataaa
     5581 cagggttaga ttgtgattcc gagcgttaat cggcggtaga tccaactctg gcggttgcat
     5641 ggctagggtt gccttattgc tgatctggtg gtgcacatat acaagttaca atgggcaaca
     5701 aatacctacc tcataagtat aacgtcccga ccggcaatcg acaccccaat gatggggcca
     5761 atgatggggc caatgatgga gatggatgcc taggtgttgt cgggcacggt gtctgcggcc
     5821 accgcggcta gggtggcggc ggaaatcaaa ctcacgatgc gctgtccggg agtcggtgac
     5881 aggggccgct cggtagtcca caccagcaag tcgccgctat ttgtgatcac aaagagagac
     5941 aaggcgcagt gctgataata ggcctgaaag gtatcgtagt caaattgctc actgagaccg
     6001 gtggttttga tcgtcgcacc ggtggccaaa tggatgctga gcgcgttgta attggcgttt
     6061 tcatcaaaga gaaaatggcc gcgcagatgc gacacggttt cgctgtccgc ggtgctggga
     6121 acgagttgat acgcttcggt gcgcccgaat agttcggcga agtggagggc ggcaagggca
     6181 ttggcttcat cattggaggt gagcgcgagg atgcgaccaa tgccgtcgag atcgatgttg
     6241 tcgagggcgt tttcggtgag ggcattgcca taatgggttt tgaagccgct caagcgggcg
     6301 gtggtaatat tggaccagtt gctatcggcc aagcaggtgg cgatgtcttc ggcttggagg
     6361 gcttcggcta gcgcccgcga cagcggcgag gcgccgatga agagaacgcc ttggggattg
     6421 tcttgagcca cccccagcca gcgcgccact ggggcggcgg tgagaccgta aaccgcgacg
     6481 cagccaatga tgaccaaaaa ggtaatcggc acgagttggt cggcttgcgc atagccttca
     6541 gcttctaagc gcaaggtgaa aatggaggcc atggccgccg ccacaatgcc gcgcggcgcc
     6601 acccaagcga ggaaggcgcg ctcttgccaa ggcatgtccg agcccatggt ggagagcgcc
     6661 accgcggccg ggcgggcgat gaggatgagc acggccagaa aggcgagact gacccaaccc
     6721 aattgggcga gatcgctgaa gtttaagcgg gcggataaaa gaatgaatag gccggagatc
     6781 agcaggaccg tcagggtttc tttgaactcg ataatgtgcc gcacaataat ggctttttgg
     6841 ttggccatga cgatgcccat gacggtgacg gtaaacaagc cggcttcgtg atggagcaca
     6901 ttggcgaggg taaaggagac caccacgacc atgagggtga cggcattgtg cagatagtcg
     6961 ggtatgaggc cacgctggat gagccatacc accattttgg cactgacaaa ccccagtgca
     7021 ctgccgacca ccaccatttt gagcatgccg gtgatcacca aggtggtggc cgcgcgcagt
     7081 tcgcctatga gaatcacttc aaagacgaga accgcgagca ggaccccaat ggggtcgatg
     7141 agaatcccct cccattgcaa cgtcgagcgc aagcggtcga tgggacggac atgtcgcaag
     7201 agcggtccga ccacggtggg gccagagacc accagcatgg cgccgatgag tacggccatc
     7261 gagcggtcga gccctagaag gaaataggct gcgacagagg taatgagcca agtgacgagc
     7321 acgccaagcg tgacgagatt gcgcaagact cggccaatat ctcgcaggac caccgtccgg
     7381 agggtgagcc cgccttcaaa taaaatgact gctacggata gcgatacggc tgggaacaac
     7441 agctcgccaa agagctgttg cgggtgcaac cacccggtga gaggccctgc ggccaagccg
     7501 attagcagca gtagaaagat cgaggggatg cggataaacc aggcgagcca ttgggcggca
     7561 atgcccagga ccacgatgct ggcgaggccg agaaggatgg gttcggtcat gcggatgctc
     7621 cggtagatga atgctcaggt gatgtatcgc agtgtagtat gtgatgtcga ggggaggccg
     7681 tcaagtcacg agcagaagct gttttgctca atcgagcgta taatagacgc gatggtgatc
     7741 gtttgagggc aaaggccaac aagaacgtgc caaaaggaat gtgatgaacg acgcatgtgt
     7801 tttttgccgc attgttgctg gggtggtacc ttctcaccag gtgtttgaag atgacgatgt
     7861 gttggcgttt atggatcatc ggccgttgaa tccgggccac gtgctcgtga ttcccaaatg
     7921 gcatgaaccc gatatacacc gtctggatga ccacacctat ctggcggtca tgaaggcggg
     7981 caaacggttg actgaagtcc tggccgagtt gtttgaaccg ccaaaagtcg gcctttttgt
     8041 cattggcttt cacgtgccgc acgtgcatgt gcacgtcgtg ccgctttaca ccatcgacga
     8101 tttttcggcc gacgcgatta agctggccat gcggacgcgc ccggatgagg gtgcgctgct
     8161 agagacctgc cggcgcatcc gcgagccctt gtcaagaact gactgacgaa tgcatcgcct
     8221 aaggctgaac ggagatcaac aatggtgaga tggatgaacc ctcaagccgc cgccgctgat
     8281 gcacggcgag atcgcgctga tctcaagctt gagtttgaag atgtgtttcg caacgaggct
     8341 ctggccgggc tcaaattggc cacctggggg cggcttgtgt ctttggccgt gattgcggta
     8401 ttggtgttct ttctgatgcc tatacccatt ttgtattact attacattct catcgcggtc
     8461 tttgtactcc taggcattat tccgtatgtc ctgagcagca agggcgcagg cccctgggtc
     8521 gtcgacgcct tcattgcctt ggatttcgcc gtgttgacgt ttactgtgtt ttcgcccaac
     8581 ccctttgaca cgaatgcact gccactgcaa ttgctctttc gctatgaccc cattgtctac
     8641 tactttttgt tgttatctat tgtcgccttg agcttctcac ctcgccgcat gtggttggcc
     8701 ggcatctccg ccggactgag ttggacggcg ggtgtggttt ggctggtcac cttacccggc
     8761 tcactcacgc gatgggatca tgcgccgaat ttgacgcctg agcagcatta catggagcat
     8821 cttcaccctc tctttgtgga taccaacttg tggttgcaag acctcattgt cttgttgctc
     8881 atgtccggta ttctggcctt ggtggtgcgg cggtcgcggc agttggtcat ccgccaggcc
     8941 gaggtcacgc gtcaacgcgc ctctttgtcg cgctattttt cgcctaatgt gttggatgaa
     9001 gtcatggaca gcgcggggcc actcaccacg gtgcgcaagt acgacgtggc gattttgttt
     9061 gccgatattg tcggctttac acacctgtgt gaaacgatac cgccggaaaa tatcatggac
     9121 ctgctgcgca actatcacag tcgcctagag gcagaggtgt ttcgctttgg cggcacgctc
     9181 gacaagttta ttggcgatgc ggtcatggcc tcgtttggtg cgccccgtcc cggctcccaa
     9241 gatgccacgc agagcttgca atgtgcccag gcgatgctcc ggaccatggc cgactggaat
     9301 gcagagcgcg agctggctgg ggaggtgccg attcgcattg gcataggtat tcactatggc
     9361 ccggcggtga tgggggatgt cggtagcgag cgttgtgccg cctttgcggt gatcggggac
     9421 acgacgaaca caacaagtcg cctgcaatcg ctcacccgca gtttagaggc ggaagttgtg
     9481 gccagccaga cgctactgga cgcggtgcag cgggagacac cagatgataa ggcgctgctc
     9541 gacggcttcg aagacgcggg gtggcaagcg attcggggtc gccaaaacgc catgcatgtc
     9601 tggatactca gggacttgtc gcagggtgag tccggcatca ctggcatttc tgggccgtca
     9661 tgacgtagcg aaaaggccac cgccaggtga tggccgagtt cgttaaccca ctcatctcgc
     9721 tcaatgcctc aagatcggct ctctgaaagc cacgcagcac actgatcggg ccatcgtgtt
     9781 gaaacatggg gctgagtgac aagaggcgac ccagccaggt aatgctgtaa tatgccaagg
     9841 gatggcggtg caggtcattg acgatgatgc cgcggtggca gaggttatac atgatccgta
     9901 aaatggcggc ggctcgtggc tgtgggaaat ggtgcaggaa catcgcacag tgcaccacgt
     9961 caaacgtttc tgagtccgtc atggcaaaga catccgcttc ccggacggta atctccgagt
    10021 aggcagcggt gcgctgccgt gccacttcac agatggcggg gttaaaatcc accgccgtga
    10081 tgtccatcgc gatccccccg ccggcgagcc cagcgcacca gggcaatagg aatatccgct
    10141 gaaccggtac ccaaatcgag caagcttaag gactgccgat tgtcggttgt cagcaagcgg
    10201 ttgagcgcat ctcgcgtggc gttgatgccg ccgagcagac ggttgacata cgcgatctcg
    10261 ttgagcgtcg cgaccacctc ctcgccgtcg atcgtggcat gatccatata ctcggacgcc
    10321 gtactgcgct gccggaagtc aaccatgtcc gccgcctcgg tgccacagga tcccttctaa
    10381 agtcacccca ggcccaaagc cgagtgacag cccgtgtcgc acccgcgtcg gctcctgcgg
    10441 atctgctttc tcaagcaagt gatccatgac aaataacagg gttgccgacg acatattgcc
    10501 atagtggcgc aggatcgccc gcgagctggc cagggcacct ggggcaagcc ccagcgtccg
    10561 ctcacaggta tcgagcacgg ctcggccgcc cggatgaatt gcccagagat cgatatcatc
    10621 ctgctgcatc tcgtgagacg agagccaacg gtccacaaaa tccgcgatga acggacggag
    10681 atctttggca ttggacaggg ccaagcccat gtcaaacccc tgattgccca cccgccaagc
    10741 aatggcatgg cgcgcctccg ggtagacccg cgagccaaag gcatcgaggt agcaacgcgg
    10801 ctgaccttcc gtataccctc gcccactgag cagcgtggcg gcggccccat cgccgaacag
    10861 actggaaatg accagattct cttccgtcgg ggtggtctga aagtggaggg tgcagagttc
    10921 gacgctgacc aacagcacca cggcctgcgg ctcgctgcgg cagatcgcgg tggcggtgtg
    10981 cagaccattc atcgccccat ggcaccccat gaaccccact tggacgcgcc gcacgtccgg
    11041 ttgcaacccg aggtgctcaa agagcaccac atctggccca ggcgctacaa agcccgtgca
    11101 cgtcaccatc accaggtggg tgatatcggc cgccgtgaag tgcggctgct gagccagtgc
    11161 ccgcttggcc gccgtcgccg cgagctccgc cgcctgagct tcgtacgcct gcatgcgctc
    11221 tgcggtgctc atctcatccc ccgtcaccgc ctcggtccca aactgaatcg cattgtagag
    11281 ggcctgactg cagctataac gcgagtcgat ctgcgaacgc cggtagagaa actggaggtg
    11341 cctgaccatc tccgctggaa cacgggagag cgcaaacgcc aggacttttt gctggctgag
    11401 gtggaagtcc ggcaccgccg tgccaatgga ccacagcgcg gtcgactctg tctcgtggct
    11461 cacatcgggc tccttgcgag aggttgtagg tcatcggagg gacatgtgga ctcgatcaac
    11521 atgttaacgt gggggttaat atcgtgcaaa tgtttcgaca attctttatg gtggagttga
    11581 ttggcgactg gccaatccct ttttccacgt catgaatgac ttggcgtccg tatcaatgcg
    11641 tatcaaggag ggatcaacat ggctgcatca gatggcgtga tgaccgcgct cgagcgcaac
    11701 tgggcaatgg tcgatgccgc attggcgggg ctcgatgaga cgactttggc atggcgtcca
    11761 accgcccagt gcaattcgat tgcctggaat ctgtggcaca tgaaccgggt gttggattcg
    11821 tttgtaaata cgcgattgca aggcacgccg caactgtggg tgcaagacgg atggcatcag
    11881 cagttcggca tgggcgccga tcccgacgag cgcggagtgg gctggagcat ggagcaagtg
    11941 gccgcatgga cgcccccgaa tacagaggta caactcggtt actacgaggc gattaaagcc
    12001 gccacgcggg cgtatgtgac atcgttgagt tttgcagact tagaagtcga acgggttatt
    12061 ccgccagtag ccgagccccg caccgtgggc gccgcgctgg gtcaagtgac gtgggacaac
    12121 gtgtcgcacg gtggacaaat ttcatttttg cgggggctgt ttttaggcag cggctggttc
    12181 agccgttagc ccgcttcatc gccttcgtct tcgtcatcca tcgcttgttc gagccaggta
    12241 tcgaagtcga aggtttgcaa gcgttgccga tgggcttcca gcagttgatg gggcgtggtg
    12301 gtttccatgg ttgggtcatc gagatcatga tcatcatcat gggcggcttc gaccacctcg
    12361 gtccaagagg tcaaccgacc aaaggcggat tgcaaacaca gctcccacat gtggccacac
    12421 gccgagctgt aaaattgcac gtgtgtggtg ccgcccgcat ccgcgtaagt ggcgtgataa
    12481 aatacttgct cgcggttcca acacaccggg cattgggcct gcatttgacc cacgtcggga
    12541 tgcccggcca agagccaaat gccgggcggg gtttgttgcg ccgccttggc catggcggct
    12601 tcgacatggt ccgtcacctg ataatggagt tgctgcagga tggccaatac atagccgtga
    12661 cggctgatat gaatgagcca tacccggcgc ccagcatgcc aggcacgctg atcggtcggc
    12721 atgtttttga gcatggcgac gagggctggg tcgtatgtgc ttttgagtgc gaattggtcc
    12781 gggggttccg gattgagaga tgccgttttg gccatatctc acctcgtgtc gccagcctgg
    12841 tgccatcggc gattgcggtt gtcgttgtag atgttgtggc ggctctcatc acacatacag
    12901 tttcgcattt ttcaatggct gtcaagggag aataccgatc tggtgccagc ccgcattctc
    12961 tagtaggatc caaccccatc gccagccaca tcgattgaaa aaccgcatcg attgaaatgg
    13021 aagggatgac catgcaccaa cctggcttga acgtctatca acctgagaaa gcctgccagg
    13081 gttacaccct ttttagcccg atgaccgcga gcacgacgta cctgatcgat atgcaagggg
    13141 ccattgtgca ccgctggtcc ttgctagggc ctcgggtggg ttcctacggc tatttgttgg
    13201 acaacggcca ccttttggtg aatctgcgca ccggcgagga accgctgtcg ttcgggggac
    13261 gcggcagccg cattgtcgaa ttggactggg agggtcgggt gctgtgggag tatgccgagc
    13321 ctacgttgca ccacgacttt tgccgtatgc ccaacggcaa caccatggtg ctggcgtggg
    13381 agcgggtgcc ggatgagatg gcgtcagata ttcaaggcgg cttgccgggc acggagcacg
    13441 acgagggcat ctggggcgat tgttttcgtg agatcacccc gaatcaccag gtggtgtggg
    13501 agtggcatgg ccacgaacac ttggatgtga agacagacca cattggccct ctgcaccggc
    13561 gggcggagtg gacgcatgcc aacacttgcg aggtgttgcc cgatggcaat atcttgat
//
