BGC0002336: bolagladin A biosynthetic gene cluster from Burkholderia gladioli
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Location: 2,674,967 - 2,728,619 nt. (total: 53,653 nt).
This entry is originally from NCBI GenBank NZ_CADEQC010000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General information about the BGC

MIBiG accession | BGC0002336
Short description | bolagladin A biosynthetic gene cluster from Burkholderia gladioli
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)

Loci
NZ_CADEQC010000001.1
2674967 - 2728619
via Knock-out studies, Enzymatic assays
Compounds

- bolagladin A
- bolagladin B

Species Burkholderia gladioli [taxonomy]
References

- [1] Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates**. Dashti, Y et al., Angewandte Chemie (2020) DOI:10.1002/ange.202009110
- [2] Discovery and biosynthesis of gladiochelins: unusual lipodepsipeptide siderophores fromBurkholderia gladioli. Dashti, Y et al., preprint (2020) DOI:10.1101/2020.06.16.153940
- [3] An unusual . Jenner M et al., Chem Sci (2019) PMID:31293732

Chemical products information
bolagladin A Evidence: NMR [1]
Copy SMILES
C39H61N5O14
bolagladin B Evidence: NMR [1]
Copy SMILES
C40H63N5O14
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
H9D14_RS10815 WP_103692572.1 | 2675818 - 2676738 (+) | LysR family transcriptional regulator |  |  | copy AA seq copy Nt seq
H9D14_RS10820 WP_105827528.1 | 2676820 - 2677224 (+) | DUF2946 domain-containing protein |  |  | copy AA seq copy Nt seq
H9D14_RS10825 WP_126241396.1 | 2677300 - 2679717 (+) | TonB-dependent receptor |  |  | copy AA seq copy Nt seq
H9D14_RS10830 WP_126241397.1 rbsK | 2679933 - 2680859 (+) | ribokinase |  |  | copy AA seq copy Nt seq
H9D14_RS10835 WP_126241398.1 fucP | 2680919 - 2682292 (+) | L-fucose:H+ symporter permease |  |  | copy AA seq copy Nt seq
H9D14_RS10840 WP_126241399.1 | 2682295 - 2683377 (+) | aldose 1-epimerase family protein |  |  | copy AA seq copy Nt seq
H9D14_RS10845 WP_103692576.1 deoR | 2683397 - 2684167 (-) | DNA-binding transcriptional repressor DeoR |  |  | copy AA seq copy Nt seq
H9D14_RS10850 WP_036055817.1 deoC | 2684317 - 2684997 (+) | deoxyribose-phosphate aldolase |  |  | copy AA seq copy Nt seq
H9D14_RS10855 WP_126241400.1 | 2685120 - 2685542 (-) | type II toxin-antitoxin system VapC family toxin |  |  | copy AA seq copy Nt seq
H9D14_RS10860 WP_043216562.1 | 2685529 - 2685762 (-) | DNA-binding protein |  |  | copy AA seq copy Nt seq
H9D14_RS10865 WP_105850350.1 | 2686084 - 2687073 (-) | LysR substrate-binding domain-containing protein |  |  | copy AA seq copy Nt seq
H9D14_RS10870 WP_241238501.1 | 2687693 - 2689426 (+) | AMP-binding protein |  |  | copy AA seq copy Nt seq
H9D14_RS10875 WP_013690725.1 | 2689551 - 2689799 (+) | acyl carrier protein |  |  | copy AA seq copy Nt seq
H9D14_RS10880 WP_105850352.1 | 2689897 - 2690886 (+) | ferritin-like domain-containing protein |  |  | copy AA seq copy Nt seq
H9D14_RS10885 WP_105850353.1 | 2690967 - 2692409 (+) | FAD-binding oxidoreductase |  |  | copy AA seq copy Nt seq
H9D14_RS10890 WP_036055811.1 | 2692485 - 2693516 (+) | fatty acid desaturase family protein |  |  | copy AA seq copy Nt seq
H9D14_RS10895 WP_126241402.1 | 2693552 - 2694877 (+) | MFS transporter |  |  | copy AA seq copy Nt seq
H9D14_RS10900 WP_126241403.1 | 2694967 - 2708619 (+) | non-ribosomal peptide synthetase |  |  | copy AA seq copy Nt seq
H9D14_RS10905 WP_017921608.1 | 2708634 - 2708828 (+) | MbtH family protein |  |  | copy AA seq copy Nt seq
H9D14_RS10910 WP_105850355.1 | 2708955 - 2709377 (+) | nuclear transport factor 2 family protein |  |  | copy AA seq copy Nt seq
H9D14_RS10915 WP_013690732.1 | 2709467 - 2709952 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
H9D14_RS10920 WP_126241845.1 | 2710032 - 2710874 (-) | ferritin-like domain-containing protein |  |  | copy AA seq copy Nt seq
H9D14_RS10925 WP_126241404.1 | 2711305 - 2712435 (+) | 3-oxoacyl-ACP synthase |  |  | copy AA seq copy Nt seq
H9D14_RS10930 WP_126241405.1 | 2712425 - 2713621 (+) | PLP-dependent decarboxylase |  |  | copy AA seq copy Nt seq
H9D14_RS10935 WP_105852536.1 | 2713632 - 2715215 (+) | acyl-CoA ligase (AMP-forming), exosortase A system-associated |  |  | copy AA seq copy Nt seq
H9D14_RS10940 WP_241238502.1 | 2715212 - 2716327 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
H9D14_RS10945 WP_126241406.1 | 2716324 - 2718171 (+) | acyl-CoA dehydrogenase |  |  | copy AA seq copy Nt seq
H9D14_RS10950 WP_105857830.1 | 2718173 - 2719534 (+) | citrate/2-methylcitrate synthase |  |  | copy AA seq copy Nt seq
H9D14_RS10955 WP_013690740.1 | 2719578 - 2720240 (+) | class I SAM-dependent methyltransferase |  |  | copy AA seq copy Nt seq
H9D14_RS10960 WP_036055807.1 | 2720244 - 2721317 (+) | TauD/TfdA family dioxygenase |  |  | copy AA seq copy Nt seq
H9D14_RS10965 WP_126241407.1 | 2721375 - 2721767 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
H9D14_RS10970 WP_241238503.1 | 2721889 - 2723004 (+) | flavodoxin family protein |  |  | copy AA seq copy Nt seq
H9D14_RS10975 WP_036055804.1 | 2723223 - 2724359 (+) | glutathione-independent formaldehyde dehydrogenase |  |  | copy AA seq copy Nt seq
H9D14_RS10980 WP_036055803.1 | 2724696 - 2725346 (+) | uracil-DNA glycosylase family protein |  |  | copy AA seq copy Nt seq
H9D14_RS10985 WP_155296550.1 | 2725352 - 2725492 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
H9D14_RS10990 WP_126241408.1 | 2725566 - 2725883 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
H9D14_RS10995 WP_160294106.1 | 2726115 - 2726627 (-) | BON domain-containing protein |  |  | copy AA seq copy Nt seq
H9D14_RS11000 WP_103692582.1 | 2726810 - 2727892 (+) | catalase family protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2024-05-14
MIBiG v4 annotathon

- (ID: JYES6HFUFY5A364LX52FGPY5)
- (ID: MGLE5JJ3S32DQA3YR5WPYH4W)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Entry added

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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