BGC0002333 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002333 (Streptomyces cyanogenus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	87,922	High	lucensomycin	PKS

BGC0002333 - Region 1 - T1PKS

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Location: 1 - 87,922 nt. (total: 87,922 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 87,923
Label		BGC0002333

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

lcm10: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

lcm6: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

lcmA: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase glycosyltransferase

lcm4: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

lcm5: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: esterase

lcm3: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

lcm2: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

lcmB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

lcmC: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

lcmD: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002333.3	1.00	PKS	lucensomycin	Streptomyces cyanogenus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000041.3	0.65	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.5	0.63	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002333.3	1.00	PKS	lucensomycin	Streptomyces cyanogenus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000041.3	0.65	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.5	0.63	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 87922:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - redmal) + (ohmal - ccmal - ccmal - ccmal) + (ccmal - ohmal - Me-ohmal - ohmal - mal - ohmal) + (ccmal) + (ccmal)
Non-colinear ordering:: lcmA + lcmB + lcmC + lcmD + lcmE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

lcmB: mal - mal - mal - mal

PKS_AT (552..827): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.3
inactive: 96.1
Methoxymalonyl-CoA: 65.4
Methylmalonyl-CoA: 51.2
Propionyl-CoA: 23.0
Isobutyryl-CoA: 20.7
Ethylmalonyl-CoA: 17.1
fatty_acid: 11.3
Acetyl-CoA: 10.0
Benzoyl-CoA: 7.2
CHC-CoA: 6.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2010..2285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.8
inactive: 88.6
Methoxymalonyl-CoA: 56.0
Methylmalonyl-CoA: 43.5
Propionyl-CoA: 20.9
Acetyl-CoA: 14.2
Isobutyryl-CoA: 13.4
fatty_acid: 11.0
Benzoyl-CoA: 8.7
CHC-CoA: 6.0
Ethylmalonyl-CoA: 2.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (3680..3955): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.5
inactive: 95.6
Methoxymalonyl-CoA: 64.9
Methylmalonyl-CoA: 51.6
Propionyl-CoA: 23.0
Isobutyryl-CoA: 20.5
Ethylmalonyl-CoA: 17.5
fatty_acid: 11.3
Acetyl-CoA: 10.3
CHC-CoA: 8.6
Benzoyl-CoA: 5.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (5290..5565): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.9
inactive: 92.1
Methoxymalonyl-CoA: 61.1
Methylmalonyl-CoA: 47.0
Propionyl-CoA: 18.7
Isobutyryl-CoA: 18.2
fatty_acid: 11.0
Acetyl-CoA: 10.8
Ethylmalonyl-CoA: 9.2
CHC-CoA: 6.4
Benzoyl-CoA: 5.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

lcmA: mmal - mal

PKS_AT (531..828): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.7
Ethylmalonyl-CoA: 195.0
Methoxymalonyl-CoA: 171.2
2-Methylbutyryl-CoA: 130.4
trans-1,2-CPDA: 126.4
Propionyl-CoA: 108.0
CHC-CoA: 99.9
Isobutyryl-CoA: 86.8
Malonyl-CoA: 82.8
Benzoyl-CoA: 57.1
3-Methylbutyryl-CoA: 41.6
Acetyl-CoA: 40.5
fatty_acid: 28.6
inactive: 17.3

PKS_AT (1509..1794): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 182.6
inactive: 76.5
Methoxymalonyl-CoA: 52.9
Methylmalonyl-CoA: 43.0
Propionyl-CoA: 18.6
Isobutyryl-CoA: 17.9
Ethylmalonyl-CoA: 17.4
Acetyl-CoA: 16.6
Benzoyl-CoA: 10.3
CHC-CoA: 10.2
trans-1,2-CPDA: 9.2
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

lcmE: mal

PKS_AT (556..831): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.5
inactive: 88.1
Methoxymalonyl-CoA: 55.2
Methylmalonyl-CoA: 45.3
Isobutyryl-CoA: 27.1
Ethylmalonyl-CoA: 21.8
Propionyl-CoA: 20.7
Acetyl-CoA: 18.8
Benzoyl-CoA: 12.6
fatty_acid: 9.5
CHC-CoA: 7.2
2-Methylbutyryl-CoA: 5.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

lcmD: mal

PKS_AT (557..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.7
inactive: 67.6
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 50.4
Ethylmalonyl-CoA: 30.8
fatty_acid: 29.7
Propionyl-CoA: 26.3
Isobutyryl-CoA: 14.9
Acetyl-CoA: 14.0
2-Methylbutyryl-CoA: 11.5
Benzoyl-CoA: 8.0
trans-1,2-CPDA: 6.0
CHC-CoA: 5.7
3-Methylbutyryl-CoA: 3.1

lcmC: mal - mal - mmal - mal - mal - mal

PKS_AT (562..852): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 223.0
inactive: 104.1
Methoxymalonyl-CoA: 74.6
Methylmalonyl-CoA: 65.1
Isobutyryl-CoA: 35.8
Propionyl-CoA: 30.7
Benzoyl-CoA: 24.6
Ethylmalonyl-CoA: 22.7
Acetyl-CoA: 22.7
CHC-CoA: 17.2
2-Methylbutyryl-CoA: 13.8
trans-1,2-CPDA: 10.6
fatty_acid: 9.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (2276..2558): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.0
inactive: 99.9
Methoxymalonyl-CoA: 63.2
Methylmalonyl-CoA: 58.8
Ethylmalonyl-CoA: 33.1
Propionyl-CoA: 31.0
Isobutyryl-CoA: 24.6
Acetyl-CoA: 23.6
Benzoyl-CoA: 20.9
2-Methylbutyryl-CoA: 15.7
trans-1,2-CPDA: 14.4
fatty_acid: 9.9
3-Methylbutyryl-CoA: 9.4
CHC-CoA: 9.3

PKS_AT (3757..4053): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.1
Ethylmalonyl-CoA: 199.2
Methoxymalonyl-CoA: 172.5
2-Methylbutyryl-CoA: 138.1
trans-1,2-CPDA: 126.9
Propionyl-CoA: 107.3
CHC-CoA: 100.8
Malonyl-CoA: 93.0
Isobutyryl-CoA: 82.7
Benzoyl-CoA: 66.1
fatty_acid: 39.1
Acetyl-CoA: 38.5
3-Methylbutyryl-CoA: 29.7
inactive: 27.0

PKS_AT (5278..5570): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 226.8
inactive: 125.2
Methoxymalonyl-CoA: 59.0
Methylmalonyl-CoA: 56.7
Propionyl-CoA: 25.9
Isobutyryl-CoA: 24.3
Ethylmalonyl-CoA: 21.1
Acetyl-CoA: 20.1
Benzoyl-CoA: 17.9
fatty_acid: 13.6
CHC-CoA: 12.6
2-Methylbutyryl-CoA: 11.5
trans-1,2-CPDA: 10.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (6763..7048): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.7
inactive: 104.4
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 52.9
Propionyl-CoA: 30.8
Isobutyryl-CoA: 26.7
Benzoyl-CoA: 21.9
Ethylmalonyl-CoA: 20.7
Acetyl-CoA: 14.8
CHC-CoA: 12.1
fatty_acid: 9.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (8181..8476): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 229.8
inactive: 113.2
Methoxymalonyl-CoA: 70.7
Methylmalonyl-CoA: 66.9
Propionyl-CoA: 41.5
Isobutyryl-CoA: 25.6
Benzoyl-CoA: 22.6
Acetyl-CoA: 22.6
Ethylmalonyl-CoA: 20.0
CHC-CoA: 12.9
2-Methylbutyryl-CoA: 11.8
trans-1,2-CPDA: 6.6
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor