BGC0002340: pyrroloformamide A biosynthetic gene cluster from Streptomyces sp. CB02980
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Location: 1 - 28,112 nt. (total: 28,112 nt).
This entry is originally from NCBI GenBank JACSCH020000013.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002340
Short description pyrroloformamide A biosynthetic gene cluster from Streptomyces sp. CB02980
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • other (other)
Loci
JACSCH020000013.1
1 - 28112
via Knock-out studies
Compounds
  • pyrroloformamide A
  • pyrroloformamide B
  • pyrroloformamide D
  • pyrroloformamide C
Species Streptomyces sp. CB02980 [taxonomy]
References
Chemical products information
pyrroloformamide A Evidence:
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Chemical database entries
NPAtlas
pyrroloformamide B Evidence:
(no structure information available)
pyrroloformamide D Evidence:
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Chemical database entries
NPAtlas
pyrroloformamide C Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • E0F75_025300
  • MCB8905699.1
 195 - 992 (+) putative protein N(5)-glutamine methyltransferase
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    • E0F75_025305
    • MCB8905700.1
    		 1085 - 1723 (-) NAD(P)H-dependent oxidoreductase
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      • E0F75_025310
      • MCB8905701.1
      		 1886 - 2785 (+) shikimate dehydrogenase
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        • E0F75_025315
        • MCB8905702.1
        		 2782 - 3630 (+) metallophosphoesterase
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          • E0F75_025320
          • MCB8905703.1
          		 3627 - 4331 (+) 4'-phosphopantetheinyl transferase superfamily protein
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            • E0F75_025325
            • MCB8905704.1
            		 4563 - 4982 (+) ASCH domain-containing protein
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              • E0F75_025330
              • MCB8905705.1
              		 5051 - 5728 (-) GAP family protein
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                • E0F75_025335
                • MCB8905706.1
                		 5952 - 6962 (+) NAD(P)/FAD-dependent oxidoreductase
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                  • E0F75_025340
                  • MCB8905707.1
                  		 7032 - 7634 (-) XRE family transcriptional regulator
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                    • E0F75_025345
                    • MCB8905708.1
                    		 7872 - 9032 (-) acyl-CoA dehydrogenase family protein
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                      • E0F75_025350
                      • MCB8905709.1
                      		 9036 - 9791 (-) thioesterase
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                        • E0F75_025355
                        • MCB8905710.1
                        		 9788 - 11428 (-) GMC family oxidoreductase N-terminal domain-containing protein
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                          • E0F75_025360
                          		 11503 - 14778 (-) amino acid adenylation domain-containing protein
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                            • E0F75_025365
                            • MCB8905711.1
                            		 15044 - 15637 (+) flavoprotein
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                              • E0F75_025370
                              • MCB8905712.1
                              		 15755 - 16162 (-) RidA family protein
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                                • E0F75_025375
                                • MCB8905713.1
                                		 16224 - 17687 (-) FAD-dependent oxidoreductase
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                                  • E0F75_025380
                                  • MCB8905714.1
                                  		 17830 - 18579 (-) methyltransferase
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                                    • E0F75_025385
                                    • MCB8905715.1
                                    		 18664 - 19941 (-) MFS transporter
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                                      • E0F75_025390
                                      • MCB8905716.1
                                      		 20258 - 20770 (-) group II truncated hemoglobin
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                                        • E0F75_025395
                                        • MCB8905717.1
                                        		 20831 - 21715 (-) AfsR/SARP family transcriptional regulator
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                                          • E0F75_025400
                                          • MCB8905718.1
                                          		 22056 - 23021 (-) methyltransferase domain-containing protein
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                                            • E0F75_025405
                                            • MCB8905719.1
                                            		 23018 - 23875 (-) thioesterase
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                                              • E0F75_025410
                                              • MCB8905720.1
                                              		 23872 - 24480 (-) hypothetical protein
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                                                • E0F75_025415
                                                • MCB8905721.1
                                                		 24951 - 28112 (+) DUF2791 family P-loop domain-containing protein
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                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  Unk01
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  E0F75_025360
                                                  Substrates
                                                  cysteine (evidence: Structure-based inference, Feeding study)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Annotation changelog

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Added chemical structures for compounds: pyrroloformamide A.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-10-07
                                                  Added NPAtlas links to compounds: pyrroloformamide A.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Entry added
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Added NRP substrate specificities
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Detailed domain annotation
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